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Spinal lesions: a comprehensive radiologic overview.

Spinal lesions encompass a diverse range of pathologies, including primary and secondary tumors, infectious processes, vascular malformations, traumatic injuries, and degenerative conditions, each with distinct imaging characteristics crucial for accurate diagnosis and management. Imaging plays vital roles in assessing lesion morphology, anatomical localization, and neurological impact, guiding clinical decision-making and therapeutic planning. This review systematically explores spinal lesions based on their anatomical compartments, highlighting key radiological features and providing a compr

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… Sagittal T2 PROP (A) , coronal T1 FLAIR + C (B) , sagittal T1 FLAIR FAT + C (C) , and axial 3D FSPGR Fat + C (D) MRI of the cervical spine showing C5-C6 cord compression (yellow arrow) resulting from posterior disc/osteophyte complex herniation. …

EANM guidelines on the use of [18F]FDG PET/CT in diagnosis, staging, prognostication, therapy assessment, and restaging of plasma cell disorders.

We provide updated guidance and standards for the indication, acquisition, and interpretation of [18F]FDG PET/CT for plasma cell disorders. Procedures and characteristics are reported and different scenarios for the clinical use of [18F]FDG PET/CT are discussed. This document provides clinicians and technicians with the best available evidence to support the implementation of [18F]FDG PET/CT imaging in routine practice and future research.

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… Additionally, significant focal inflammatory uptake may be observed in tendons, osteophytes, and arthrosic degeneration. In such cases, low-dose computed tomography (LDCT) images can be helpful for accurate assessment. …

Rapid Fire Presentations

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… Associated pathologies, such as calcified discs or osteophytes, and spinal longitudinal extradural collection (SLEC) were analyzed. All patients underwent microscopic, open, posterior, intradural primary surgical repair of leak with intraoperative neuromonitoring. …

E-Posters

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… Cervical spondylosis, characterized by osteophytes in the cervical spine, can compress the esophagus, leading to swallowing difficulties. … The technique of direct decompression should include peculiar L5 osteophyte removal and should be evolved by new microscopic techniques. …

Oral Presentations

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Algae-Derived Bioactive Compounds as Platforms for Translational Biotechnology and Health Applications.

Marine macroalgae, microalgae, and associated microorganisms are increasingly recognised as valuable sources of bioactive compounds with applications across biotechnology and health. The environmental and ecological conditions they inhabit shape their metabolite diversity, leading to the production of high-value compounds such as sulphated polysaccharides, lipids, pigments, phenolics, and peptides. These compounds exhibit conserved biological activities that underpin potent antioxidant, anti-inflammatory, cytotoxic, and pro-regenerative effects with strong potential for translation. Although e

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… Pioneering work from Murphy et al. [ 169 ] showed amelioration of the osteoarthritic joint environment after intra-articular injection of autologous MSCs: typical signs of OA progression such as cartilage erosion, osteophyte formation, and subchondral sclerosis were significantly less evident in the …

Е-постеры.

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… We categorized patients into 3 groups according to the radiographic grading of bone loss—Group N: no bone loss; Group 1: diminish of the anterior osteophyte or minimal bone loss not extending beyond the anterior keel line; Group 2: significant bone loss that extending pass the anterior keel line. …

Nucleic acid aptamers in orthopedic diseases: promising therapeutic agents for bone disorders.

Precision medicine has become a cornerstone in modern therapeutic strategies, with nucleic acid aptamers emerging as pivotal tools due to their unique properties. These oligonucleotide fragments, selected through the Systematic Evolution of Ligands by Exponential Enrichment process, exhibit high affinity and specificity toward their targets, such as DNA, RNA, proteins, and other biomolecules. Nucleic acid aptamers offer significant advantages over traditional therapeutic agents, including superior biological stability, minimal immunogenicity, and the capacity for universal chemical modificatio

Proceedings of the RAMI Intern Section Meeting.

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Biomimetic materials for medical applications.

AbstractRecent advances in biomedical research have facilitated the exploration of biomimetic materials and their potential for diagnosing and treating diseases. This review synthesizes reports of recent research into biomimetic materials and provides a focused analysis of their therapeutic and diagnostic efficacy across multiple physiological systems, including the locomotor, digestive, respiratory, urinary, endocrine, nervous, integumentary, hematopoietic, and circulatory systems. These findings highlight the transformative potential of these materials in the management of systemic diseases.

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… Abnormal biomechanics, subchondral bone sclerosis, and synovial inflammation cause joint space narrowing and osteophyte formation, leading to severe pain and loss of function. …

Всемирный конгресс по болезням остеопороза, остеоартрита и мускулоскелета 2025).

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Электронные постеры

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Chest and Mediastinum

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… Lateral displacement results from osteophytes, elongated aorta or aneurysm, dilated azygous, and vertebral or paraspinal soft tissue masses (e.g., abscess, lymph nodes, extramedullary haematopoiesis, etc.). …

Targeting strategies for bone diseases: signaling pathways and clinical studies.

Since the proposal of Paul Ehrlich's magic bullet concept over 100 years ago, tremendous advances have occurred in targeted therapy. From the initial selective antibody, antitoxin to targeted drug delivery that emerged in the past decades, more precise therapeutic efficacy is realized in specific pathological sites of clinical diseases. As a highly pyknotic mineralized tissue with lessened blood flow, bone is characterized by a complex remodeling and homeostatic regulation mechanism, which makes drug therapy for skeletal diseases more challenging than other tissues. Bone-targeted therapy has b

Biology and Diseases of Dogs

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Diseases of the Nervous System

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Oral Presentations

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Oral Presentations

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Oral Presentations

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Extracellular matrix dysregulation in aging, calcification, and cancer diseases: insights into cellular senescence, inflammation, and novel therapeutic strategies.

This review underscores the dynamic role of the extracellular matrix (ECM) in regulating cellular behavior and maintaining tissue homeostasis, highlighting its pivotal involvement in aging, calcification, and cancer diseases. In healthy tissues, controlled ECM remodeling provides essential biochemical and mechanical cues, but dysregulation (driven by chronic inflammation, cellular senescence, and altered intercellular communication) leads to fibrosis, calcification, and the creation of a pro-tumorigenic microenvironment. Senescent cells contribute to these changes through senescence-associated