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Italian Real-Life Experience of Patients with Hereditary Transthyretin Amyloidosis Treated with Patisiran.

Hereditary transthyretin amyloidosis (ATTRv) is a multisystemic, rare, inherited, progressive and adult-onset disease, affecting the sensorimotor nerves, heart, autonomic function and other organs. The actual scenario of pharmaceutical approaches for ATTRv amyloidosis includes five main groups: TTR stabilizers, TTR mRNA silencers, TTR fibril disruptors, inhibitor of TTR fibril seeding and gene therapy. Patisiran is a small, double-stranded interfering RNA encapsulated in a lipid nanoparticle, able to penetrate into hepatocytes, where it selectively targets TTR mRNA, reducing TTR production. We

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… Besides, a worsening of vibratory sensation in upper limbs with hypopallesthesia up to his elbows and of proprioception with akinesthesia in the toes was observed. The total NIS score was 65.25 and the PND score was IIIa. …

Гипоксия в множестве склерозов.

Низкая доступность кислорода (гипоксии) является заметной, но плохо понимаемой особенностью множественного склероза (МС). Неизвестно, вызывает ли гипоксия патологию и симптомы MS или она является следствием других патологических явлений, таких, как воспаление и сосудистая дисфункция. Здесь мы резюмируем имеющуюся литературу о взаимосвязи между гипоксией и как патологическими, так и симптомными характеристиками MS. Острая экологическая гипоксия (т.е. высота) может вызвать или облегчить события, связанные с MS, возможно, путем усиления гипоксии тканей в центральной нервной системе. Соответственн

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… Diagnosis of MS The diverse symptomatic manifestations of MS include motor symptoms (limb-weakness, paroxysmal symptoms, rubral tremor), fatigue and depression, paresthesia (sensory abnormalities on the skin like numbness, burning, tingling or itching; sensation of vibration in the feet; impaired proprioception …

Neuropsychiatric Adverse Events with Monoclonal Antibodies Approved for Multiple Myeloma: An Analysis from the FDA Adverse Event Reporting System.

Background/Objectives: Monoclonal antibodies (mAbs) have revolutionized multiple myeloma (MM) treatment. However, post-marketing data on their neuropsychiatric safety are limited. This study aimed to evaluate neuropsychiatric adverse events (AEs) related to mAbs used for MM through a retrospective pharmacovigilance analysis using the Food and Drug Administration (FDA) Adverse Events Reporting System (FAERS) database. Methods: Individual case safety reports (ICSRs) from 2015 to 2023 with at least one neuropsychiatric AE and one of the MM-approved mAbs as the suspected drug (i.e., daratumumab, e

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… 3.17) | Uk (peripheral sensory neuropathy) Pleocytosis | 4 | 11.42 (4.25–30.68) | 3.72 (1.95–4.8) | No VI th nerve paralysis | 4 | 6.48 (2.42–17.35) | 2.95 (1.19–4.03) | Uk (nerve damage causing tingling, numbness or pain) Cerebellar haemorrhage | 4 | 3.04 (1.14–8.11) | 1.97 (0.2–3.04) | No Loss of proprioception …

The Effect of Exercise-Based Interventions on Health-Related Quality of Life of Patients with Hematological Malignancies: A Systematic Review and Meta-Analysis.

Background/Objectives: Hematological cancers encompass a collection of heterogeneous conditions. The need for repeated treatments and prolonged hospitalization leads to a decrease in health-related quality of life. This systematic review and meta-analysis evaluate the effect of exercise interventions on functioning scales, global health status, and symptoms in patients with hematological cancers. Methods: PubMed, Web of Science, and Scopus databases were systematically screened, and randomized controlled trials were included. The primary outcome was health-related quality of life assessed thro

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… Exercise” OR “Physical Exercise” OR “Exercise Therapy” OR “Resistance Training” OR “Walking” OR “Circuit-Based Training” OR “Strength Training” OR “Weight-Bearing Exercise” OR “Aerobic Training” OR “Cardiorespiratory Training” OR “Endurance Training” OR “Exercise Prescription” OR “Muscle Strength” OR “Proprioception …

Infectious Diseases

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

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… (iritis, Argyll Robertson pupil), bones/soft tissues (gummas), and neurologic system (general paresis, a rapidly progressive dementia with psychotic features and tabes dorsalis which affects posterior columns of the spinal cord and the dorsal roots, leading to pain episodes, decreased vibration and proprioception … )—erysipelas, cellulitis DEEP SOFT TISSUE INFECTIONS —necrotizing fasciitis (polymicrobial, S. pyogenes ), gas gangrene ( C. perfringens ) Pathophysiology RISK FACTORS FOR CELLULITIS compromised skin —trauma, IDU, psoriasis, eczema, fungal disease (especially tinea pedis) compromised sensory / proprioceptive …

Оценка киберзаболевания в бессмертных виртуальных средах: систематический обзор с последствиями для неврологической реабилитации.

Введение. Распространение виртуальных технологий виртуальной реальности (ВР) изменило характер взаимодействия людей с цифровой средой, открывая беспрецедентные возможности в различных областях: от развлечений и образования до здравоохранения и лечения психических заболеваний. Велосипедный VR все чаще внедряется в моторные и когнитивные программы в нейро-абилитации, где крайне важно обеспечить безопасность пациентов и соблюдение курса лечения. Несмотря на свою актуальность, концептуализация и измерение киберболезни (КШ) остаются фрагментированными в разных дисциплинах, при этом различные инстру

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… They highlighted four main domains: (a) Balance: Perceiving and controlling movement requires the integration of multisensory signals (vision, hearing, proprioception, and vestibular sense) to obtain accurate information about the body in space. …

Chemotherapy-Induced Peripheral Neuropathy (CIPN): A Narrative Review and Proposed Theoretical Model.

BackgroundChemotherapy-induced peripheral neuropathy (CIPN) is a common and debilitating symptom experienced by cancer survivors. Despite the burden of CIPN-related symptoms, interventions remain limited.ObjectivesThis narrative review seeks to propose a framework for CIPN predisposing, precipitating, and perpetuating factors (3Ps), which will provide a foundation for future research and clinical interventions aimed at mitigating CIPN-related symptoms and morbidity.MethodsA comprehensive literature search was performed using PubMed, guided by keywords related to "chemotherapy-induced periphera

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… CIPN is characterized by a variety of sensory and motor symptoms, including burning/shooting pain, numbness, tingling, a reduced sense of touch, reduced proprioception, weakness, poor balance, and deficits in fine motor skills [ 3 ]. …

Magnetic Resonance Imaging in 50 Captive Non-domestic Felids - Technique and Imaging Diagnoses.

Magnetic resonance imaging (MRI) is the recognized gold standard for diagnostic imaging of the central nervous system in human and veterinary patients. Information on the use of this modality and possible imaging abnormalities in captive non-domestic felids is currently limited to individual case reports or small case series. This retrospective study provides information on technique and imaging findings in a cohort of cases undergoing MRI at an academic Veterinary Medical Center. The University of Tennessee College of Veterinary Medicine MRI database was searched for non-domestic felids under

От удобства использования до клинического воздействия: систематический обзор цифровых технологий для реабилитации движений у пациентов с множественной скlerозом.

ОБЪЕКТ: Систематический обзор удобства использования, приемлемости и предварительного клинического влияния цифровых интервенций по восстановлению двигательной функции в группе людей с множественной склерозом (ПМС).МЕТОДЫ: Систематический поиск литературы был проведен в PubMed, Scopus, Embase и Web of Science до июня 2025 года для идентификации исследований, оценивающих удобство использования в контексте цифровых платформ, используемых для моторной реабилитации. Включены только исследования, участвовавшие в pwMS. РЕЗУЛЬТАТЫ: Включено девять исследований. Вмешательства использовали кинетон-бази

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… These aspects are critical in populations with neurological disorders, who often face cognitive, sensory, or motor limitations that may interfere with system interaction, such as reduced proprioception or motor control, cognitive slowing or attentional deficits, and sensory processing impairments, all …

Understanding and Managing Fracture Risk in Patients With Cancer: A Literature Review.

One of the most important complications of cancer and its treatments is the increased fracture risk. Fractures can have a significant impact on the patient's quality of life and may be associated with morbidity, mortality, and reduced functional status. The present study aims to investigate the mechanisms underlying the increased risk of fractures in cancer patients, the effect of cancer treatments on fracture risk, and strategies to prevent fractures in this population. This is a literature review using the PubMed - National Center for Biotechnology Information (NCBI), Web of Science, Cochran

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… Some chemotherapy drugs can cause peripheral neuropathy, affecting sensation and proprioception, making it more difficult for patients to maintain balance and avoid falls [ 41 ]. …

Assessment of Psychiatric Disorders in Consultation-Liaison Setting.

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

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… ophthalmological and neurological workup (visual evoked potential) is a must | NOVL[ 23 ]–in either visual acuity or field loss – should be a diagnosis of exclusion after detailed ophthalmological evaluation | Optokinetic Nystagmus is often a differentiating feature for organic lesion | Altered test of proprioception …

A review of neurotoxicities associated with immunotherapy and a framework for evaluation.

Immuno-oncology agents, including immune checkpoint inhibitors (ICIs) and chimeric antigen receptor T (CAR-T) cell therapies, are increasing in use for a growing list of oncologic indications. While harnessing the immune system against cancer cells has a potent anti-tumor effect, it can also cause widespread autoimmune toxicities that limit therapeutic potential. Neurologic toxicities have unique presentations and can progress rapidly, necessitating prompt recognition. In this article, we review the spectrum of central and peripheral neurologic immune-related adverse events (irAEs) associated

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… Motor weakness with paraparesis and gait difficulty is present in nearly all reported cases; other common symptoms included sensory deficits, sphincter dysfunction, and proprioception loss. 25 , 28 Recommended work-up includes MRI of the brain and spine, LP, and autoantibody evaluation. 25 , 28 Diagnostic …

Иммунитет в нейромодуляции: исследование нейронных и иммунных путей в расстройствах мозга.

Иммунитет четко регулирует функцию мозга. Она непосредственно участвует в патологических процессах таких нейродегенеративных заболеваний, как болезнь Паркинсона и Альцгеймера, посттравматические заболевания, множественный склероз, травма головного мозга и психические расстройства (большое расстройство организма, серьезное депрессивное расстройство (МДС), расстройства тревожности, расстройства психоза и шизофрения, а также расстройства нервного развития (НРД). Нейромодулирование в настоящее время является одной из ведущих терапевтических стратегий лечения этих расстройств, однако пока мало что

Obesity and Cancer Rehabilitation for Functional Recovery and Quality of Life in Breast Cancer Survivors: A Comprehensive Review.

Obesity is a global health challenge with increasing prevalence, and its intricate relationship with cancer has become a critical concern in cancer care. As a result, understanding the multifactorial connections between obesity and breast cancer is imperative for risk stratification, tailored screening, and rehabilitation treatment planning to address long-term survivorship issues. The review follows the SANRA quality criteria and includes an extensive literature search conducted in PubMed/Medline, Web of Science, and Scopus. The biological basis linking obesity and cancer involves complex int

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… The vibrational stimulus delivered through these platforms has demonstrated benefits in enhancing bone density and joint proprioception, potentially alleviating small joint pain and discomfort experienced by patients on aromatase inhibitors [ 63 , 115 ]. …

Peripheral neuropathy associated with monomethyl auristatin E-based antibody-drug conjugates.

Since the successful approval of gemtuzumab ozogamicin, antibody-drug conjugates (ADCs) have emerged as a pivotal category of targeted therapies for cancer. Among these ADCs, the use of monomethyl auristatin E (MMAE) as a payload is prevalent in the development of ADC drugs, which has significantly improved overall therapeutic efficacy against various malignancies. However, increasing clinical observations have raised concerns regarding the potential nervous system toxicity associated with MMAE-based ADCs. Specifically, a higher incidence of peripheral neuropathy has been reported in ADCs inco

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… Additionally, spontaneous burning, radiation, shock pain, mechanical/thermal dysalgesia, or hyperalgesia may be experienced. 88 Conversely, motor symptoms are relatively infrequent and milder, presenting as mild weakness in the lower limbs and reduced or absent ankle reflexes. 13 , 89 Furthermore, altered proprioception …

Long-Term Outcomes of Pituitary Gland Preservation in Pituitary Macroadenoma Apoplexy: Case Series and Review of the Literature.

Introduction  For patients presenting with neurological changes from pituitary tumor apoplexy, urgent surgical intervention is commonly performed for diagnosis, tumor resection, and optic apparatus decompression. Although identification and preservation of the pituitary gland during the time of surgery can be challenging, it may lead to improve endocrine outcomes. Methods  A retrospective case series of all patients with macroadenomas presenting with apoplexy at Loyola University Medical Center from 2016 to 2018 was studied. Demographic, radiographic, and intraoperative characteristics were co

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… decreased descending inhibitory modulation of pain. 28 – 34 , 89 , 90 Although subtle pathological changes in peripheral and central nervous system are hard to be confirmed clinically, they still may explain sensory and neurological abnormalities including mechanical hyperalgesia and allodynia and loss of proprioception …

Спортивные представления в виртуальных мирах: систематический обзор спортивной имитации у неврологических паралимпийских спортсменов и неатлетических групп населения.

СВЯЗЬ: виртуальная реальность спорт-симулирования (ВР) может воспроизвести специфические для спорта ограничения в восприятии-моторе с тунцом и дополнительной обратной связью, открывая потенциальный мост от клиники до конкуренции для людей с неврологическими условиями. Мы систематически проводили оценку того, способствует ли погруженная и неимперативная спортивная имитация VR совершенствованию функции, связанной со спортом, обеспечивает ли она адекватную аэробную дозу и является ли она безопасной по сравнению с соответствующими компараторами. МЕТОДЫ: Мы проверили шесть баз данных с момента созд

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… intermittent loss of precision Table‑tennis returns; goalball blocks; virtual rifle/archery stability Predictable→stochastic timing; frequency‑matched tasks; external focus; low‑latency HMDs Hit rate; reaction time; movement variability indices Med‑on/off scheduling; fatigue breaks Sensory loss/neuropathy/proprioception … loss of precision | Table‑tennis returns; goalball blocks; virtual rifle/archery stability | Predictable→stochastic timing; frequency‑matched tasks; external focus; low‑latency HMDs | Hit rate; reaction time; movement variability indices | Med‑on/off scheduling; fatigue breaks Sensory loss/neuropathy/proprioception …

Virtual Reality-Based Exercise Rehabilitation in Cancer-Related Dysfunctions: Scoping Review.

BackgroundVirtual reality-based exercise rehabilitation (VRER) is a promising intervention for patients with cancer-related dysfunctions (CRDs). However, studies focusing on VRER for CRDs are lacking, and the results are inconsistent.ObjectiveWe aimed to review the application of VRER in patients with CRDs.MethodsThis scoping review was conducted following the PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews) checklist framework. Publications were included from the time of database establishment to October 14, 2023. The databases were

Modulation by Ozone Therapy of Oxidative Stress in Chemotherapy-Induced Peripheral Neuropathy: The Background for a Randomized Clinical Trial.

(1) Background: Chemotherapy-induced peripheral neuropathy (CIPN) decreases the quality of life of patients and can lead to a dose reduction and/or the interruption of chemotherapy treatment, limiting its effectiveness. Potential pathophysiological mechanisms involved in the pathogenesis of CIPN include chronic oxidative stress and subsequent increase in free radicals and proinflammatory cytokines. Approaches for the treatment of CIPN are highly limited in their number and efficacy, although several antioxidant-based therapies have been tried. On the other hand, ozone therapy can induce an ada

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… Taxanes typically cause a sensory neuropathy, mostly affecting small diameter sensory fibers, described as paresthesia, numbness, neuropathic pain or altered proprioception, and loss of ability, predominantly in feet and/or hands (stocking-and-glove distribution). …

Paraneoplastic Neuropathies: What's New Since the 2004 Recommended Diagnostic Criteria.

The diagnostic criteria published by the PNS (Paraneoplastic Neurological Syndromes) Euronetwork in 2004 provided a useful classification of PNS, including paraneoplastic neuropathies. Subacute sensory neuronopathy (SSN) was the most frequently observed peripheral PNS, whereas other forms of neuropathy, as sensory polyneuropathy, sensorimotor polyneuropathy, demyelinating neuropathies, autonomic neuropathies, and focal nerve or plexus lesions, were less frequent. At the time of publication, the main focus was on onconeural antibodies, but knowledge regarding the mechanisms has since expanded.

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… Clinically they had a subacute, asymmetric presentation with sensory (e.g., paresthesias and impaired proprioception) and motor signs, as asymmetric weakness, and long tract signs. Pain and bladder dysfunction were frequent clinical findings. …