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Needs assessment for novel Gram-negative antibiotics in US hospitals: a retrospective cohort study.

BACKGROUND: Evidence-based needs assessments for novel antibiotics against highly-resistant Gram-negative infections (GNIs) are scarce. We a … quating to 210·7 DOT per 10 000 encounters. DTR Stenotrophomonas maltophilia, Burkholderia spp, and Achromobacter spp represented less than 1 DOT per 10 000 encounters each. The estimated need for DTR-GNI-targeted antibiotics saw minor contributions by outbreaks and varied from 0·5 to 73·1 DOT per 10 000 encounters by hospital type. INTERPRETATION: Suspected o …

Multiple drug-resistant Alcaligenes xylosoxidans keratitis in a sanitation worker.

PURPOSE: To report a case of daily wear soft contact lens-associated keratitis caused by Alcaligenes xylosoxidans in a portable toilet sanitation worker. METHODS: A previously healthy 30-year-old man presented with bilateral decreased vision, redness, and irritation, beginning 1 week earlier. The patient had been treated with moxifloxocin for 1 week before presentation without improvement. Bacterial staining cultures were performed from corneal scrapings, contact lenses, contact lens case, and solution. Preliminary culture results and antibiotic sensitivities were generated using an automated

Effects of Dietary Application of the Probiotic Lactobacillus paracasei N1115 on Growth, Hepatic Antioxidant and Immune Biomarkers, and Intestinal Microbiota and Histology of Hybrid Sturgeon (Acipenser baerii ♀ × A. schrenckii ♂).

The objective of this study was to investigate the effects of incorporating Lactobacillus paracasei N1115 (LP N1115) into the diet on growth … s (Lactobacillus, Candidatus Arthromitus, and Bifidobacterium) and a reduction in harmful bacteria (Achromobacter) at the genus level. Fish fed 0.03% LP and 0.30% LP diets had significantly higher survival rates at 96 h under ammonia stress compared to the control group (77.78% and 66.67% versus 55.56%) (p < 0.05). In conclusion, dietary LP N1115 supplementatio …

Quality Control Testing for Tracking Endotoxin-Producing Gram-Negative Bacteria during the Preparation of Polyvalent Snake Antivenom Immunoglobulin.

UNLABELLED: Snake bites represent a serious public health problem, particularly in rural areas worldwide. Antitoxic sera preparations are an … owed by surfaces (37.5%) and then personnel (14%). The most common bacterial isolates detected were Achromobacter xylosoxidans, Ochrobactrum anthropi, and Pseudomonas aeruginosa, which together with Burkholderia cepacia were both also detected in cleaning water and certain equipment parts. A heavy bacterial growth with no fungal contamination was observed in al …

The hospital sink drain biofilm resistome is independent of the corresponding microbiota, the environment and disinfection measures.

In hospitals, the transmission of antibiotic-resistant bacteria (ARB) may occur via biofilms present in sink drains, which can lead to infec … a, and Gram-positive Staphylococcus, while the NICU SDBs were dominated by the Gram-negative genera Achromobacter, Serratia, and Acidovorax, as well as the Gram-positive genera Weisella and Lactiplantibacillus. In contrast, the resistome of the SDBs exhibited no significant differences between the two ICUs, indicating that the abundance of ARGs and MGEs is inde …

Pneumonia in the Cancer Patient

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… Other nonfermentative Gram-negative bacteria (NF-GNB) such as Stenotrophomonas maltophilia [ 12 – 15 ], Achromobacter, and Alcaligenes species have also increased in the recent years and often lead to difficult-to-treat infections [ 14 , 16 ]. … Recently, other NF-GNB such as Stenotrophomonas , Burkholderia , Chryseobacterium , Achromobacter , and Alcaligenes species have been increasingly recognized as etiologic agents in both CAP and nosocomial infections [ 16 , 17 ]. …

Epidemiology of infections in cancer patients.

Although major advances in the care of cancer patients over the past several decades have resulted in improved survival, infectious complications remain a significant cause of morbidity and mortality. To successfully identify, treat, and prevent infections, a comprehensive understanding of risk factors that predispose to infection and of commonly encountered pathogens is necessary. In addition, clinicians must keep abreast of the changing epidemiology of infections in this population. As therapeutic modalities continue to evolve, as established pathogens become increasingly drug resistant, and

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… Achromobacter spp. and Alcaligenes spp. are gram-negative bacteria that are increasingly associated with infections in cancer patients. … Achromobacter xylosoxidans was the most common pathogen (94 %), followed by Achromobacter denitrificans (4 %) and A lcaligenes faecalis (2 %). The majority of patients had infected intravascular catheters, followed by pneumonia and urinary tract infections. …

Respiratory Tract Infections: Sinusitis, Bronchitis, and Pneumonia

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… Recently, other non-lactose fermenting (NF)-GNB such as Stenotrophomonas , Burkholderia , Chryseobacterium , Achromobacter , and Alcaligenes species have been increasingly recognized as etiologic agents in both CAP and nosocomial infections [ 64 ]. … Bacteremia caused by Achromobacter and Alcaligenes species in 46 patients with cancer (1989–2003) Cancer. 2004;101:2134–2140. doi: 10.1002/cncr.20604. 65. Patterson TF, Kirkpatrick WR, White M, Hiemenz JW, Wingard JR, Dupont B, et al. Invasive aspergillosis. …

Resolution of long standing hypergammaglobulinemic purpura of Waldenström after initiating treatment for cystic fibrosis with Elexacaftor-Tezacaftor-Ivacaftor.

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… Case report A 27-year-old woman with CF, severe lung disease, with chronic pulmonary Staphylococcus aureus and Achromobacter xylosoxidans infection presented with a 6-year history of recurrent purpuric rash of the lower extremities accompanied by pain and burning sensation, which were exacerbated by …

Sphingobacterium multivorum cellulitis: case report and mini-review.

BACKGROUND: Sphingobacterium multivorum is a gram-negative, non-fermentative, oxidase-positive, catalase-positive bacillus. S multivorum has been identified in urinary tract infections, respiratory tract infections, spontaneous peritonitis, septic arthritis, meningitis, bacteraemia and septic shock. Ours is the second case of skin and soft tissue infection sustained by S. multivorum (a case of necrotizing fasciitis with septic shock has been previously reported). In this paper, we furnish a review of the literature on all the cases of S multivorum described in the medical literature (with the

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… Acinetobacter, achromobacter, alcaligenes, Moraxella, methylobacterium and other nonfermentative gram-negative rods; p. 539. 4. Mendonça R.G., Olival G.S., Mimica L.M., et al. Potential infeccioso do transporte publico de passageiros da cidade de Sao Paulo. …

Long-Term Clinical Outcomes of Optimizing Combination Therapy for Primary Pulmonary Mucosa-Associated Lymphoid Tissue Lymphoma: A Retrospective Study.

INTRODUCTION: Pulmonary mucosa-associated lymphoid tissue (MALT) lymphoma progresses with advancing disease stage. However, no standard treatment approach has been established. This single-center retrospective study evaluated clinical and radiological characteristics, treatment modalities, and long-term prognosis of pulmonary MALT lymphoma. METHODS: The study included 42 patients diagnosed with pulmonary MALT lymphoma between October 2004 and July 2019. Primary therapeutic modalities were determined using modified Ann Arbor staging. Therapeutic response was evaluated via computed tomography a

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… Furthermore, we did not analyze the prevalence of Achromobacter xylosoxidans , which has been associated with the incidence of pulmonary MALT lymphoma, especially in European countries [ 23 ]. … Prevalence of Achromobacter xylosoxidans in pulmonary mucosa-associated lymphoid tissue lymphoma in different regions of Europe. Br J Haematol. 2014;164(6):804–10. …

Indwelling time of peripherally inserted central catheters and incidence of bloodstream infections in haematology patients: a cohort study.

BackgroundWe aimed to assess whether longer indwelling time of peripherally inserted central catheters (PICC) increases risk of central line associated bloodstream infections (CLABSI) in haematology patients.MethodsMulticentre retrospective cohort study among haematology patients receiving PICCs between 2013 and 2015. Occurrence of CLABSI based on CDC definitions was assessed. We calculated incidence rates, determined risk factors for CLABSI and used Poisson regression models to assess the risk of developing CLABSI as a function of PICC dwell time. We compared diagnoses and treatment character

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… . | 5 (5) Pseudomonas fluorescens | 4 (4) Serratia marcescens | 3 (3) Escherichia coli | 3 (3) Achromobacter spp. | 2 (2) Klebsiella pneumoniae | 2 (2) Pseudomonas putida | 2 (2) Pantoea spp. | 2 (2) Brevundimonas diminuta | 2 (2) Enterobacter cloacae/asburiae | 2 (2) Other (all n = 1)** | 15 (16) Risk …

Effect of Bacterial Nanocellulose with Chemisorbed Antiseptics on Alveolar Bone Repair in Rats Undergoing Bisphosphonate Therapy.

Objectives: This work investigated the effect of bacterial nanocellulose (BNC) alone or with chemisorbed chlorhexidine or povidone-iodine on post-tooth extraction repair in rats undergoing bisphosphonate therapy. Methods: Forty Wistar rats were treated with zoledronic acid, subjected to tooth extractions and allocated into groups according to the material inserted in the post-extraction socket: (1) BNC (n = 10); (2) BNC/Iodine (n = 10); (3) BNC/Chlorhex (n = 10); (4) Control (n = 10). Maxillae were dissected and macro- and microscopically analyzed. Results: Oral lesion frequency on macroscopic

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… BNC is a natural cellulose synthesized by gram-negative bacteria of the genera Komagataeibacter (Gluconacetobacter) , Agrobacterium , Achromobacter , Enterobacter , Rhizobium , Pseudomonas , Salmonella , Azotobacter and Alcaligenes , as well as gram-positive bacteria Sarcina ventriculi and Rhodococcus …

Bloodstream Infections in Hematologic Malignancy Patients With Fever and Neutropenia: Are Empirical Antibiotic Therapies in the United States Still Effective?

BackgroundRising antimicrobial resistance rates may impact the efficacy of empirical antibiotic treatment for febrile neutropenia in high-risk cancer patients. Lacking contemporary data about the epidemiology, antibiotic resistance patterns, and clinical outcomes from bloodstream infections (BSIs) in US cancer patients, it is unclear if current guidelines remain relevant.MethodsIn a cross-sectional study, 14 US cancer centers prospectively identified BSIs in high-risk febrile neutropenic (FN) patients, including those receiving chemotherapy for hematologic malignancies or hematopoietic stem ce

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… Bacterial Isolates Causing Bacteremia a Two Citrobacter freundii, 2 Serratia marcescens, 1 Pantoea agglomerans . b Three Achromobacter sp., 1 Acetobacter , 1 Capnocytophaga , 1 Moraxella catarrhalis , 1 Burkholderia cepacia . …

Поздние осложнения после Европейского агентства медицины - усовершенствованный антигенный приемник T-Cell терапия в гематологических злокачествах: обзор скопирования.

Лечение химерного антигенного рецептора T-клетка (CAR-T) значительно улучшило результаты лечения пациентов с гематологическими заболеваниями, связанными с B-клетками. Хотя острые и ранние токсичные вещества хорошо известны, поздние осложнения (ОС) по-прежнему плохо понимаются. Цель этого аналитического обзора заключалась в выявлении и картировании имеющихся данных о ЛК у взрослых пациентов с гематологическими заболеваниями, обработанных продуктами ЦАР-Т, утвержденными Европейским агентством по медицине (ЕМА). Были проведены обыски в Пубмеде, на веб-сайте науки и в Кокранской библиотеке на пред

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… Infectious; Cardiopulmonary and vascular; SMs; Other | Confirmed: >12–24 months after CAR-T therapy, reported separately for >12–18 and >18–24 months | 7/172 (4.1%); cumulative incidence 4.4% at 12 months and 6.3% at 24 months | 12 and 24 months | All infections: COVID-19 pneumonia ( n = 3), E. coli /Achromobacter …

Perspective Applications and Associated Challenges of Using Nanocellulose in Treating Bone-Related Diseases.

Bone serves to maintain the shape of the human body due to its hard and solid nature. A loss or weakening of bone tissues, such as in case of traumatic injury, diseases (e.g., osteosarcoma), or old age, adversely affects the individuals quality of life. Although bone has the innate ability to remodel and regenerate in case of small damage or a crack, a loss of a large volume of bone in case of a traumatic injury requires the restoration of bone function by adopting different biophysical approaches and chemotherapies as well as a surgical reconstruction. Compared to the biophysical and chemothe

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… Microorganisms The microorganism-derived nanocellulose (i.e., BNC or BC) ( Yuen et al., 2017 ) is mainly produced by the Gram-negative acetic acid bacteria belonging to genera Gluconacetobacter , Acetobacter , Sarcina , Salmonella , Achromobacter , Agrobacterium , Alcaligenes , Rhodobacter , Azotobacter …

Coexistence of Autoantibodies against the Golgi Complex and Ro52 Antigen in a Patient with Nonspecific Interstitial Pneumonia.

Nonspecific interstitial pneumonia (NSIP) is often associated with connective tissue diseases (CTD). The diagnosis of NSIP was confirmed in a 63-year-old man by high-resolution computed tomography and an open lung biopsy. Anti-Golgi complex autoantibodies (AGA) and anti-Ro52 antibodies were simultaneously detected at high concentrations. Autoantibodies to aminoacyl-tRNA synthetases (ARS) were negative. The patient was treated with corticosteroids for six months. During the seven-year follow-up, NSIP had a slow progression and patient had not developed the clinical features of CTD. The present

Prophylaxis and Empirical Therapy of Infection in Cancer Patients

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… Infusate contamination is a rare but possible event, and in this case, gram-negative rods, such as Klebsiella, Enterobacter, Citrobacter, Achromobacter, Serratia, and Pseudomonas (other than P. aeruginosa ), are more likely involved. …

Acute Pneumonia

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… The roles of Moraxella catarrhalis, Legionella, Chlamydia, and aerobic gram-negative rods including P. aeruginosa have been established. 63 , 64 , 65 Cystic fibrosis is commonly associated with Pseudomonas and staphylococcal pulmonary infections. 51 Burkholderia spp., Stenotrophomonas spp., Achromobacter …

ECC-4 Abstracts

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