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Epicatechin and quercetin exhibit in vitro antioxidant effect, improve biochemical parameters related to metabolic syndrome, and decrease cellular genotoxicity in humans.

Metabolic syndrome is a condition whose incidence has been increasing around the world. It promotes a metabolic state of chronic systemic inflammation, correlated to cellular stress and genetic mutations, and subsequently with deadly chronic diseases, such as type 2 diabetes mellitus, cardiovascular diseases, and cancer. A randomized placebo-controlled study (n = 156) was conducted to determine the effects of consuming an enriched bread with 0.05% of a 1:1 mixture of (-)-epicatechin and quercetin on anthropometric and biochemical parameters of the participants. As a result, total cholesterol, …

Optimization of iodine intake in Belgium.

Mild iodine deficiency (MID) is a long-standing problem in Belgium and was recognized only recently as public health issue by the Ministry of Health (MOH). The main MID-related health problems in Belgium are a high prevalence of thyroid nodules and multinodular goiter. The economic cost of thyroid nodular disease only in Belgium was estimated at about €40 millions per year. The Belgian health authorities adopted a selective strategy to optimize iodine intake through the fortification of bread with iodized salt. A progressive, step-by-step increase of the iodine content of salt was chosen in or…

TaNAM-6A is essential for nitrogen remobilisation and regulates grain protein content in wheat (Triticum aestivum L.).

Grain protein content (GPC) is a crucial quality trait in bread wheat, which is influenced by the key transcription factor TaNAM. However, the regulatory mechanisms of TaNAM have remained largely elusive. In this study, a new role of TaNAM was unveiled in regulating nitrogen remobilisation which impacts GPC. The TaNAM knockout mutants generated by clustered regularly interspaced short palindromic repeats/Cas9 exhibited significantly delayed senescence and lower GPC, while overexpression of TaNAM-6A resulted in premature senility and much higher GPC. Further analysis revealed that TaNAM directl…

CEA-targeted fluorescence endoscopy for the detection of high-grade dysplasia and early invasive rectal cancer: A proof-of-concept trial.

PURPOSE: Accurate recognition of high-grade dysplasia (HGD) and early invasive carcinoma (IC) within colorectal polyps is essential for sele … ng was performed using a rigid Quest-Olympus NIRF-endoscope, followed by ex vivo whole-specimen and bread-loaf imaging using the PEARL imaging system. The primary endpoint was the NIRF tumour-to-low-grade-dysplasia ratio (TDR; HGD/IC divided by LGD) performed on bread loafs, as this method enabled direct pathological correlation. Secondary endpoints inc …

Pasta Consumption and Cardiometabolic Risks in Older Adults with Overweight/Obesity: A Longitudinal Analysis.

OBJECTIVE: Low Glycemic Index (GI) diets improve cardiometabolic risk (CMR) specifically in those with insulin resistance. However, the pros … association with other outcomes. Additionally, substituting equivalent servings of pasta for white bread or white rice or potato was significantly associated with greater 2 y decreases in body weight and BMI. Replacing white bread with pasta was associated with higher 2 y reductions in WC. Replacing potato with pasta was associated with improvements in …

Lifestyle and chronic kidney disease: A machine learning modeling study.

BACKGROUND: Individual lifestyle varies in the real world, and the comparative efficacy of lifestyles to preserve renal function remains ind … y. RESULTS: During a median of the 11-year follow-up, 13,555 participants developed the CKD event. Bread, walking time, moderate activity, and vigorous activity ranked as the top four risk factors of CKD. A healthy lifestyle mainly consisted of whole grain bread, walking, moderate physical activity, oat cereal, and muesli, which have scored 12, 12, 10, …

Selected Probiotic Lactobacilli Have the Capacity To Hydrolyze Gluten Peptides during Simulated Gastrointestinal Digestion.

The aim of this study was to demonstrate the capacity of probiotic lactobacilli to hydrolyze immunogenic gluten peptides. Eighteen commercia … intestinal conditions, the pool of 10 selected probiotic lactobacilli strongly hydrolyzed the wheat bread gluten (ca. 18,000 ppm) to less than 10 ppm after 360 min of treatment. As determined by multidimensional chromatography (MDLC) coupled to nanoelectrospray ionization (nano-ESI)-tandem mass spectrometry (MS/MS), no known immunogenic peptides were de …

Диет и риск множественного склероза: доказательства с Biobank Nested Case-Control and Mendelian Randomization Analysis.

Генетические и экологические факторы совместно влияют на возникновение множественных склерозов (МС), среди которых диеты представляют значительный интерес в качестве потенциально изменяемого фактора. Было проведено исследование по вопросам контроля за конкретными случаями, в котором приняли участие 303 участника с MS и 1212 - совпадающих по возрасту и полу контроль из Биобанка Соединенного Королевства. Для оценки взаимосвязи между рационом питания и НР использовались модели условной логистической регрессии. Для изучения генетических связей между различными видами продуктов питания и риском, св

Совпадение в аннотации оригинала
Genetic and environmental factors jointly affect the onset of multiple sclerosis (MS), among which diet holds considerable interest as a pot … sing the Karlson-Holm-Breen method. Participants who regularly consumed oily fish and consumed more bread per week had a decreased risk of MS. Increased consumption of oily fish and cereal was genetically associated with a lower risk of MS. The association between oily fish intake and reduced risk of MS remained robust among several subgroups. Besides, …

Dietary Factors and Tinnitus among Adolescents.

The number of people suffering from constant tinnitus is ever-increasing and has spread to all age groups, including adolescents. The etiolo … ence. On the other hand, the risk of constant tinnitus increased with the increased intake of white bread, carbonated beverages, and fast food. In conclusion, we show that fresh fruit and vegetable intakes may be negatively related to tinnitus frequency, while sweetened sodas, fast food, and white bread may raise the odds for tinnitus.

Associations between multiple food intake and glioblastoma risk: A Mendelian randomization study.

Emerging evidence suggests that food intake is possibly associated with glioblastoma (GBM), potential causal links between food intake and GBM risk remain unclear. Two-sample Mendelian randomization and multivariable Mendelian randomization analyses were conducted using pooled statistics from genome-wide association studies for GBM (European ancestry, N = 218,792) and 6 exposure factors: bread intake (N = 452,236) and bacon intake (N = 64,949) from European populations, and Danish pastry, oat crunch, latte, and chocolate bar intake (each N ≈ 1469) from the UK Biobank South Asian ancestry cohor…

Causal association between dietary factors and Primary Biliary Cholangitis: A Mendelian randomization study.

The potential relationship between dietary intake and primary biliary cholangitis (PBC) remains uncertain. This study employed a 2-sample Me … ab: OR = 0.038, 95% CI: 0.002-0.597, P = .020; MRC-IEU: OR = 0.059, 95% CI: 0.006-0.549, P = .013), bread intake (OR = 61.404, 95% CI: 1.558-2419.859, P = .028), salad/raw vegetable intake (OR = 0.012, 95% CI: 0-0.714, P = .034), and tea intake (OR = 0.169, 95% CI: 0.037-0.767, P = .021). Notably, the effect estimates for bread and nonoily fish intake w …

Water chlorination increases the relative abundance of an antibiotic resistance marker in developing sourdough starters.

UNLABELLED: Multiple factors explain the proper development of sourdough starters. Although the role of raw ingredients and geography, among … ria. IMPORTANCE: Proper development of sourdough starters is critical for making tasty and healthy bread. Although many factors contributing to sourdough development have been studied, the effect of water chlorination on the bacterial communities in sourdough has been largely ignored. Researchers used sequencing techniques to investigate this effect an …

An acute gastroenteritis outbreak associated with breakfast contaminated with norovirus by asymptotic food handler at a kindergarten in Shenzhen, China.

BACKGROUND: An outbreak of acute gastroenteritis occurred in a kindergarten located Shenzhen City on March 4, 2018. We were invited to investigate to the risk factors associated with this outbreak. METHODS: We conducted retrospective cohort-studies on three different groups of subjects in order to figure out the difference of incidence of acute gastroenteritis among subjects of different activities on March 2: group one consisted of people who attended the Lantern festival activities; group two consisted of children and employees who ate breakfast and bread provided by the kindergarten; and g…

Chemical Composition and Nutritional Profile of Quinoa Sourdough Enriched with Quinoa Malts.

This study investigated the combined effects of quinoa malt addition (0%, 5%, 10%) and grain variety (white, red, black) on the nutritional and sensory properties of quinoa sourdoughs. Quinoa malt supplementation significantly (p < 0.05) enhanced fermentation characteristics, increasing titratable acidity from 20.0-20.4 to 21.2-23.8 mL NaOH/10 g and dynamic viscosity up to 733 ± 5.59 mPa·s compared to 474-611 mPa·s in controls. Malt enrichment expanded the volatile profile from predominantly alcohols and acids to include 25 distinct compounds spanning esters, terpenes, aldehydes, phenols, and

Ileal Digestibility of Crude Protein and Amino Acids in Bakery and Biscuit Byproducts Fed to Growing Pigs.

This study evaluated the apparent ileal digestibility (AID) and standardized ileal digestibility (SID) of crude protein (CP) and amino acids (AAs) in three bakery and biscuit byproducts fed to growing pigs. Five crossbred barrows fitted with a T-cannula at the distal ileum were allotted to a 5 × 5 Latin square design. The AID of CP was higher in the plain bread meal (PB) and sweet bread meal (SB) than in corn (CN) and biscuit meal (BC) (p < 0.05), while the AID of most indispensable AAs was higher in CN and PB than in BC (p < 0.05), reflecting the dietary CP and total AA concentrations. After …

Diet, physical activity, and body mass index on gallbladder recovery time: An exploratory ultrasound pilot study.

PURPOSE: This study aimed to evaluate the effects of dietary composition, physical activity, and body mass index on gallbladder recovery tim … ULTS: Recovery time significantly varied among meal types (χ²(2) = 18.42, p < .001), with wholemeal bread yielding the fastest and yogurt the slowest recovery. Physical activity significantly enhanced wall recovery (p = 0.002) but did not affect volume (p = 0.317). Body mass index showed no significant effect. Moderate and excellent intraclass correlati …

Genome-wide analysis of complex wheat gliadins, the dominant carriers of celiac disease epitopes.

Gliadins, specified by six compound chromosomal loci (Gli-A1/B1/D1 and Gli-A2/B2/D2) in hexaploid bread wheat, are the dominant carriers of celiac disease (CD) epitopes. Because of their complexity, genome-wide characterization of gliadins is a strong challenge. Here, we approached this challenge by combining transcriptomic, proteomic and bioinformatic investigations. Through third-generation RNA sequencing, full-length transcripts were identified for 52 gliadin genes in the bread wheat cultivar Xiaoyan 81. Of them, 42 were active and predicted to encode 25 α-, 11 γ-, one δ- and five ω-gliadin…

Presence of alkylresorcinols, potential whole grain biomarkers, in human adipose tissue.

Alkylresorcinols (AR) in plasma samples have been suggested to be short- to medium-term biomarkers of whole grain wheat and rye intake. In the present study, we investigated whether AR are present in human adipose tissues, and if content correlated with long-term whole grain bread intake. Furthermore, we investigated if the relative AR homologue composition reflected what has been found previously in the habitual diet of Swedes. Biopsy samples (10-25 mg) from free-living Swedish women (n 20) were analysed by GC-MS. The mean total AR concentration in the samples was 0.54 (SD 0.35) microg/g, ran…

Synergistic interactions between Kluyveromyces marxianus and Lactiplantibacillus plantarum enhance quality and functionality in fermented dough.

The unique characteristics of fermented foods are derived from the complex microbial diversity and metabolic interactions within their dynamic ecosystems. While Kluyveromyces marxianus and Lactiplantibacillus plantarum coexist in naan sourdough, their synergy remains unclear. This study assessed their co-fermentation effects on dough and naan quality. Co-fermentation improved physicochemical properties, pH dropped to 4.13, titratable acidity rose (2.58 mL), and water-holding capacity increased (2.15 g g-1). Bioactive compounds surged, with phenolics and flavonoids reaching 13.20 mg GAE g-1 and