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Nanomaterial-induced modulation of morpho-physio-biochemical attributes and enhancement of anticancer compounds in Tagetes erecta L. callus cultures.

Seeds of Tagetes erecta L. (Asteraceae) variety sweet orange were inoculated on half-strength Murashige and Skoog (MS) basal medium. Seedlin … ncreased antioxidant enzyme activities, including superoxide dismutase (SOD; 726.71±0.08 U g-1 FW), guaiacol peroxidase (GPX; 4.82±0.03 µM min-1 g-1 FW), catalase (CAT; 457.56±0.56 µM min-1 g-1 FW) and polyphenol oxidase (PPO; 10.06±0.09 nM min-1 g-1 FW). Concurrently, MWCNTs significantly reduced malondialdehyde (MDA; 13.48±0.11 nM g-1 FW) and hydrogen pe …

Dihydro-stilbene gigantol relieves CCl4-induced hepatic oxidative stress and inflammation in mice via inhibiting C5b-9 formation in the liver.

In general, anti-inflammatory treatment is considered for multiple liver diseases despite the etiology. But current drugs for alleviating liver inflammation have defects, making it necessary to develop more potent and safer drugs for liver injury. In this study, we screened a series of (dihydro-)stilbene or (dihydro-)phenanthrene derivatives extracted from Pholidota chinensis for their potential biological activities. Among 31 compounds, the dihydro-stilbene gigantol exerted most potent protective effects on human hepatocytes against lithocholic acid toxicity, and exhibited solid antioxidative

Zingerone attenuates aortic banding-induced cardiac remodelling via activating the eNOS/Nrf2 pathway.

Cardiac remodelling refers to a series of changes in the size, shape, wall thickness and tissue structure of the ventricle because of myocardial injury or increased pressure load. Studies have shown that cardiac remodelling plays a significant role in the development of heart failure. Zingerone, a monomer component extracted from ginger, has been proven to possess various properties including antioxidant, anti-inflammatory, anticancer and antidiabetic properties. As oxidative stress and inflammation contribute to acute and chronic myocardial injury, we explored the role of zingerone in cardiac

Fenugreek extract as an inducer of cellular death via autophagy in human T lymphoma Jurkat cells.

BACKGROUND: Drugs used both in classical chemotherapy and the more recent targeted therapy do not have cancer cell specificity and, hence, cause severe systemic side effects. Tumors also develop resistance to such drugs due to heterogeneity of cell types and clonal selection. Several traditional dietary ingredients from plants, on the other hand, have been shown to act on multiple targets/pathways, and may overcome drug resistance. The dietary agents are safe and readily available. However, application of plant components for cancer treatment/prevention requires better understanding of antican

Protective Effect of Gigantol Against Streptozotocin-Induced Gestational Diabetes Mellitus via Modulation of the Nrf2/HO-1, TLR4/MyD88/NF-κB, and PI3K/Akt/GSK-3β Signaling Pathways.

Gestational diabetes mellitus (GDM) is a chronic metabolic disease occur during the pregnancy which is characterized via insulin resistance, hyperglycemia, inflammation and oxidative stress. Gigantol, a naturally occurring bibenzyl phytoconstituents showed the anti-inflammatory and antioxidant potential against various disease. The aim of the current study was to investigate the protective effect of gigantol against streptozotocin (STZ) induced GDM in female rats. Intraperitoneal administration of STZ (25 mg/kg) was used for induction the GDM in the rats and rats were received the oral adminis

Combined treatment of zingerone and nilotinib induces cytotoxicity and reverses nilotinib resistance in chronic myeloid leukemia cells via inhibition of the PI3K signaling.

INTRODUCTION: Tyrosine kinase inhibitors (TKIs) have revolutionized the treatment of chronic myeloid leukemia (CML); however, TKI resistance remains a persistent challenge. This study investigates the effects of zingerone on CML cell growth and nilotinib resistance. METHODS: K562 and LAMA84 cells were treated with zingerone (5-100 μM) or nilotinib (1-50 nM), and cytotoxicity was assessed using cell counting Kit-8 assay. Nilotinib-resistant cells (K562R, LAMA84R) were generated through gradual exposure to increasing nilotinib concentrations (1-10 nM) over six months. Subsequently, cells were t

Catalytic Conversion of Lignin into Valuable Chemicals: Full Utilization of Aromatic Nuclei and Side Chains.

ConspectusIn recent years, significant efforts have been directed toward achieving efficient and mild lignocellulosic biomass conversion int … in synthesizing targeted aromatic products. We begin with model compounds (such as anisole, phenol, guaiacol, etc.) and then transition to protolignin feedstocks. Various reaction routes are developed, including self-supported hydrogenolysis, direct Caryl-Csp3 cleavage, coupled Caryl-Csp3 cleavage and Caryl-O hydrogenolysis, and tandem selective hydrogenat …

Hepatoprotective effects of zingerone on carbon tetrachloride- and dimethylnitrosamine-induced liver injuries in rats.

In this study, we investigated the hepatoprotective and anti-fibrotic effects of zingerone, one of the active components of ginger, against carbon tetrachloride (CCl4)- and dimethylnitrosamine (DMN)-induced liver injuries in rats, respectively. Oral administration of zingerone (10 mg/kg) reduced CCl4-induced abnormalities in liver histology, serum alanine aminotransferase and aspartate aminotransferase levels, and liver malondialdehyde levels. Zingerone treatment attenuated CCl4-induced increases in inflammatory mediators, including tumor necrosis factor-α, interleukin-1β, cyclooxygenase-2, an

Nature of the inhibition of horseradish peroxidase and mitochondrial cytochrome c oxidase by cyanyl radical.

Previous studies established that the cyanyl radical ((*)CN), detected as 5,5-dimethyl-1-pyrroline N-oxide (DMPO)/(*)CN by the electron spin resonance (ESR) spin-trapping technique, can be generated by horseradish peroxidase (HRP) in the presence of hydrogen peroxide (H(2)O(2)) and by mitochondrial cytochrome c oxidase (CcO) in the absence of H(2)O(2). To investigate the mechanism of inhibition by cyanyl radical, we isolated and characterized the iron protoporphyrin IX and heme a from the reactions of CN(-) with HRP and CcO, respectively. The purified heme from the reaction mixture of HRP/H(2)

Suppression of Cartilage Degradation by Zingerone Involving the p38 and JNK MAPK Signaling Pathway.

Zingerone, an active compound that is present in cooked ginger, has been claimed to be a bioactive ingredient that holds the potential of preventing and/or treating diseases involving inflammation. In this study, zingerone was used to discover its properties against joint inflammation using interleukin-1β-induced osteoarthritis in cartilage explant and cell culture models. Zingerone was supplemented into the cartilage explant and cell culture media at different concentrations along with the presence of interleukin-1β, an inducer of osteoarthritis. Markers indicating cartilage degradation, infl

Antiplatelet effects of some aporphine and phenanthrene alkaloids in rabbits and man.

Two aporphines (boldine and laurolitsine) and five phenanthrene alkaloids (litebamine, secoboldine, N-cyanosecoboldine, N-methylsecoglaucine and N-methylsecopredicentrine) were evaluated in-vitro for their ability to inhibit platelet aggregation. All seven alkaloids inhibited aggregation of rabbit platelets and inhibited the release of ATP induced by arachidonic acid and collagen in rabbit platelets. Those aggregations induced by platelet-activating factor (PAF), thrombin, U46619 and ADP were inhibited by the three N-substituted secoboldine derivatives only. Thromboxane B2 formation caused by

Допуск на засуху в хлопковых генотипах с помощью интегрированных морфофизиологических и биохимических маркеров на стадии цветения.

Засушливый стресс one из основных абиотических факторов, которые серьезно ограничивают глобальный урожай хлопка, нарушая основные морфофизиологические и биохимические функции. В этом исследовании forty В разделе, посвященном генетически разнообразным генотипам хлопка, была проведена оценка three ирригационные уровни: контроль100% мощность на местах), умеренная (60% FC) и сильная засуха40% FC) на стадии цветения в контролируемой стеклянной среде. Повышение интенсивности засухи привело к постепенному снижению темпов роста и физиологических характеристик. Острый стресс: уменьшение длины выстрела

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… Peroxidase (POD) activity was determined via a guaiacol oxidation assay, measuring the increase in absorbance at 470 nm due to guaiacol oxidation catalyzed by the enzyme in the presence of H 2 O 2 . Catalase (CAT) activity was evaluated by monitoring the decomposition rate of H 2 O 2 at 240 nm 27 . …

Bioactivities and Mechanisms of Action of Sinomenine and Its Derivatives: A Comprehensive Review.

Sinomenine, an isoquinoline alkaloid extracted from the roots and stems of Sinomenium acutum, has been extensively studied for its derivatives as bioactive agents. This review concentrates on the research advancements in the biological activities and action mechanisms of sinomenine-related compounds until November 2023. The findings indicate a broad spectrum of pharmacological effects, including antitumor, anti-inflammation, neuroprotection, and immunosuppressive properties. These compounds are notably effective against breast, lung, liver, and prostate cancers, exhibiting IC50 values of appro

Meeting abstracts from the 21st European Symposium on Radiopharmacy and Radiopharmaceuticals

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