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Glucagonoma syndrome: a case report.

IntroductionGlucagonoma syndrome is a rare paraneoplastic phenomenon, with an estimated incidence of one in 20 million, characterized by necrolytic migratory erythema, hyperglucagonemia, diabetes mellitus, anemia, weight loss, glossitis, cheilitis, steatorrhea, diarrhea, venous thrombosis and neuropsychiatric disturbances in the setting of a glucagon-producing alpha-cell tumor of the pancreas. Necrolytic migratory erythema is the presenting manifestation in the majority of cases, so its early suspicion and correct diagnosis is a key factor in the management of the patient.Case presentationWe p

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… The most specific feature on skin histological examination is necrolysis of the upper epidermis with vacuolated keratinocytes, leading to focal or confluent necrosis, but this histopathologic feature may be seen in other deficiency states like pellagra, necrolytic acral erythema or zinc deficiency [ …

Chapter 29: historical aspects of the major neurological vitamin deficiency disorders: overview and fat-soluble vitamin A.

The vitamine doctrine: Although diseases resulting from vitamin deficiencies have been known for millennia, such disorders were generally at … that they were "vital amines," were responsible for such diseases as beriberi, scurvy, rickets, and pellagra. Vitamin A deficiency eye disease: Night blindness was recognized by the ancient Egyptians and Greeks, and many authorities from Galen onward advocated liver as a curative. Outbreaks of night blindness were linked to nutritional causes in the 18th a …

[Clinical studies of pediatric malabsorption syndromes].

Multiple cases with various types of pediatric malabsorption syndromes were evaluated. The clinical manifestations, laboratory findings, pat … atment with MCT formula diet corrected the lipid malabsorption. 5. A 5-year-old girl presented with pellagra-like rashes, mental retardation and cerebellar ataxia. An oral tryptophan (Trp) and dipeptide (Trp-Phe) loading test were conducted and the renal clearance of amino acids was also evaluated in this patient and in controls. Following the oral Trp loa …

Clinical practice guidelines on addressing cognitive impairment in treatable dementias.

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… Memory loss may precede anaemia • Myelopathy • Neuropathy • Pernicious anaemia Folate deficiency | • Myelopathy • Neuropathy • Associated with malabsorption syndromes like alcohol use, and use of phenytoin Thiamine deficiency | • Confusion • Ophthalmoplegia • Ataxia • Neuropathy Niacin deficiency | • Pellagra …

Cutaneous paraneoplastic syndromes in cats: a comparative clinical review.

PRACTICAL RELEVANCE: Cutaneous paraneoplastic syndromes (CPSs) in cats represent a diverse group of rare dermatological manifestations that occur as indirect consequences of underlying neoplasia. These syndromes are thought to arise due to tumour-associated systemic effects, including dysregulation of immune responses, metabolic disturbances and aberrant production of cytokines or growth factors. Recognising CPSs is clinically relevant, as they may serve as early indicators of occult neoplasia, guiding timely diagnosis and intervention. CLINICAL CHALLENGES: Diagnosing CPSs requires a high ind

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… Waldenstrom’s macroglobulinaemia | Combination of the following: chemotherapy (melphalan/ cyclophosphamide), steroids, immunomodulatory drugs (thalidomide/ lenalidomide), proteasome inhibitors, monoclonal antibody drugs and high dose therapy/stem cell transplantation Carcinoid syndrome | ✜ Flushing, pellagra-like …

Окисляющий стресс в функции мозга.

Окисляющий стресс (OS) является важным фактором в патофизиологии многочисленных нейродегенеративных расстройств, таких, как болезнь Паркинсона, множественный склероз, цереброваскулярная патология или болезнь Альцгеймера. OS также оказывает значительное влияние на прогресс между различными нейродегенеративными расстройствами. Несбалансированность между образованием реактивных видов кислорода (РОС) и способностью организма нейтрализовать эти токсичные побочные продукты делает мозг подверженным окислительным повреждениям. Увеличение количества ROS может привести к сбоям в клетке, апоптозу и нейро

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… Optimal niacin levels are essential, as a lack may result in pellagra, characterized by dementia, dermatitis, diarrhea and sometimes death. Niacin was even utilized for dyslipidemia management before the widespread adoption of statins in doses of up to 3000 mg/day [ 188 , 189 ]. …

Skin manifestations associated with systemic diseases - Part II.

The skin, by reflecting internal processes, externalizes what happens inside the body in many diseases. Thus, the skin, as an organ, extrapolates its functions of protection, barrier and signals the existence of systemic diseases, expanding the importance of the dermatologist beyond the skin surface. Thus, the dermatologist investigates diagnostic hypotheses for conditions related to all systems and refers patients to the appropriate specialty. Combined with examination by a trained eye, the skin, due to its easy access, is still the ideal place for performing biopsies, which often clarify the

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… There may be symptoms of niacin deficiency (pellagra) due to the use of tryptophan (the precursor of niacin), which is the raw material for the production of the secreted hormones. 11 Thromboembolic phenomena Thromboembolic phenomena of different origins have cutaneous manifestations that are the “ …

Vitamin D: A Bridge between Kidney and Heart.

Chronic kidney disease (CKD) and cardiovascular disease (CVD) are highly prevalent conditions, each significantly contributing to the global burden of morbidity and mortality. CVD and CKD share a great number of common risk factors, such as hypertension, diabetes, obesity, and smoking, among others. Their relationship extends beyond these factors, encompassing intricate interplay between the two systems. Within this complex network of pathophysiological processes, vitamin D has emerged as a potential linchpin, exerting influence over diverse physiological pathways implicated in both CKD and CV

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… The Etiology of the Deficiency Diseases, Beri-Beri, Polyneuritis in Birds, Epidemic Dropsy, Scurvy, Experimental Scurvy in Animals, Infantile Scurvy, Ship Beri-Beri, Pellagra. Nutr. Rev. 1975;33:176–177. doi: 10.1111/j.1753-4887.1975.tb05095.x. 213. …

Classification of Dystonia.

Dystonia is a hyperkinetic movement disorder characterized by abnormal movement or posture caused by excessive muscle contraction. Because of its wide clinical spectrum, dystonia is often underdiagnosed or misdiagnosed. In clinical practice, dystonia could often present in association with other movement disorders. An accurate physical examination is essential to describe the correct phenomenology. To help clinicians reaching the proper diagnosis, several classifications of dystonia have been proposed. The current classification consists of axis I, clinical characteristics, and axis II, etiolo

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… The usual clinical manifestations of rare symptomatic HD are intermittent, pellagra-like skin rashes, reversible attacks of cerebellar ataxia, and occasionally behavioral changes, ranging from emotional instability to psychosis and delirium. Some patients are mildly retarded. …

What is the Reason That the Pharmacological Future of Chemotherapeutics in the Treatment of Lung Cancer Could Be Most Closely Related to Nanostructures? Platinum Drugs in Therapy of Non-Small and Small Cell Lung Cancer and Their Unexpected, Possible Interactions. The Review.

Over the course of several decades, anticancer treatment with chemotherapy drugs for lung cancer has not changed significantly. Unfortunately, this treatment prolongs the patient's life only by a few months, causing many side effects in the human body. It has also been proven that drugs such as Cisplatin, Carboplatin, Oxaliplatin and others can react with other substances containing an aromatic ring in which the nitrogen atom has a free electron group in its structure. Thus, such structures may have a competitive effect on the nucleobases of DNA. Therefore, scientists are looking not only for

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… Deficiency may lead to pellagra, disorders of the nervous system, and the glycolysis process. 201 , 202 , 217–219 Vitamin B6 is a group of six chemically similar compounds that can transform into each other and have a common active form, pyridoxal 5′-phosphate. …

Brazilian Nutritional Consensus in Hematopoietic Stem Cell Transplantation: children and adolescents.

The Brazilian Nutritional Consensus in Hematopoietic Stem Cell Transplantation: Children and Adolescents was developed by dietitians, physicians, and pediatric hematologists from 10 Brazilian reference centers in hematopoietic stem cell transplantation. The aim was to emphasize the importance of nutritional status and body composition during treatment, as well as the main characteristics related to patient´s nutritional assessment. This consensus is intended to improve and standardize nutrition therapy during hematopoietic stem cell transplantation. The consensus was approved by the Brazilian

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… papilla | Folic acid and vitamin B12 Teeth | Tooth enamel stains | Fluorine Gingiva | Spongy: bleeding and oozing | Vitamin C Glands | Enlarged thyroid | Iodine Enlarged parathyroid | Starvation Skin | Xerosis | Vitamin A Follicular hyperkeratosis (sandpaper skin) | Petechias | Vitamin C Dermatosis, pellagra …