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Changes in Quantitative Pupillometry After General Anesthesia and Neuromuscular Blockade.

PURPOSE: Quantitative pupillometry (QP) standardizes pupillary assessment and may assist in the assessment of patients undergoing general an … dure start time. FINDINGS: Of 109 enrolled, 59 (53.6%) received rocuronium and 50 (46.4%) received succinylcholine. Following the induction of general anesthesia, several QP values were significantly reduced, including the Neurological Pupil index (4.23 to 3.47; P < .0001 for the left eye and 4.24 to 3.31; P < .0001 for the right eye), constriction velocity (1.6 …

The reduction of skeletal muscle lesions after experimental stress in stress-susceptible pigs protected with dantrolene.

Malignant hyperthermia (MH) is a naturally occurring disease of stress-susceptible (SS) pigs subjected to triggering agents or stress. MH is … l restraint stress provoked by a 12 min intravenous (i.v.) infusion of the depolarizing myorelaxant succinylcholine. Five pigs were orally dosed with dantrolene (5 mg/kg), twice, about 24 and 5 h before the stress (group A). The other four pigs were treated with a single i.v. infusion of dantrolene (5 mg/kg), 30 min before stress (group B). The animals were necro …

A successful electroconvulsive treatment of neuroleptic malignant syndrome.

A case of neuroleptic malignant syndrome (NMS) treated successfully with electroconvulsive therapy (ETC) is described. Repeated exposures of the patients to succinylcholine during ECT did not cause malignant hyperthermia. The efficacy of ECT is probably related to its facilitatory effect upon dopamine (DA) activity in CNS.

[Malignant hyperthermia. The need for anesthesia in a patient manifesting this syndrome].

Successful treatment of malignant hyperthermia, following its prompt recognition in a young patient during general anaesthesia with halothane and succinylcholine, preceded the equally successful employment of ketamin, with no signs of enzyme alteration and circulatory stability, when the same subject had to be operated 20 days later.

Improving neuromuscular monitoring and reducing residual neuromuscular blockade via e-learning: A multicentre interrupted time-series study (INVERT study).

BACKGROUND: Neuromuscular monitoring should be applied routinely to avoid residual neuromuscular block. However, anaesthetists often refrain … muscle relaxants until 30 April 2017. Main outcome was application of acceleromyography, grouped as succinylcholine only and non-depolarising relaxants. Secondary outcomes were last recorded train-of-four ratio (non-depolarising) relaxants and score on a ten-question pre- and post-course multiple-choice test. RESULTS: The post-intervention data consisted of 6525 …

Neuromuscular nicotinic receptors mediate bladder contractions following bladder reinnervation with somatic to autonomic nerve transfer after decentralization by spinal root transection.

PURPOSE: We investigated whether the reinnervated neuronal pathway mediates contraction via the same neurotransmitter and receptor mechanism … essure in 9 of 10 dogs (90%) with unilateral left femoral nerve to bilateral pelvic nerve transfer. Succinylcholine virtually eliminated the bladder pressure increases induced by electrical stimulation of the transferred somatic nerves or of the lumbar spinal segments that contribute axons to these donor nerves. In unoperated or sham operated controls succinylcho …

Intraocular pressure--physiology and implications for anaesthetic management.

The major factors controlling intraocular pressure during surgery are the dynamic balance between aqueous humour production in the ciliary b … n of aqueous production, facilitation of aqueous drainage or relaxation of extraocular muscle tone. Succinylcholine administration is associated with a significant rise in intraocular pressure, with a peak increase between two to four minutes following administration and a return to base line values after six minutes. The intraocular hypertensive effect may be du …

Dynamic changes in cerebrospinal fluid pressure during neurosurgical operations.

The effects of hyperventilation, osmotic and diuretic agents (urea, frusemide), thiopentone and succinylcholine chloride on the intracranial pressure were studied in neurosurgical patients with brain tumours. We have shown that hyperventilation together with osmotic and diuretic agents is very useful for reducing increased intracranial pressure.

Pseudocholinesterase Deficiency: What the Proceduralist Needs to Know.

Pseudocholinesterase deficiency is a rare genetic as well as an acquired disorder that affects the body's ability to metabolize choline esters such as succinylcholine and mivacurium. It can be inherited as an autosomal recessive trait, occurring in approximately 1 in 3,200 to 1 in 5,000 people. In most cases of pseudocholinesterase deficiency, no signs or symptoms of the condition exist. It is first suspected after a prolonged recovery from paralysis following general anesthesia in which succinylcholine or mivacurium are administered. We emphasize the importance of obtaining a detailed history…

Association of vaginal bleeding and electroconvulsive therapy use in pregnancy.

Electro-convulsive (ECT) therapy is frequently the treatment of choice in pregnant patients. It has been reported that administration of ECT in pregnancy is safe and effective. However, there are few controlled studies of the effects of ECT on pregnancy. The literature is not conclusive regarding ECT-related complications in pregnancy. We describe here the case of a primigravida with bipolar disorder who underwent nine sessions of ECT during pregnancy. The patient experienced vaginal bleeding after each session of ECT. Thiopental and succinylcholine were administered as an anesthetic (4 mg/kg …

Strabismus as a possible sign of subclinical muscular dystrophy predisposing to rhabdomyolysis and myoglobinuria: a study of an affected family.

Administration of succinylcholine to normal individuals results in alterations in muscle membrane integrity expressed as a slight increase in the concentrations of creatine phosphokinase (CK) in serum and appearance of small amounts of myoglobin in the urine, but without clinical symptoms. Subjects with strabismus due to congenital muscular dystrophy may develop more significant rhabdomyolysis expressed as muscle stiffness and weakness, massive myoglobinuria, marked elevation of serum CK and other enzymes, metabolic acidosis, tachycardia and moderate elevation of body temperature. In some case…

[Resuscitation of patients poisoned by organo-phosphorus neurotoxic agents].

Poisoning by Neurotoxic organo phosphorus products is frequent problem in Iran. Reanimation of these patients depends on the following: 1 - To begin reanimation rapidly. 2- Usage of atropine and special anticholisterasics antidotes. In case of need for surgical intervention, the use of succinylcholin is prohibited and other muscle relexants should be used with most care.

Emerging significance of butyrylcholinesterase.

Butyrylcholinesterase (BChE; EC 3.1.1.8), an enzyme structurally related to acetylcholinesterase, is widely distributed in the human body. It plays a role in the detoxification of chemicals such as succinylcholine, a muscle relaxant used in anesthetic practice. BChE is well-known due to variant forms of the enzyme with little or no hydrolytic activity which exist in some endogamous communities and result in prolonged apnea following the administration of succinylcholine. Its other functions include the ability to hydrolyze acetylcholine, the cholinergic neurotransmitter in the brain, when its …

The Effects of Intravenous Dexmedetomidine Injections on IOP in General Anesthesia Intubation: A Meta-Analysis.

Objective. The aim of this meta-analysis is to evaluate the effects of dexmedetomidine on intraocular pressure (IOP) in patients with genera … ound between IOP of the two groups. (2) The IOP of the dexmedetomidine group that was administrated succinylcholine was lower than that of placebo group which was administrated succinylcholine [WMD = -4.13 mmHg, 95% CI (-6.01, -2.25), P < 0.0001]. (3) Compared with the IOP of patients in the placebo group, patients with intubation in the dexmedetomidine group mai …

Аварийное применение внутрисемейного вливания.

Доступ к стене является важным шагом в деле ухода за критически больным ребенком, однако он может быть очень трудным и длительным. В последнее время вспыхнула инфильтрация внутри страны как быстрая альтернатива венозной консервации. Ряд случаев иллюстрируют полезность этого метода в департаменте экстренной помощи. В него включены первые доклады об использовании внутриособых диазепама и сукцинилхолина.

Совпадение в аннотации оригинала
Vascular access is an important step in the care of the critically ill child but can be very difficult and time consuming. Recently, intraos … in the emergency department. Included are the first reports of the use of intraosseous diazepam and succinylcholine.

Xenon does not trigger malignant hyperthermia in susceptible swine.

BACKGROUND: Xenon is a noble gas with anesthetic properties currently under investigation for use in humans. This study was performed to eva … r a 30-min xenon washout phase followed by subsequent administration of halothane (1% inspired) and succinylcholine (3 mg/kg intravenous). During the investigation, no malignant hyperthermia-specific therapy was instituted. RESULTS: Xenon exposure did not induce any changes in metabolic and hemodynamic parameters nor elevations of the plasma catecholamine levels …

"Testicular Torsion in a Child With CPT-1 Deficiency and History of Viral Myositis: Anesthesia Considerations".

Tailored anesthetic management is crucial for pediatric patients with inborn metabolic disorders like CPT-1 deficiency and conditions, such as viral myositis. Avoiding inhalational anesthetics and succinylcholine, using glucose infusion, safe anesthetics, and appropriate monitoring are essential to prevent metabolic crises and malignant hyperthermia during surgery, ensuring patient safety.

Risk Factors for Postoperative Urinary Retention After Lumbar Fusion Surgery: Anesthetics and Surgical Approach.

INTRODUCTION: Postoperative urinary retention (POUR) after lumbar fusion surgery can lead to longer hospital stays and thus increased risk o … acteristics. On bivariant analysis, patients who developed POUR were more likely to have been given succinylcholine (13.7% vs. 3.92%, P = 0.020) as an induction agent. The independent predictors of POUR identified by multivariable analysis included the use of succinylcholine {odds ratio (OR), 4.37 (confidence interval [CI], 1.26 to 16.46), P = 0.022} and reduced …

Is there an ideal approach for rapid-sequence induction in hypertensive patients?

STUDY OBJECTIVE: To compare 4 different anesthesia induction protocols, in a simulated model of rapid-sequence induction, in controlled hype … was the induction agent. Study groups were as follows: group LS (n = 30), lidocaine (1.5 mg/kg) and succinylcholine (1 mg/kg); group LR (n = 30), lidocaine (1.5 mg/kg) and rocuronium (1 mg/kg); group RS (n = 30), remifentanil (1 microg/kg) and succinylcholine (1 mg/kg); group RR (n = 30), remifentanil (1 microg/kg) and rocuronium (1 mg/kg). Patients were intubate …