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Can Oritavancin Be Used for Treatment and/or Suppressive Antimicrobial Therapy of Bone and Joint Infections Caused by Vancomycin-resistant Enterococcus faecium ?

BACKGROUND: Vancomycin-resistant enterococcus (VRE) infections pose substantial challenges for the treatment and suppression of bone and joint infections. Oritavancin, a long-acting lipoglycopeptide antibiotic, has shown promising in vitro activity against VRE. Limited data are available on using oritavancin for bone and joint infections caused by VRE, both for treatment (therapy to eliminate active infection) and suppressive antimicrobial therapy (long-term antibiotic administration to prevent infection recurrence in patients at high risk for that complication). QUESTIONS/PURPOSES: (1) What

Safety and efficacy of continuous subcutaneous levodopa-carbidopa infusion (ND0612) for Parkinson's disease with motor fluctuations (BouNDless): a phase 3, randomised, double-blind, double-dummy, multicentre trial.

BACKGROUND: Conventional oral levodopa therapy for the treatment of Parkinson's disease can be associated with variations in plasma concentrations. Levodopa infusion strategies might provide more consistent drug delivery and fewer motor fluctuations. We aimed to assess the safety and efficacy of a continuous 24 h/day subcutaneous infusion of ND0612 (a levodopa-carbidopa solution) compared with oral immediate-release levodopa-carbidopa for the treatment of motor fluctuations in people with Parkinson's disease. METHODS: We conducted a phase 3, randomised, double-blind, double-dummy, active-cont

Antibiotics for acute rhinosinusitis in adults.

BACKGROUND: Acute rhinosinusitis is an acute infection of the nasal passages and paranasal sinuses that lasts less than four weeks. Diagnosi … H 19, 95% CI 15 to 27; I² = 21%; 12 trials; high-quality evidence). A disease-related complication (brain abscess) occurred in one participant (of 3057) one week after receiving open antibiotic therapy (clinical failure, control group). AUTHORS' CONCLUSIONS: The potential benefit of antibiotics to treat acute rhinosinusitis diagnosed either clinically (low ris …

Nocardia Infection Presented as Intramuscular Abscess in a Kidney Transplant Recipient: Case Report and Literature Review.

BACKGROUND: Nocardia is a gram-positive bacterium capable of causing both local and systemic infections, typically in immunocompromised patients. The most common clinical presentation is pulmonary infection. Muscle abscess due to Nocardia infection without disseminated nocardiosis is rare. CASE REPORT: In this report, we describe the case of a 67-year-old male kidney transplant recipient who developed a swelling of the right biceps muscle. CT imaging showed an intramuscular abscess, which was subsequently surgically drained. The drained fluid grew Nocardia pseudobrasiliensis, which was resist

Treatment of Fusarium Infection of the Central Nervous System: A Review of Past Cases to Guide Therapy for the Ongoing 2023 Outbreak in the United States and Mexico.

INTRODUCTION: Fusariosis of the central nervous system (CNS) is extremely uncommon. Treatment and outcome data from previously published cases may provide some guidance in light of the ongoing fungal meningitis outbreak in 2023 involving Fusarium spp. in the United States and Mexico. METHODS: We reviewed the published literature describing cases of invasive fusariosis of the (CNS) that included data on patient demographic characteristics, treatment, and outcome. RESULTS: Twenty-six cases met inclusion criteria. The mean age was 36 years, 55% involved females, 60% had underlying hematologic m

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… Brain mass VOR + TER + AMB + surgery Alive (18 months) 7[ 36 ] / 2008 53 F Promyelocytic leukemia F. oxysporum Brain abscess VOR Alive (5 months) 8[ 37 ] / 1998 NA NA ALL Fusarium spp. Brain abscess surgery Alive (NA) 9[ 38 ] / 1983 17 F Prednisone (60 mg/day) Fusarium spp. … abscess | VOR | Alive (5 months) 8[ 37 ] / 1998 | NA | NA | ALL | Fusarium spp. | Brain abscess | surgery | Alive (NA) 9[ 38 ] / 1983 | 17 | F | Prednisone (60 mg/day) | Fusarium spp. | Brain abscess and meningitis | AMB + intrathecal AMB + surgery (burrhole aspiration) | Deceased (7 days) 10[ 39 ] …

Распространяется жизнь, угрожая вирусом Нокардии отитидискавиарум у молодой женщины с недавно диагностированным системным волшебством эритематос, отчетом по делу и анализом литературы.

По сообщениям, инфекция, вызванная нокардией, наблюдается главным образом у иммунокомпромиссированных пациентов. Обычно он представляет собой легочную или распространенную болезнь с предрасположенностью к мозгу. Инфекции - это редкая этиология внутричерепной сосудистой аневризмы. В этой связи мы сообщаем о случае распространения Nocardia otitidiscaviarum (N. otitidiscaviarum) у молодой женщины, у которой недавно был диагностирован системный волчан (SLE), осложняемый развитием инфекционной внутричерепной аневризмы. Насколько нам известно, это четвертый случай внутричерепной аневризмы, связанной

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… A CT of the brain done after 6 months of treatment showed complete resolution of the brain abscesses and a repeat chest Xray ( Fig. 3 -C) showed clearance of the initial changes. … Brain abscess of greater than 2.5 cm size is considered as an indication for aspiration. A clinical pathway published in 2014 recommends craniotomy for nocardial brain abscess in those with systemic infections and multiple brain lesions [70] . …

Инфекция Нокардии: редкое сообщение о мозжечках.

ВВЕДЕНИЕ: Нокардиоз центральной нервной системы (ЦНС) представляет собой редкое, но смертоносное оппортунистическое заболевание, которое представляет собой колоссальную диагностическую и терапевтическую проблему, особенно среди населения с иммунокомпромиссной популяцией. Наиболее распространенным представлением является церебральный абсцесс. ПРЕДСТАВЛЕНИЕ СЛУЧАИ: Мы сообщаем о случае 53-year-old Мужчина с историей рецидива и рефрактной множественной миэломы, которая претерпела серьезные изменения в умственном состоянии и атаксии. Первичное клиническое подозрение было сосредоточено на задней иш

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… A crucial diagnostic principle underscored by this case is the low utility of CSF analysis for encapsulated brain abscesses. … European society of clinical microbiology and infectious diseases guidelines on diagnosis and treatment of brain abscess in children and adults. Clin Microbiol Infect. (2024) 30:66–89. doi: 10.1016/j.cmi.2023.08.016, PMID: 14. …

The utility of stereotactic biopsy of intracranial lesions in the diagnosis of leukemia complicated by central nervous system lesions.

BACKGROUND: Leukemia complicated by central nervous system (CNS) lesions (LCNSL) includes leukemia involving the CNS (CNSL) and CNS secondary lesions related to leukemia treatment (e.g., CNS infections, leukoencephalopathy, inflammatory demyelination, and vascular diseases). The clinical manifestations and imaging characteristics of different types of LCL are similar, increasing the possibility of misdiagnosis. This study aimed to enhance our understanding and management of LCL. METHODS: We retrospectively collected clinical data from 22 patients with LCL and analyzed their magnetic resonance

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… Diffusion imaging shows high signal intensity within the lesions Brain abscess Brain abscess (Fungal) 2 20 M ALL Headache, Vomitig, Seizures Multiple nodular lesions with long T1 and long T2 signals in the cortex and subcortex of both cerebral hemispheres, with unclear boundaries. … The clinical diagnosis for Cases 2, 4, 5, 6, and 7 was CNSL; however, the pathological diagnoses were fungal brain abscess, brain abscess of unknown etiology, tuberculoma, and gliosis (two cases). …

MR imaging findings in some rare neurological complications of paediatric cancer.

Neurological complications of paediatric cancers are a substantial problem. Complications can be primary from central nervous system (CNS) spread or secondary from indirect or remote effects of cancer, as well as cancer treatments such as chemotherapy and radiation therapy. In this review, we present the clinical and imaging findings of rare but important neurological complications in paediatric patients with cancer. Neurological complications are classified into three phases: pre-treatment, treatment and post-remission. Paraneoplastic neurological syndromes, hyperviscosity syndrome, haemophag

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… Meningeal enhancement is observed on contrast MRI (Fig. 4 ), and it may progress to brain abscess if meningeal inflammation spreads to the brain parenchyma. … In brain abscess, sudden onset headache and focal nervous disturbance like motor paralysis, convulsions, visual disturbance and cerebellar ataxia are observed. Progression of clinical symptoms in a matter of hours is characteristic for brain abscess. Fever is recognised only in about half of cases. …

Листерия моноцитогены и ауреат ауреуса Staphylococus у пациента с множественной миеломой: отчет по делу.

ВВЕДЕНИЕ: Listeria monocitogenes представляет собой грозный патоген, который представляет собой значительную угрозу для иммунокомпромизации и может вызвать редкие нетипичные формы заболевания, особенно осложненные при кондиционировании Staphylococcus aureus. КАСЕ: Мы представляем случай пациента с моноцитогенесом менингоэнцефалитом, эндокардитом, сепсисом и С. ауреусом остеомиелитом, высветив сложность лечения распространяемой полимикробной инфекции. A 64-year-old Женщина с множественной миеломой лечится химиотерапией с температурой, изменившимся психическим состоянием, тошнотой и диареей в от

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… Most commonly the disease manifests as septicemia, central nervous system (CNS) infections (meningoencephalitis, rhombencephalitis, cerebritis, brain abscesses) and pregnancy-associated infection [ 1 , 5 ]. … European Society of Clinical Microbiology and Infectious Diseases Guidelines on Diagnosis and Treatment of Brain Abscess in Children and Adults. 13. Bal A.M., Ashcroft G., Gould I., Laing R. Listeria monocytogenes and Staphylococcus aureus coinfection of a prosthetic joint. …

Medical imaging.

There is now a wide choice of medical imaging to show both focal and diffuse pathologies in various organs. Conventional radiology with plain films, fluoroscopy and contrast medium have many advantages, being readily available with low-cost apparatus and a familiarity that almost leads to contempt. The use of plain films in chest disease and in trauma does not need emphasizing, yet there are still too many occasions when the answer obtainable from a plain radiograph has not been available. The film may have been mislaid, or the examination was not requested, or the radiograph had been misinter

Факторы риска и результаты новой инфекции моноцитогенов листерии в Пакистане: понимание из больницы третичной медицинской помощи.

Listeria monocitogenes — грэм-положительный стержень, ответственный за листериоз. Она стала одним из основных патогенов, передающихся через пищевые продукты, и была причастна к многочисленным вспышкам во всем мире, часто встречающимся с бактерией, и может привести к серьезным проявлениям, таким, как менингоэнцефалит, особенно у лиц с иммунокомпромиссом и у пожилых людей. Инфекция материнства связана с худшими последствиями беременности. Цель этого исследования заключается в оценке факторов риска, клинических особенностей и результатов лечения пациентов, инфицированных моноцитогенами Листерии,

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… Neurolisteriosis was also common in our study, with most patients experiencing meningitis or meningoencephalitis, and only one patient presenting with a brain abscess. … and showed complete recovery after 6 weeks of antibiotics.There is limited evidence available, primarily derived from case reports, about the management of Listeria brain abscess. …

Nontraumatic Spinal Cord Injury: Epidemiology, Etiology and Management.

The spinal cord is a conduit within the central nervous system (CNS) that provides ongoing communication between the brain and the rest of the body, conveying complex sensory and motor information necessary for safety, movement, reflexes, and optimization of autonomic function. After a traumatic spinal cord injury (SCI), supraspinal influences on the peripheral nervous system and autonomic nervous system (ANS) are disrupted, leading to spastic paralysis, sympathetic blunting, and parasympathetic dominance, resulting in cardiac dysrhythmias, systemic hypotension, bronchoconstriction, copious re

Epidemiology, Clinical Data, and Management of Aseptic Abscess Syndrome: Review of Published Cases Outside France.

Aseptic abscess syndrome is a clinical entity that is being increasingly documented. Unfortunately, apart from the French registry, there are no other studies presenting collective data. In this review, we sought to analyze clinical and laboratory data from case reports published from the rest of the world. A total of 107 articles were found through our literature search in PubMed, Scopus, and Google, which contained 108 patients who met our eligibility criteria, including pediatric cases. The mean age at diagnosis was 39.1 years, and 54.6% of the patients were female. Cases were found affecti

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… Central nervous system manifestation of lupus erythematosus resembling brain abscess. Int. J. Pediatr. Adolesc. Med. 2019;6:29–37. doi: 10.1016/j.ijpam.2018.11.001. 68. Xu P., Cai Y., Ying X., Shi S., Song W. …

Сепсис, вызванный Clostridium Perfringens у женщины пожилого возраста, больной раком груди: доклад по делу.

ЦЕЛЬ: Сообщить о редком случае заболевания раком груди, у которого септический шок и множественные повреждения органов. В нем анализируются клинические характеристики, патогенные факторы и прогноз, связанные с смешанной инфекцией, вызванной Clostridium perfringens и Escherichia coli, в целях обеспечения основы для раннего выявления и вмешательства аналогичных клинических случаев. МЕТОДЫ: Был проведен ретроспективный анализ клинических данных 75-year-old Женщина, больная раком груди, которая также страдала гипертонией и диабетом. Были резюмированы клинические проявления, результаты этиологическ

Spinal lesions: a comprehensive radiologic overview.

Spinal lesions encompass a diverse range of pathologies, including primary and secondary tumors, infectious processes, vascular malformations, traumatic injuries, and degenerative conditions, each with distinct imaging characteristics crucial for accurate diagnosis and management. Imaging plays vital roles in assessing lesion morphology, anatomical localization, and neurological impact, guiding clinical decision-making and therapeutic planning. This review systematically explores spinal lesions based on their anatomical compartments, highlighting key radiological features and providing a compr

Воспаление и воспаление болезней, маркеры и посредники: роль КПИ в некоторых воспламенительных заболеваниях

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Diseases of the Nervous System

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… Asymmetric lesions of the forebrain such as a brain abscess, some cases of PEM, verminous larval migration, or head trauma may cause an animal to hold its head and neck turned to one side, but there is no head tilt and the circle is large in diameter. … Principal sign | Secondary signs | Location of lesion | Example Circling | | | (1) Rotation of the head | Nystagmus, circles, muscle weakness, falls easily, may roll, other cranial nerves affected | Vestibular nucleus | Brain abscess, listeriosis | Nystagmus, walks in circles, falls occasionally …