Результаты поиска

Азиатские культурные ценности и поиск помощи: перекрестное исследование на тему навязчивого сексуального поведения.

Сексуальность является сложной конструкцией, на которую влияют различные социальные и культурные факторы, и хотя сексуальное поведение, как правило, считается адаптивным к физическому и психическому благополучию, оно может стать неконтролируемым и вредным, что ведет к навязчивому сексуальному поведению (CSB). Ограниченные исследования были посвящены изучению вопроса о том, как азиатские культурные ценности могут способствовать психологическим последствиям деятельности ЦСБ и влиять на отношение к поиску профессиональной психологической помощи. В этом исследовании рассматриваются взаимосвязи меж

Glucosylsphingosine (Lyso-Gb1) as a reliable biomarker in Gaucher disease: a narrative review.

BACKGROUND: Gaucher disease (GD) is a rare, inherited, autosomal recessive disorder caused by a deficiency of the lysosomal enzyme, acid β-glucosidase. Its diagnosis is achieved via measurements of acid β-glucosidase activity in either fresh peripheral blood leukocytes or dried blood spots, and confirmed by identifying characteristic mutations in the GBA1 gene. Currently, several biomarkers are available for disease monitoring. Chitotriosidase has been used over the last 20 years to assess the severity of GD, but lacks specificity in GD patients. Conversely, the deacylated form of glucosylcera

The Calcium Conundrum: Hypercalcemia of Unknown Etiology.

Hypercalcemia is a common clinical finding with a wide variety of clinical presentations and etiologies. The differential is broad and includes hyperparathyroidism, malignancy, medication adverse effects, endocrinopathies, and a variety of granulomatous diseases. We present the case of an 84-year-old woman with severe parathyroid hormone-independent hypercalcemia and elevated 1,25-OH Vitamin D. Non-necrotizing granulomas were identified on bone marrow biopsy. After an exhaustive workup for granulomatous disease, the patient was felt to have sarcoidosis isolated to the bone marrow and started o

Nanomaterials in gene therapy and genome editing: challenges and emerging directions.

Nanomaterials are redefining the landscape of gene and genome editing, yet their translation to clinical reality remains constrained by multiple unresolved challenges. While they provide structural and functional advantages for delivering nucleic acids and CRISPR/Cas systems across biological barriers, their behavior within living systems is often unpredictable, leading to issues such as off-target editing, immune activation, and inconsistent biodistribution. The design of nanocarriers, whether lipid-based, polymeric, inorganic, must therefore balance efficiency with safety, integrating physic

Acupuncture for post-chemoradiotherapy complications in lung cancer with bone metastasis: a case report and literature review.

Despite significant advances in oncologic therapeutics, chemoradiotherapy-induced complications, including chemotherapy-induced peripheral neuropathy (CIPN) and hip dysfunction, remain clinically challenging to manage with pharmacological interventions alone. This report presents the case of a 52-year-old male with a history of right-sided lung cancer resection performed more than three years previously and confirmed bone metastasis for over two years. Following metastasis to the right ilium and acetabulum, the patient developed pain, numbness, gait disturbance, and impaired mobility in the ri

Social support and care burden in family caregivers of patients with hematologic malignancies: a parallel mediation model of coping strategies.

ObjectiveWith the rising incidence of hematologic malignancies (HMs) in recent years, caregivers of HMs patients have increasingly emerged as a significant factor affecting the treatment of these conditions. This study aimed to explore the association of coping strategies on the relationship between care burden and social support among family caregivers of HMs patients.MethodologyA questionnaire survey was conducted involving 207 family caregivers of hospitalized HMs patients in a tertiary hospital in Dalian from October 2023 to May 2024 and 200 valid responses were collected. We used hierarch

Exploring Healthcare Continuity in Pediatric-Onset Multiple Sclerosis in the United States.

OBJECTIVE: Little is known about shifting from pediatric to adult-focused multiple sclerosis (MS) care. This study aims to explore transition of care and follow-up in the US pediatric-onset MS (POMS) population. METHODS: Surveys were distributed to 10 sites in the US Network of Pediatric MS Centers (US NPMSC) about transition-of-care practices. A cohort of POMS/clinically isolated syndrome (CIS) at 12 US NPMSC sites was analyzed. The primary comparison was between < 18 and ≥ 18-years of age. The primary outcome was 1- and 2-year lapse in last follow-up visit, measured from last recorded datab

Improved functional assessment in cancer patients using home-based digital technologies.

Accurate assessment of performance status (PS) in oncology care is crucial for improving clinical decisions, therapy selection and anticipated risks of treatment toxicity. While physical function is traditionally assessed in the clinic, in-clinic instruments do not capture the full spectrum of daily functioning. Digital health technologies (DHTs) can address this limitation by passively monitoring patients in their daily environment. Our study showed at-home physical activity and gait metrics from DHTs were associated with self-reported PS in participants with cancer, and these metrics had gre

Voices of Survivorship: The Unmet Needs of Italian Cancer Survivors. A Qualitative Study.

BackgroundThe increasing number of cancer survivors (CSs) globally highlights the critical need for healthcare systems to address their unmet needs. These needs span physical, psychosocial, spiritual, informational, and practical dimensions and, if unaddressed, can impact quality of life and healthcare satisfaction.AimsThis study aimed to identify and understand the unmet needs of CSs in Italy to guide the development of patient-centered survivorship care services.MethodsA cross-sectional qualitative study was conducted between April 2023 and January 2024 at the Comprehensive Cancer Centre of

MASCC/ISOO Clinical Practice Statement: imaging and clinical laboratory tests in the diagnosis and management of medication-related osteonecrosis of the jaw.

PURPOSE: A MASCC/ISOO Clinical Practice Statement (CPS) is aimed at generating a concise resource for clinicians that concentrates practical information needed for the management of oral complications of cancer patients. This CPS focuses on the use of imaging and clinical laboratory tests for the diagnosis, staging, monitoring, treatment decision, and prediction of medication-related osteonecrosis of the jaw (MRONJ) in cancer patients. METHODS: This CPS was developed based on a critical evaluation of the literature followed by a structured discussion of a group of leading experts, members of

Subventricular Zone Microstructure in Pediatric-Onset Multiple Sclerosis.

OBJECTIVE: The aim of this study was to explore the microstructural dynamics of the subventricular zone (SVZ) with aging and their associations with clinical disability and brain structural damage in pediatric-onset multiple sclerosis (MS) patients. METHODS: One-hundred and forty-one pediatric-onset MS patients (67 pediatric and 74 adults with pediatric-onset) and 233 healthy controls (HC) underwent neurological and 3.0 T MRI assessment. Fractional anisotropy (FA) and mean diffusivity (MD) were extracted from the SVZ and the thalamus (as control region). RESULTS: In HC, SVZ FA was higher unt

Реактивность антител против EBNA1 и GlialCAM отличает пациентов с множественным склерозом от здорового контроля.

Множественный склероз (MS) — аутоиммунное демиелионирующее расстройство центральной нервной системы (CNS), которое связано с вирусом Эпштейн-Барр (EBV) перед заболеванием. Молекулярные механизмы, лежащие в основе этой связи, понимаются лишь частично. Ранее мы описали молекулярную анимацию между коэффициентом транскрипции EBV ядерный антиген 1 (EBNA1) и тремя человеческими белками CNS: аноктамином-2 (ANO2), альфа-B кристаллом (CRYAB) и молекулой глиального сцепления клеток (GlialCAM). Здесь мы изучили антителные реакции на EBNA1 и GlialCAM в большой группе из 650 пациентов MS и 661 популяционны

Моделирование использования первой линии Daratumumab для новых диагностированных, трансплантированных, не отвечающих установленным требованиям, множественных миелом: анализ эффективности затрат и рисков для работников системы здравоохранения.

СПРАВОЧНАЯ ИНФОРМАЦИЯ И ЦЕЛЬ: Это исследование было направлено на оценку эффективности затрат two Режимы, рассматриваемые в качестве стандарта для лечения недавно диагностированной, сносимой трансплантацией множественной миеломы в Сингапуре:1) Даратумумаб, линалидомид и дексаметасон и ()2Бортезомиб, линалидомид и дексаметасон. Кроме того, она направлена на изучение потенциальных стратегий регулирования неопределенности при принятии решений и снижения финансового риска.МЕТОДЫ: Анализ эффективности затрат с точки зрения системы здравоохранения был проведен с использованием модели раздельного выж

Клинический консенсус в отношении лечения санитарной трансплантации, недавно диагностировавшийся множественным миэлома: двойной склейка Делфи.

Цель: Получение клинического консенсуса в отношении факторов, влияющих на установление первой линии для пациентов, имеющих право на трансплантацию (TIE), с недавно поставленным диагнозом множественной миеломы (NDMM). В качестве экспертов были выбраны базирующиеся в США гематологи/онкологи, которые лечат пациентов ТИЭ с NDMM. Все участники дискуссии согласились с тем, что в первую очередь важно использовать наиболее эффективное обращение; 88% По мнению участников дискуссии, наиболее эффективными являются дератумумаб-содержащие режимы. Группировщики согласились с тем, что лечение следует продолж

Development and validation of a chemotherapy tolerance prediction model for Chinese multiple myeloma patients: The TM frailty score.

ObjectiveThe physical fitness of older individuals is heterogeneous, making it difficult to know their chemotherapy tolerance. The toxicities may offset the benefits of anti-myeloma therapy in frail patients. The accurate evaluation of frailty status before chemotherapy is essential. We aimed to explore the applicability of the IMWG GA and develop a new frailty screening tool more suitable for Chinese MM patients.Cases and methodsWe performed the IMWG GA and the full CGA in 167 MM patients and validated the applicability of the IMWG GA to chemotherapy and prognosis. The CGA domains were screen

Isatuximab in combination with cemiplimab in patients with relapsed/refractory multiple myeloma: A phase 1/2 study.

BACKGROUND: Given the incurable nature of multiple myeloma (MM), efforts are made to improve the efficacy of anti-CD38 monoclonal antibodies via combinations with other potentially synergistic therapies. This Phase 1/2 trial (NCT03194867) was designed to determine whether cemiplimab (anti-PD-1) enhances the anti-myeloma activity of isatuximab (anti-CD38) in patients with relapsed and refractory multiple myeloma (RRMM), to confirm the feasibility of the combination, determine its efficacy, and further evaluate its safety. METHODS: Patients received isatuximab 10 mg/kg once weekly for 4 weeks f

Integrating Quality of Life in the Care Pathway of Cancer Patients Undergoing Immunotherapy Treatment: Descriptive, Cross-sectional Survey of an Online Patient Community's Experiences and Expectations.

BackgroundNew cancer treatments, such as immune checkpoint inhibitors (ICIs), can improve survival and health-related quality of life (HRQoL) in patients with cancer. Although long-term monitoring of HRQoL has been shown to improve survival, integration of HRQoL into everyday practice remains poorly documented.ObjectiveThis study describes experiences and expectations of patients treated with ICIs regarding a discussion of HRQoL with health care professionals (HCPs) in cancer management.MethodsThis cross-sectional study was conducted in an online patient community (Carenity) in France. Patient

Molecular Characterization of a First-in-Human Clinical Response to Nimesulide in Acute Myeloid Leukemia.

Acute myeloid leukemia (AML) is a hematologic malignancy associated with high morbidity and mortality. Here we describe a case of a patient with AML who presented a partial response after utilization of the non-steroidal anti-inflammatory drug nimesulide. The response was characterized by complete clearance of peripheral blood blasts and an 82% decrease of bone marrow blasts associated with myeloblast differentiation. We have then shown that nimesulide induces in vitro cell death and cell cycle arrest in all AML cell lines (HL-60, THP-1, OCI-AML2, and OCI-AML3). Weighted Correlation Network An

Multiple Extramedullary-Bone Related and/or Extramedullary Extraosseous Are Independent Poor Prognostic Factors in Patients With Newly Diagnosed Multiple Myeloma.

BackgroundExtramedullary (EM) lesions are common in multiple myeloma (MM) and are often related to the poor prognosis of MM but are scarcely understood.MethodsIn this retrospective study, the baseline characteristics of 357 newly diagnosed patients with extramedullary multiple myeloma (EMM) and their impact on the prognosis were analyzed. All patients received first-line treatment with bortezomib-based regimen.ResultsThe overall incidence rate of EM was 22.4%, and the detection rate of PET/CT was significantly higher than other imaging methods (P = 0.015). The cohorts consisted of 10 cases of

CeRNA Expression Profiling Identifies KIT-Related circRNA-miRNA-mRNA Networks in Gastrointestinal Stromal Tumour.

Gastrointestinal stromal tumours (GISTs) are the most common human sarcomas and are typically located in the stomach or small intestine. Although circular RNAs (circRNAs) reportedly play vital roles in tumour oncogenesis and progression, the molecular basis of the aggressive tumour biology of these circRNAs in GISTs remains unclear. In this study, we applied SBC ceRNA microarrays to screen for tumour-specific circRNA profiles in GISTs and identified that a total of 5,770 circRNAs and 1,815 mRNAs were differentially expressed in GISTs. Three significantly differential circRNAs (circ_0069765, ci

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… All patients had understood all aspects of the informed consent and signed the informed consent forms before undergoing surgeries. …