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INvestigational Vertebroplasty Efficacy and Safety Trial (INVEST): a randomized controlled trial of percutaneous vertebroplasty.

BACKGROUND: The treatment of painful osteoporotic vertebral compression fractures has historically been limited to several weeks of bed rest, anti-inflammatory and analgesic medications, calcitonin injections, or external bracing. Percutaneous vertebroplasty (the injection of bone cement into the fractured vertebral body) is a relatively new procedure used to treat these fractures. There is increasing interest to examine the efficacy and safety of percutaneous vertebroplasty and to study the possibility of a placebo effect or whether the pain relief is from local anesthetics placed directly on

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… The subjects will have their electrocardiogram (ECG), blood pressure, heart rate and pulse oximetry continuously monitored throughout the procedure in both treatment arms. Lidocaine will be placed subcutaneously to numb the skin. …

Left Atrial Strain Correlation with Functional Capacity and Additional Prognostic Value of Speckle Tracking in Cardiac Amyloidosis: A Prospective, Single-Center Study.

Background: Cardiac amyloidosis (CA) is mainly characterized by diastolic dysfunction, with gradually worsening functional capacity and poor prognosis. Left atrial (LA) strain by speckle tracking echocardiography (STE) is an index of diastolic function and heart failure (HF) symptoms. The aim of this study was to evaluate the relationship of LA strain with functional capacity in CA and the potential prognostic value of speckle tracking variables. Methods: In this single-center study, we prospectively enrolled consecutive outpatients with CA (n = 75). Clinical, echocardiographic evaluation, six

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… We measured arterial oxygen saturation via pulse oximetry at the beginning and at the end of the test. We evaluated the results according to the American Thoracic Statement Guidelines for the 6MWT. Healthy subjects’ 6-minutes’ walking distance range was considered to be from 400 to 700 m [ 9 ]. …

Cardiac Amyloidosis: A Rare TTR Mutation Found in an Asian Female.

BACKGROUND: Transthyretin cardiac amyloidosis (ATTR) is a life-threatening, debilitating disease caused by abnormal formation and deposit of transthyretin (TTR) protein in multiple tissues, including myocardial extracellular matrix. It can be challenging to diagnose due to the myriad of presenting signs and symptoms. Additionally, numerous TTR mutations exist in certain ethnicities. Interestingly, our patient was discovered to have a very rare Gly67Ala TTR mutation typically not found in individuals of Asian descent. Recent advances in cardiovascular imaging techniques have allowed for earlier

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… Physical Exam and Review of Systems upon Admission On initial physical examination, she was afebrile with a blood pressure of 86/73, heart rate of 88 beats/min, respiratory rate of 18 breaths/min, and pulse oximetry saturation of 97% on room air. …

Sleepwalking and sleep terrors in prepubertal children: what triggers them?

OBJECTIVES: To evaluate the clinical presentation and polysomnography of prepubertal children with repetitive sleep terrors and sleepwalking … rate, body position, oro-nasal flow, chest impedance, breathing noises (neck microphone), and pulse oximetry. Movements are deduced from artifact, and leg movements may be recorded on one channel if the equipment is preset for such recording. Subjects used logs to record "lights out" time, "lights on" time, nocturnal awakenings, and other events that occur …

Cerebral near-infrared spectroscopy monitoring for prevention of death or neurodevelopmental disability in very preterm infants.

RATIONALE: Very preterm infants (i.e. born before 32 weeks of gestation) are at risk of cerebral injury and long-term neurodevelopmental imp … ny) vital sign monitoring methods have demonstrated patient-relevant benefits in RCTs. For cerebral oximetry in preterm infants, trials using clinically meaningful endpoints (e.g. neurodevelopment at two years assessed with the Bayley Scales) may be infeasible due to the large sample sizes required. In this context, surrogate outcomes, such as electrophysi …

A Phase I Study of Carfilzomib with Cyclophosphamide and Etoposide in Relapsed and Refractory Leukemia and Solid Tumors.

BackgroundNovel therapies are needed for children, adolescents, and young adults with relapse/refractory leukemia or solid tumors. The proteasome inhibitor carfilzomib has demonstrated pre-clinical activity against several pediatric malignancies when used alone or in combination. Therefore, a multicenter dose-escalation phase 1 study of carfilzomib administered in combination with cyclophosphamide and etoposide was conducted.MethodsStudy eligibility included an age of 6 months to 2/day, etoposide 100 mg/m2/day, and carfilzomib was administered every 28 days with growth factor support. The carf

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… ULN for age; direct bilirubin ≤ ULN for age unless elevation can be clearly attributed to liver leukemia or metastases); (5) adequate renal function (serum creatinine ≤ ULN for age or a glomerular filtration rate ≥ 70 mL/min/1.73 m 2 ); (6) an echocardiography shortening fraction ≥ 27%; and (7) pulse oximetry …

Inpatient Medicine

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Educational Case: Osteoporosis.

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… Oxygen saturation by pulse oximetry is 88% on room air. Head, ears, eyes, neck, and throat (HEENT) examination demonstrates no head trauma, dry mucous membranes, no palpable thyroid nodules, or glandular enlargement or atrophy; otherwise, the HEENT examination is normal. …

Упражнение пациентов с множественной миеломой: аналитическая оценка.

КОЛИЧЕСТВО: Пациенты с множественной миеломой (ММ) часто сталкиваются с нарушениями двигательной функции и снижением качества жизни. Хотя практические занятия играют жизненно важную роль, в настоящее время отсутствуют какие-либо стандартные руководящие принципы, специально предназначенные для пациентов из числа ОМ. В этой статье рассматривается сфера охвата физических упражнений пациентов с MM и дополнительно анализируется нынешняя ситуация, и в ней содержатся рекомендации в отношении ранней реабилитации.ЦЕЛЬ: Цель данной статьи заключается в систематическом анализе применения практических мер

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… In terms of physical sign monitoring, studies [ 19 , 22 , 27 ] employed portable oximetry to track heart rate and oxygen saturation, ensuring that the maximum heart rate and exercise heart rate (calculated as 220 minus age, with a target range of 50–75%) were maintained. …

Comprehensive Insights into Metastasis-Associated Spinal Cord Compression: Pathophysiology, Diagnosis, Treatment, and Prognosis: A State-of-the-Art Systematic Review

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… In addition, assessing arterial blood gases and pulse oximetry for signs of hypoxia or carbon dioxide retention is vital. Respiratory dysfunction severity correlates with spinal cord injury level [ 27 , 28 ]. 3.4. …

Efficacy of phosphodiesterase type 5 inhibitors in univentricular congenital heart disease: the SV-INHIBITION study design.

AIMS: In univentricular hearts, selective lung vasodilators such as phosphodiesterase type 5 (PDE5) inhibitors would decrease pulmonary resistance and improve exercise tolerance. However, the level of evidence for the use of PDE5 inhibitors in patients with a single ventricle (SV) remains limited. We present the SV-INHIBITION study rationale, design, and methods. METHODS AND RESULTS: The SV-INHIBITION trial is a nationwide multicentre, randomized, double blind, placebo-controlled, Phase III study, aiming to evaluate the efficacy of sildenafil on the ventilatory efficiency during exercise, in

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… volume in 1 second; FVC, forced vital capacity; mPAP, mean pulmonary arterial pressure; MRI, magnetic resonance imaging; OUES, oxygen uptake efficiency slope; PA‐Sat, pulmonary artery oxygen saturation; PCWP, pulmonary capillary wedge pressure; PVRi, indexed pulmonary vascular resistance; SpO 2 , pulse oximetry …

How I approach optimization of patients at risk of cardiac and pulmonary complications after CAR T-cell therapy.

Chimeric antigen receptor (CAR) T cells have transformed the care for patients with hematologic malignancies. Patients treated with CAR T cells may experience cardiovascular and pulmonary complications, which primarily occur in the setting of cytokine release syndrome. In addition, many patients considered for CAR T-cell therapy have preexisting cardiac and pulmonary comorbidities. Among patients with good functional status, these conditions should not prevent patients from being offered these lifesaving therapies. In this article, we use a case-based approach to discuss how we evaluate and op

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… For example, Zuma-1 required a LVEF ≥50% and pulse oximetry >92% when breathing room air, 7 whereas the Juliet trial required an LVEF of ≥45% and grade 1 or lower dyspnea as part of its inclusion criteria. 8 Recent studies have revealed that in the real-world setting, many patients referred for CAR T-cell …

[Guidelines for the diagnosis and treatment of obstructive sleep apnea in adults (2025)].

Obstructive sleep apnea (OSA) is a highly prevalent sleep-related breathing disorder with a considerable healthcare burden. Previously, the … d primary care settings, simplified criteria incorporating history, physical examination, and pulse oximetry may be used (1, A).OSA severity should be classified primarily based on the apnea-hypopnea index (AHI), with nocturnal minimum pulse oxygen saturation as a supplementary measure of hypoxemia burden (1, A). Emerging indices such as HB and SBII may be …

Discharge or admit? Emergency department management of incidental pulmonary embolism in patients with cancer: a retrospective study.

BackgroundHospitalization and early anticoagulation therapy remain standard care for patients who present to the emergency department (ED) with pulmonary embolism (PE). For PEs discovered incidentally, however, optimal therapeutic strategies are less clear-and all the more so when the patient has cancer, which is associated with a hypercoagulable state that exacerbates the threat of PE.MethodsWe conducted a retrospective review of a historical cohort of patients with cancer and incidental PE who were referred for assessment to the ED in an institution whose standard of care is outpatient treat

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… Routine practice for these patients included further evaluation with pulse oximetry during ambulation and blood testing (including platelets, coagulation studies, d -dimer, and renal function). …

Association of obstructive sleep apnea with bone metabolism in older adults: a hospital-based study.

PURPOSE: Obstructive sleep apnea (OSA) significantly affects patients' quality of life; however, the mechanisms, such as its effects on bone mineral density (BMD) and bone turnover marker (BTM) expression, remain unclear. In this study, we investigated the relationships among OSA, BMD, and (BTMs) in older adults. METHODS: This retrospective study enrolled 260 participants (114 women; 44.5%). Data of an established system (Alice NightOne) were used to diagnose OSA and analyze nocturnal hypoxia. Participants were divided into four groups according to respiratory event index (REI) (control, < 5

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… Nasal airflow, chest and abdominal movements, and pulse oximetry results were recorded. The results were analyzed automatically using an analysis software and after that manually interpreted according to the the American Academy of Sleep Medicine definitions [ 15 , 16 ]. …

Резюме МКАРЕ 2023 77th Национальный конгресс &quot; СИААРТИ &quot;

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… Zanusso Journal of Anesthesia, Analgesia and Critical Care 2023, 3(Suppl 1): A5 Local perfusion on the measurement site affects the accuracy of pulse oximetry to estimate arterial hemoglobin oxygen saturation [1]. … Moreover, multi-wave CO-oximetry can estimate arterial partial pressure of oxygen (PaO2) between 100 to 200 mmHg calculating the Oxygen Reserve index (ORi) based on the simultaneous measurement of arterial and venous blood light absorption using a similar technology of traditional pulse oximetry [3,4 …

Intrathoracic manifestations of hematologic malignancies: a narrative review.

BACKGROUND AND OBJECTIVE: Although the global incidence of hematologic malignancies is decreasing, the risk of developing these cancers is increasing due to increased lifespan and modern treatments including targeted therapy, chemotherapy, and radiation. Intrathoracic manifestations of hematologic malignancies may be the presenting sign leading to diagnosis or result from various treatment toxicity. The most common respiratory manifestation of hematologic malignancies is infectious, but up to half of pulmonary findings are from non-infectious etiologies. We aim to summarize the current literat

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… Pulse oximetry is the preferred method of monitoring of oxygenation ( 62 ). Therapy-related complications Pulmonary sequelae of chemotherapeutic agents such as bleomycin, busulfan, and cyclophosphamide have been well described. …

Outpatient CAR T-Cell Therapy as Standard of Care: Current Perspectives and Considerations.

Chimeric antigen receptor T-cell therapy (CAR-T) has altered the treatment landscape of several hematologic malignancies. Until recently, most CAR-T infusions have been administered in the inpatient setting, due to their toxicity profile. However, the advent of new product constructs, as well as improved detection and management of adverse effects, have greatly increased the safety in administering these therapies. CAR-T indications continue to expand, and inpatient administration is associated with increased healthcare resource utilization and overall cost. Therefore, transitioning CAR-T admi

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… CAR-T infusion RN coordinates with cellular therapy lab to determine time of product availability, and appropriate administration of pre-medications CAR-T product is administered per SOP following appropriate independent double-checks of CAR-T product RN performs and documents vital signs and pulse oximetry …

Multiple Myeloma Outpatient Transplant Program in the Era of Novel Agents: State-of-the-Art.

Multiple myeloma (MM) is the most common indication for autologous stem cell transplantation (ASCT), and outpatient models have been widely developed in this setting. Although numerous studies have demonstrated the safety and feasibility of outpatient ASCT, it is not a routine procedure. Stringent guidelines for patient selection and clinical management, including functional status, caregiver support, and psychological aspects, are essential to identify eligible patients. However, there is still no general agreement on these criteria. Quality of life data are limited and contradictory. There i

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… Suggested criteria for readmission are reported in Table 3 : hemodynamic instability (e.g., tachycardia and low blood pressure), impaired respiratory function (increased respiratory frequency and low oximetry on room air), oliguria, altered mental status and other signs of clinical instability ; Grade …

Efficacy of repetitive transcranial magnetic stimulation on postoperative pain in patients undergoing video-assisted thoracoscopic surgery: study protocol for a prospective, single-center, randomized controlled trial.

BACKGROUND: Video-assisted thoracoscopic surgery (VATS) is a key treatment for many cardiothoracic issues, but intraoperative factors can lead to acute postoperative pain (APSP), impacting recovery and quality of life. While multimodal analgesic methods are used, they have notable side effects. Repetitive transcranial magnetic stimulation (rTMS) offers a non-invasive pain relief option by stimulating the primary motor cortex (M1), effective in chronic pain management. However, its role in preventing and treating APSP after VATS needs confirmation through high-quality clinical trials. METHODS/

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… Once in the operating room, peripheral venous access is established, and noninvasive blood pressure, electrocardiogram, and pulse oximetry are monitored. …