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Informed appropriate imaging for low back pain management: A narrative review.

Most patients with acute low back pain (LBP), with or without radiculopathy, have substantial improvements in pain and function in the first 4 weeks, and they do not require routine imaging. Imaging is considered in those patients who have had up to 6 weeks of medical management and physical therapy that resulted in little or no improvement in their LBP. It is also considered for those patients presenting with suspicion for serious underlying conditions, such as cauda equina syndrome, malignancy, fracture and infection. In western country primary care settings, the prevalence has been suggeste

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… Figure 7 Myelography computed tomography (A) Arachnoiditis; (B) postsurgical canal stenosis (C): Post-traumatic medullary compression. Figure 7 Lumbar radiography and CT contribute to cumulative radiation exposure, which could promote carcinogenesis. …

Dysregulation of sphingolipid metabolism contributes to bortezomib-induced neuropathic pain.

The development of chemotherapy-induced painful peripheral neuropathy is a major dose-limiting side effect of many chemotherapeutics, including bortezomib, but the mechanisms remain poorly understood. We now report that bortezomib causes the dysregulation of de novo sphingolipid metabolism in the spinal cord dorsal horn to increase the levels of sphingosine-1-phosphate (S1P) receptor 1 (S1PR1) ligands, S1P and dihydro-S1P. Accordingly, genetic and pharmacological disruption of S1PR1 with multiple S1PR1 antagonists, including FTY720, blocked and reversed neuropathic pain. Mice with astrocyte-sp

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… The pia-arachnoid membrane was removed from the section before it was attached with cyanoacrylate glue to a cutting support and then glued onto the stage of a vibratome (Series 1000; Technical Products International). …

Abstracts - IANCON 2024

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Targeting HDACs with dacinostat amplifies radiation-induced DNA damage via sustained phosphorylated p53 and repair inhibition in aggressive meningioma.

The lack of standard systemic treatments in meningioma presents a therapeutic challenge, making radiotherapy a crucial intervention for recurrent, high-grade, or inoperable tumours. Nonetheless, the efficacy of radiotherapy is constrained by the inherent radioresistance of meningiomas, attributed to their proficient DNA damage repair and robust cell cycle checkpoint regulation. These biological barriers, along with anatomical constraints of avoiding damage to adjacent neural tissues, restrict dose escalation and therapeutic gains. Histone deacetylases (HDACs) are mediators of radioresistance i

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… These tumours arise from the arachnoid cap cells and dural border cells found within the meninges [ 1 ]. …

Krill oil extract suppresses the proliferation of colorectal cancer cells through activation of caspase 3/9.

BackgroundCurrently available treatments for colorectal cancer (CRC) associate with numerous side-effects that reduce patients' quality of life. The effective nutraceuticals with high anti-proliferative efficacy and low side-effects are desirable. Our previous study has reported that free fatty acids extract (FFAE) of krill oil induced apoptosis of CRC cells, possibly associated with changes in mitochondrial membrane potential (MMP). The aims of this study were to compare the anti-proliferative efficacy of FFAE from krill oil on CRC cells with commonly used chemotherapeutic drug, Oxaliplatin,

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… Abbreviations Arachnoid Acid protein kinase apoptotic protease activating factor American Tissue Culture Collection pro-apoptotic Bcl-2 proteins B cell lymphoma protein cyclo-oxygenase-2 Colorectal cancer 4,6-diamidino-2-phenylindole docosahexaenoic acid Dulbecco’s Modified Eagle’s Medium …

Последние достижения в области мезенхимической стволовой клеточной терапии для множественных склерозов: клинические виды применения и проблемы.

Множественный склероз (MS), хроническое аутоиммунное расстройство центральной нервной системы (CNS), характеризуется воспалением, обезвоживанием и нейродегенерацией, что приводит к различным клиническим проявлениям, таким, как усталость, сенсорное расстройство и когнитивная дисфункция. Текущее фармакологическое лечение направлено прежде всего на иммунную модуляцию, но не позволяет остановить прогрессию заболеваний или полностью обратить на нет повреждения CNS. Лечение стволовыми клетками (MSC) является многообещающей альтернативой, используя иммуномудуляторы, нейрозащиту и регенеративные спосо

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… No lasting negative impact on cognition Cohen et al. (2023) Phase II/18 participants Autologous MSCs (NurOwn ® ) IT injection, three treatments administered (specific timing not provided) Two participants developed low back and leg pain, consistent with arachnoiditis, after one of the IT treatments …

The advancement and utility of multimodal imaging in the diagnosis of degenerative disc disease.

Degenerative disc disease (DDD) is a common spinal condition characterized by the deterioration of intervertebral discs, leading to chronic back pain and reduced mobility. While magnetic resonance imaging (MRI) has long been the standard for late-stage DDD diagnosis, its limitations in early-stage detection prompt the exploration of advanced imaging methods. Positron emission tomography/computed tomography (PET/CT) using 18F- fluorodeoxyglucose (FDG) and 18F-sodium fluoride (NaF) has shown promise in identifying metabolic imbalances and age-related spinal degeneration, thereby complementing CT

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… Importantly, myelography remains relevant to the postoperative examination as well since the contrast-filled thecal sac presents arachnoid adhesions, CSF leaks, and epidural hemorrhage more clearly without being obscured by metal-induced artifacts to the degree that CT is ( 33 ). …

ИАНКОН 2023 Выдержки из плаката

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Электронные постеры

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Клеточная терапия в многоразовом склерозе: Клинические достижения, ограничения и перспективы на будущее из клинических исследований - систематический обзор.

Фон: Множественный склероз (MS) — хроническое аутоиммунное демиелинирующее заболевание центральной нервной системы (CNS), характеризующееся воспалением, обезвоживанием и прогрессивным нейродегенерацией. Несмотря на то, что нынешняя медикаментозная терапия (ДМТ) может снизить частоту рецидивов и провокационной активности, они редко останавливают долгосрочное развитие или устраняют неврологические повреждения. В последние годы клеточная терапия стала многообещающим подходом к содействию иммунальному регулированию и нейрогенерации в MS. Методы: Настоящий обзор резюмирует текущие клинические данны

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… Post-injection pain, arachnoiditis; no SAEs. …

Вирусы и "Мозг-отношение к беде".

Неврологические расстройства, некоторые из которых связаны с вирусными инфекциями, растут из-за старения и увеличения численности населения. Несмотря на крепкую защиту центральной нервной системы, некоторые вирусы эволюционировали, чтобы пробить их, что часто приводит к ужасным последствиям. В этом обзоре мы рассказываем о различных способах проникновения различных вирусов в ЦНС и о последствиях таких вторжений. Последствия могут проявляться в виде острых заболеваний, таких, как энцефалит, менингит, или приводить к долгосрочным последствиям, таким, как нервно - мышечная дисфункция, как это име

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… The BCSF barrier is formed by a pair of membranes—one, composed of choroid plexus epithelial cells, and the second, the arachnoid membrane, composed of several layers of fibroblasts [ 17 ], that envelops the brain [ 18 ]. …

Leptomeningeal disease: current diagnostic and therapeutic strategies.

OBJECTIVES: We determined the efficacy of the use of a tension free prolene mesh to correct a grade III anterior vaginal wall prolapse recurrence. METHODS: Twelve women (mean age 65.6 years) with stress urinary incontinence (SUI) (4 type II and 1 type III) and bladder prolapse entered the study. After vaginal incision a pretailored polypropylene mesh was fixed to its four angles by absorbable sutures to the urethropelvic ligaments and pubocervical fascia anteriorly and to the cardinal ligaments and pubocervical fascia posteriorly. When present, a posterior descensus was corrected during the s

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… INTRODUCTION Leptomeningeal disease (LMD) is a late-stage complication of systemic cancers caused by multifocal metastases to the leptomeninges, which consist of the pia mater, arachnoid, and subarachnoid space. …

Е-постеры.

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Involvement of Resveratrol against Brain Cancer: A Combination Strategy with a Pharmaceutical Approach.

A brain tumor (BT) is a condition in which there is growth or uncontrolled development of the brain cells, which usually goes unrecognized or is diagnosed at the later stages. Since the mechanism behind BT is not clear, and the various physiological conditions are difficult to diagnose, the success rate of BT is not very high. This is the central issue faced during drug development and clinical trials with almost all types of neurodegenerative disorders. In the first part of this review, we focus on the concept of brain tumors, their barriers, and the types of delivery possible to target the b

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… Even though it is well tolerated, there are a few side effects, such as arachnoiditis, meningitis, and focal neurologic injury. Besides this, if there are CSF flow abnormalities, each of these methods will result in a reduced volume of distribution (and potentially increased toxicity). …

A scoping review of biopsychosocial risk factors and co-morbidities for common spinal disorders.

OBJECTIVE: The purpose of this review was to identify risk factors, prognostic factors, and comorbidities associated with common spinal disorders. METHODS: A scoping review of the literature of common spinal disorders was performed through September 2016. To identify search terms, we developed 3 terminology groups for case definitions: 1) spinal pain of unknown origin, 2) spinal syndromes, and 3) spinal pathology. We used a comprehensive strategy to search PubMed for meta-analyses and systematic reviews of case-control studies, cohort studies, and randomized controlled trials for risk and pro

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… (ankylosing spondylitis, juvenile rheumatoid arthritis, psoriatic arthritis, reactive arthritis, rheumatoid arthritis, seronegative spondyloarthropathy) | Traumatic | • Dislocation • Subluxation • Fractures • Spinal cord disorders • Myelopathy | • Not applicable | Infectious | • Tuberculosis | • Arachnoiditis …

E-Posters

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… Fortunately, spinal arachnoid cysts are treatable with surgery. We present our experience in managing spinal arachnoid cysts, based on a study of 13 patients. … MRI showed solitary arachnoid cyst in 12 cases. Only one patient presented 2 lumbar arachnoid cysts. The arachnoid cyst was epidural in 11 cases and intramedullary in 2 cases. All the cysts were posterior or posterolateral. All cysts had cerebrospinal intensity on T1 and T2 weighted images. …

Электронные постеры

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СРП 2013

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… Radiologic-Pathologic Correlation and Clinical Outcome in Congenital Glioblastoma PA-094 | 9:40 | Dixon | Arachnoid Cysts Diagnosed Prenatal and in Young Children: Is there a High Requirement for Surgical intervention? …

Diseases of the Nervous System

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Rare Diseases of the Orbit.

This article provides an overview of rare orbital diseases. Congenital malformations, inflammatory diseases, benign and malignant neoplasias are described. Although it represents a relatively small area of the body the orbit contains multiple different tissues. Therefore, a great variety of diseases can be found within the orbital space. That is the reason, why both the completeness and the level of detail in the description of particular diseases must be somewhat limited. Nevertheless, clinical manifestations, important aspects of diagnosis, treatment strategies, and, when specific data are a

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… occurrence of microphthalmos mostly associated with systemic pathologies agenesis of corpus callosum, basal encephaloceles, heterotopia of the gray matter facial clefts, saddle nose, choanal atresia, sphenoid anomalies genital malformations finger malformations Cave : possible connection to the arachnoid … possible secondary ulceration and infection of the cephaloceles Therapy excision and closure of the bone defect duraplasty Note Generally, these lesions are present at birth but sometimes will manifest only later in life (especially when located dorsally). 4.2.4 Other neurogenic cysts 27 Primary arachnoid …