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The impact of obesity: a narrative review.

Obesity is a disease with a major negative impact on human health. However, people with obesity may not perceive their weight to be a significant problem and less than half of patients with obesity are advised by their physicians to lose weight. The purpose of this review is to highlight the importance of managing overweight and obesity by discussing the adverse consequences and impact of obesity. In summary, obesity is strongly related to >50 medical conditions, with many of them having evidence from Mendelian randomisation studies to support causality. The clinical, social and economic burde

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… intra-abdominal and intrathoracic pressure as a result of excessive adiposity impedes inflation of the lung, which can significantly affect the lung function, thereby leading to hypoventilation and ventilation–perfusion imbalance.[ 44 ] A constellation of obesity, daytime hypoventilation characterised by hypercapnia …

COVID-19: The Impact in Oncology Care.

The COVID-19 pandemic has imposed a critical challenge to the current oncology care and practices including late diagnoses, delayed anti-cancer treatment, and static clinical trials. With the increasing risk of cancer patients acquiring infection during receiving the essential care, the debate ensues on how to balance the risk factors and benefits out of the oncologic emergencies in cancer patients. In this review article, we have focused on the current global re-organization of the integrity and effectiveness of the treatment modalities depending on the patient and cancer-specific urgencies w

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… For this reason, older persons are sensible for dyspnea and diminished ventilatory response to hypoxia and hypercapnia. Due to this, they are more vulnerable to ventilatory failure (i.e., heart failure, pneumonia) [ 27 ]. …

Pulmonary Hypertension in an Oncologic Intensive Care Unit

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… Finally, continuous vigilance to correct metabolic abnormalities including acidosis, hypoxemia, hypercapnia, hypothermia, and hypocalcemia is vital to sustain RV contractility negatively affected by these factors. …

Coexistence of Autoantibodies against the Golgi Complex and Ro52 Antigen in a Patient with Nonspecific Interstitial Pneumonia.

Nonspecific interstitial pneumonia (NSIP) is often associated with connective tissue diseases (CTD). The diagnosis of NSIP was confirmed in a 63-year-old man by high-resolution computed tomography and an open lung biopsy. Anti-Golgi complex autoantibodies (AGA) and anti-Ro52 antibodies were simultaneously detected at high concentrations. Autoantibodies to aminoacyl-tRNA synthetases (ARS) were negative. The patient was treated with corticosteroids for six months. During the seven-year follow-up, NSIP had a slow progression and patient had not developed the clinical features of CTD. The present

Hypertonic-hyperoncotic solutions improve cardiac function in children after open-heart surgery.

OBJECTIVES: Hypertonic-hyperoncotic solutions are used for the improvement of micro- and macrocirculation in various types of shock. In pedi … minutes after volume loading (15.6 +/- 1.5 mL/kg). In all patients, no hypoxia (Pa(O2)<60 mm Hg) or hypercapnia (Pa(CO2) >60 mm Hg) was observed. Arterial blood gas analysis showed pH and base excess within physiologic range, and this did not change throughout the whole period of observation. After infusion of hypertonic-hyperoncotic solution, sodium concentr …

Cancer in Pregnancy: Therapeutic Decisions at the Intersection of Two Lives.

Background: Cancer during pregnancy is a rare but increasingly encountered condition due to delayed childbearing and improved survival of women with cancer. The coexistence of malignancy and pregnancy poses complex diagnostic and therapeutic challenges, requiring careful balance between maternal prognosis and fetal safety. Objective: This review aims to summarize current evidence on the diagnosis and multidisciplinary management of cancer during pregnancy, focusing on the safe use of oncologic therapies, obstetric decision-making, and maternal and fetal outcomes. Methods: A narrative review wa

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… In addition to the risk of fetal loss, surgery may lead to hypercapnia, perforation of the enlarged uterus, and reduced uterine blood flow due to increased intra-abdominal pressure and the use of carbon dioxide [ 2 , 47 ]. …

SUBJECT INDEX Volume 125 (JANUARY–JUNE, 2004)

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… affected, eg , Breast neoplasms Cancer recurrence: See Neoplasm recurrence Cancer staging: See Neoplasm staging Capillary wedge pressure: See Pulmonary capillary wedge pressure Capnography, volumetric, as a screening test for pulmonary embolism in the emergency department, 841 Carbon dioxide: See also Hypercapnia …

Sepsis in multimorbidity: a domain-based framework for systemic vulnerability and precision care.

Sepsis is a leading cause of morbidity and mortality, amplified by multimorbidity. This narrative review synthesizes epidemiological, pathophysiological, and immunological evidence to show how prevalent conditions-type 2 diabetes and obesity, heart failure and cerebrovascular disease, COPD, chronic kidney disease, cancer/HIV, and severe mental illness-reshape sepsis biology and outcomes. Convergent mechanisms include low-grade inflammation, impaired innate and adaptive immunity, endothelial injury with immunothrombosis/NETosis, barrier disruption with dysbiosis, and neuroendocrine maladaptatio

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… COPD | Cautious fluids; avoid/worsening hypercapnia. | Respiratory/Gram-negative coverage; corticosteroids per COPD-exacerbation guidelines. | Arterial blood gases; SOFA; PaO₂/FiO₂. | Non-invasive ventilation or lung-protective invasive ventilation; consider APRV; prevent barotrauma. | Pulmonology follow-up …

Перенос дисфункции химического обмена MRI для нейродегенеративных заболеваний: Обновленная информация о клинических и предклинических исследованиях.

Перенос магнитного резонанса через химический обмен с высокой степенью чувствительности и пространственного разрешения представляет собой передовой метод визуализации, позволяющий обнаруживать соединения при низких концентрациях и широко изучается для диагностики злокачественных свойств и инсульта. В последние годы новые возможности для раннего обнаружения и повторного сканирования без ионизирующего излучения открылись в связи с новыми исследованиями передачи магнитных резонансных изображений с целью обнаружения патологических изменений в нейродегенеративных заболеваниях. Этот обзор служит обз

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… The research examined CrCEST signal variations influenced by creatine concentration and pH, validated by MRS-based methods and hypercapnia experiments. …

SCS 6th Annual Meeting-EEVFA-11th International Congress of Biochemistry and Physiology of Exercise, Athens, Greece, 2023.

On behalf of the Strength and Conditioning Society (SCS) and the Hellenic Society of Biochemistry and Exercise Physiology (EEVFA), we are pleased to present the abstracts of the SCS 6th Annual Meeting and EEVFA-11th International Congress of Biochemistry and Physiology of Exercise. The event was held at the Hellenic Olympic Committee headquarters in Athens, Greece, on 19-22 October 2023, and comprised several invited sessions from international and national speakers on a variety of topics related to biochemistry and exercise physiology, strength and conditioning practices and their application

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… .: 00306973070602 Abstract: Finswimming (FS) athletes often train by swimming short distances under apnoea conditions, which results in the gradual development of arterial hypoxaemia and hypercapnia, but also in the manifestation of the diving reflex (1). … Keywords: arterial hypoxia; hypercapnia; diving reflex; apnoea. Funding: This research received no external funding. References Vašíčková, J.; Neumannová, K.; Svozil, Z. The effect of respiratory muscle training on fin-swimmers’ performance. J Sports Sci Med 2017 , 16 , 521. …

Pharmacological Treatments and Therapeutic Drug Monitoring in Patients with Chronic Pain.

Pain is an unpleasant sensory and emotional experience that affects every aspect of a patient's life and which may be treated through different pharmacological and non-pharmacological approaches. Analgesics are the drugs most commonly used to treat pain, and in specific situations, the use of opioids may be considered with caution. These drugs, in fact, do not always induce optimal analgesia in patients, and several problems are associated with their use. The purpose of this narrative review is to describe the pharmacological approaches currently used for the management of chronic pain. We rev

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… Their stimulation can lead to hypercapnia and hypoxia [ 19 , 24 , 25 ]. …

Autonomic control of ventricular function in health and disease: current state of the art.

PurposeCardiac autonomic dysfunction is one of the main pillars of cardiovascular pathophysiology. The purpose of this review is to provide an overview of the current state of the art on the pathological remodeling that occurs within the autonomic nervous system with cardiac injury and available neuromodulatory therapies for autonomic dysfunction in heart failure.MethodsData from peer-reviewed publications on autonomic function in health and after cardiac injury are reviewed. The role of and evidence behind various neuromodulatory therapies both in preclinical investigation and in-use in clini

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… Chemosensory neurites in these same peripheral vessels as well as central chemoreceptors in the ventral medulla and retrotrapezoid nucleus sense and transmit information on hypoxemia and hypercapnia, respectively. …

Delayed gastric emptying in critical illness: is enhanced enterogastric inhibition with cholecystokinin and peptide YY involved?

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… Acidosis persisting after transfusion suggests inadequate tissue perfusion. 119 Empiric administration of bicarbonate to counter the acid load is not warranted and may contribute to the deleterious effects of hypercapnia in patients with impaired ventilation. …

ESICM LIVES 2016: part three : Milan, Italy. 1–5 October 2016

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Obesity as a Multifactorial Chronic Disease: Molecular Mechanisms, Systemic Impact, and Emerging Digital Interventions.

Obesity is a multifactorial chronic disease resulting from complex genetic, molecular, environmental, and behavioral interactions. Its prevalence rises worldwide, affecting cardiovascular, metabolic, oncological, hepatic, respiratory, and skeletal health. Beyond caloric excess, genetic predisposition, epigenetic modifications, gut microbiota dysbiosis, endocrine-disrupting agents, circadian misalignment, and intergenerational and prenatal influences are critical determinants of obesity risk. Core pathophysiological mechanisms include insulin resistance, dyslipidemia, chronic low-grade inflamma

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… OSA is defined by recurrent collapse of the pharyngeal airway during sleep, resulting in impaired gas exchange—specifically hypoxemia and hypercapnia—and intermittent surges in catecholamines and other counter-regulatory hormones [ 47 ]. …

Management of Potential Organ Donor: Indian Society of Critical Care Medicine-Position Statement.

This position statement is documented based on the input from all contributing coauthors from the Indian Society of Critical Care Medicine (ISCCM), following a comprehensive literature review and summary of current scientific evidence. Its objective is to provide the standard perspective for the management of potential organ/tissue donors after brain death (BD) in adults only, regardless of the availability of technology. This document should only be used for guidance only and is not a substitute for proper clinical decision making in particular circumstances of any case. Endorsement by the IS

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… Reason for spinal reflexes according to one hypothesis: the reflex movements represent hypoxia- and hypercapnia-induced activity of cervical cord neurons. Alternatively, they might be due to the disinhibition of movement generators of the spinal cord. …

Proceedings of Reanimation 2023, the French Intensive Care Society International Congress.

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Emergency Care

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Abstracts of the ICARE 2024 78th SIAARTI National Congress

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Резюме МКАРЕ 2023 77th Национальный конгресс &quot; СИААРТИ &quot;

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… Patients with the clinical features of OHS undergo blood gas analysis: if hypoxemia and hypercapnia (>45mmHg) are present, then CPAP treatment should be considered (Figure 1). …