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Comparison of the efficacy and safety of flexible vacuum-assisted ureteral access sheath-assisted flexible ureteroscopic lithotripsy, conventional ureteral access sheath-assisted flexible ureteroscopic lithotripsy, and mini-percutaneous nephrolithotomy for 2-3 cm renal stones.

BACKGROUND: The optimal management of 2-3 cm renal stones remains challenging because effective stone clearance must be balanced against per … ospital stay, total hospitalization costs, and postoperative adverse events, including fever, renal colic, urinary tract infection, and steinstrasse. SFR was assessed on postoperative day 3 and at 1 month postoperatively. RESULTS: Operative time differed significantly among the three groups (FV-UAS 77.56 ± 15.04 min vs mPCNL 67.60 ± 10.44 min vs UAS 85 …

Performance Comparison of a Neuro-Symbolic Large Language Model System Versus Human Experts in Acute Cholecystitis Management.

Background/Objectives: Large language models (LLMs) have shown promising results in medical decision support; however, their effectiveness i … uding gangrenous, emphysematous, and perforated variants (n = 5), chronic cholecystitis and biliary colic (n = 4), gallbladder polyps and adenomyomatosis (n = 3), Mirizzi syndrome (n = 2), gallbladder carcinoma (n = 4), and post-cholecystectomy complications (n = 4). Questions were categorized into diagnosis (n = 10), treatment (n = 10), and complicatio …

Same-admission versus interval cholecystectomy for mild gallstone pancreatitis (PONCHO): a multicentre randomised controlled trial.

BACKGROUND: In patients with mild gallstone pancreatitis, cholecystectomy during the same hospital admission might reduce the risk of recurr … itis, cholangitis, cholecystitis, choledocholithiasis needing endoscopic intervention, or gallstone colic) or mortality within 6 months after randomisation, analysed by intention to treat. The trial was designed to reduce the incidence of the primary endpoint from 8% in the interval group to 1% in the same-admission group. Safety endpoints included bile …

Intravenous lysine clonixinate for the acute treatment of severe migraine attacks: a double-blind, randomized, placebo-controlled study.

BACKGROUND: Several nonsteroidal anti-inflammatory drugs (NSAIDs) have been shown to be effective in the treatment of migraine. However, few commercially available NSAIDs can be administered IV. Lysine clonixinate (LC), an NSAID derived from nicotinic acid, has been proved effective in various algesic syndromes (eg, renal colic, muscular pain, nerve compression, odontalgia). The oral formulation of LC has been shown to be effective in the treatment of migraine of moderate severity. OBJECTIVE: The aim of this study was to assess the efficacy and tolerability of the IV formulation of LC in the …

Disorders of the Gastrointestinal System

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… : a comparative study of variables used to assess individual cases Equine Vet J 15 1983 211 215 6884310 10.1111/j.2042-3306.1983.tb01768.x 6 King JN Gerring EL Observations on the colic motor complex in a pony with a small intestinal obstruction Equine Vet J Suppl 7 1989 43 45 10.1111/j.2042-3306.1989 … J Am Vet Med Assoc 193 1988 927 931 3192473 19 Moore JN Owen RR Lumsden JH Clinical evaluation of blood lactate levels in equine colic Equine Vet J 8 1976 49 54 4300 10.1111/j.2042-3306.1976.tb03289.x 20 Gossett KA Cleghorn B Martin GS Correlation between anion gap, blood L-lactate concentration and …

2021 Scientific Session of the Society of American Gastrointestinal and Endoscopic Surgeons (SAGES), Las Vegas, Nevada, 31 August–3 September 2021: Video Loops

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… In addition to the middle colic artery (MCA) and left colic artery (LCA), the accessory middle colic artery (AMCA) has been recognized as a feeding artery for the left-sided colon. … After division of gastro-colic ligament and dissection of Toldt fascia, transverse colon and terminal ileum were divided with linear stapler. Lateral mobilization of the colon was completed. A side to side ileo-colic intracorporeal mechanical anastomosis was performed. …

[Features of urolithiasis recurrence in the Far North regions].

AIM: To improve the diagnosis and treatment of urolithiasis in the conditions of the Far North. MATERIALS AND METHODS: The study included 1 … d of the ureter in 51 patients (37.5%). Indications for surgery included frequent episodes of renal colic, hematuria, and chronic calculous pyelonephritis. Preoperatively, 29 patients (21.3%) had recurrent stone formation, whereas in 107 patients (78.7%) the stone was detected for the first time. Extracorporeal shock wave lithotripsy (ESWL) was performe …

Cholelithiasis and cholecystitis.

Gallstone disease remains one of the most common medical problems leading to surgical intervention. Every year, approximately 500,000 cholec … d with gallstone disease. The diagnosis of chronic cholecystitis is made by the presence of biliary colic with evidence of gallstones on an imaging study. Ultrasonography is the diagnostic test of choice, being 90-95% sensitive. The surgical literature suggests that 3-10% of patients undergoing cholecystectomy will have CBD stones. Intraoperative laparo …

Safety, clinical activity, pharmacodynamics, and pharmacokinetics of IMU-856, a SIRT6 modulator, in coeliac disease: a first-in-human, randomised, double-blind, placebo-controlled, phase 1 trial.

BACKGROUND: IMU-856 is an orally available and systemically acting small molecule modulator of sirtuin 6 (SIRT6), a protein that serves as a … s occurred with IMU-856 treatment (one in part B [bacterial myocarditis] and one in part C [biliary colic]), both of which were unrelated to IMU-856. No dose-limiting toxicities, systematic safety laboratory changes, or deaths occurred during the study. In part C, mean decrease in villous height was -20·9 μm (SD 34·8) among patients who received IMU-856 …

Outcomes of Xanthogranulomatous cholecystitis in laparoscopic era: A retrospective Cohort study.

INTRODUCTION: Xanthogranulomatous cholecystitis (XGC) is a rare variant of cholecystitis and reported incidence of XGC varies from different … he most common clinical features were abdominal pain and tenderness in right hypochondrium. Biliary colic and acute cholecystitis were the most common preoperative diagnosis. Ultrasonogram was performed in all patients and CT scan abdomen in 5 patients. In study population (XGC), 10 were patients in group I, 8 in group II and 9 in group III. Conversion …

[Evaluation of inferior mesenteric vessel and ureter by contrast-enhanced abdominal pelvic CT and its clinical influence on laparoscopic rectal surgery].

Objective: To assess the anatomic relationship of inferior mesenteric artery (IMA)/inferior mesenteric vein (IMV) with ureter by contrast-en … tance between major branches, distance between IMA/IMV and ureter at the level of root of IMA, left colic artery (LCA) root, abdominal aortic bifurcation, and sacral promontory were measured and association between IMA/IMV and ureter site was summarized. Results: The distance from IMA root to the aortic bifurcation and sacral promontory was (42.0±8.5) m …

[Pathophysiology, diagnosis and conservative therapy in calcium kidney calculi].

Annual incidences of kidney stones are about 0.1-0.4% of the population, and lifetime prevalences in the USA and Europe range between 8 and … rystal adhesion to urothelial surfaces may be enhanced in stone formers. Medical treatment of renal colic is based on nonsteroidal antiinflammatory drugs, because prostaglandins appear to play a crucial role in the pathophysiology of pain during ureteral obstruction. In addition, centrally acting analgesics such as pethidine-HCl may be required in many …

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[Changes in the kidneys in patients with successive findings of Mycobacterium xenopi and Mycobacterium fortuitum in the urine--report of 16 cases]].

INTRODUCTION: Environmental or MOTT (mycobacteria other than tubercle bacilli) mycobacteria are found in both living environment and most of … ents. Regarding functional disorders, haematuria, leukocytes in the sediment, proteinuria and renal colics were most frequently registered. Two patients with successive findings of Mycobacterium fortuitum were presented with neither significant patho-anatomic nor functional renal disorders. DISCUSSION: The following conclusions have emerged from the co …

Posterior 'superior mesenteric artery first' approach for resection of locally advanced pancreatic cancer.

BACKGROUND: En bloc resection of the superior mesenteric vein (SMV), portal vein (PV), and/or splenic vein (SV) with concomitant venous reco … sive peripancreatic inflammation. These difficulties may be overcome by utilizing an 'inferior supracolic (anterior) approach', but this necessitates early division of the pancreatic neck and stomach.5 METHODS: Select video clips were compiled from several pancreatoduodenectomies to demonstrate this technique. A variety of bipolar devices were utilized …

Two Types of Variational Arteries' Courses From the Superior Mesenteric Artery to Supply the Splenic Flexure: Gross Anatomical Study.

BACKGROUND: Complete mesocolic excision with central vascular ligation is a standard method for managing colon cancer. However, there is no consensus on its procedure, especially for cancer in the splenic flexure of the transverse colon. This is because various types of variational arteries are distributed to the region, and their running course below and near the pancreas leads to difficulty in ligating the artery. OBJECTIVE: To clarify the arterial distribution to the splenic flexure of the transverse colon using cadavers. DESIGN: The arteries in the transverse mesocolon distributed to the…

Interventions for men and women with their first episode of genital herpes.

BACKGROUND: Genital herpes is incurable, and is caused by the herpes simplex virus (HSV). First-episode genital herpes is the first clinical … n adverse events reported for oral acyclovir were coryza, dizziness, tiredness, diarrhoea and renal colic. For intravenous acyclovir these were phlebitis, nausea and abnormal liver function tests and for topical acyclovir there was pain with the topical application.Those undergoing interferon treatment had significantly more adverse events compared to t …

Single dose dipyrone (metamizole) for acute postoperative pain in adults.

BACKGROUND: Dipyrone (metamizole) is a nonsteroidal anti-inflammatory drug used in some countries to treat pain (postoperative, colic, cancer, and migraine); it is banned in other countries because of an association with life-threatening blood disorders. This review replaces a 2010 Cochrane review that has been withdrawn. OBJECTIVES: To assess the analgesic efficacy and associated adverse events of single dose dipyrone for moderate to severe acute postoperative pain using methods that permit comparison with other analgesics evaluated in standardised trials using almost identical methods and o…

Short-term outcomes of laparoscopic D2 lymphadenectomy with complete mesogastrium excision for advanced gastric cancer.

BACKGROUND: D2 lymphadenectomy has been widely accepted as a standard procedure of surgical treatment for local advanced gastric cancer [1, … ee. The standard surgical procedures in the video are described as follows. Dissect along the gastrocolic ligament and then toward the left colic flexture with special made gauze. Bluntly separate the adipose tissues to find fascia plane. Expose along the plane toward the splenic inferior polar area. Precede to the origins of left gastroepiploic vessels …

Post-traumatic diaphragmatic rupture with pericardial denudation: A case report.

INTRODUCTION: Post-traumatic diaphragmatic rupture is a lesion of variable severity. It is a rare and difficult to diagnose pathology, it ha … . The thoraco-abdomino-pelvic CT scan revealed the presence of a left thoracic hernia with gastric, colic and epiploic contents through a lateral defect of the left diaphragmatic dome. The decision was to directly send the patient to the operating room. Exploration found a large left diaphragmatic breach of 20 cm, a denudation of the pericardia, a mediu …