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Acute Respiratory Failure in Patients with Hematologic and Solid Malignancies: Global Approach

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… Signs and symptoms include dyspnea, wheezing, hoarseness, and stridor. These patients usually require emergent airway management including cricothyroidotomy or tracheostomy. Central airway obstruction can be endoluminal, extraluminal, or a combination of both. …

Skeletal-related events and overall survival of patients with bone metastasis from nonsmall cell lung cancer - A retrospective analysis.

Because of improving treatments and survival, 40% to 58% of patients with bone metastases from nonsmall cell lung cancer (NSCLC) will suffer from at least one skeletal-related event (SRE), affecting their quality of life, but the natural history of SRE is poorly understood. The study aimed to examine the factors involved in SRE-free survival (SRS) and overall survival (OS) of patients with NSCLC and bone metastases.This was a retrospective study of 211 patients with bone metastasis from NSCLC and treated at the Tumor Hospital Affiliated to Harbin Medical University between January 2007 and Jan

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… All patients have been confirmed to be with NSCLC according to symptoms and signs (cough, bloody sputum or hemoptysis, shortness of breath or stridor, fever, weight loss, chest pain, hoarseness, dysphagia, hydrothorax, symptoms and signs caused by metastasis, and paraneoplastic syndrome) and histological …

Macroglossia due to Systemic Amyloidosis: Is There a Role for Radiotherapy?

BACKGROUND: Macroglossia due to amyloid depositions can cause cosmetic problems and functional disability, and can lead to life-threatening airway obstruction. Management of macroglossia in systemic amyloidosis is controversial, and the role of surgery is unclear. CASE DESCRIPTION: We present a case of a 66-year-old woman affected by macroglossia due to light chain amyloidosis who presented with eating and breathing difficulties. Because of prior successful results of radiotherapy for localized amyloid disease, our patient was treated with external beam radiation therapy (20 Gy in 10 fraction

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… 11499828 10.1016/S0025-6196(11)63233-3 24 Monroe AT Walia R Zlotecki RA Jantz MA Tracheobronchial amyloidosis: a case report of successful treatment with external beam radiation therapy Chest 2004 125 784 789 14769766 10.1378/chest.125.2.784 25 Gallivan GJ Gallivan HK Laryngeal amyloidosis causing hoarseness …

Belantamab mafodotin, carfilzomib, lenalidomide и дексаметазон для рецидива или рефракта множественной миеломы.

Резюме Belantamab mafodotin (Belamaf), антитела-наркотики, направленные против антигена ячеек B-клеток, продемонстрировало активность одного агента в повторной/охлажденной миеломе (RRMM), но связано с окулярной токсичностью. Это фазы 1/2 в ходе исследования была проведена оценка безопасности и предварительной эффективности использования беналафа 8 Недели в сочетании с карфилзомидом, линалидомидом и дексаметасоном (KRd-b) у пациентов с RRMM. Пациенты, имеющие право на получение помощи, по крайней мере, 1 :: предыдущая терапия и не продвинулась по полной дозе леналидомида. На стадии " доза-

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… 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 1 (7.7) 1 (7.7) 0 (0.0) 2 (15.4) Fever 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 1 (7.7) 1 (7.7) 0 (0.0) 2 (15.4) Influenza-like symptoms 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 1 (7.7) 1 (7.7) 0 (0.0) 2 (15.4) Flushing 2 (33.3) 0 (0.0) 0 (0.0) 2 (33.3) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) Hoarseness … (0.0) | 2 (15.4) Fever | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 1 (7.7) | 1 (7.7) | 0 (0.0) | 2 (15.4) Influenza-like symptoms | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 1 (7.7) | 1 (7.7) | 0 (0.0) | 2 (15.4) Flushing | 2 (33.3) | 0 (0.0) | 0 (0.0) | 2 (33.3) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) Hoarseness …

Oral health in patients scheduled for hematopoietic stem cell transplantation in the Orastem study.

Despite advances in transplant medicine, prevalence of complications after hematopoietic stem cell transplantation (HSCT) remains high. The impact of pre-HSCT oral health factors on the incidence and severity of complications post-HSCT is poorly understood. The aim of this prospective, observational study was to analyze oral health in patients planned for HSCT. Patients ≥18 years requiring HSCT were included from five sites between 2011-2018. General health, oral findings and patient-reported symptoms were registered in 272 patients. Oral symptoms around disease onset were reported by 43 patie

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… Table 3 Patient-reported oral symptoms a) around disease onset and b) from previous chemotherapy. a Other: Swollen jaw/cheek 2, Unfit denture 1, Other oral symptom, not specified 9. b Other: Herpes 4, Aphthae 3, Sandpaper feeling 3, Increased vomiting reflexes 2, Hoarseness 1, Myalgia 1, Bacterial infection … (29.4) | 13 (32.5) | 2 (25.0) | 1 (6.3) | 5 (55.6) | 4 (26.7) | 0 (0.0) | 27 (34.6) | 3 (27.3) Missing data | 5 | 0 | 0 | 2 | 0 | 1 | 1 | 0 | 0 | 1 | 0 Type of other oral symptom * , n Dry mouth | 46 | 6 | 4 | 7 | 1 | 0 | 1 | 3 | 0 | 22 | 2 Taste changes | 28 | 7 | 0 | 5 | 1 | 1 | 3 | 2 | 0 | 8 | 1 Hoarseness …

Case Report: Management of Primary Tracheobronchial Light Chain Amyloidosis in a Patient With Biclonal Gammopathy Using a Systemic Bortezomib-Based Regimen.

Primary tracheobronchial light chain (AL) amyloidosis is a rare and heterogeneous disease characterized by the buildup of amyloid deposits in the airway mucosa. Although its treatment remains challenging, the current view is that the localized form can be treated conservatively due to its slow progression. While radiotherapy has proven effective in treating localized form of the disease, some patients do not respond to local treatment and continue to experience poor quality of life, highlighting the need to explore additional treatment strategies. In this report, we discuss a case of primary t

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… Laryngeal amyloidosis causing hoarseness and airway obstruction. J Voice. (2010) 24:235–9. 10.1016/j.jvoice.2008.07.006 27. Poovaneswaran S, Razak AR, Lockman H, Bone M, Pollard K, Mazdai G. Tracheobronchial amyloidosis: utilization of radiotherapy as a treatment modality. …

Small cell carcinoma with neuroendocrine differentiation of subglottic larynx- a case report.

Small cell cancer (SCC) is a neuroendocrine neoplasm, which is most frequently found in the lungs. Extrapulmonary location of SCC is rare and may involve 2.5-5% of SCCs. We present a case of a 31-year-old male patient with an extremely uncommon subglottic SCC. The patient was qualified for a radical sequential chemoradiotherapy. After treatment, patient's condition suggested complete remission. Recurrence was detected one year later, and the disease rapidly progressed, despite a second line chemotherapy. The patient died 29 months after initial diagnosis. This case aims to raise awareness on t

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… The disease may manifest with multiple symptoms, including hoarseness, dyspnea, or dysphagia ( 11 ). Poorly differentiated NECs are associated with elevated mitotic activity and necrosis ( 12 ). …

Utility of Bruton's Tyrosine Kinase Inhibitors in Light Chain Amyloidosis Caused by Lymphoplasmacytic Lymphoma (Waldenström's Macroglobulinemia).

Of the variety of immunoglobulin related amyloidosis (AL), immunoglobulin M (IgM) related AL represents only 6 to 10% of affected patients, and the majority of these cases are associated with underlying non-Hodgkin's Lymphoma including Waldenström's macroglobulinemia (WM). Ibrutinib, acalabrutinib, and zanubrutinib are Bruton tyrosine kinase (BTK) inhibitors approved for certain indolent B cell non-Hodgkin's lymphoma (NHL). BTK is a nonreceptor kinase involved in B-cell survival, proliferation, and interaction with the microenvironment. We retrospectively evaluated the tolerability and effecti

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… Patient 1 Patient 1 is a male with a history of WM for 14 years, managed with hematologic monitoring without therapy, presented in 2020 with 22 lbs. of weight loss over a period of two years along with poor appetite, hoarseness of the voice, dyspnea with minimal exertion, early satiety, abdominal bloating …

Dermatological Manifestations of Amyloid Light-Chain (AL) Amyloidosis: A Case Report Highlighting Early Diagnosis and Treatment.

This case report describes a 52-year-old man who presented with gradually progressive dark cutaneous discoloration over the upper trunk and periorbital region, accompanied by painless enlargement of the tongue, which initially interfered with speech and eating. Over the subsequent months, he experienced marked unintentional weight loss, persistent fatigue, and symptoms consistent with autonomic involvement, including postural dizziness and altered bowel habits. Clinical examination revealed waxy skin changes and macroglossia. Laboratory evaluation demonstrated a monoclonal light-chain abnormal

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… A similar case is of a 26-year-old male who presented with closely set skin-coloured papules on the eyelids, around the nose and mouth, and over the scalp, and a history of generalized weakness, hoarseness of voice, and an increase in the size of his tongue. …

Anabolic steroids for rehabilitation after hip fracture in older people.

BACKGROUND:: Hip fracture occurs predominantly in older people, many of whom are frail and undernourished. After hip fracture surgery and re … idual adverse events. Three participants in the steroid group of one trial reported side effects of hoarseness and increased facial hair. The other trial reported better quality of life in the steroid plus group. AUTHORS' CONCLUSIONS:: The available evidence is insufficient to draw conclusions on the effects, primarily in terms of functional outcome and adv …

Anabolic steroids for rehabilitation after hip fracture in older people.

BACKGROUND: Hip fracture occurs predominantly in older people, many of whom are frail and undernourished. After hip fracture surgery and reh … idual adverse events. Three participants in the steroid group of one trial reported side effects of hoarseness and increased facial hair. The other trial reported better quality of life in the steroid plus group. AUTHORS' CONCLUSIONS: The available evidence is insufficient to draw conclusions on the effects, primarily in terms of functional outcome and adve …

Symmetrical Skin Lesions on the Gluteal Region in a Patient with Anti-Laminin-332 Mucous Membrane Pemphigoid.

Mucous membrane pemphigoid (MMP), previously called cicatricial pemphigoid, is a rare subepidermal immunobullous disorder that primarily aff … rs on the mucous membranes and skin, with conjunctival hyperemia, nasal obstruction, oral pain, and hoarseness of voice. Three days before the first visit, he was diagnosed with gastric cancer with liver metastasis by gastrointestinal endoscopy and abdominal ultrasound examination for tarry stool. Physical examination demonstrated erosions and tense bullae o …

Purpura fulminans secondary to Capnocytophaga canimorsus bacteraemia following a dog bite: A case report and review of literature.

IntroductionInfection due to Capnocytophaga canimorsus may result in a wide variety of clinical presentations. We present a case of life-threatening Capnocytophaga canimorsus infection with evolution of ecchymosis to purpura fulminans.Case descriptionWe present a case of a 43-year-old male with a history of excessive alcohol consumption who presented with features of sepsis following a dog bite. This was associated with a striking, widespread purpuric rash. A causative pathogen, C. canimorsus was identified through blood culture and 16S RNA sequencing. His initially purpuric rash underwent bul

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… Nil noted | Splenectomy (Hogkin lymphoma) | Nil noted | Nil noted | Nil noted Symptoms/ signs on admission | Abdominal pain Headache Myalgia Fever | Malar purpura Gangrene of tip of nose | Flu-like symptoms | Febrile Bilateral purpuric rash affecting feet and pretibial areas | Lower extremity pain Hoarseness …

Combination of Novel Therapies and New Attempts in Anaplastic Thyroid Cancer.

Anaplastic thyroid cancer (ATC) is one of the most lethal human malignancies, and it is rapidly falling without any effective therapeutic options. Although radical surgery, radiotherapy, and chemotherapy are performed on patients, the curative effect is suboptimal, and the survival rate is still poor. The discovery of altered gene pathways involved in this aggressive disease has advanced, but molecular targeted drugs targeting these pathways are still in clinical trials. To date, there is no effective way to treat this disease, so it is particularly urgent to find new treatments. At present, m

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… When the mass grows beyond the thyroid gland, it can invade the adjacent organs, trachea, esophagus, and recurrent laryngeal nerve and can appear dyspnea, dysphagia, neck pain, and hoarseness. 5 , 6 Approximately 15% of ATC patients show extensive local invasion and distant metastasis through blood and …

What should rheumatologists know about Gaucher disease and Fabry disease? Connecting the dots for an overview.

Gaucher and Fabry diseases are lysosomal storage disorders in which deficient enzyme activity leads to pathological accumulation of sphingolipids. These diseases have a broad phenotypic presentation. Musculoskeletal symptoms and pain complaints are frequently reported by patients. Thus, rheumatologists can be contacted by these patients, contributing to the correct diagnosis, earlier indication of appropriate treatment and improvement of their prognosis. This review describes important concepts about Gaucher and Fabry diseases that rheumatologists should understand to improve patients' quality

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… Farber disease | ASAH1 | Acid ceramidase | Ceramide | Type I: early onset and premature death, organomegaly, joint contractures, voice hoarseness, neurological manifestations. Type II: intermediate. Type III: mild. Type IV: neonatal-visceral. Type V: neurological-progressive. …

Is radioiodine necessary for patients with low-risk differentiated thyroid cancer after thyroidectomy: a pooled analysis of ESTIMABL2 and IoN trials.

BackgroundThe clinical utility of postoperative radioiodine therapy in patients with low-risk differentiated thyroid cancer (DTC) remains a subject of ongoing debate. Although radioiodine has been widely employed to reduce the risk of recurrence, its necessity in low-risk populations is increasingly questioned, given the favorable outcomes observed with surgery alone. To address this issue, we conducted a meta-analysis exclusively based on randomized controlled trials (RCTs) to comprehensively evaluate the efficacy and safety of radioiodine therapy in this specific patient population.MethodsWe

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… [0.50, 1.52] | 0.62 Depression | 18/253 | 7.11% | 16/251 | 6.37% | 1.12 [0.58, 2.14] | 0.74 Dizziness | 16/253 | 6.32% | 12/251 | 4.78% | 1.32 [0.64, 2.74] | 0.45 Headache | 14/253 | 5.53% | 17/251 | 6.77% | 0.82 [0.41, 1.62] | 0.56 Nausea | 13/253 | 5.14% | 8/251 | 3.19% | 1.61 [0.68, 3.82] | 0.28 Hoarseness …

Hereditary epidermolysis bullosa: clinical-epidemiological profile of 278 patients at a tertiary hospital in São Paulo, Brazil.

BACKGROUND: Epidermolysis bullosa (EB) is a group of rare hereditary diseases, characterized by fragility of the skin and mucous membranes. Epidemiological data on EB in Brazil are scarce. OBJECTIVES: To describe epidemiological aspects of patients with EB diagnosed in the Dermatology Department of a tertiary hospital, from 2000 to 2022. METHODS: An observational and retrospective study was conducted through the analysis of medical records. The evaluated data included clinical form, sex, family history, consanguinity, age at diagnosis, current age, time of follow-up, comorbidities, histopath

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… Conjunctivitis (1) | Symblepharon (1) Blepharitis (1) | Retinal detachment (1) | Myopia (2) Macula staphyloma (1) | | Gastroenterological | | Esophageal stenosis (40) | Megacolon (1) | Dyspeptic Syndrome (3) Gastroesophageal reflux disease (3) | Constipation (7) | Otorhinolaryngological | | Otitis (3) | Hoarseness …

Review of Hematology-Oncology Emergencies for Internal Medicine Residents.

The prevalence of cancer continues to grow globally every year. With therapeutic advances over the recent decades, the prevalence of individuals living with cancer continues to increase. Internal medicine residents can see patients admitted to the hospital for cancer-related emergencies. Early identification and appropriate management of these emergencies have been shown to improve mortality and morbidity. In this article, we aim to review the recent updates in the management of commonly encountered oncologic emergencies in the practice of internal medicine residents. This review will cover sp

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… Presenting symptoms can include swelling of the face and neck, distension of the neck veins, cough, dyspnea, stridor, hoarseness, facial plethora, upper body edema, headache, altered mental state, stupor, coma, vision changes, syncope, nausea, and dysphagia. …

Systematic review of patient-reported outcome item libraries in cancer research: an EORTC Quality of Life Group study.

BackgroundPatient-reported outcome (PRO) item libraries support flexible PRO assessment in cancer research by facilitating the development of customized item lists. However, little is known about the use of item lists in clinical research. This systematic review addresses this by assessing utilization of PRO item libraries and lists in oncology research.MethodsA systematic review of MEDLINE, Embase, and CINAHL identified cancer studies using PRO item libraries to develop item lists, regardless of study design, published between October 2021 and September 2025. Key features of item library usag

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… 2025) 63 | Observational (UK) | Gastrointestinal | Surgery | Symptomatic adverse event tracking | N/A | EORTC | 39 | Number of items not specified: difficulties eating; problems with senses scale; anorexia; vomiting; nausea; weight loss; reflux scale; pain in chest; tiredness; diarrhea; constipation; hoarseness … depression (3); insomnia (2); neuropathy (2); fatigue (2) Ruddy (2024) 94 | Observational (United States) | Head and neck | Chemotherapy | Symptomatic adverse event tracking | N/A | PRO-CTCAE | 27 | Dry mouth (1); difficulty swallowing (1); mouth or throat sores (2); skin cracking (1); voice changes (1); hoarse …

Papillary thyroid carcinoma in a patient with long-standing chronic lymphocytic leukemia: A case report.

The synchronous occurrence of papillary thyroid carcinoma (PTC) and chronic lymphocytic leukemia (CLL) is rare and poses diagnostic challenges, particularly in distinguishing metastatic thyroid disease from hematological lymphadenopathy. The present report documents the case of a 64-year-old female patient with long-standing CLL who presented with a malignant thyroid nodule accompanied by multiple enlarged cervical lymph nodes. A diagnosis was established through integrated immunohistochemistry, flow cytometry and multimodal imaging. After the diagnosis of synchronous PTC and CLL/SLL was confi

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… The patient had experienced no neck pain, hoarseness, dysphagia or dyspnea. Systemic symptoms, such as fever, palpitations, diarrhea and facial flushing, were also absent. …