Результаты поиска

Light-Chain Amyloidosis: The Great Impostor.

Light-chain amyloidosis (AL) is a disease of protean manifestations due to a wide spectrum of organs that can be affected. The disorder is caused by the deposition of an extracellular amorphous material, the amyloid, which is produced by malignant plasma cells. The latter usually reside in the bone marrow; plasma cell infiltration is often low, in sharp contrast to what we observe in multiple myeloma. The disease may run below the physician's radar for a while before clinical suspicion is raised and targeted tests are performed. In this short review, we try to answer most of the questions that

Совпадение в полном тексте источника
… The patient might suffer from dyspnea and hoarseness if the disease affects the lungs and the airways, including the vocal cords. In such cases, the imaging tests might reveal pleural effusions, pulmonary nodules and cysts, and finally, diffuse alveolar deposits. …

Videolaryngoscopy versus direct laryngoscopy for adult patients requiring tracheal intubation.

BACKGROUND: Successful tracheal intubation during general anaesthesia traditionally requires a line of sight to the larynx attained by posit … cts 0.68, 95% CI 0.48 to 0.96; 29 studies; 3110 participants) and fewer incidences of postoperative hoarseness (M-H OR, fixed-effect 0.57, 95% CI 0.36 to 0.88; six studies; 527 participants) when a VLS was used. A greater number of laryngoscopies performed with a VLS achieved a view of most of the glottis (M-H OR, random-effects 6.77, 95% CI 4.17 to 10.98; 2 …

Prognostic models for radiation-induced complications after radiotherapy in head and neck cancer patients.

BACKGROUND: Radiotherapy is the mainstay of treatment for head and neck cancer (HNC) but may induce various side effects on surrounding norm … alidations were judged as having unclear ROB in the analysis domain. Models for outcomes related to hoarseness, fatigue, nausea-vomiting, throat pain, aspiration No models were externally validated at least twice. AUTHORS' CONCLUSIONS: Amongst 592 developed models, a limited number had adequate quality. Only one-fifth were externally validated, of which, on …

Anaplastic thyroid carcinoma.

Thyroid cancers represent about 1% of all human cancers. Differentiate thyroid carcinomas (DTCs), papillary and follicular cancers, are the most frequent forms, instead Anaplastic Thyroid Carcinoma (ATC) is estimated to comprise 1-2% of thyroid malignancies and it accounts for 14-39% of thyroid cancer deaths. The annual incidence of ATC is about one to two cases/million, with the overall incidence being higher in Europe (and area of endemic goiter) than in USA. ATC has a more complex genotype than DTCs, with chromosomal aberrations present in 85-100% of cases. A small number of gene mutations

Совпадение в полном тексте источника
… Locally, ATC shows a rapidly enlarging anterior neck mass, with accompanying dysphagia (40%), voice change or hoarseness (40%), and stridor (24%). Regional symptoms included a noticeable lymph node mass (54%) and neck pain (26%). …

Relapsing polychondritis: tracheobronchial involvement and differential diagnoses.

This review is describing the diagnostic and therapeutic approach to tracheobronchial involvement in relapsing polychondritis (RP), with a focus on differential diagnoses of inflammatory origin. RP is a systemic auto-immune disease that mainly affects cartilage structures, progressing through inflammatory flare-ups between phases of remission and ultimately leading to deformation of the involved cartilages. Besides the damage of auricular or nasal cartilage, tracheobronchial and cardiac involvement are the most severe, and can seriously alter the prognosis. Tracheobronchial lesions are assesse

Совпадение в полном тексте источника
… Laryngeal chondritis Laryngeal chondritis is observed in 40% of cases ( 15 - 18 , 21 ), with various manifestations such as dry cough, hoarseness, dysphonia/aphonia, or thyroid cartilage pain. …

The Risk of Sarcoidosis Misdiagnosis and the Harmful Effect of Corticosteroids When the Disease Picture Is Incomplete.

Sarcoidosis is a complex granulomatous disease of unknown etiology. Due to the heterogeneity of the disease, the diagnosis remains challenging in many cases, often at the physician's discretion, requiring a thorough and complex investigation. Many other granulomatous diseases have the potential to mimic sarcoidosis, whether infectious, occupational, or autoimmune diseases and starting an unnecessary corticosteroid treatment can worsen the patient's prognosis, leading to side effects that can be harder to treat than the actual disease.

Совпадение в полном тексте источника
… Meningeal irritation Symmetrical mono/polyneuropathies, polyradiculopathy Affecting the pituitary gland—diabetes insipidus, amenorrhea, galactorrhea Otolaryngological involvement 5–15% of cases | Sinonasal involvement—nasal obstruction, rhinitis, epistaxis, rhinorrhea, anosmia Laryngeal sarcoidosis—hoarseness …

Professional oral care in end-of-life patients with advanced cancers in a hospice ward: improvement of oral conditions.

BackgroundIn end-of-life patients with advanced cancers, oral examination, oral care, and oral re-examination are crucial. Although oral symptoms are among the major complaints of end-of-life patients, few studies have focused on oral care in these patients. In this study, the association between oral symptoms and oral dryness among end-of-life patients was examined, and improvement of oral conditions after oral care interventions by a professional dentist was quantified.MethodsThis prospective intervention study included 27 terminally ill patients with advanced cancers in a hospice ward. Prof

Совпадение в полном тексте источника
… pain | 0.0 | (0.0–0.0) | 0.0 | (0.0–0.0) | | 0.371 Oral function Voice Normal | 5 | (33.3%) | 0 | (0.0%) | 0.047 a * | Abnormal | 10 | (66.7%) | 12 | (100.0%) | | Swallow (+) | 8 | (57.1%) | 8 | (66.7%) | 0.701 a | (−) | 6 | (42.9%) | 4 | (33.3%) | | MWST Swallowing with neither cough nor wet hoarseness …

Immunoglobulin Light-Chain Amyloidosis: Clinical Presentations and Diagnostic Approach.

Systemic immunoglobulin light-chain (AL) amyloidosis is a rare disorder arising from a plasma cell clone that produces misfolded immunoglobulin light chains, which are deposited in various tissues and organs as amyloid fibrils. Signs and symptoms are typically vague and overlap with those arising from other common diseases; consequently, diagnosis of AL amyloidosis is challenging for clinicians. Substantial delays between onset of symptoms and diagnosis are common, and result in poorer outcomes, particularly in patients with cardiac AL amyloidosis and others who develop advanced organ dysfunct

Bridging the gap - Establishing a dental-oncology service in a cancer centre.

Dental disease remains the most common non-communicable disease worldwide. It predisposes patients to significant morbidities following bone modifying agents or radiation therapy to the head and neck. Preventative dental regimes effectively reduce the risk of both medication-related osteonecrosis of the jaw (MRONJ) and osteoradionecrosis (ORN) in these patients. Co-ordination of routine dental care as a component of mainstream oncology treatment optimises long term outcomes for oncology patients. This case series offers insights into patient, institutional and social difficulties that challeng

Совпадение в полном тексте источника
… Radiation toxicity is implicated in hyposalivation, mucositis, dermatitis, dysphagia, dysgeusia and hoarseness. …

Educational Case: Atypical presentation of primary hyperparathyroidism with brown tumor.

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Совпадение в полном тексте источника
… So, damage to one causes hoarseness or voice change, whereas damage to both causes bilateral vocal cord paralysis, dyspnea, and potential airway compromise. The external branch of the SLN innervates the cricothyroid muscle involved in vocal cord tightening. …

Stakeholder Perceptions of Key Aspects of High-Quality Cancer Care to Assess with Patient Reported Outcome Measures: A Systematic Review.

Performance measurement is the process of collecting, analyzing, and reporting standardized measures of clinical performance that can be compared across practices to evaluate how well care was provided. We conducted a systematic review to identify stakeholder perceptions of key symptoms and health domains to test as patient-reported performance measures in oncology. Stakeholders included cancer patients, caregivers, clinicians, and healthcare administrators. Standard review methodology was used, consistent with PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses). MEDLIN

Совпадение в полном тексте источника
… interview | Patients | 66 | Social/psychological Physical symptoms Pain Sleep disturbance Holländer-Mieritz, 2019 [ 35 ] | Hospital | Copenhagen, Denmark | Head and neck | Radiotherapy with or without chemotherapy | Interview | Patients | 13 | Oral pain Decreased appetite Dysphagia Dry mouth Fatigue Hoarseness …

Current evidence for the treatment of hypothyroidism with levothyroxine/levotriiodothyronine combination therapy versus levothyroxine monotherapy.

ObjectiveHypothyroidism is relatively common, occurring in approximately 5% of the general US population aged ≥12 years. Levothyroxine (LT4) monotherapy is the standard of care. Approximately, 5%-10% of patients who normalise thyroid-stimulating hormone levels with LT4 monotherapy may have persistent symptoms that patients and clinicians may attribute to hypothyroidism. A long-standing debate in the literature is whether addition of levotriiodothyronine (LT3) to LT4 will ameliorate lingering symptoms. Here, we explore the evidence for and against LT4/LT3 combination therapy as the optimal appr

Sclerosing diseases of the skin.

Sclerosing skin diseases comprise a group of distinct dermatological conditions characterized by fibrotic changes that may severely impair patients' quality of life. These conditions often present with cutaneous manifestations and, in some cases, may extend to extracutaneous tissues, potentially resulting in significant morbidity and mortality. This review explores the current understanding of the four most prevalent sclerosing skin diseases - localized scleroderma (morphea), systemic sclerosis (SSc), scleromyxedema, and scleredema adultorum of Buschke - as well as sclerotic conditions induced

Совпадение в полном тексте источника
… joints with noninflammatory synovial fluids ‐ Fibromyalgia and severe weakness ‐ In rare cases, dermatomyositis, rhabdomyolysis Heart | ‐ Congestive heart failure ‐ Myocardial ischemia ‐ Heart block ‐ Pericardial effusion Gastrointestinal system | ‐ Dysphagia ‐ Nasal regurgitation Lungs | ‐ Dyspnea ‐ Hoarseness …

Adverse events among older adults receiving chiropractic spinal manipulation and related treatments: an updated systematic review.

BACKGROUND: This systematic review updated adverse events (AEs) reporting in persons aged > 55 years who received chiropractic treatment, including spinal manipulation. METHODS: Protocol was registered prospectively with the Prospective Register of Systematic Reviews (PROSPERO)(CRD42024629286). Search strategy was audited with Peer Review of Electronic Search Strategies (PRESS) methodology. We searched PubMed, Cochrane Central Register of Controlled Trials, CINAHL, AMED, and Index to Chiropractic Literature on December 12, 2025. We included AEs attributed to treatment provided by chiropractors

Совпадение в полном тексте источника
… Rating Adverse Event Body System Baruch 2023 [ 63 ], High 59, Male 30–40 pack years smoking high work stress Intermittent nocturnal numbness to the right hand Chiropractic manipulation, bilateral cervical spine 0–2 days Dyspnea, saliva accumulation, dysphagia, and shortness of breath; dysarthria and hoarseness … Event Body System Baruch 2023 [ 63 ], High | 59, Male | 30–40 pack years smoking | high work stress | Intermittent nocturnal numbness to the right hand | Chiropractic manipulation, bilateral cervical spine | 0–2 days | Dyspnea, saliva accumulation, dysphagia, and shortness of breath; dysarthria and hoarseness …

Chronic pruritus: a narrative review.

Chronic pruritus encompasses a manifestation of several cutaneous, allergic, infectious, neurological, psychological, and systemic conditions, whose etiological investigation and therapeutic strategy can be challenging. This comprehensive review aims to enhance the understanding of pruritus by highlighting important elements in its pathogenesis, including keratinocytes, Merkel cells and mast cells, nerve fibers, histaminergic and nonhistaminergic pathways, and the interaction of itch signals with the central nervous system. Diagnostic evaluation of chronic pruritus may require a meticulous app

Pulmonary Hypertension in an Oncologic Intensive Care Unit

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Совпадение в полном тексте источника
… Definition of abbreviations: CT, computed tomography As the pulmonary artery enlarges further, it may exert mass effect on adjacent structures to cause wheezing from compression of airways, hoarseness from compression of the recurrent laryngeal nerve, or cardiac ischemia from compression of the left …

A review of potential suggested drugs for coronavirus disease (COVID-19) treatment.

The latest pandemic, coronavirus disease-2019 (COVID-19), is associated with high prevalence and easy transmission, which is expanding globally with no conventional treatment or vaccine. The new virus revealed 79% and 50% genomic similarities with severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV), respectively. Accordingly, since the disease resists testing and adopting new therapeutics, repositioning pre-existing drugs may present a fast and attractive strategy with known safety, characteristics, and dosage used. However, they

Совпадение в полном тексте источника
… Investigational drug ( NCT04365725 ) ( NCT04323761 ) ( NCT04302766 ) ( NCT04410354 ) Hypersensitivity to Remdesivir or any component of the formulation Authorized emergency use Ribavirin (Virazole) Antiviral Viral protein synthesis inhibitor 6 g over 12–18 h daily, Oral inhalation Anxiety, Cough or hoarseness … Investigational drug | ( NCT04365725 ) ( NCT04323761 ) ( NCT04302766 ) ( NCT04410354 ) | Hypersensitivity to Remdesivir or any component of the formulation | Authorized emergency use Ribavirin (Virazole) | Antiviral | Viral protein synthesis inhibitor | 6 g over 12–18 h daily, Oral inhalation | Anxiety, Cough or hoarseness …

Systemic complications of rheumatoid arthritis: Focus on pathogenesis and treatment.

As a systemic autoimmune disease, rheumatoid arthritis (RA) usually causes damage not only to joints, but also to other tissues and organs including the heart, kidneys, lungs, digestive system, eyes, skin, and nervous system. Excessive complications are closely related to the prognosis of RA patients and even lead to increased mortality. This article summarizes the serious complications of RA, focusing on its incidence, pathogenesis, clinical features, and treatment methods, aiming to provide a reference for clinicians to better manage the complications of RA.

Совпадение в полном тексте источника
… Because the midline of the vocal folds is adducted, cricoarytenoid arthritis manifests as hoarseness, sore throat, dyspnea, and stridor, which are primarily due to thickening of the synovial membrane of the cricoarytenoid joint and persistent cartilage erosion ( 82 ). 3.2 Treatment of lung disease in …

One Giant Step for Giant Cell Arteritis: Updates in Diagnosis and Treatment.

Purpose of reviewGiant cell arteritis (GCA), a medium and large vessel vasculitis occurring in the aged, remains a formidable disease, capable of taking both vision and life, through a multitude of vascular complications. Our understanding of the spectrum of its manifestations has grown over the years, to include limb claudication, aortitis, and cardiac disease, in addition to the more classic visual complications resulting from of ischemia to branches of the external and internal carotid arteries. While a clinical presentation of headache, jaw claudication, scalp tenderness, fever and other s

Совпадение в полном тексте источника
… Giant cell arteritis presenting with pericardial effusion, hoarseness, and amaurosis. Anatol J Cardiol. 2020;23(4):235–237. doi:10.14744/AnatolJCardiol.2019.00502 33. Truffaut L, Lefebvre P. Tongue necrosis in Giant-cell arteritis. N Engl J Med. 2018;378(26):2517. doi: 10.1056/NEJMicm1709412. 34. …

A systems-pharmacology analysis of herbal medicines used in health improvement treatment: predicting potential new drugs and targets.

For thousands of years, tonic herbs have been successfully used all around the world to improve health, energy, and vitality. However, their underlying mechanisms of action in molecular/systems levels are still a mystery. In this work, two sets of tonic herbs, so called Qi-enriching herbs (QEH) and Blood-tonifying herbs (BTH) in TCM, were selected to elucidate why they can restore proper balance and harmony inside body, organ and energy system. Firstly, a pattern recognition model based on artificial neural network and discriminant analysis for assessing the molecular difference between QEH an

Совпадение в полном тексте источника
… Usual side effects have been reported mainly in adolescents, young men and women and are consist of flushing of the skin and acne, hirsutism, deepening and hoarseness of the voice, masculinization, amenorrhea and increase in libido [ 96 ]. …