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Efficacy of bortezomib as first-line treatment for patients with multiple myeloma.

Recent years have seen a dramatic change in the approach towards diagnosing and treating Multiple Myeloma. Newer and more target specific approach to treatment has prolonged the survival for patients with multiple myeloma. The proteasome inhibitors make an important class of anti-myeloma drugs that disrupts the proteolytic machinery of the tumor cells preferentially, enhancing their susceptibility to apoptosis. Bortezomib, in particular has shown significant clinical efficacy in myeloma treatment. It is the most commonly used proteasome inhibitor and has been tested to be effective in prolongi

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… /muscle pain Muscle cramps Muscle weakness Cardiovascular Tachycardia Hypotension Dizziness Lower limb swelling Dermatological and immunological Rash Hives Itchiness Skin blistering Non-specific Sleep disturbances Anxiety Restlessness Mood changes Hallucinations Tiredness Thirst Decreased urination Hoarseness …

Abstracts for NAPCON 2025

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… Case Study: 39 year old male presented with h/o cough of 4 months duration, followed by left sided pleuritic chest pain for 3 months, hoarseness of voice, loss of weight and loss of appetite, features of superior vena caval obstruction like dilated veins over chest and left upper limb. …

Allergy in Cancer Care: Antineoplastic Therapy-Induced Hypersensitivity Reactions.

As the backbone of oncological treatments, systemic chemotherapy is still one of the main pawns in cancer care, alone or in combination with newer targeted agents. All chemotherapy agents can be associated with a type of adverse event called an infusion reaction, which can be characterized as unpredictable, non-dose related, and unexplained by the cytotoxic profile of the drug. For some of these events, a certain immunological mechanism can be identified by blood or skin testing. In this case, we can speak of true hypersensitivity reactions that occur as a response to an antigen/allergen. The

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… The oral cavity and lips are involved through itching or tingling, metallic taste, and angioedema, while the larynx is targeted through symptoms such as the sense of swelling, dysphonia, hoarseness, dysphagia, and stridor. The involvement of the respiratory tract induces bronchospasm. …

Endovascular repair of descending thoracic aortic aneurysm: an evidence-based analysis.

OBJECTIVE: To conduct an assessment on endovascular repair of descending thoracic aortic aneurysm (TAA). CLINICAL NEED: Aneurysm is the mos … wallowing), dyspnea (shortness of breath), cough, stridor (a harsh, high-pitched breath sound), and hoarseness. Significant aortic regurgitation causes symptoms of congestive heart failure. Embolization of the thrombus to the distal arterial circulation may occur and cause related symptoms. The aneurysm may eventually rupture and create a life-threatening co …

TB AND OTHER CHEST INFECTIONS

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… Case Study: A 51years old male came to OPD with complaints of fever, cough, loss of appetite and weight since 3months and change in voice,hoarseness of voice, odynophagia since 10days and he was investigated with Chest X Ray, Hrct Thorax, Blood Investigations, Ent Examination, Sputum Examination And …

Acute Pneumonia

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The 2024 revised clinical guidelines on the management of thyroid tumors by the Japan Association of Endocrine Surgery.

The Japan Association of Endocrine Surgery published the first edition of the "Clinical guidelines on the management of thyroid tumors" in 2010 and the revised edition in 2018. The guideline presented herein is the English translation of the revised third edition, issued in 2024. The aim is to enhance health outcomes for patients suffering from thyroid tumors by facilitating evidence-based shared decision-making between healthcare providers and patients, as well as standardizing the management of thyroid tumors. The focus is on adult patients with thyroid tumors, addressing clinically signific

Analysis of medical malpractice liability disputes related to novel antineoplastic drugs and research on risk prevention and control strategies.

OBJECTIVE: To investigate the general characteristics of litigation cases of medical malpractice liability disputes (MMLDs) related to novel antineoplastic drugs (NADs), the drugs involved, as well as the common types of medical errors related to NADs and their damages in the process of diagnosis and treatment, with the aims of improving the level of rational medication use in the clinical application of NADs and actively prevent medical disputes. METHODS: The China Judgments Online was searched for the cause of action using the key word "MMLDs" along with the name of 77 kinds of NADs. A tota

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… Zeng DX et al. [ 70 ] reported that four advanced lung adenocarcinoma patients with a KRAS mutation were orally administered apatinib (250 mg/d) after second-line treatment, and one patient developed manageable hoarseness and hemoptysis (grade 1). Gastrointestinal bleeding . …

Lysosomal storage diseases.

Lysosomes are cytoplasmic organelles that contain a variety of different hydrolases. A genetic deficiency in the enzymatic activity of one of these hydrolases will lead to the accumulation of the material meant for lysosomal degradation. Examples include glycogen in the case of Pompe disease, glycosaminoglycans in the case of the mucopolysaccharidoses, glycoproteins in the cases of the oligosaccharidoses, and sphingolipids in the cases of Niemann-Pick disease types A and B, Gaucher disease, Tay-Sachs disease, Krabbe disease, and metachromatic leukodystrophy. Sometimes, the lysosomal storage ca

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… Farber disease manifests clinically with the diagnostic triad of hoarseness, painful and swollen joints, and periarticular and subcutaneous nodules ( Fig. 23 ) particularly over pressure points [ 126 ]. Cherry-red spots have been occasionally described [ 127–129 ]. … The presentation may be in infancy, with hoarseness, respiratory difficulty, vomiting, swollen painful joints, and failure to thrive. There is significant clinical variability among sibs with Farber disease [ 130 ], and some patients follow a more prolonged course. …

A year in pharmacology: new drugs approved by the US Food and Drug Administration in 2023.

With 54 new drugs and seven cellular and gene therapy products, the approvals by the US Food and Drug Administration (FDA) recovered 2023 from the 2022 dent back to the levels of 2020-2021. As in previous years of this annual review, we assign these new drugs to one of three levels of innovation: first drug against a condition ("first-in-indication"), first drug using a novel molecular mechanism ("first-in-class"), and "next-in-class," i.e., a drug using an already exploited molecular mechanism. We identify four (7%) "first-in-indication," 22 (36%) "first-in-class," and 35 (57%) "next-in-class

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… The most common AE were increased blood pressure and thyroid-stimulating hormone levels, palmar-plantar erythrodysesthesia, proteinuria, and hoarseness (Shirley 2018 ). …

Extraglandular Manifestations of Sjögren’s Syndrome (SS): Dermatologic, Arthritic, Endocrine, Pulmonary, Cardiovascular, Gastroenterology, Renal, Urology, and Gynecologic Manifestations

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… This reflux may also present as hoarseness in talking or singing due to vocal cord irritation . Nausea, epigastric pain, and dyspepsia are other frequent complaints [ 79 , 128 ]. Histological examination may show an atrophic gastritis, with an infiltrate of predominantly CD4 + T cells. …

Image-Guided Percutaneous Ablation for Primary and Metastatic Tumors.

Image-guided percutaneous ablation methods have been further developed during the recent two decades and have transformed the minimally invasive and precision features of treatment options targeting primary and metastatic tumors. They work by percutaneously introducing applicators to precisely destroy a tumor and offer much lower risks than conventional methods. There are usually shorter recovery periods, less bleeding, and more preservation of organ parenchyma, expanding the treatment options of patients with cancer who may not be eligible for resection. Image-guided ablation techniques are c

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… The typical ones include hoarseness, hematomas, hypothyroidism, nerve injuries (especially to the laryngeal nerve), nodule rupture, skin burns, and hypocalcemia [ 156 , 157 ]. 9. …

Molecular targeted therapy for anticancer treatment.

Since the initial clinical approval in the late 1990s and remarkable anticancer effects for certain types of cancer, molecular targeted therapy utilizing small molecule agents or therapeutic monoclonal antibodies acting as signal transduction inhibitors has served as a fundamental backbone in precision medicine for cancer treatment. These approaches are now used clinically as first-line therapy for various types of human cancers. Compared to conventional chemotherapy, targeted therapeutic agents have efficient anticancer effects with fewer side effects. However, the emergence of drug resistanc

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… Advanced HCC (2018) | KIT V654A, D816V mutation | Hypertension, hand-food skin reaction, diarrhea, fatigue | 220 , 222 VEGFR1/2/3 PDGFR-β c-Kit | Tivozanib (AV-951, KRN-951) | Fotivda (AVEO Pharmaceuticals /Kyowa Kirin) | Relapsed or refractory RCC (2021) | | Infiltration of myeloid cells | Hypertension, hoarseness …

Coexistence of Autoantibodies against the Golgi Complex and Ro52 Antigen in a Patient with Nonspecific Interstitial Pneumonia.

Nonspecific interstitial pneumonia (NSIP) is often associated with connective tissue diseases (CTD). The diagnosis of NSIP was confirmed in a 63-year-old man by high-resolution computed tomography and an open lung biopsy. Anti-Golgi complex autoantibodies (AGA) and anti-Ro52 antibodies were simultaneously detected at high concentrations. Autoantibodies to aminoacyl-tRNA synthetases (ARS) were negative. The patient was treated with corticosteroids for six months. During the seven-year follow-up, NSIP had a slow progression and patient had not developed the clinical features of CTD. The present

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… Hoarseness of voice may rarely arise in patients with sarcoidosis due to vocal cord thickening and granulomas formation. It is a rare manifestation affecting 1–3 % of patients. Paranasal sarcoidosis may occur, especially with lupus pernio. …

Устные доклады

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Chemotherapy for small cell lung cancer: a comprehensive review.

Combination chemotherapy is the current strategy of choice for treatment of small cell lung cancer (SCLC). Platinum containing combination regimens are superior to non-platinum regimens in limited stage-SCLC and possibly also in extensive stage-SCLC as first and second-line treatments. The addition of ifosfamide to platinum containing regimens may improve the outcome but at the price of increased toxicity. Suboptimal doses of chemotherapy result in inferior survival. Early intensified, accelerated and high-dose chemotherapy gave conflicting results and is not considered a standard option outsi

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… Greater symptomatic improvement was seen in patients who received topotecan for symptoms of dyspnea (P=0.002), anorexia (P=0.042), hoarseness (P=0.043), and fatigue (P=0.032), and for interference with daily activities (P=0.023). …

Exosomes: innovative biomarkers leading the charge in non-invasive cancer diagnostics.

Exosomes, nanoscale extracellular vesicles secreted by diverse cell types, have emerged as promising biomarkers for non-invasive tumor diagnostics, offering significant advantages over traditional methods. These vesicles, typically ranging from 30 to 150 nanometers in size, carry a diverse cargo of proteins, lipids, RNA, and microRNAs, which reflect the molecular alterations occurring within their parent cells. Notably, exosomes can be isolated from easily accessible biofluids such as blood, urine, and saliva, making them ideal candidates for liquid biopsy applications. This review explores th

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… Symptoms include a painless neck lump, hoarseness, and difficulty swallowing or breathing. Diagnosis involves imaging, biopsy, and thyroid function tests, with treatment typically including surgery, radioactive iodine, and sometimes chemotherapy for advanced cases 122 . …

Chemotherapy-induced peripheral neuropathy in children and adolescent cancer patients.

Brain cancer and leukemia are the most common cancers diagnosed in the pediatric population and are often treated with lifesaving chemotherapy. However, chemotherapy causes severe adverse effects and chemotherapy-induced peripheral neuropathy (CIPN) is a major dose-limiting and debilitating side effect. CIPN can greatly impair quality of life and increases morbidity of pediatric patients with cancer, with the accompanying symptoms frequently remaining underdiagnosed. Little is known about the incidence of CIPN, its impact on the pediatric population, and the underlying pathophysiological mecha

Электронные постеры

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Influence of the TGF-β Superfamily on Osteoclasts/Osteoblasts Balance in Physiological and Pathological Bone Conditions.

The balance between bone forming cells (osteoblasts/osteocytes) and bone resorbing cells (osteoclasts) plays a crucial role in tissue homeostasis and bone repair. Several hormones, cytokines, and growth factors-in particular the members of the TGF-β superfamily such as the bone morphogenetic proteins-not only regulate the proliferation, differentiation, and functioning of these cells, but also coordinate the communication between them to ensure an appropriate response. Therefore, this review focuses on TGF-β superfamily and its influence on bone formation and repair, through the regulation of

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… However, many studies also reported complications related to the use of BMP-2, especially for cervical fusions associated with pain, wound infections, dysphagia, and hoarseness, leading to a large increase in hospital costs [ 392 , 393 , 394 ]. …