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Selected Abstracts from the 13th Annual Meeting of the Clinical Immunology Society: 2022 Annual Meeting: Immune Deficiency and Dysregulation North American Conference

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Multiple myeloma presenting as a cervical intraforaminal tumor: A case report and review of literature.

Multiple myeloma (MM) is a hematological malignancy with characteristic clonal plasma cell proliferation and production of monoclonal immunoglobulins. Although it can often metastasize to the bony spine, completely extravertebral and extra-/intradural manifestations are exceedingly rare. In this case report, we describe a 51-year-old male patient with cervical extradural and intraforaminal MM who was surgically treated in our department. Clinical findings and radiological images were retrieved from medical records and an imaging system. This unusual localization of MM and similar cases in the

An unusual presentation of metastatic prostate cancer in a 44-year-old man: A case report and review of the literature.

UNLABELLED: Prostate cancer is one of the two most common non-cutaneous cancers in men. Its presentation might be with unusual symptoms and cause the wrong initial diagnosis. This case report discusses a rare neurologic manifestation of advanced metastatic cancer in a low-risk man. He had been receiving treatment for multiple sclerosis incorrectly due to unusual manifestations such as claudication and pelvic, leg, and shoulder pain. The patient underwent a whole-body bone scan and then a transrectal ultrasound-guided biopsy, which confirmed metastatic prostate cancer with a Gleason score betwe

Supportive care needs of adults living with a peripherally inserted central catheter (PICC) at home: a qualitative content analysis.

BackgroundPeripherally inserted central catheters (PICCs) are common vascular access devices inserted for adults undergoing intravenous treatment in the community setting. Individuals with a PICC report challenges understanding information and adapting to the device both practically and psychologically at home. There is a lack of research investigating the supportive care needs of individuals with a PICC to inform nursing assessment and the provision of additional supports they may require to successfully adapt to life with a PICC. The aim of this study was to identify the supportive care need

Резюме докладов 38th - ежегодное собрание общества общей внутренней медицины.

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The leptomeninges as a critical organ for normal CNS development and function: First patient and public involved systematic review of arachnoiditis (chronic meningitis).

BACKGROUND & IMPORTANCE: This patient and public-involved systematic review originally focused on arachnoiditis, a supposedly rare "iatrogenic chronic meningitis" causing permanent neurologic damage and intractable pain. We sought to prove disease existence, causation, symptoms, and inform future directions. After 63 terms for the same pathology were found, the study was renamed Diseases of the Leptomeninges (DLMs). We present results that nullify traditional clinical thinking about DLMs, answer study questions, and create a unified path forward. METHODS: The prospective PRISMA protocol is pu

Inpatient Medicine

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… A) Brain abscess B) Herpes simplex encephalitis C) Locked-in syndrome D) Metabolic encephalopathy E) Nonconvulsive status epilepticus Answer: D Triphasic waves have been associated with a wide range of toxic, metabolic, and structural abnormalities. …

Epidemiology of infections in cancer patients.

Although major advances in the care of cancer patients over the past several decades have resulted in improved survival, infectious complications remain a significant cause of morbidity and mortality. To successfully identify, treat, and prevent infections, a comprehensive understanding of risk factors that predispose to infection and of commonly encountered pathogens is necessary. In addition, clinicians must keep abreast of the changing epidemiology of infections in this population. As therapeutic modalities continue to evolve, as established pathogens become increasingly drug resistant, and

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… Interestingly, meningitis, encephalitis, and brain abscesses are uncommon in patients with CNS tumors unless related to problems of surgery [ 66 , 72 ]. …

Доклиническая оценка клеток DC-CCK как потенциально эффективной иммунотерапии для лечения глиобластомы.

Несмотря на благоприятное воздействие иммунотерапии на различные виды раковых заболеваний, ее полный успех в борьбе с вредителями CNS по-прежнему сопряжен с трудностями. Недавно в результате успешного клинического испытания клеточной иммунотерапии, вызванной цитокинами, у пациентов с глиобластомой (ГБМ) открылась новая возможность для иммунотерапии с использованием клеточной селекции в малиньях CNS. На основе этих выводов мы изучили вопрос о том, могут ли дендритные клетки (DC) в сочетании с цитокиновыми клетками-убийцами (DC-CCK) также обеспечить альтернативный и более эффективный способ повы

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… Hassel B Niehusmann P Halvorsen B Dahlberg D Pro-inflammatory cytokines in cystic glioblastoma: A quantitative study with a comparison with bacterial brain abscesses. With an MRI investigation of displacement and destruction of the brain tissue surrounding a glioblastoma Front. … Pro-inflammatory cytokines in cystic glioblastoma: A quantitative study with a comparison with bacterial brain abscesses. With an MRI investigation of displacement and destruction of the brain tissue surrounding a glioblastoma. Front. …

Нейрохирургические подходы к сбору тканей мозга для создания клеточной культуры в нейроэкспериментальных моделях клеток.

В последние десятилетия клеточная биология быстро прогрессировала. Методы изоляции и выращивания клеток, подкрепленные современными лабораторными процедурами и экспериментальными возможностями, обеспечивают широкий спектр возможностей для проведения исследований in vitro в целях изучения физиологических и патофизиологических процессов в области здоровья и болезней. Они также могут быть весьма эффективно использованы для анализа биоматериалов. До того как новый биоматериал будет готов для имплантации в ткани и широкого использования в клинической практике, он должен быть подвергнут тщательному

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… The neuroendoport technique has become the standard of care for resection of astrocytomas, glioblastomas, ependymomas and papilomas, neurocytomas, gangliogliomas, cavernous angiomas, brain abscesses, intraparenchymal hematomas, massive hematocephalus, intraventricular meningiomas, metastasis, colloid …

Coexistence of Autoantibodies against the Golgi Complex and Ro52 Antigen in a Patient with Nonspecific Interstitial Pneumonia.

Nonspecific interstitial pneumonia (NSIP) is often associated with connective tissue diseases (CTD). The diagnosis of NSIP was confirmed in a 63-year-old man by high-resolution computed tomography and an open lung biopsy. Anti-Golgi complex autoantibodies (AGA) and anti-Ro52 antibodies were simultaneously detected at high concentrations. Autoantibodies to aminoacyl-tRNA synthetases (ARS) were negative. The patient was treated with corticosteroids for six months. During the seven-year follow-up, NSIP had a slow progression and patient had not developed the clinical features of CTD. The present

Rare Diseases of the Orbit.

This article provides an overview of rare orbital diseases. Congenital malformations, inflammatory diseases, benign and malignant neoplasias are described. Although it represents a relatively small area of the body the orbit contains multiple different tissues. Therefore, a great variety of diseases can be found within the orbital space. That is the reason, why both the completeness and the level of detail in the description of particular diseases must be somewhat limited. Nevertheless, clinical manifestations, important aspects of diagnosis, treatment strategies, and, when specific data are a

Сверхурочные проблемы с диагностикой и лечением у двух педиатрических пациентов с обширным церебральным церебральным церебральным стечением, иллюстрирующие множественный склероз типа Baló.

Концентрический склероз Бало выделяется как редкая форма множественного склероза, в котором имеются большие повреждения, подобные опухоли, которые напоминают опухоли мозга и создают значительные диагностические и терапевтические препятствия для педиатрических пациентов. КИСЛОТЫ: Мы представляем два тематических исследования педиатрических пациентов в возрасте 11 и 15 лет, у которых диагностирован обширный церебральный тюпфективный провокационный поражение, указывающий на множественный склероз (MS) типа Balo. В обоих случаях подчеркиваются уникальные проблемы, с которыми приходится сталкиваться

Oncological emergencies associated with gastrointestinal tumors.

Oncological emergencies are defined as acute life-threatening conditions in cancer patients either as a result of the malignancy or as a result of its treatment. In this review, we focus on oncological emergencies associated with gastrointestinal tumors. They can be categorized by their system of origin as hematologic, neurologic or metabolic. Furthermore, we discuss mechanical emergencies such as intestinal obstruction and vena cava superior syndrome as well as acute gastrointestinal bleeding and pulmonary embolism. The patients' performance status as well as prognosis are essential during de

Respiratory and Thoracic Medicine

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Интратективный иммуноглобулин А Обобщение в множестве склероза: от биологических аспектов к клинической значимости.

Интратекальский иммуноглобулин А (IgA) синтез в множестве склерозов (MS) давно не получал достаточного внимания, несмотря на потенциальное значение патогенеза и прогноза заболеваний. Наличие доброкачественных плазменных клеток IgA в повреждениях MS и вдоль поврежденных аксонов свидетельствует о роли в патогенезе болезней. Имеющиеся клинические данные о потенциальной позитивной или негативной прогнозируемой роли являются скудными и неточными. Вместе с тем последние наблюдения свидетельствуют о переходе от кишечника к центральной нервной системе (КНС) в экспериментальные аутоиммунные энцефалитны

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… Accordingly, a dominant intrathecal IgA synthesis is diagnostically informative in neurotuberculosis [ 51 ], brain abscesses, or adrenoleukodystrophy [ 52 ]. …

Chronic pruritus: a narrative review.

Chronic pruritus encompasses a manifestation of several cutaneous, allergic, infectious, neurological, psychological, and systemic conditions, whose etiological investigation and therapeutic strategy can be challenging. This comprehensive review aims to enhance the understanding of pruritus by highlighting important elements in its pathogenesis, including keratinocytes, Merkel cells and mast cells, nerve fibers, histaminergic and nonhistaminergic pathways, and the interaction of itch signals with the central nervous system. Diagnostic evaluation of chronic pruritus may require a meticulous app

Bone metastasis in colorectal cancer: Pathophysiology, prognostic factors, survival outcomes, and treatment strategies - A comprehensive review.

BackgroundColorectal cancer ranks as the third most prevalent cancer globally, with over 1.9 million new cases and 930,000 deaths in 2020. While the liver and lungs are the most common site of colorectal cancer metastases, bone metastasis is relatively rare but clinically significant. The rarity of bone metastasis in colorectal cancer, early diagnosis challenges, and the poorly understood mechanisms underlying bone metastasis have resulted in lesser research compared to other metastatic sites of colorectal cancer.ObjectiveThe goal of this review is to summarize pathophysiology, clinical presen

Fungal, Viral, and Other Oddball Infections and the Immunosuppressed Patient

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Diffuse Bone Marrow Metastasis as the Initial Presentation of an Occult Breast Cancer.

IntroductionBreast cancer is one of the malignancies which tend to involve the bone marrow, but initial presentation with diffuse bone marrow metastasis from an occult breast cancer is very rare. Prognosis is generally very poor for marrow metastasis from solid tumors except that breast cancer is a treatable disease even in such a dismal condition.CaseA 64-year-old woman's headache was found to result from diffuse adenocarcinoma metastasis in the bone marrow from an unknown primary site. Intensive immunohistochemistry study of bone marrow biopsy specimen confirmed the disease nature to be an e