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Обнаружение новых листьев с использованием большой языковой модели: прикладные программы в массивах данных с множественным склерозом в реальном мире.

ЦЕЛЬ: Нейроимация обычно используется для выявления новых видов подстрекательской деятельности при множественном склерозе (МС). Крупная языковая модель классификации описей магнитного резонанса в электронной медицинской записи (ЭПЧ) в качестве дискретных данных может принести значительные выгоды для исследований в области НР. Цели нынешнего исследования заключались в разработке такой оперативной иллюстрации его исследовательской деятельности на основе общего клинического сценария: мониторинг реакции на разрушающую клетки B (BCDT). МЕТОДЫ: Институциональная экосистема, которая надежно увязывает

Improving Access to Patient Education: an Audit of Extant Educational Materials.

Health information exchange between provider and patient, along with patient participation in their care (self-management), can lead to improved health outcomes. A step towards achieving better outcomes is the systematic provision of education materials to patients and caregivers throughout the cancer trajectory. An audit of patient education (PE) materials was conducted at a cancer center to identify content gaps and determine areas for future development. The PE audit was conducted in all outpatient clinics (13) and clinic-specific PE materials were identified, reviewed, and categorized by c

A Pilot Program Implementing an Evidence-Based Walking Plan to Improve Cancer-Related Fatigue in Adult Patients on Oral Cancer Treatments.

BackgroundFatigue is a prevalent symptom among cancer patients, even after completing treatment. The National Comprehensive Cancer Network Guidelines recommend incorporating physical activity as a strategy to combat cancer-related fatigue.ObjectivesThe goal was to develop and implement an evidence-based translational research quality improvement project to improve fatigue in patients starting oral cancer treatment.MethodsOutpatient oncology nurses (registered nurses and licensed practical nurses) responsible for educating patients starting treatment for cancer were provided education about the

Clinician preferences on treatment of smoldering myeloma: a cross-sectional survey.

BackgroundSmoldering myeloma (SMM) is an asymptomatic precursor condition to multiple myeloma (MM) with a variable risk of progression. The management of high-risk SMM (HR-SMM) remains controversial, particularly with changes in diagnostic criteria that led to reclassifying of some patients with SMM to MM. This study aimed to assess clinician preferences for whether to treat patients with HR-SMM and/or patients with MM diagnosed solely by SLiM criteria (free light chain ratio >100, bone marrow plasma cell percentage >60, greater than two focal marrow lesions on MRI) through an electronic surve

Visual analysis of the research frontiers, hotspots and trends of exercise therapy intervention in tumor-related sleep-wake disorders.

ObjectiveTo systematically understand the research frontiers, hotspots and development trends of exercise therapy in the intervention of tumor-related sleep-wake disorders, and to provide scientific basis for follow-up research.MethodsDownloaded the original research papers on February 26, 2024, from the Web of Science core collection database, on tumor-associated sleep-wake disorders. The data that met the inclusion criteria were imported into the Bibliometric Analysis Platform (http://biblimetric.com), CiteSpace 6.3.R1 and VOSviwer1.6.20 software for visual analysis, and imported into Excel2

Forgoing life-sustaining treatment - a comparative analysis of regulations in Japan, Korea, Taiwan, and England.

BackgroundRegulations on forgoing life-sustaining treatment (LST) have developed in Asian countries including Japan, Korea and Taiwan. However, other countries are relatively unaware of these due to the language barrier. This article aims to describe and compare the relevant regulatory frameworks, using the (more familiar) situation in England as a point of reference. We undertook literature reviews to ascertain the legal and regulatory positions on forgoing LST in Japan, Korea, Taiwan, and England.Main textFindings from a literature review are first presented to describe the development of th

Priorities in Cardio-Oncology Basic and Translational Science: GCOS 2023 Symposium Proceedings: JACC: CardioOncology State-of-the-Art Review.

Despite improvements in cancer survival, cancer therapy-related cardiovascular toxicity has risen to become a prominent clinical challenge. This has led to the growth of the burgeoning field of cardio-oncology, which aims to advance the cardiovascular health of cancer patients and survivors, through actionable and translatable science. In these Global Cardio-Oncology Symposium 2023 scientific symposium proceedings, we present a focused review on the mechanisms that contribute to common cardiovascular toxicities discussed at this meeting, the ongoing international collaborative efforts to impro

Доступ к терапии перенаправления T-Cell в Мультимиломе: пациент, сторож и физиологическая точка зрения на осведомленность и барьеры.

Справочная информация: Лечение перенаправления Т-клеток (TCRTs), включая терапию CAR-T-клеток и биконкретные антитела, изменило методы лечения повторной/охлажденной множественной миеломы (MM), однако реальное усыновление по-прежнему ограничено из-за ограничений в плане осведомленности и доступа пациентов, лиц, обеспечивающих уход, и врачей. Методы: Мы провели перекрестное исследование (июнь-сентябрь) 2025) с использованием одобренных IRB обследований СВОД, распространяемых среди пациентов, имеющих MM (через MyChart), лиц, обеспечивающих уход за получателями ТСПР (по электронной почте) и общинн

Patient-reported data informing early benefit assessment of rare diseases in Germany: A systematic review.

BackgroundSince the implementation of the Regulation on Patient Integration (2003), the Act on the Reorganization of the Pharmaceutical Market (2011), and the Patient Rights Law (2013), the inclusion of patient perspectives has been further anchored in the German early benefit assessment process. During the assessment of rare disease interventions, patient perspectives are particularly important, as clinical studies are often designed acknowledging small samples and patients suffering from severe symptoms and the chronic course of the disease. Therefore, our research question is whether patien

The state of the science of interprofessional collaborative practice: A scoping review of the patient health-related outcomes based literature published between 2010 and 2018.

IntroductionIf interprofessional collaborative practice is to be an important component of healthcare reform, then an evidentiary base connecting interprofessional education to interprofessional practice with significantly improved health and healthcare outcomes is an unconditional necessity. This study is a scoping review of the current peer reviewed literature linking interprofessional collaborative care and interprofessional collaborative practice to clearly identified healthcare and/or patient health-related outcomes. The research question for this review was: What does the evidence from t

Методы машинного обучения для классификации множественного склероза и болезни Альцгеймера с использованием геномных данных.

Сложные заболевания создают трудности в прогнозировании из-за их многофакторного и полигенного характера. В этом исследовании используется машинное обучение (ML) для анализа геномных данных из британского биобанка с целью прогнозирования геномной предрасположенности к таким сложным болезням, как множественный склероз (MS) и болезнь Альцгеймера (AD). Мы проверили логистическую регрессию (LR), методы ансамбля деревьев и модели глубокого обучения с этой целью. LR продемонстрировал замечательную стабильность в различных поднаборах данных, превосходя глубинные подходы к обучению, которые продемонст

Специальный выпуск: резюме 11th Конгресс Европейской академии неврологии, Хельсинки, Финляндия.

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

The Burden of Metastatic Cancer-Induced Bone Pain: A Narrative Review.

Bone pain is one of the most common forms of pain reported by cancer patients with metastatic disease. We conducted a review of oncology literature to further understand the epidemiology of and treatment approaches for metastatic cancer-induced bone pain and the effect of treatment of painful bone metastases on the patient's quality of life. Two-thirds of patients with advanced, metastatic, or terminal cancer worldwide experience pain. Cancer pain due to bone metastases is the most common form of pain in patients with advanced disease and has been shown to significantly reduce patients' qualit

Industry funding of patient organisations in the UK: a retrospective study of commercial determinants, funding concentration and disease prevalence.

ObjectivesTo assess the relationship between UK-based patient organisation funding and companies' commercial interests in rare and non-rare diseases in 2020.DesignRetrospective analysis of the value and volume of payments from pharmaceutical companies to patient organisations in the UK matched with data on the conditions supported by patient organisations and drugs in companies' approved portfolios and research and development pipelines.SettingUK.Participants74 pharmaceutical companies making payments to 341 UK-based patient organisations.Main outcome measuresAlignment between the commercial i

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… Comparing pharmaceutical company payments in the four UK countries: a cross-sectional and social network analysis. BMJ Open 2023;13:e061591. 10.1136/bmjopen-2022-061591 17. Wouters OJ, McKee M, Luyten J. Estimated research and development investment needed to bring a new medicine to market. …

Curcumin as a Multi-Target Bioactive Molecule: Mechanistic Insights and Translational Perspectives.

Curcumin, a natural polyphenolic compound derived from the curcuma genus, has attracted considerable attention due to its simple chemical structure, favorable safety profile, and broad-spectrum pharmacological activities. This review provides a comprehensive summary of recent advances in curcumin research, with a specific focus on its therapeutic potential in cancer, inflammation, depression, and metabolic disorders, including non-alcoholic fatty liver disease, hypertension, and osteoporosis. It highlights curcumin's modulation of critical signaling pathways, such as PI3K/Akt, NF-κB, JAK/STAT,

Exploring Healthcare Continuity in Pediatric-Onset Multiple Sclerosis in the United States.

OBJECTIVE: Little is known about shifting from pediatric to adult-focused multiple sclerosis (MS) care. This study aims to explore transition of care and follow-up in the US pediatric-onset MS (POMS) population. METHODS: Surveys were distributed to 10 sites in the US Network of Pediatric MS Centers (US NPMSC) about transition-of-care practices. A cohort of POMS/clinically isolated syndrome (CIS) at 12 US NPMSC sites was analyzed. The primary comparison was between < 18 and ≥ 18-years of age. The primary outcome was 1- and 2-year lapse in last follow-up visit, measured from last recorded datab

Clinical practice guidelines on addressing cognitive impairment in treatable dementias.

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The International Headache Congress - IHS and EHF joint congress 2021 : Virtual. 8-12 September 2021.

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Patient perceptions of copay card utilization and policies.

BackgroundCopay cards are intended to mitigate patient out-of-pocket (OOP) expenses. This qualitative, exploratory focus group study aimed to capture patient perceptions of copay cards and copay adjustment programs (CAPs; insurers' accumulator and maximizer policies), which redirect the copay card utilization benefits intended for patients' OOP expenses.MethodsPatients with chronic conditions were recruited through Janssen's Patient Engagement Research Council program. They completed a survey and attended a live virtual session to provide feedback on copay cards.ResultsAmong 33 participants (m

Protocol for the TMaC Study: A Patient-Blinded, Randomised, Sham-Controlled, Parallel-Group Study Evaluating Effects of Repetitive Transcranial Magnetic Stimulation on Chronic Chemotherapy-Induced Pain in Bowel Cancer Patients.

IntroductionChemotherapy-induced peripheral neuropathy (CIPN) is a common and debilitating consequence for people undergoing treatment for cancer, especially bowel cancer. Painful CIPN contributes to psychological distress, functional decline and reduced quality of life. Additionally, it is a dose-limiting factor for anticancer agents, compromising chemotherapy effectiveness and patient survival. To date, no effective long-term management options exist for painful CIPN. Whilst evidence suggests analgesic effects of repetitive transcranial magnetic stimulation (rTMS), little is known regarding