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Опыт пациентов и медицинских работников в дироксимеле фумарате: соображения для выбора терапии, направленной на изменение болезней.

ЦЕЛЬ: Оценка представлений о лечении дироксимеля фумарата (ДФ) для повторного склероза (МС) с использованием контекстуальных данных пользователей диметилфумарата (ДМП) на основе обследований пациентов и медицинских работников (ПОЗ). МЕТОДЫ: Было проведено перспективное обследование с использованием Интернета среди пользователей MyMSTeam в возрасте ≥ 21 года в Соединенных Штатах, которые представили информацию об их болезни MS и истории лечения. В ходе обследования ГЦП в Сфериксе были собраны ретроспективные данные о ХЦП пациентам, которые изменили методы лечения заболеваний (ДМТ). Результаты:

Совпадение в аннотации оригинала
PURPOSE: To evaluate treatment perceptions of diroximel fumarate (DRF) for relapsing multiple sclerosis (MS), with contextual data from dimethyl fumarate (DMF) users, based on patient and healthcare provider (HCP) surveys. METHODS: A prospective web-based survey was conducted among MyMSTeam users aged ≥ 21 years in the United States, who provided informatio…

Activated Thiol Sepharose-based proteomic approach to quantify reversible protein oxidation.

Reactive oxygen species (ROS) can act as second messengers in various signaling pathways, and abnormal oxidation contributes to multiple dis … any metabolic proteins such as the pyruvate kinase M2 isoform (PKM2). Treatment of HLRCC cells with dimethyl fumarate or PKM2 activators altered PKM2 oxidation levels. Finally, we found that ATSP could detect Src homology region 2 domain-containing phosphatase-2 and PKM2 oxidation in cells stimulated with platelet-derived growth factor. This newly developed redox p …

Real-world evidence from Türkiye on cancer risk and treatment exposure in multiple sclerosis: A histopathology-verified, registry-based study.

BACKGROUND: Multiple sclerosis (MS) is a chronic, immune-mediated neurological disease with potential malignancy risks linked to disease-mod … MS treatments (interferons, glatiramer acetate, fingolimod, natalizumab, ocrelizumab, alemtuzumab, dimethyl fumarate, teriflunomide, azathioprine, cyclophosphamide, methotrexate, mitoxantrone, mycophenolic acid, and rituximab). Malignancies were classified based on histopathological confirmation, using ICD-O codes in pathology reports. Systemic distributions of ca …

Benefit-risk Assessment of Cladribine Using Multi-criteria Decision Analysis (MCDA) for Patients With Relapsing-remitting Multiple Sclerosis.

PURPOSE: We applied Multi-Criteria Decision Analysis (MCDA) methods in a structured benefit-risk assessment of cladribine and newer approved … DMDs available in European Union countries at the time of assessment (December 2015): alemtuzumab, dimethyl fumarate, fingolimod, natalizumab, and teriflunomide. To account for the relative importance of DMD effects, scores for the MCDA model were weighted to ensure that the most clinically important attributes carried more weight in the final benefit-risk calcula …

Cascade oxime formation, cyclization to a nitrone, and intermolecular dipolar cycloaddition.

Simple haloaldehydes, including enolisable aldehydes, were found to be suitable for the formation of cyclic products by cascade (domino) con … intermolecular dipolar cycloaddition reactions to give isoxazolidines. The cycloadducts from using dimethyl fumarate were treated with zinc/acetic acid to give lactam products and this provides an easy way to prepare pyrrolizinones, indolizinones, and pyrrolo[2,1-a]isoquinolinones. The chemistry is illustrated with a very short synthesis of the pyrrolizidine alkal …

Management of Nail Disease in Patients With Psoriatic Arthritis: An Updated Literature Review Informing the 2021 GRAPPA Treatment Recommendations.

OBJECTIVE: Nail psoriasis is common, impairs fine motor finger functioning, affects cosmesis, and is associated with a lower quality of life … the use of topical corticosteroids, topical calcipotriol, topical tazarotene, topical cyclosporine, dimethyl fumarates/fumaric acid esters, phototherapy, and alitretinoin. There is a low strength of evidence to support the use of calcipotriol and corticosteroid preparations, topical tacrolimus, oral cyclosporine, oral methotrexate, intralesional corticosteroids, pu …

Child Neurology: A Case of Concurrent Neurofibromatosis Type 1 and Multiple Sclerosis by 2024 Criteria.

We present a female pediatric patient with known neurofibromatosis type 1 (NF1) whose surveillance imaging began showing multifocal periventricular and juxtacortical lesions with transient enhancement, initially attributed to NF1-related focal areas of signal intensity. Over time, the radiographic pattern raised concern for demyelinating disease. CSF studies revealed 10 unique oligoclonal bands. Despite the absence of neurologic symptoms, treatment with dimethyl fumarate was initiated and later transitioned to rituximab in the setting of ongoing active radiographic disease. Although the patien…

Прогресс, не зависящий от возобновления биологии в множестве склерозов: исследование реальных слов.

Прогресс, не зависящий от рецидивной активности (ИПРА), подразумевает развитие инвалидности у людей с повторно излучающимся множественным склерозом (RRMS) вторичного до нейродегенерации. Механистическая и биологическая ПИРА может повлиять на традиционное различие между прогрессивными и повторными СМС. В данном случае мы подсчитали прогресс, не зависящий от восстановления биологии (PIRB), в группе из 823 участников с клинически изолированным синдромом/RRMS в Калгари, Канада, с использованием модифицированного критерия [исключая рецидивы, подстрекательскую активность MRI, промежуточное ухудшение

Совпадение в аннотации оригинала
Progression independent of relapse activity (PIRA) implies disability progression in people with relapsing-remitting multiple sclerosis (RRM … gressive MS]. PIRB was rare and rates remained consistent across disease-modifying therapies (3.75% dimethyl fumarate, 3.67% fingolimod, 3.72% ocrelizumab, 3.52% minocycline) despite varied rates of disability progression. PIRB may offer a practical alternative to the concept of PIRA.

MicroRNA Express Profiles как биомаркеры реакции на корректирующую болезнь терапию при множественном склерозе: системный обзор.

Хотя микроРНК (миРНК) являются активной областью исследований в области множественного склероза (МС) и были предложены в качестве потенциальных биомаркеров реакции на лечение, имеющиеся данные по-прежнему трудно интерпретировать. В рамках этого систематического обзора изучается взаимосвязь между выражением miRNA и реакцией на корректирующие заболевания методы лечения (DMT) у взрослых с MS. С момента создания базы данных PubMed/MedLINE и веб-страницы научных исследований проводились систематические обыски 11 Февраль 2026. Fifteen исследования, которые сравнивали выражение miRNA между респондент

Совпадение в аннотации оригинала
Although microRNAs (miRNAs) are an active area of research in multiple sclerosis (MS) and have been proposed as potential biomarkers of trea … thods, miR-548a-3p in fingolimod-treated patients and miR-223-3p, miR-23a/b-3p, and miR-27a/b-3p in dimethyl fumarate (DMF)-treated patients appeared the most promising miRNAs investigated; however, each was assessed in a single study and has not yet been validated in independent external cohorts. However, they were notable because they had been evaluated in clinic …

Antineuroinflammatory drugs in HIV-associated neurocognitive disorders as potential therapy.

Today, HIV-infected (HIV+) patients can be treated efficiently with combined antiretroviral therapy (cART), leading to long-term suppression … sses can be targeted using medications with immunomodulatory and neuroprotective properties such as dimethyl fumarate, teriflunomide, or minocycline. In this review, we will summarize the knowledge about key pathogenic processes involved in HAND and potential therapeutic avenues to target HAND.

The Nrf2-Antioxidant Response Element Signaling Pathway Controls Fibrosis and Autoimmunity in Scleroderma.

Systemic sclerosis (SSc) is an autoimmune disease with fibrosis of the skin and internal organs and vascular alterations. Dysregulations in … njections of hypochloric acid. In addition, diseased BALB/c mice were treated with an nrf2 agonist, dimethyl fumarate, or placebo. A drop in nrf2 and target genes mRNA levels was observed in skin fibroblasts of SSc patients compared to controls. Moreover, the nrf2 pathway is also downregulated in skins and lungs of SSc mice. In addition, we observed that nrf2-/- mi …

Health-Related Quality of Life with Diroximel Fumarate in Patients with Relapsing Forms of Multiple Sclerosis: Findings from Qualitative Research Using Patient Interviews.

INTRODUCTION: Diroximel fumarate (DRF) is an oral fumarate for relapsing multiple sclerosis (MS). Clinical and real-world studies of DRF have demonstrated improved gastrointestinal (GI) tolerability and low (< 1%) GI-related treatment discontinuation versus dimethyl fumarate (DMF) and high rates of treatment adherence. Our aim was to conduct a concept elicitation study to identify treatment-related concepts most meaningful to patients and to evaluate how these concepts shape the patient perspective of DRF. METHODS: In-depth qualitative interviews were conducted with patients from October to D…

Efficacy of the Mediterranean diet in the treatment of multiple sclerosis (RRMS): A systematic review and meta-analysis.

BACKGROUND: Evidence supports a role for the Mediterranean Diet (MeD) in the treatment of Multiple Sclerosis (MS). This study aimed to evaluate the efficacy and safety of the MeD in patients with relapsing-remitting multiple sclerosis (RRMS) receiving with dimethyl fumarate (DMF) to provide a basis for clinical practice. METHODS: A comprehensive search was conducted to identify all relevant publications until September 1, 2025, across databases including PubMed, Web of Science, EMBASE, Cochrane Library, Medline via Web of Science, and Google Scholar. We included studies that evaluated the eff…

Предсказатели высоко- и низкоинтенсивного лечения склероза первой линии.

КОЛИЧЕСТВО: Лекарства для лечения различных склерозов (MS) могут быть либо с высокой, либо с низкой интенсивностью. Цель этого исследования заключается в изучении прогнозов, связанных с высокоинтенсивными стратегиями обработки MS с использованием данных о коммерческих претензиях. Мы использовали коммерческие и дополнительные базы данных &quot; Merative MarketScan &quot; для обследования пациентов с помощью: амбулаторного диагноза MS ( &quot; Merative MarketScan &quot; )ICD-9/-10:: 340xx, G35.xx); заполнение ДМТ; отсутствие ДМТ 1 год, предшествующий диагностике MS с помощью DMT; и 6 Непрерывная

Совпадение в аннотации оригинала
BACKGROUND: Disease-modifying therapies (DMTs) for multiple sclerosis (MS) can be either high- or low-intensity. This study aims to examine … rituximab, ofatumumab, cladribine) or low-intensity (interferon, glatiramer acetate, teriflunomide, dimethyl fumarate, diroximel fumarate, fingolimod, ponesimod, siponimod, ozanimod). We used logistic regression to examine factors associated with high-intensity first-line MS treatments, and multilevel modelling to characterize provider-level variance. RESULTS: A t …

Steatotic Hepatocytes Release Mature VLDL Through Methionine and Tyrosine Metabolism in a Keap1-Nrf2-Dependent Manner.

BACKGROUND AND AIMS: NAFLD is a lipotoxic disease wherein hepatic steatosis and oxidative stress are key pathogenic features. However, wheth … d by the deprivation of Met and Tyr were prevented in hepatic organoids generated from Keap1∆hepa . Dimethyl fumarate, an Nrf2 inducer, ameliorated the steatosis and increased the hepatic fumarate reduced by the deprivation of Met and Tyr in vitro. OA/Met or Tyr ratio in peripheral blood was associated with the hepatic steatosis in patients with NAFLD. CONCLUSIONS …

Topical calcipotriol plus oral fumaric acid is more effective and faster acting than oral fumaric acid monotherapy in the treatment of severe chronic plaque psoriasis vulgaris.

BACKGROUND: Calcipotriol is an established topical therapy for psoriasis vulgaris. OBJECTIVE: This study aimed to investigate whether the addition of calcipotriol to fumaric acid ester (FAE) monotherapy had an additive efficacy and an FAE-sparing effect in patients with severe plaque psoriasis. METHODS: This multicentre, randomised, double-blind, vehicle-controlled study included 143 patients for up to 13 weeks treatment. Group A received FAE tablets (Fumaderm) with an increasing daily dosage from 105 to 1,075 mg + ointment vehicle. Group B received FAE tablets + calcipotriol ointment (50 mi

Proteomic Cysteine Profiling Links DMI and DMF to Antiviral Activity.

Dimethyl fumarate (DMF) and dimethyl itaconate (DMI) are electrophilic metabolite derivatives with potent immunomodulatory properties. Both have been reported to covalently modify cysteine residues in proteins, thereby altering their structure and function. Thus, we hypothesized that DMI and DMF share common cysteine targets that account for their overlapping immunosuppressive effects. Using tandem mass tag activity-based protein profiling (TMT-ABPP) in mouse embryonic fibroblasts (MEFs), we systematically mapped cysteine sites whose activity toward an iodoacetamide-desthiobiotin probe was alt…

Using an animal model to predict the effective human dose for oral multiple sclerosis drugs.

The objective of this study was to determine the potential usefulness of an animal model to predict the appropriate dose of newly developed … proach would have also provided useful predictions of the approved human oral doses for cladribine, dimethyl fumarate, ozanimod, ponesimod, siponimod, and teriflunomide, drugs developed with more than one supposed mechanism of action. The procedure was not useful for i.v. dosed drugs, including monoclonal antibodies. We maintain that drug development scientists sho …

Targeting immunometabolism as an anti-inflammatory strategy.

The growing field of immunometabolism has taught us how metabolic cellular reactions and processes not only provide a means to generate ATP and biosynthetic precursors, but are also a way of controlling immunity and inflammation. Metabolic reprogramming of immune cells is essential for both inflammatory as well as anti-inflammatory responses. Four anti-inflammatory therapies, DMF, Metformin, Methotrexate and Rapamycin all work by affecting metabolism and/or regulating or mimicking endogenous metabolites with anti-inflammatory effects. Evidence is emerging for the targeting of specific metaboli

New biological agents in the treatment of multiple sclerosis.

Multiple sclerosis (MS) is an inflammatory disease induced by autoimmune processes. Their understanding has resulted in an introduction of b … ulation of lymphocyte migration (fingolimod, ozanimod) or in induction of lymphopenia by apoptosis (dimethyl fumarate, cladribine). In the article, we shortly describe their efficacies, adverse reactions and perspectives of a future development in MS biologics. A treatment of neuromyelitis optica by monoclonal antibodies (rituximab, aquaporumab) is given too (Tab. …