Результаты поиска

Preparation and optimization of aloe ferox gel loaded with Finasteride-Oregano oil nanocubosomes for treatment of alopecia.

Alopecia areata is a skin disorder characterized by scarless, localized hair loss that is usually managed by topical treatments that might further worsen the condition. Therefore, the current study aimed to develop nano-cubosomes loaded with finasteride (FI) and oregano oil (Or) to improve drug solubility and permeation through skin and then incorporate it into an aloe ferox gel base. An l-optimal coordinate exchange design was adopted to optimize nano-cubosomes. Phytantriol and Alkyl Acrylate were employed as the lipid material, and surfactant respectively for cubosomes manufacture. The produ

Oregano essential oil vapour prevents Plasmopara viticola infection in grapevine (Vitis Vinifera) and primes plant immunity mechanisms.

The reduction of synthetic fungicides in agriculture is necessary to guarantee a sustainable production that protects the environment and consumers' health. Downy mildew caused by the oomycete Plasmopara viticola is the major pathogen in viticulture worldwide and responsible for up to 60% of pesticide treatments. Alternatives to reduce fungicides are thus utterly needed to ensure sustainable vineyard-ecosystems, consumer health and public acceptance. Essential oils (EOs) are amongst the most promising natural plant protection alternatives and have shown their antibacterial, antiviral and antif

The Application of Lamiaceae Lindl. Promotes Aroma Compounds Formation, Sensory Properties, and Antioxidant Activity of Oat and Buckwheat-Based Cookies.

Aroma plays an important role in designing innovative functional foods. This study aimed to study the influence of incorporating herbs from the Lamiaceae family (sage, mint, rosemary, oregano, thyme) on aroma compound formation and sensory properties in oat-buckwheat products. DPPH, FRAP and PCL have been used to describe possible antioxidant activity changes and reduce power of cookies after Lamiaceae Lindl. addition. The volatiles analysis by HS-SPME-GC/MS, has shown that Lamiaceae addition significantly influences the volatiles composition (29 molecules) with a predominance of molecules wit

Functionalization of Lipid-Based Nutrient Supplement with β-Cyclodextrin Inclusions of Oregano Essential Oil.

UNLABELLED: Intestinal parasitic infection is one of the main causes of acute undernutrition in children. Oral consumption of oregano essential oil (OEO) can reduce intestinal parasitic infections, however, its addition to therapeutic and supplementary foods is hampered by its undesirable flavor. The objective of this study was to develop a functional lipid-based nutrient supplement (LNS) containing OEO, which is stable, acceptable and provides targeted intestinal delivery of bioactive. β-cyclodextrin (β-CyD) inclusion complexes of OEO (β-CyD-OEO), and carvacrol (β-CyD-CV) (1:1 molar) were pre

Monoterpene Sabinene Suppresses Hepatocarcinoma by Regulating the AKT/mTOR and Bcl-2/Bax Signaling Pathways: An In Vivo and In Vitro Analysis.

Essential oils (EOs) are aromatic compounds derived from plants, recognized for their diverse pharmacological properties that enable various therapeutic applications. Sabinene is a bicyclic monoterpene found in essential oils from plants such as Piper nigrum, Myristica fragrans, Origanum majorana and citrus fruits. It possesses pharmacological properties, can modulate immune responses, and may exhibit anticancer activity by inhibiting tumor cell proliferation and inducing apoptosis. We aimed to assess the anticancer efficacy of sabinene against hepatocarcinoma cells through both animal and in …

A Comprehensive Review of Herbal Supplements Used for Persistent Symptoms Attributed to Lyme Disease.

CONTEXT: Lyme disease is the most common, tick-borne disease in the USA. While most patients successfully recover with antibiotics, some pat … , (14) teasle root (Dipsacus fullonum), (15) lemon balm (Melissa officinalis), (16) oil of oregano (Origanum vulgare), (17) peppermint (Mentha x piperita), and (18) thyme (Thymus vulgaris). The team also searched for terms related to protocols, including Dr. Rawls' protocol and the Buhner protocol. SETTING: University of Maryland Medical Center, Baltimore …

Antibacterial Efficacy of Oregano-Carbon Nanotubes Coated Silk Sutures: An In Vitro Experimental Study.

INTRODUCTION: Microbial infections following surgery or other medical procedures are a major health issue. To avoid or reduce the risk of infections, research is now concentrated on creating novel drug-free materials with antibacterial qualities. Sutures coated with antimicrobial agents are one way to prevent surgical site infections. AIM: To develop and characterize an oregano-carbon nanotubes/polycaprolactone (PCL)-chitosan composite coating and evaluate the antimicrobial activity of sutures coated with this formulation. METHODS: The dipping solution was prepared, and characterization was

ZnO nanoparticles stabilized oregano essential oil Pickering emulsion for functional cellulose nanofibrils packaging films with antimicrobial and antioxidant activity.

The growth and reproduction of microorganisms can cause food spoilage in the process of food transportation and storage. Active packaging is a good way to inhibit food spoilage and prolong the shelf lives of foods. In this study, O/W Pickering emulsion with ZnO nanoparticles as solid particles and oregano essential oil as the oil phase was prepared and used to functionalize cellulose nanofibrils (CNFs) film, and excellent antimicrobial and antioxidant activity was obtained. When the concentration of ZnO nanoparticles was 1.5 wt% and the mass fraction of the oil phase was 20%, the Pickering emu

Tolerability and benefit of a tetramethoxyluteolin-containing skin lotion.

As many as 40% of people have sensitive skin and at least half of them suffer from pruritus associated with allergies, atopic dermatitis (AD), chronic urticaria (CU), cutaneous mastocytosis (CM), and psoriasis. Unfortunately, the available topical formulations contain antihistamines that are often not as effective as those containing corticosteroids. Certain natural flavonoids have anti-inflammatory actions. We recently reported that the natural flavonoid tetramethoxyluteolin has potent antiallergic and anti-inflammatory actions in vitro and in vivo. This flavonoid was formulated in a skin lot

Anti-proliferative effects of carvacrol on a human metastatic breast cancer cell line, MDA-MB 231.

PURPOSE: Although the anti-tumor effects of carvacrol have been demonstrated earlier, the exact underlying molecular mechanisms involved in its action have not been defined and in the present study an attempt has been made to identify the mechanism of carvacrol induced cell death in human metastatic breast cancer cells, MDA-MB 231. METHODS: Apoptosis induced by carvacrol was determined based on different assays like MTT assay, Annexin V, mitochondrial membrane potential assay, multicaspase activation assay and cell cycle analysis by flow cytometer. Cleavage of PARP, cytochrome c release and m

Antimicrobial activity of whey protein isolate edible films with essential oils against food spoilers and foodborne pathogens.

UNLABELLED: The use of antimicrobial edible film is proposed as a means of improving food safety and extending the shelf-life of food systems by controlling the release of antimicrobials on food surfaces. In this work we first selected and studied 8 different essential oils (EOs) from plants, namely, oregano, clove, tea tree, coriander, mastic thyme, laurel, rosemary, and sage as natural antimicrobials against 2 gram-positive bacteria (Listeria innocua and Staphylococcus aureus) and 2 gram-negative bacteria (Salmonella enteritidis and Pseudomona fragi) by using the agar disk diffusion method.

Marjoram Extract Modulates Ion Currents, Intracellular Calcium Signaling, and MTT-Reducing Activity in Bovine Chromaffin Cells and Rat Cortical Neurons.

Background/Objectives: Origanum majorana L. has reported antioxidant and other bioactive properties, but its effects on excitability and intracellular Ca2+ handling in excitable cells remain poorly defined. We investigated how a hydroalcoholic marjoram extract modulates membrane ion currents, cytosolic Ca2+ signaling, and MTT-reducing activity in bovine chromaffin cells and primary rat cortical neurons. Methods: A pressurized liquid O. majorana extract (ethanol:water, 70:30) was chemically characterized by HPLC-PAD. Whole-cell patch-clamp and current-clamp recordings were used to assess voltag…

Natural plant products inhibits growth and alters the swarming motility, biofilm formation, and expression of virulence genes in enteroaggregative and enterohemorrhagic Escherichia coli.

The purpose of this study was to determine the effects of plant products on the growth, swarming motility, biofilm formation and virulence gene expression in enterohemorrhagic Escherichia coli O157:H7 and enteroaggregative E. coli strain 042 and a strain of O104:H4 serotype. Extracts of Lippia graveolens and Haematoxylon brassiletto, and carvacrol, brazilin were tested by an antimicrobial microdilution method using citral and rifaximin as controls. All products showed bactericidal activity with minimal bactericidal concentrations ranging from 0.08 to 8.1 mg/ml. Swarming motility was determined

Extract of oregano, coffee, thyme, clove, and walnuts inhibits NF-kappaB in monocytes and in transgenic reporter mice.

The transcription factor NF-kappaB is a promising target for chemoprevention. Several dietary plants are efficient inhibitors of NF-kappaB activation in vitro and could act synergistically on the NF-kappaB signaling pathway. In this study, we tested whether dietary plant extracts could inhibit NF-kappaB activation in a synergistic manner in vitro. Second, we investigated the potency of the same dietary plant extracts in the inhibition of NF-kappaB activation in vivo. A combined extract of clove, oregano, thyme, walnuts, and coffee synergistically inhibited lipopolysaccaride (LPS)-induced NF-ka

Essential oils and their constituents as anticancer agents: a mechanistic view.

Exploring natural plant products as an option to find new chemical entities as anticancer agents is one of the fastest growing areas of research. Recently, in the last decade, essential oils (EOs) have been under study for their use in cancer therapy and the present review is an attempt to collect and document the available studies indicating EOs and their constituents as anticancer agents. This review enlists nearly 130 studies of EOs from various plant species and their constituents that have been studied so far for their anticancer potential and these studies have been classified as in vitr

Совпадение в полном тексте источника
… Antimicrobial activities of methanol extracts and essential oils of Rosmarinus officinalis , depending on location and seasonal variations Food Chemistry 2007 100 2 553 559 2-s2.0-33745251671 15 Özkan A Erdoğan A A comparative evaluation of antioxidant and anticancer activity of essential oil from origanum … syriacum, Origanum vulgare , and Salvia triloba against human breast adenocarcinoma cells Nutrition Research 2010 30 4 271 278 2-s2.0-77953345597 20534330 10.1016/j.nutres.2010.04.001 136 Bendaoud H Romdhane M Souchard JP Cazaux S Bouajila J Chemical composition and anticancer and antioxidant activities …

Targeted phytotherapy: essential oils, multi-target cancer action & nanodelivery.

Biochemical components of essential oils (EOs) are an innovative but largely underexplored type of precision phytotherapy (PT) in oncology owing to their anticancer activity against many types of tumors. This article discusses the important multitargeted molecular mechanisms of EOs (apoptosis, cell cycle arrest, angiogenesis, metastasis, tumor microenvironment) and their role as antitumor agents. In particular, an effort has been made to emphasize on the most notable volatile EOs such as thymol, eugenol, limonene, β-caryophyllene, and their interaction with oncogenic signaling pathways (NF-κB,

Совпадение в полном тексте источника
… For example, EOs extracted from Origanum vulgare ( 6 ) and Melaleuca alternifolia ( 7 ) has shown to suppress growth of cancer cells in a dose-dependent manner while also reducing oxidative stress and inflammatory response. … Some of the most frequently used essential oils as cancer treatments include: Origanum vulgare, Thymus vulgaris, Cymbopogon citratus, Lavandula angustifolia, Melaleuca alternifolia, and Cinnamomum verum, along with several of the essential oil active components: carvacrol, thymol, citral, linalool, linalyl …

Redox Remodeling by Nutraceuticals for Prevention and Treatment of Acute and Chronic Inflammation.

Antioxidant-rich dietary regimens are considered the best practice to maintain health, control inflammation, and prevent inflammatory diseases. Yet, nutraceuticals as food supplements are self-prescribed and purchasable over the counter by healthy individuals for the purpose of beneficial effects on fitness and aging. Hence, the effectiveness, safety, and correct intake of these compounds need to be better explored. Since redox-modulating activity of these compounds appears to be involved in activation and or suppression of immune cells, the preventive use of nutraceuticals is very attractive

Совпадение в полном тексте источника
… (blueberries), Vaccinium macrocarpon (cranberry), Olea europaea (olive), as well as in spicy herbs such as Ocimum basilicum (basil), Origanum vulgare, Rosmarinus officinalis, Salvia, and Thymus (thyme). … Methanolic Extract of Origanum Vulgare Ameliorates Type 1 Diabetes through Antioxidant, Anti-Inflammatory and Anti-Apoptotic Activity. Br. J. Nutr. 2015;113:770–782. doi: 10.1017/S0007114514004048. 48. …

Rosmarinic Acid and Related Dietary Supplements: Potential Applications in the Prevention and Treatment of Cancer.

Cancer constitutes a severe threat to human health and quality of life and is one of the most significant causes of morbidity and mortality worldwide. Natural dietary products have drawn substantial attention in cancer treatment and prevention due to their availability and absence of toxicity. Rosmarinic acid (RA) is known for its excellent antioxidant properties and is safe and effective in preventing and inhibiting tumors. This review summarizes recent publications on culture techniques, extraction processes, and anti-tumor applications of RA-enriched dietary supplements. We discuss techniqu

Совпадение в полном тексте источника
… Extracts and processed products from Origanum vulgare L. are condiments in cooking, essential oils, and wine. It is a medicinal plant used to treat asthma, indigestion, headaches, and rheumatism in Turkey. … Isolation and identification of chemical constituents from Origanum majorana and investigation of antiproliferative and antioxidant activities J. Sci. Food Agric. 2016 96 822 836 10.1002/jsfa.7155 25721137 32. Baranauskaite J. Kubiliene A. Marksa M. Petrikaite V. Vitkevičius K. Baranauskas A. …

Advances in Drug Delivery and Biomaterials: Facts and Vision.

Drug delivery and biomaterials are different fields of science but, at the same time, are tightly related and intertwined. The 2018 CRS Italy Chapter Annual Workshop aims to explore recent advances in design and development in these areas. Many colleagues from Europe participated to the Workshop, stimulating the discussion. To foster the discussion on recent research and networking opportunities, especially among younger attendees, all poster-presenting authors were asked to provide a short talk. The very friendly and stimulating atmosphere allowed the attendees to explore new frontiers and ta

Совпадение в полном тексте источника
… The optimized NLC obtained with the mixture Kolliphor/Labrafil using Rosmarinus, Lavandula and Origanum EOs, showed a single peak in the distribution (PDI < 0.15) of small sized nanoparticles (Zave < 200 nm). … A dose-dependent anti-inflammatory activity was observed in the order Lavandula > Rosmarinus ≥ Origanum, both as free oils or loaded into NLC, the latter being the only component with a significant concentration-dependent free-radical scavenging activity. …

ER-mitochondria tethering and its signaling: A novel therapeutic target in breast cancer.

Communication between the endoplasmic reticulum (ER) and mitochondria through mitochondria-associated ER membranes (MAMs) is assisted by tethering proteins and signaling pathways, manifesting the dynamic exchange of lipids, calcium, and signaling molecules. However, dysregulation of tethering and signaling proteins contributes to the progression of breast cancer (BC). Abnormal MAM structures and altered ER-mitochondrial tethering impair mitochondrial functions and thereby drive BC progression. Altered mitochondrial dynamics, often characterized by dysregulated dynamin-related protein 1 (Drp1)

Совпадение в полном тексте источника
… This study showed that the dephosphorylation of Drp1 and cofilin is mediated by specific phosphatases via activating the ROCK1 signaling pathway. 119 Algebaly et al. demonstrated that an aqueous extract of Origanum majorana (AEOM) enriched with polyphenols inhibited proliferation and induced apoptosis … Aqueous Extract of Origanum majorana at Low Temperature (0°C) Promotes Mitochondrial Fusion and Contributes to Induced Apoptosis in Human Breast Cancer Cells. Asian Pac. J. Cancer Prev. APJCP. 2021;22:2959–2967. doi: 10.31557/apjcp.2021.22.9.2959. 121. …