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Передача БСЕ путем переливания крови в овцах.

Мы доказали, что можно передавать говядину с губчатой энцефалопатией (BSE) овце путем переливания крови, взятой из другой овцы, на стадии, свободной от симптомов экспериментальной инфекции BSE. Болезнь Креуцфельда-Якоба (vCJD) вызывается одним и тем же инфекционным агентом, а экспериментальная модель "овца-БСЭ" имеет патогенез, аналогичный патогенезу человека. Несмотря на то, что переливание крови в Соединенном Королевстве лейкодополняется - возможная мера защиты от любого риска, связанного с передачей крови, - в этом отчете говорится, что кровь, пожертвованная без симптомов ВИЧ-инфицированным

Совпадение в аннотации оригинала
We have shown that it is possible to transmit bovine spongiform encephalopathy (BSE) to a sheep by transfusion with whole blood taken from another sheep during the symptom-free phase of an experimental BSE infection. BSE and variant Creutzfeldt-Jakob disease (vCJD) In human beings are caused by the same infectious agent, and the sheep-BSE experimental model …

A serological survey of leptospirosis in sheep in Chile.

In order to investigate exposure to Leptospira spp. in sheep in the Xth Region in the south of Chile, 629 ovine serum samples were collected from 11 convenience selected sheep farms, using within farm random sampling. The sera collected were examined for antibodies to the following serovars; icterohaemorrhagiae, autumnalis, hardjo, pomona, ballum, and canicola, using the Microscopic Agglutination Test. Ten out of eleven flocks had sheep which were seropositive for at least one Leptospira spp. Positive tests, the majority at low titres, were obtained from 36/629 (5.7%) of all the serum samples …

Copper toxicosis in sheep: a case report.

Two ewes died after being fed rabbit ration and mineral salts designated for cows. This food is known to contain copper levels above that indicated for sheep. Blood counts revealed anemia, and serological tests showed high blood urea nitrogen, glutamic pyruvic transaminase and glutamic oxalacetic transaminase values. At necropsy, the animals had hepatopathy and nephropathy. Hepatic copper levels were 414 ppm. Histological examination revealed chronic active hepatitis with bile casts and tubular nephrosis. The liver, spleen and kidneys had hemosiderosis. This was attributed to the massive hemol…

A physiologic assessment of intrathecal amitriptyline in sheep.

BACKGROUND: Intrathecal injection of amitriptyline enhances antinociception from intravenous morphine and reduces neuropathic pain behavior … mg amitriptyline produced mild antinociception, whereas 10 mg produced intense sedation and, in one sheep, seizures and death. CONCLUSIONS: Although other preclinical toxicity studies are necessary before introducing intrathecal amitriptyline for use in humans, this study did not reveal dangerous changes in blood pressure or spinal cord blood flow from …

Traumatic myiasis of sheep in Europe: a review.

The two most important fly species causing traumatic cutaneous myiasis of sheep in Europe are Wohlfahrtia magnifica (Diptera: Sarcophagidae), which causes a form of myiasis known as wound myiasis, mainly in southern and eastern Europe, and Lucilia sericata (Diptera: Calliphoridae), which causes sheep strike, mainly in the middle latitudes of Europe. Other calliphorid blow-flies play a role mainly as secondary agents of myiasis, but in northern latitudes the L. caesar/illustris group are primary agents. Infestation levels vary greatly from region to region depending on a wide range of factors r…

Tick virus diseases of sheep and goats.

Tick-borne viruses affecting sheep and goats can be be locally important diseases. Viruses of the tick-borne encephalitis complex occur across Europe to North-East Asia and are the cause of significant losses in small ruminant production. Thogoto virus which can be transmitted by Ixodid ticks has been associated with abortion storms in sheep, it may contribute to the large proportion of abortions which are due to unknown causes. Nairobi sheep disease is the most pathogenic virus disease known for sheep and goats in East Africa. Ganjam virus in India may ultimately be shown to be a significant …

An outbreak of bacillary haemoglobinuria in sheep in India.

An outbreak of bacillary haemoglobinuria was recorded in 60 out of 110 sheep in Ludhiana, Punjab, India. The condition was clinically characterised by fever, haemoglobinuria, constipation, weakness of hind quarters followed by recumbency, respiratory distress and death in 16 sheep. Haematological studies revealed moderate to severe degrees of anaemia associated with leucocytosis. Plasma gamma-glutamyl transferase, alkaline phosphatase and creatinine phosphokinase activities were significantly higher in haemoglobinuric sheep. Babesiosis and copper poisoning were ruled out on stained blood film …

Epidermal growth factor as a diuretic in sheep.

1. Epidermal growth factor (EGF) has recently been shown to stimulate both polydipsia and polyuria and the aim of this study was to determin … mal. 4. This experiment demonstrates that EGF infused at a dose rate of 10 micrograms h-1 I.V. into sheep has a direct renal diuretic effect.

Lymphocytic enteritis and systemic vasculitis in sheep.

Lymphocytic enteritis and systemic lymphocytic vasculitis may be a new or previously unrecognized syndrome in sheep suffering from chronic wasting. Seven cases in three separate flocks were seen over an eight-year period at Veterinary Laboratory Services in Brighton, Ontario. Most of the animals were between five and twelve months of age and exhibited weight loss and inappetance, with or without diarrhea. All were Suffolks or crossbred Suffolks. In one of the flocks, there were also several sheep with lymphoma. Postmortem examination of carcasses and ancillary testing did not reveal an etiolog…

Observation of duodenal bile shuttle in the sheep.

Relation between duodenal anatomy and function was studied in cannulated sheep. It was concluded that during the interperistaltic periods, gravitational backflow of bile and admixed pancreatic juice towards the pylorus may provide a means for desorption of enterokinase from the mucosal surface of the cranial duodenum. The biliary back and forth ("bile shuttle") may contribute to the utilization of duodenal enterokinase.

Reflex control of the tracheal vasculature of sheep.

Arteries to the cervical trachea were perfused at constant flow in anesthetized sheep. Perfusion pressures (PP), blood pressure (BP), and changes in tracheal smooth muscle tone (Ptr) were measured. Stimulation of pulmonary C-fiber receptors decreased PP (-6.5%) and BP (-16.8%) and increased Ptr (+61.5%), changes prevented by vagotomy and therefore reflex. Stimulation of cardiac receptors and slowly adapting pulmonary stretch receptors decreased PP (-7.9%) and BP (-21.0) and increased Ptr (+19.0%), changes reversed by vagotomy and therefore reflex. Stimulation and inhibition of slowly adapting …

Alternative methods for the control of sheep scab.

For nearly 17 years, plunge dipping has been the only method of scab control in the UK under a Government-controlled eradication campaign. Dipping is inconvenient and has been incriminated in the post-dipping illness of stockowners and contractors, and the disposal of large volumes of used dipwash is a potential hazard to the environment. Upon the deregulation of sheep scab in July 1992, stockowners are no longer obliged to dip and will seek alternative methods of scab control, ie, systemic injectables or synthetic pyrethroid pour-ons. Plunge dipping still offers the only fully effective metho…

Tannic acid intoxication in sheep and mice.

Acute tannic acid intoxication was studied in mice and sheep. In mice, following oral administration of 2.0 to 4.6 g of tannic acid kg-1 bodyweight, periacinar coagulative and haemorrhagic necrosis occurred in the liver. In sheep, following oral (8 g kg-1 bodyweight) administration of tannic acid, liver necrosis was not observed either histologically or detected biochemically, although transmission electron microscopy showed focal hepatocellular necrosis, steatosis and acicular crystal cleft formation. In sheep given tannic acid intraperitoneally (0.1 g kg-1 bodyweight), liver necrosis occurre…

[Effect of dopamine on cecum motility in sheep].

The influence of dopamine on the motility of the caecum were studied. The experiments were carried out on 4 sheep with chronic fistulas of the caecum. The contractions of the caecum were recorded by the balloon method. Dopamine infused intravenously at a rate 29-38 micrograms.kg-1.min-1 inhibited the motility of the caecum. Dopamine infused after beta-adrenergic blocker propranolol (0.5-1.0 mg.kg-1) inhibited the movements of the caecum, however administrated after domperidone (0.2-0.4 mg.kg-1) didn't change its movements. It has been concluded that dopamine inhibits the caecum motility in she…

Asymptomatic cryptosporidiosis in nomadic shepherds and their sheep.

The formed stool samples of 276 asymptomatic members of 36 households of a group of nomadic shepherds and 215 non-diarrhoeal faecal samples from their sheep were examined for cryptosporidial infection by a modified Ziehl-Nielsen technique. Thirty-six (13%) human samples and 37 (17.2%) samples from sheep were positive. A strong possibility of asymptomatic zoonotic transmission of cryptosporidiosis due to prolonged and constant association of shepherds and their sheep was an important finding.

Hypothalamo-pituitary disconnection in the fetal sheep.

In this study we have applied the technique of hypothalamo-pituitary disconnection (HPD) to the fetal sheep at 108-112 days of gestation. The pituitary is surgically disconnected from the hypothalamus by the removal of the neural component of the median eminence above the level of the portal circulation. This procedure results in the complete disconnection of the pituitary from the hypothalamus. After HPD, the lactotroph response to the dopamine antagonist chlorpromazine was significantly reduced (p less than 0.005) indicating the functional isolation of the pituitary gland from the hypothalam…

Subpopulations of lymphocytes in the mammary gland of sheep.

The subpopulations of lymphocytes in the pregnant and non-pregnant mammary glands of the sheep were delineated by a panel of monoclonal antibodies. The most striking feature observed was that in the mammary gland of both pregnant and non-pregnant sheep the great majority of the lymphocytes in the ductal and alveolar epithelium were agranulated CD8+ CD5- cells. A small subpopulation of granulated lymphocytes in the epithelium expressed the CD45R antigen but not the major histocompatibility complex (MHC) class II molecules. Other subpopulations, especially B lymphocytes, were present in much low…

The effects of Ipomoea carnea on goats and sheep.

The clinical signs and lesions of Nubian goats and Desert sheep orally dosed with fresh and dry leaves and stems of Ipomoea carnea at 2.5, 5 and 10 g/kg/day were studied. The signs of Ipomoea poisoning were inappetence, depression, weakness of the hind limbs, dyspnea, staggering, and pallor of the visible mucous membranes. The main lesions were focal necrosis and fatty vacuolation of centrilobular hepatocytes, accumulation of fibroblasts in hepatic portal tracts, degeneration or necrosis of the cells of the renal proximal convoluted tubules, hemorrhage in renal cortices, in renal medullas and …