[Streptomycin toxicity on dark cells of utricles in guinea pigs].
Thirty guinea pigs were divided into three groups. The first group received intramuscular injection of streptomycin sulfate 400 mg/kg/day for one week; the second group received the same dosage for two weeks; the third group served as the control. The cochlea was dissected after treatment and the utricle observed under electron microscope. The nystagmus lasted 11.3 sec. clockwise and 12.75 sec. counter-clockwise before treatment, 10.75 sec. and 9.25 sec. after one week and 6.0 sec. and 5.5 sec. after two weeks. Histopathologic study showed the normal dark cells in the control group. In the one…
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