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Renal Involvement in Cancer Patients Undergoing Oncology Therapies: Implications for Personalized Treatment Strategies.

Introduction: Oncological therapies have significantly improved patient outcomes but are increasingly associated with renal toxicity, which can markedly influence therapeutic decisions. Integrating early identification of kidney injury into clinical workflows is essential for personalized medicine, allowing treatment tailoring based on individual risk profiles. Aim: To evaluate the incidence of acute kidney injury (AKI) and chronic kidney Disease (CKD); assess indices of renal function recovery in patients who developed AKI; and investigate the incidence of renal immune-related adverse events

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… The study protocol was approved by the Clinical Research Ethics Committee of Sapienza, University of Rome, Italy, and Policlinico Umberto I hospital with Rif. 7641 and Prot. 0716/2024. 2.2. … Institutional Review Board Statement The study was conducted in accordance with the Declaration of Helsinki and approved by the Clinical Research Ethics Committee of Sapienza, University of Rome, Italy, and Policlinico Umberto I hospital with Rif. 7641 and Prot. 0716/2024, date 31 July 2024. …

The 48th Annual Meeting of the European Society for Blood and Marrow Transplantation: Physicians - Oral Sessions (O009-O155).

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… Maciejewski 1 1 Cleveland Clinic Foundation, Cleveland, OH, USA, 2 Tor Vergata University, Rome, Italy, 3 Hôpital Saint Louis, AP-HP, Paris, France, 4 The European Society for Blood and Marrow Transplantation Paris Study Office, Paris, France, 5 University of São Paulo, Riberão Preto, Brazil Background …

Antiviral and immunomodulatory interferon-beta in high-risk COVID-19 patients: a structured summary of a study protocol for a randomised controlled trial.

OBJECTIVES: The primary objective of the study is to demonstrate the efficacy of low-dose IFN-β in reducing the risk of SARS-CoV-2 recently … -2 infection and mild COVID-19 symptoms are eligible for the study. The trial is being conducted in Rome. Participants will be either hospitalized or home isolated. A group of physicians belonging to the Special Unit for Regional Continued Care (USCAR), specifically trained for the study and under the supervision of the National Institute for Infectiou …

Donor's age influences outcome in haploidentical hematopoietic stem cell transplantation with post-transplant cyclophosphamide - a single center experience.

Haploidentical stem cell transplantation (haplo-SCT) using post-transplantation cyclophosphamide (post-Cy) is considered a reasonable therapeutic option for patients who lack matched donor or who urgently need transplant procedure due to high risk disease. We analyzed the results of haplo-SCT performed in years 2018-2023. Eighty one patients (46 males) at median age of 52 years underwent haplo-SCT using peripheral blood as a stem cell source in most cases. Indications included hematological malignancies (acute leukemias in 88% of cases). In 25 cases (31%) transplantation was performed in relap

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… McCurdy SR Zhang MJ St Martin A Al Malki MM Bashey A Gaballa S Keesler DA Hamadani M Norkin M Perales MA Reshef R Rocha V Romee R Solh M Urbano-Ispizua A Waller EK Fuchs EJ Eapen M Effect of donor characteristics on haploidentical transplantation with posttransplantation cyclophosphamide Blood Adv 2018 … 13 3 299 307 10.1182/bloodadvances.2017014829 PMC5812334 29440002 McCurdy SR, Zhang MJ, St Martin A, Al Malki MM, Bashey A, Gaballa S, Keesler DA, Hamadani M, Norkin M, Perales MA, Reshef R, Rocha V, Romee R, Solh M, Urbano-Ispizua A, Waller EK, Fuchs EJ, Eapen M (2018) Effect of donor characteristics …

The 45th Annual Meeting of the European Society for Blood and Marrow Transplantation: Physicians - Oral Session.

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… Camillo-Forlanini, Rome, Italy , 8 European Institute of Oncology, Milano, Italy , 9 Ospedale San Gerardo, Monza, Italy , 10 Hospital Clinic, Barcelona, Spain , 11 Grande Ospedale Metropolitano Bianchi Melacrino Morelli - Centro Unico Trapianti A. … Bonifazi, on behalf of GITMO. 15 1 University of Udine, Santa Maria Misericordia Hospital, Udine, Italy , 2 Universita' degli Studi di Milano and Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII, Bergamo, Bergamo, Italy , 3 University of Perugia, Perugia, Italy , 4 University ‘Tor Vergata', Rome …

Злоумышленная малярия: результаты вскрытия и морфологические характеристики.

ВАЖНЯЯ малярия, обусловленная инфекцией плазмодия фальципарума, передающейся москитами < < Анофелес > > , представляет собой чрезвычайную ситуацию, угрожающую жизни людей и приводящую к высокому уровню смертности в странах Африки к югу от Сахары. P. falciparum инфицирует красные кровяные клетки, вызывая их агрегацию и сцепление с эндотелиальной облицовкой малых сосудов. Этот микроваскулированный секвестр может препятствовать кровотоку, что приводит к ишемии и кровоизлиянию в организм, вызванному разрывом небольших судов. В случае внезапной смерти диагноз возможен только после вскры

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… Case report A 54-year-old woman with a history of multiple myeloma, diagnosed in 2019, was referred to the emergency room of a hospital in Rome due to asthenia, headache, and fever that had started the previous day. … The patient was subsequently transferred to National Institute for Infectious Diseases Lazzaro Spallanzani-IRCCS, Rome, Italy, where clinical examination was performed. …

The 46th Annual Meeting of the European Society for Blood and Marrow Transplantation: Physicians Oral Session (O010-O173).

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Selected abstracts from the XXXVIII National Congress of the Italian Society of Hypertension (SIIA)

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… , Rome, Italy, 2 Department of AngioCardioNeurology and Translational Medicine, IRCCS Neuromed, Pozzilli, Italy Introduction : Angiotensin II (AngII) acts through neuronal AT1 (AT1R) receptors in the main cardiovascular control centers of the brain. … Pulmonary Embolism and Lockdown: Treatment in Grey Zone Maria Lo Monaco, Francesco Cava, Ernesto Cristiano, Antonella Romaniello, Camillo Autore, Massimo Volpe Department of Cardiovascular Disease, School of Medicine and Psychology, “Sapienza” University of Rome, Rome, Italy Introduction : Pulmonary …

The 44th Annual Meeting of the European Society for Blood and Marrow Transplantation: Physicians Oral Session

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… United Kingdom; 11 Queen Elizabeth Medical Centre, University Hospital Birmingham NHS Trust, Department of Haematology, Birmingham, United Kingdom; 12 Erasmus MC Cancer Institute, University Medical Center Rotterdam, Department of Haematology, Rotterdam, Netherlands; 13 ¨Tor Vergata¨ University of Rome … , Stem Cell Transplant Unit, Policlinico Universitario Tor Vergata, Rome, Italy; 8 Hopital St. …

Relationship between sodium and diffusion MRI metrics in multiple sclerosis.

Sodium MRI can measure in vivo sodium concentrations in people with multiple sclerosis, but the extent to which these alterations reflect metabolic dysfunction in the absence of tissue damage or neuroaxonal loss remains uncertain. Increases in total sodium concentration and extracellular sodium concentration are believed to be indicative of tissue disruption and extracellular space expansion. Conversely, increase in intracellular sodium concentration may represent early and transient responses to neuronal insult, preceding overt tissue damage. Here, we explored the relationship between total s

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… Maria Petracca, Department of Human Neurosciences, Sapienza University of Rome, 00185 Rome, Italy. Simona Schiavi, Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), University of Genoa, 16132 Genoa, Italy. …

Effect of Distress, Anxiety, and Depressive Symptoms on SARS-CoV-2 mRNA BNT162b2 Vaccine Efficacy in Cancer Patients.

Background/objectivesOur previous study of 291 cancer patients, we showed that 20% did not respond to two doses of COVID-19 vaccine administered six weeks apart.MethodsHere, we investigated if psychological factors (distress, anxiety, and depressive symptoms) affected antibody response and markers of vaccine activation (D-dimer) after 6 months from initial vaccination.ResultsOverall, 31 subjects (14.2%) had no antibody response at 6 months. Our analysis revealed significant predictors of vaccine failure, including the stage of metastatic disease and high-stress levels (OR = 2.46, 95% CI, 1.05-

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… This study was registered on ClinicalTrials.gov (ID: NCT04932863 ) and received ethical approval from the National Institute for Infectious Diseases in Rome as well as the local Ethical Committee. … Institutional Review Board Statement This study was conducted in accordance with the Declaration of Helsinki, and the trial (ClinicalTrials.gov ID: NCT04932863 ) was approved by the National Institute for Infectious Diseases, Rome, and the local Ethical Committee. …

Внутриядерное периферальное перевыражение Pituitary-Tumor-transforming Gene 1:: Иммуногистохимическая биомаркировка лимфатического узла в яичной семиноме.

Фон/цели: Опухоли яичных микробных клеток, особенно полунома, являются основной причиной рака у мужчин в возрасте 15-40 Годы. Решение о адъютантной терапии основывается на гистологических особенностях с неопределенной перспективной ценностью. Ген Pituitary-Tumor-Transforming Gene 1 (PTTG1), который кодирует секуриновый протеин, имеет решающее значение для разделения сестринских хроматидов. Наши предыдущие исследования in vitro показали, что ядерное выражение PTTG1 поощряет инвазивность, дедифференцацию и неолимфангиогенез в яичниковой полуноме. Методы: Мы провели гипотетическое ретроспективное

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… All had undergone orchifunicolectomy at the Fondazione Policlinico Universitario Agostino Gemelli—IRCCS (Rome, Italy), or at the Policlinico Umberto I (Rome, Italy) between 2015 and 2024. … Immunohistochemistry The archival cases were provided by the Unit of Pathological Anatomy at the Fondazione Policlinico Universitario Agostino Gemelli—IRCCS, Rome and by the Department of Radiological, Oncological and Pathological Sciences, Sapienza University of Rome, Italy. …

An Italian cartography of VEXAS-related thrombosis.

Thrombotic events (TEs) occur in up to 40% of patients with vacuoles, E1 enzyme, X-linked, autoinflammatory, and somatic (VEXAS) syndrome, but data on its clinical-genomics features and anticoagulation strategies are limited. To gain more insight into this, we conducted a two-step study evaluating the prevalence and outcome of TE in VEXAS. First, among 1086 patients followed for TEs, 198 were men aged >40 years with unprovoked thrombosis and no known thrombophilia; 21 also had at least one VEXAS-compatible feature and underwent UBA1 exon 3 testing. No UBA1 mutation was detected in these 21 pat…

The impact of level of documentation on the accessibility and affordability of new drugs in Norway.

Introduction: Over the preceding decade, an increasing number of drugs have been approved by the European Medicines Agency (EMA) with limited knowledge of their relative efficacy. This is due to the utilization of non-randomized, single-arm studies, surrogate endpoints, and shorter follow-up time. The impact of this trend on the accessibility and affordability of newly approved drugs in Europe remains uncertain. The primary objective of this study is to provide insights into the issues of accessibility and affordability of new drugs in the Norwegian healthcare system. Method: The presented stu

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… In the United States, there has been a 20% increase in launch prices for new drugs over the last decade ( Rome et al., 2022 ). … Rome B. N., Egilman A. C., Kesselheim A. S. (2022). Trends in prescription drug launch prices, 2008-2021. JAMA 327 (21), 2145–2147. 10.1001/jama.2022.5542 Russo P., Zanuzzi M., Carletto A., Sammarco A., Romano F., Manca A. (2023). …

Clinical experience with Zarzio® in Europe: what have we learned?

Biosimilars are similar, but non-identical, versions of existing biological drugs for which patents have expired. Despite the rigorous approval process for biosimilars, concerns have been expressed about the efficacy and safety of these products in clinical practice. Biosimilars of filgrastim, based on the originator product Neupogen®, have been available since 2008 and are now in widespread clinical use in Europe and elsewhere. Three biosimilar G-CSFs have been approved based on a combination of physicochemical and biological protein characterisation, pharmacokinetic and pharmacodynamic asses

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… Hamburg, Germany (SC) 77 Breast, n = 22 PP, n = 32 Verpoort et al. 2011 [ 28 ] Lymphoma/leukaemia, n = 17 SP, n = 40 Colorectal, n = 10 Unknown, n = 5 Other, n = 28 Gaeta, Italy (SC) 48 Lung, n = 17 PP, n = 37 Salesi et al. 2012 [ 29 ] Colorectal, n = 11 SP, n = 11 Breast, n = 10 Other solid, n = 10 Rome … Breast, n = 22 | PP, n = 32 Verpoort et al. 2011 [ 28 ] | Lymphoma/leukaemia, n = 17 | SP, n = 40 Colorectal, n = 10 | Unknown, n = 5 Other, n = 28 | Gaeta, Italy (SC) | 48 | Lung, n = 17 | PP, n = 37 Salesi et al. 2012 [ 29 ] | Colorectal, n = 11 | SP, n = 11 Breast, n = 10 | Other solid, n = 10 | Rome …

Multiple Myeloma: Cast Nephropathy, VTE, and Neurologic Complications.

Multiple myeloma accounts for approximately 1% of neoplastic diseases and 13% of hematologic cancers. Complications often associated with MM include neurologic and hematologic issues, infections, renal insufficiency, and bone involvement. It is crucial for advanced practice professionals caring for myeloma patients to assess patients accurately, be keenly aware of possible associated complications, and be familiar with appropriate interventions to prevent further injury. This article will provide an overview of MM-related renal insufficiency, with a focus on cast nephropathy, venous thromboemb

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… Central venous catheters and surgeries such as vertebroplasty and kyphoplasty lead to vascular wall injury and damage (Rome et al., 2008). … The lancet oncology 2010 11 29 37 19853510 10.1016/S1470-2045(09)70284-0 PMC3042271 38 Rome Sandra Doss Deborah Miller Kena Westphal Jeanne Thromboembolic events associated with novel therapies in patients with multiple myeloma: consensus statement of the IMF Nurse Leadership Board. …

Cancer Cure and Consequences on Survivorship Care: Position Paper from the Italian Alliance Against Cancer (ACC) Survivorship Care Working Group.

A multidisciplinary panel of experts and cancer patients developed a position paper to highlight recent evidence on "cancer cure" (ie, the possibility of achieving the same life expectancy as the general population) and discuss the consequences of this concept on follow-up and rehabilitation strategies. The aim is to inform clinicians, patients, and health-care policy makers about strategies of survivorship care for cured cancer patients and consequences impacting patient lives, spurring public health authorities and research organizations to implement resources to the purpose. Two identifiabl

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… Pavia, Italy; Antonio Silvani, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy; Daniela Costardi, Vittorina Zagonel, Veneto Institute of Oncology IOV-IRCCS, Padua, Italy; Francesca Sanseverino, IRCCS CROB Rionero in Vulture, Potenza, Italy; Cristina Deppermen Fortes, IDI-IRCCS-FLMM, Rome … dei Tumori (IRST) “Dino Amadori”, Meldola, Italy; Stefania Costi, Azienda USL-IRCCS of Reggio Emilia, Italy; Michele Spina, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Italy; Angelo Ricci, Presidente FIAGOP (Federazione Italiana Associazioni Genitori e Guariti Oncoematologia Pediatrica) Rome …

Natural killer cells, macrophages and dendritic cells as innate immune therapies for blood cancers.

Innate immune cells are emerging as powerful allies in the fight against blood cancers. Natural Killer (NK) cells, macrophages, and dendritic cells (DCs)—once viewed mainly as supporting players—are now at the forefront of next-generation immunotherapies, owing to their rapid, antigen-independent tumor recognition and potent effector functions. This review highlights their distinct anti-tumor roles: NK cells’ cytotoxicity and “missing-self” recognition, the dual and adaptable nature of macrophages in the tumor microenvironment (TME), and the antigen-presenting capabilities of DCs that bridge i

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… 24434782 Leong JW, Chase JM, Romee R, Schneider SE, Sullivan RP, Cooper MA et al (2014) Preactivation with IL-12, IL-15, and IL-18 induces CD25 and a functional high-affinity IL-2 receptor on human cytokine-induced memory-like natural killer cells. … Tarannum M Romee R Shapiro RM Innovative strategies to improve the clinical application of NK Cell-Based immunotherapy Front Immunol 2022 13 859177 35401529 10.3389/fimmu.2022.859177 PMC8990319 Tarannum M, Romee R, Shapiro RM (2022) Innovative strategies to improve the clinical application of NK Cell-Based …

Оказание помощи лицам, страдающим множественным склерозом, в Италии: восходящий подход проекта < < Континхом > > .

ЦЕЛЬ: В Италии, вокруг 137,000 Люди живут с множественным склерозом, сталкиваясь с организационными сложностями из-за того, что нынешняя модель уделяет ограниченное внимание уходу в непосредственной близости. Этот проект направлен на определение модели близости в соответствии с последними изменениями в итальянской системе здравоохранения, которая включает в себя: 150 Заинтересованные стороны в области здравоохранения, которые могут оказать 14,000 Пациенты. МЕТОДЫ: Был проведен анализ с целью картирования многоразового склерозового пути, после чего были проведены собеседования для выявления фак

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… Camillo Forlanini Hospital, Rome, Italy); GA. Marfia (Multiple Sclerosis Clinical and Research Unit, Fondazione Policlinico Tor Vergata, Department of Systems Medicine, Tor Vergata University, Rome, Italy); C. … Camillo Forlanini Hospital, Rome, Italy); F. Rinaldi (UOS Day Hospital, Telemedicine and Centre for Advanced Therapies in Neurology, Department for Neurosciences, DNS, University Hospital, Padua and Multiple Sclerosis Centre of the Veneto Region, Italy); E. …

A summary of our recent evidence-based works on radiographic diagnostics of prevalent osteoporotic vertebral fracture in older men and women.

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… Data based on Hong Kong Chinese were used as an example for East Asians, and data based on Rome Italians were used as an example for Caucasians. An OLVF sum score (OLVFss) was calculated for each study subject. … Assessment of fracture risk and its application to screening for postmenopausal osteoporosis: report of a WHO study group [meeting held in Rome from 22 to 25 June 1992]. World Health Organization. 1994. …