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ePoster.

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… Gemelli IRCCS, Rome, Italy; 12 Cairo University Stroke Center, Department of Neurology, Faculty of Medicine, Cairo University, Egypt; 13 Department of Neurology, St George's University Hospital, London, UK; 14 Neurology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt; 15 Department … Neurologia, Ospedale “Di Venere”, Bari, Italy; 18 Emergency Neurology ‐ Department of Neuroscience, Sensory Organs, and Thorax ‐ Policlinico Universitario Agostino Gemelli, IRCCS Rome, Italy; 19 UOC Neurologia e Stroke Unit, AOOR Villa Sofia‐Cervello, Palermo, Italy; 20 Neurology Department, Hospital …

Assessment and monitoring of patients receiving chemotherapy for multiple myeloma: strategies to improve outcomes.

Improved understanding as to the biology of multiple myeloma (MM) and the bone marrow microenvironment has led to the development of new drugs to treat MM. This explosion of new and highly effective drugs has led to dramatic advances in the management of MM and underscores the need for supportive care. Impressive and deep response rates to chemotherapy, monoclonal antibodies, and small molecule drugs provide hope of a cure or prolonged remission for the majority of individuals. For most patients, long-term, continuous therapy is often required to suppress the malignant plasma cell clone, thus

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… Table 2 Common adverse events and survivorship considerations in patients with MM Notes: Based on information from: Faiman et al; 123 Bilotti et al; 98 Faiman et al; 99 Miceli et al; 96 Rome et al; 124 Rome et al; 97 Colson; 73 Richards and Brigle; 125 and product prescribing information. … Rome SI, Jenkins BS, Lilleby KE, International Myeloma Foundation Nurse Leadership Board Mobility and safety in the multiple myeloma survivor: survivorship care plan of the International Myeloma Foundation Nurse Leadership Board. …

63rd Annual Conference of the Indian Society of Gastroenterology, ISGCON 2022-January 5th - 8th, 2023 in Jaipur.

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… Methods Four hundred and ninety-two patients with IBS (based on Rome IV criteria) were screened for anti-gliadin Ab and diagnosis of NCGS in AGA positive individuals was made on the basis of Salerno criteria. … Methods Out of 416 cases with COVID-19, finally 320 cases with 320 healthy spouses/family controls (Group-A) and 280 healthy covid serology negative controls (Group B) were prospectively followed up at 1,3 and 6 months using validated Rome IV criteria to evaluate the frequency of PI-FGID/DGBI. …

Development and validation of a patient-reported outcome tool to assess cancer-related financial toxicity in Italy: a protocol.

IntroductionFinancial toxicity (FT) is a well-recognised problem in oncology. US-based studies have shown that: (a) cancer patients have a 2.7 times risk of bankruptcy; (b) patients who declare bankruptcy have a 79% greater hazard of death; (c) financial burden significantly impairs quality of life (QoL) and (d) reduces compliance and adherence to treatment prescriptions. The aim of the project is to develop and validate a patient-reported-outcome (PRO) measure to assess FT of cancer patients in Italy, where, despite the universal health coverage provided by the National Health Service, FT is

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… Qualitative interviews of consenting patients and caregivers will be conducted by nurses in three participating centres representing Southern (Naples), Central (Rome) and Northern (Turin) Italy, with the aim of exploring the lived experience of financial difficulties that occur during cancer treatment … Item importance analysis Item importance will be ranked by a sample of 45 patients (15 for each centre, Naples, Rome and Turin, selected with the same inclusion/exclusion criteria reported above). …

Risk Factors for Mucosal Redness in the Duodenal Bulb as Detected via Linked Color Imaging.

Linked color imaging (LCI) for image-enhanced endoscopy (IEE) highlights mucosal color differences. We investigated risk factors associated with mucosal redness of the duodenal bulb using LCI. Consecutive patients were retrospectively selected after their duodenal bulbs were observed via LCI. A symptom questionnaire (Izumo scale) was completed. The LCI of the duodenal bulb was subjectively evaluated on whether redness was present and objectively evaluated based on L* a* b* color values. The clinical characteristics of the 302 study participants were: male/female, 120/182; mean age, 70.9 years.

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… Worldwide Prevalence and Burden of Functional Gastrointestinal Disorders, Results of Rome Foundation Global Study. Gastroenterology. 2021;160:99–114.e113. doi: 10.1053/j.gastro.2020.04.014. 2. Higgins P.D., Johanson J.F. Epidemiology of constipation in North America: A systematic review. Am. J. … Characteristics of Japanese patients with chronic gastritis and comparison with functional dyspepsia defined by ROME III criteria: Based on the large-scale survey, FUTURE study. Intern. Med. 2011;50:2269–2276. doi: 10.2169/internalmedicine.50.5678. 25. …

Highlighting recent achievements to advance more effective cancer immunotherapy.

From 17 to 19th October 2024, the XXI Italian Network for Bio-Immunotherapy of Tumors Meeting (NIBIT) took place in Palermo, in the marvelous historical location of Teatro Politeama, under the auspices of the Italian Association of Medical Oncology (AIOM), Italian Association of Cancer Research (AIRC), Fondazione Pezcoller, Italian Alliance against Cancer (ACC), Italian Lymphoma Foundation (FIL), Grazia Focacci Foundation and Melagioco Foundation. The conference covered a spectrum of topics ranging from target discovery to therapeutic advances in immuno-oncology, bringing world-renowned expert

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… Alessandra Metelli (Rome, Italy) unveiled compelling evidence on the role of Tissue Factor (TF) in augmenting TGFβ signaling in cancer cells by modulating plasma membrane tension and receptor dynamics. … Session 5 of the NIBIT congress, co-chaired by Anna Mondino (Milan, Italy) and Sheila Spada (Rome, Italy), was indeed dedicated to the most recent advancements in the field of cancer vaccines and DC-targeted therapies. …

Bone scintigraphy and positron emission tomography in the early diagnosis of MRONJ.

OBJECTIVES: The aim of this study is to evaluate the bone scintigraphy (BS) and positron emission tomography (PET) in the early diagnosis of medication-related osteonecrosis of the jaws (MRONJ) and their possible use in the identification of patients at risk for MRONJ. MATERIAL AND METHODS: Thirty-one patients treated with ONJ-related drugs and who had undergone BS or PET for the evaluation of bone lesions were included in the study. The jaws of each patient were divided into four areas. For each area, the presence of pathological tracer uptake was evaluated and related to the eventual MRONJ

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… Ethical approval: The study was approved by the Council of the Department of Oral Sciences and Maxillofacial Surgery at “Sapienza” University of Rome (Prot. N.5 of 20/02/2024). Results A total of 51 patients fulfilled the inclusion criteria. … Data availability statement: The data are available at the Department of Oral and Maxillofacial Sciences of Sapienza University of Rome. References [1] Di Fede O, Panzarella V, Mauceri R, Fusco V, Bedogni A, Lo Muzio L, et al. …

Риск системных ревматических заболеваний у людей с раздражающим синдромом кишечника: когортный анализ с глобальной федерацией.

Синдром кишечника (IBS) — широко распространенное расстройство взаимодействия кишечника и мозга, все больше связанное с иммунным и подстрекательским регулированием. Остается неясным, предрасположена ли IBS к системным ревматическим болезням. Methods Мы провели ретроспективное когортное исследование с использованием Глобальной сети сотрудничества TriNetX, которая объединяет анонимные электронные медицинские записи, полученные от более, чем 150 Организации здравоохранения и 150 million Пациенты по всему миру. Взрослые≥18 год) с диагнозом IBS≥2 посещения) между 2015 и 2023 были сопоставлены с соо

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BackgroundIrritable bowel syndrome (IBS) is a prevalent disorder of gut-brain interaction increasingly linked to immune and inflammatory dysregulation. Whether IBS predisposes to systemic rheumatic diseases remains uncertain.MethodsWe conducted a retrospective cohort study using the TriNetX Global Collaborative Network, which integrates anonymized electronic…

Management of Medication-Related Osteonecrosis of the Jaw (MRONJ) Using Leukocyte- and Platelet-Rich Fibrin (L-PRF) and Photobiomodulation: A Retrospective Study.

BACKGROUND: The aim of this study was to compare retrospectively the effect of three different treatment protocols on the healing outcome in patients with established medication-related osteonecrosis of the jaw (MRONJ). METHODS: A total of 34 MRONJ patients were recruited from the Department database and were divided according to the treatment protocols in a study group (G1) and two control groups (G2 and G3). G1 was treated with antibiotic therapy, surgery, leukocyte- and platelet-rich fibrin (L-PRF), and photobiomodulation; G2 was treated with antibiotic therapy and surgery; G3 was treated

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… Materials and Methods A single-center retrospective study was conducted on patients enrolled in the MoMax (Oral Medicine and Maxillofacial) project of the Department of Oral Sciences and Maxillofacial Surgery at Policlinico Umberto I, Sapienza University of Rome. … The study was approved by the Ethics Committee of Sapienza University of Rome (approval number: 981/17). …

Exercise-mobilized donor lymphocyte infusions enhanced with cytokine stimulation for the prevention and treatment of leukemic relapse after allogeneic hematopoietic cell transplantation.

Donor lymphocyte infusions (DLI) are a standard therapy following allogeneic hematopoietic cell transplantation (alloHCT) for preventing and treating leukemic relapse in high-risk patients, particularly those with myeloid malignancies such as acute myeloid leukemia (AML), chronic myeloid leukemia (CML), and myelodysplastic syndrome (MDS). However, the efficacy of DLI remains suboptimal and is accompanied by a significant risk of life-threatening graft-versus-host disease (GvHD), highlighting the urgent need for strategies that enhance graft-versus-leukemia (GvL) effects while mitigating GvHD. …

Costs and benefits of early access to new cancer drugs through the US Food and Drug Administration's accelerated approval pathway: retrospective observational study and economic evaluation.

OBJECTIVE: To evaluate the survival gains and additional Medicare spending associated with early access to new cancer drugs granted accelerated approval by the US Food and Drug Administration (FDA), compared with access to cancer drugs following completion of confirmatory trials. DESIGN: Retrospective observational study and economic evaluation. SETTING: US Medicare programme, which provides health insurance for adults aged 65 years and older. PARTICIPANTS: Medicare beneficiaries who received new cancer drug indications from the time of FDA accelerated approval to conversion to regular appr

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… Rome BN, Feldman WB, Kesselheim AS. Medicare Spending on Drugs With Accelerated Approval, 2015-2019. JAMA Health Forum . 2021;2:e213937. doi: 10.1001/jamahealthforum.2021.3937. 34. Husereau D, Drummond M, Augustovski F, et al. … Cliff ERS, Rome RS, Kesselheim AS, et al. National Comprehensive Cancer Network Guideline Recommendations of Cancer Drugs With Accelerated Approval. JAMA Netw Open. 2023;6:e2343285. doi: 10.1001/jamanetworkopen.2023.43285. 76. Wei Y, Zhang Y, Xu Z, et al. …

Correlation between Constipation Symptoms and Abdominal CT Imaging: A Cross-Sectional Pilot Study.

Evaluation of chronic constipation is important, although it is often difficult to satisfactorily treat due to the complex interplay of factors. This study aimed to determine whether the volume of intraluminal contents and lateral diameter of the colon measured from computed tomography (CT) images were correlated with the symptoms of chronic constipation and stool consistency. Consecutive patients who underwent the Constipation Scoring System (CSS), Bristol Stool Form Scale (BSFS) questionnaires and simple abdominal CT were selected retrospectively. The intestinal tract diameter at each site w

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… According to Rome III, stool generally accumulates in the transverse colon where it absorbs water and electrolytes. … Investigation of the utility of colorectal function tests and Rome II criteria in dyssynergic defecation (Anismus) Neurogastroenterol. Motil. 2004 16 589 596 10.1111/j.1365-2982.2004.00526.x 15500515 22. Roth H.P. Fein S.B. Sturman M.F. …

A Focus on Newly Diagnosed Multiple Myeloma.

Multiple myeloma (MM) is an incurable plasma cell disorder that affects nearly 35,000 people annually. Over 149,000 individuals are estimated to live in the United States with MM. Research has generated a greater understanding of the pathology of this disease, now combined with mature clinical trial data that support the use of combination therapy in treatment. This article focuses on updated diagnosis, prognosis, and treatment of newly diagnosed patients. While the diagnosis of MM remains based on the 2014 International Myeloma Working Group (IMWG) guidelines, we review these and updated reco

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… The article by Noonan, Rome, and Faiman (2022) in this supplement contains further discussion regarding treatment decision-making. … category=1&id=1445 10.6004/jnccn.2009.0061 19878637 Noonan , K. , Rome , S. , Faiman , B. , Verina , D. , & Board . ( 2017 ). Heart and lung complications: Assessment and prevention of venous thromboembolism and cardiovascular disease in patients with multiple myeloma . …

Abstract

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… – Rome Italy Background: Right ventricular (RV) adverse remodeling together with RV dysfunction, and not only tricuspid regurgitation (TR) severity, are independently associated with survival in patients with medically treated significant TR. … Materials and methods: This prospective, single-center study, conducted at Campus Bio-Medico of Rome, enrolled 35 consecutive symptomatic patients with the diagnosis of at least severe TR who underwent T-TEER from March 2021 to August 2023. Intraprocedural TEE was performed using Siemens Acuson. …

Нейрогенная желудочно-кишечная, мочевая и сексуальная дисфункция при множественном склерозе: многодисциплинарная основа для клинической практики.

Нейрогенные желудочно-кишечные, мочевые и сексуальные симптомы широко распространены у людей с множественным склерозом и существенно ухудшают качество жизни, повседневное функционирование и психосоциальное благополучие. Несмотря на их частотность и клиническую актуальность, управление по-прежнему носит разрозненный характер по различным специальностям, тесная взаимосвязь между этими симптомами зачастую игнорируется, а у клинических работников отсутствует прагматическая основа, адаптированная к различным условиям здравоохранения. Этот обзор преобразует нынешние данные в прагматичную модель уход

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… emptying in 22% of patients. 7 The study demonstrated that GI symptoms were more prevalent across all domains than in the general population 8 and highlighted that constipation and FI are more prevalent in MS subjects of old age, with spinal cord lesions and a progressive phenotype. 7 According to the Rome … What’s new in rome IV? Neuro Gastroenterol Motil. 2017;29(9) doi: 10.1111/nmo.13053. 11. Rao S.S.C., Bharucha A.E., Carrington E.V., et al. Anorectal disorders. Gastroenterology. 2026;170(6):1318–1346. doi: 10.1053/j.gastro.2026.01.037. 12. Jain M. …

The 44th Annual Meeting of the European Society for Blood and Marrow Transplantation: Physicians Poster Sessions

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… Santarone 10 , Maria Teresa Van Lint 11 , Antonin Vitek 12 , Jordi Esteve 13 , Mohamad Mohty 2 , Arnon Nagler 2,14 1 Chaim Sheba Medical Center, Hematology Division, Ramat Gan, Israel; 2 EBMT Paris Study Office, Paris, France; 3 Peking University People's Hospital, Peking, China; 4 Tor Vergata University, Rome …

Резюме МКАРЕ 2023 77th Национальный конгресс " СИААРТИ "

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… Forastiere 2 1 Department of Anesthesia, Intensive Care and Pain Therapy, Policlinico Umberto I, Sapienza University of Rome, Roma, Italy, 2 Department of Anesthesia, Intensive Care and Pain Therapy, IRCCS - Regina Elena National Cancer Institute, Rome, Roma, Italy Correspondence: G. … Case report The patient of our clinical case report is a 60-year-old woman (ASA 2, no history of allergies) admitted to the plastic surgery unit of the IRCCS -Regina Elena National Cancer Institute, Rome, undergoing removal of the left breast prosthesis, debridement of homolateral axillary scar tissue …

Минимальная информация для исследований внеклеточной везиклетки (MISEV2023): от базовых до передовых подходов.

Внеклеточные везиклолы (ЭМ) с помощью своего сложного груза могут отражать состояние клетки их происхождения и изменять функции и фенотипы других ячеек. Эти особенности свидетельствуют о значительном биомаркировании и терапевтическом потенциале и вызывают широкий интерес, о чем свидетельствует постоянное увеличение числа научных публикаций об ЭМ за год. Значительные успехи были достигнуты в области ЭВМ, а также в понимании и применении биологии ЭМ. Вместе с тем сохраняются препятствия на пути реализации потенциала ЭМ в различных областях - от базовой биологии до клинического применения - в свя

Human herpesvirus type 6 reactivation after haploidentical hematopoietic cell transplantation with post-transplant cyclophosphamide and antithymocyte globulin: risk factors and clinical impact.

Human herpesvirus type 6 (HHV6) reactivation after haploidentical hematopoietic cell transplantation (HCT) with post-transplant cyclophosphamide (PT-Cy) has been scarcely studied, especially when antithymocyte globulin (ATG) is added to the graft-versus-host disease (GvHD) prophylaxis. We conducted a retrospective cohort study in 100 consecutive patients receiving haploidentical HCT with PT-Cy. We systematically monitored HHV6 DNA loads in blood samples on a weekly basis using quantitative PCR until day +100. The 100-day cumulative incidence of HHV6 reactivation was 54%. Clinically significant

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… Romee Rizwan Komanduri Krishna V. Badawy Sherif M. Friend Brian D. … Perales Miguel-Angel Taplitz Randy Romee Rizwan Riches Marcie American Society of Hematology 3 3 2021 137 23 3291 3305 0006-4971 10.1182/blood.2020009362 10.1182/blood.2020009362 33657221 PMC8351903 Letermovir Prophylaxis for Cytomegalovirus in Hematopoietic-Cell Transplantation New England Journal …

Затраты на кладрибинные таблетки для лечения высокоактивных реплаксирующих множественных склерозов в Италии.

ВВЕДЕНИЕ: Множественный склероз (MS) представляет собой хроническое аутоиммунное заболевание, воздействующее на центральную нервную систему. Лица с весьма активными реактивными выбросами MS (HA-RRMS) часто сталкиваются с симптомами, продолжительность которых превышает 24 h, за которым следует период полной или частичной ремиссии. Цель этого исследования состояла в том, чтобы оценить экономические последствия применения таблеток кладрипина для лечения пациентов, имеющих HA-RRMS в итальянском контексте. МЕТОДЫ: модель Маркова, разработанная компанией PRECISIONheor для имитации результатов лечени

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… Funding This work, and the rapid service fee, has been funded by Merck Serono S.p.A., Rome, Italy, an affiliate of Merck KGaA (CrossRef Funder ID: 10.13039/100009945). … Declarations Conflicts of interest Anna Maria Provenzano and Caterina Rizzi are employees of Merck Serono S.p.A., Rome, Italy, an affiliate of Merck KGaA. …