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Hematology and Immune-Related Disorders

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The Proceedings of the 19th International Cancer Imaging Society Meeting and Annual Teaching Course : Verona, Italy. 7 - 9 October 2019.

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Prognostic Factors and Risk Stratification in Malignant Tumor Patients With Sepsis: A Retrospective Cohort Study.

BACKGROUND Sepsis is a life-threatening complication in cancer patients and a major contributor to ICU admission and mortality. Although tumor-related factors affect outcomes, the prognostic value of ICU-specific clinical parameters remains insufficiently explored. This study aimed to identify ICU-related predictors of mortality beyond tumor characteristics in cancer patients with sepsis. MATERIAL AND METHODS We conducted a single-center retrospective cohort study including 4301 cancer patients with sepsis. Independent predictors of 28-day mortality were identified using multivariable logistic

Disability Weights Measurement for 228 Causes of Disease in the Korean Burden of Disease Study 2012.

Disability weight for each disease plays a key role in combining years lived with disability and years of life lost in disability adjusted life year. For the Korean Burden of Disease 2012 study, we have conducted a re-estimation of disability weights for causes of disease by adapting the methodology of a recent Global Burden of Disease study. Our study was conducted through a self-administered web-based survey using a paired comparison (PC) as the main valuation method. A total of 496 physicians and medical college students who were attending in third or fourth grade of a regular course conduc

SGLT2 Inhibitors: From Structure-Effect Relationship to Pharmacological Response.

SGLT2 inhibitors have become increasingly used due to their effectiveness in improving not only type 2 diabetes but also cardiovascular, renal and hepatic diseases, as well as the obesity found in metabolic syndrome. Starting from the structure of gliflozins, modifications of the carbohydrate part, aglycone, and also the glycosidic bond between them can determine variations in pharmacokinetic and pharmacodynamic properties. SGLT2 inhibitors, in addition to reducing blood glucose levels, improve alterations in lipid metabolism by diverting excessively accumulated lipids in tissues towards mobil

ICAR 2011. Italian Conference on AIDS and Retroviruses, Florence, Italy, 27-29 March 2011. Abstracts.

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Percutaneous coronary intervention and 30-day unplanned readmission with chest pain in the United States (Nationwide Readmissions Database).

Percutaneous coronary intervention (PCI) improves anginal chest pain in most, but not all, treated patients. PCI is associated with unplanned readmission for angina and non-specific chest pain within 30-days of index PCI. Patients with an index hospitalization for PCI between January-November in each of the years 2010-2014 were included from the United States Nationwide Readmissions Database. Of 2 723 455 included patients, the 30-day unplanned readmission rate was 7.2% (n = 196 581, 42.3% female). This included 9.8% (n = 19 183) with angina and 11.1% (n = 21 714) with non-specific chest pain.

Miscellaneous Spinal Cord Diseases

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Use of MASCC score in the inpatient management of febrile neutropenia: a single-center retrospective study.

PurposeThe Multinational Association for Supportive Care in Cancer (MASCC) score is used to risk stratify outpatients with febrile neutropenia (FN). However, it is rarely used in hospital settings. We aimed to describe management, use of MASCC score, and outcomes among hospitalized patients with FN.MethodsWe conducted a retrospective cohort study of patients with cancer and FN. We collected patient demographics, cancer characteristics, microbiological profile, MASCC score, utilization of critical care therapies, documentation of goals of care (GOC), and inpatient deaths. Outcomes associated wi

Persistent lactic acidosis in ALK-positive anaplastic large cell lymphoma: a case report and literature review.

Lactic acidosis is common in the ICU, but malignancy-associated type B lactic acidosis mediated by the clinical Warburg effect (CWE) is uncommon and easily missed when infection or organ dysfunction dominates the presentation. We report a 35-year-old man with a month of fever and progressive dyspnea who presented with persistent hyperlactatemia (peak 15.46 mmol/L) and markedly elevated LDH despite stable hemodynamics. Imaging revealed generalized lymphadenopathy, multifocal osteolytic lesions, and bilateral pleural effusions; infectious studies were unrevealing apart from chronic hepatitis B.

Cutaneous adverse events to systemic antineoplastic therapies: a retrospective study in a public oncologic hospital.

BackgroundMucocutaneous adverse events are common during anticancer treatment, with variable consequences for the patient and their therapeutic regimen.ObjectiveTo evaluate the most common adverse events, as well as the drugs associated with their appearance and the consequences for cancer treatment.MethodsA retrospective study was carried out through the analysis of patients treated at the Clinical Dermatology Unit of a public oncologic hospital.ResultsA total of 138 patients with 200 adverse events were evaluated. The most commonly identified adverse events were nail and periungual changes (

Электронные постеры

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Клинические 7 Тесла магнитный резонансный снимок: воздействие и ценность пациента в неврологических расстройствах.

Магнитный резонансный снимок (MRI) является краеугольным камнем неинвазивной диагностики и контроля за лечением, особенно в случае заболеваний центральной нервной системы. Хотя 1.5- и 3 Тесла (Т) сильные стороны поля остаются клиническим стандартом, появление 7 МРТ представляет собой преобразующий шаг вперед, предлагающий высокое пространственное разрешение, контраст и чувствительность для визуализации нейроанатомии, метаболизма и функции. Последние нововведения, включая параллельную передачу и глубокую реконструкцию на основе накопленного опыта, позволили решить многие ранее возникшие техниче

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… In clinical practice, proton magnetic resonance spectroscopy is routinely applied to evaluate metabolic disorders in children and can detect lactate peaks for distinguishing brain abscesses from other pathologies. …

Extraglandular Manifestations of Sjögren’s Syndrome (SS): Dermatologic, Arthritic, Endocrine, Pulmonary, Cardiovascular, Gastroenterology, Renal, Urology, and Gynecologic Manifestations

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Proceedings of The 8th Romanian National HIV/AIDS Congress and The 3rd Central European HIV Forum : Sibiu, Romania. 5-7 May 2016.

O1 HIV-1 diversity in Bulgaria (current molecular epidemiological picture) Ivailo Alexiev, Reneta Dimitrova, Anna Gancheva, Asya Kostadinova … HIV-infected young woman with multiple opportunistic infections Irina Ianache, Cristiana Oprea O32 Brain abscess with uncertain etiology in a late-presenter HIV infected patient Anca Leuștean, Cristina Popescu, Alina Orfanu, Anca Negru, Remulus Catana, Cristina Murariu, Ioan-Alexandru Diaconu, Mihaela Rădulescu, Cătălin Tilișcan, Victoria Aramă O33 Cerebral to …

Comprehensive understanding of the adverse effects associated with temozolomide: a disproportionate analysis based on the FAERS database.

BACKGROUND: Temozolomide, which is the standard drug for glioma treatment, has several Adverse events (AEs) in the treatment of gliomas and other tumors that are not yet fully understood. This is due to the pharmacological nature of the alkylating agent. A significant proportion of these effects have not been systematically documented or reported. METHODS: We selected data from the United States FDA Adverse Event Reporting System (FAERS) database from the first quarter of 2004 to the fourth quarter of 2023. Four algorithms were used for disproportionate analysis, with the objective of assessi

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… Aspergillus terreus brain abscess mimicking tumor progression in a patient with treated glioblastoma multiforme. Clin. Neuropathol. 27, 400–407. 10.5414/npp27400 Denny B. J., Wheelhouse R. T., Stevens M. F., Tsang L. L., Slack J. A. (1994). …

Е-постеры.

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Prophylaxis and Empirical Therapy of Infection in Cancer Patients

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CAR T-Cell Terrapy Opveiled: Навигация за пределы ССЗ и ИКАНС для решения проблем, связанных с отсроченными последствиями, и оптимизации стратегий управления.

Цимерическая антигенная рецепторная (КАР) T-клетологическая терапия положила начало эпохе преобразований в регулировании рецидивов/отсутствий гематологической гематологии. Кульминацией интенсивных испытаний второго этапа, направленных на борьбу с повторной/охотничьей лимфомой, включая различные подтипы, такие, как диффузная большая лимфома B-клеток, фолликулярная лимфома и лимфома мантичной клетки, а также многочисленные миелома и острая лимфоболическая лейкемия B-клеток, стало одобрение различных продуктов CAR-T-клеток для этих конкретных указаний Администрацией по вопросам продовольствия и н

Cancer Therapy-Induced Encephalitis.

Encephalitis associated with cancer therapies is a rare but serious complication that can significantly impact patients' quality of life and it requires prompt identification and management. Over the past two decades, immunotherapy-particularly immune checkpoint inhibitors-has become a cornerstone of cancer treatment, with up to half of metastatic cancer patients in economically developed countries now receiving these therapies. The widespread adoption of immunotherapy has led to improved survival rates and long-term remissions, even in patients with advanced metastatic disease. However, as im

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… Differential Diagnosis and Work-Up Differential Diagnosis | Work-Up Infection (sepsis-induced encephalopathy; bacterial, fungal or viral meningoencephalitis; brain abscess) | Blood tests including culture, CSF analysis including culture and viral PCR (herpes simplex, varicella-zoster), MRI Brain Metastasis …