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Netupitant/palonosetron without dexamethasone for preventing nausea and vomiting in patients with multiple myeloma receiving high-dose melphalan for autologous stem cell transplantation: a single-center experience.

Chemotherapy-induced nausea and vomiting (CINV) is one of the most frequent adverse events compromising quality of life (QoL) in patients undergoing autologous stem cell transplantation (ASCT). However, CINV prophylaxis is still lacking uniformity for high-dose melphalan (HDM), which is used to condition patients with multiple myeloma (MM). Netupitant/palonosetron (NEPA) is administered with dexamethasone (DEXA) for CINV prevention in several chemotherapy regimens. Our study aims to assess the efficacy of NEPA, without DEXA, in preventing CINV in 106 adult patients with MM receiving HDM and AS

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… Tendas A, Marchesi F, Mengarelli A, Annibali O, Tomarchio V, Saltarelli D, Chierichini A, Di Venanzio M, Sollazzo F, Piedimonte M, Cupelli L, Bruno A, De Angelis G, Delbono L, Niscola P, Perrotti AP, de Fabritiis P, Arcese W, Rome Transplant N. … Tendas A, Niscola P, Perrotti A, Dentamaro T, de Fabritiis P, Arcese W, Rome Transplant Network Quality of Life Working P Chemotherapy induced nausea and vomiting in bone marrow transplant: the unmet need. Support Care Cancer. 2015;23:2211. doi: 10.1007/s00520-015-2711-z. 35. …

The Role of Purported Mucoprotectants in Dealing with Irritable Bowel Syndrome, Functional Diarrhea, and Other Chronic Diarrheal Disorders in Adults.

Chronic diarrhea is a frequent presenting symptom, both in primary care medicine and in specialized gastroenterology units. It is estimated that more than 5% of the global population suffers from chronic diarrhea. and that about 40% of these subjects are older than 60 years. The clinician is frequently faced with the need to decide which is the best therapeutic approach for these patients. While the origin of chronic diarrhea is diverse, impairment of intestinal barrier function, dysbiosis. and mucosal micro-inflammation are being increasingly recognized as underlying phenomena characterizing

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… Thompson WG Irvine EJ Pare P Functional gastrointestinal disorders in Canada: first population-based survey using Rome II criteria with suggestions for improving the questionnaire Dig Dis Sci 2002 47 225 235 11837727 10.1023/a:1013208713670 17. … Sperber AD Bangdiwala SI Drossman DA Worldwide prevalence and burden of functional gastrointestinal disorders, results of Rome Foundation Global Study Gastroenterology 2021 160 1 99 114.e3 32294476 10.1053/j.gastro.2020.04.014 19. …

Twenty-five years of type I interferon-based treatment: a critical analysis of its therapeutic use.

The clinical exploitation of type I interferon (IFN) as an antiviral and antineoplastic agent is based on the properties originally attributed to this cytokine family, with schedules reflecting only their antiviral and antiproliferative activities. Nevertheless, type I IFN has emerged as a central activator of the innate immunity. As current schedules of treatment for chronic hepatitis C and for hematological and solid tumors, based on the continuous administration of recombinant type I IFN or pegylated formulations, disregard viral resistance, host genetic variants predicting treatment outcom

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… Interferon modulation of cellular microRNAs as an antiviral mechanism Nature 449 2007 919 922 17943132 10.1038/nature06205 PMC2748825 Guido Antonelli is Full Professor of Virology at “Sapienza” University of Rome, Italy. … During in that period, he worked in Ferdinando Dianzani's lab at the Sapienza University in Rome and as visiting scientist in Samuel Baron's Lab at the UTMB in Galveston, Texas (USA). …

Abstracts of the 5(th) Cachexia Conference, Barcelona, Spain, December 5-8, 2009.

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… target in the treatment of this crucial metabolic disorder associated with cancer development. 037 Exercise counteracts cachexia and extends life span in tumor-bearing mice Emanuele Berardi, Paola Aulino, Veronica Cardillo, Emanuele Rizzuto, Serhio Adamo, Dario Coletti DIEM, Sapienza University of Rome … , Rome, Italy Cachexia, experienced by most cancer patients, is a negative prognostic factor, interfering with therapy and worsening quality of life. …

Резюме ESPR 2013Европейское общество педиатрической радиологии 50th Ежегодное совещание и 36th Курсы для аспирантов. Июнь 3–7 2013. Будапешт, Венгрия.

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… Sweden 1966 John Sutcliffe, London, England 1967 Herbert Kaufmann, Basel, Switzerland 1968 Arnold Lassrich, Hamburg, Germany 1969 Ksawery Rowinsky, Warsaw, Poland 1970 Guido Lannacone, Rome, Italy 1971 Gregers Rhomsen, Copenhagen, Denmark 1972 Jacques Sauvegrain, Paris, France 1973 Roy Astley …

Abstracts of the Cell Therapy Transplant Canada 2024 Annual Conference.

On behalf of Cell Therapy Transplant Canada (CTTC), we are pleased to present the Abstracts of the CTTC 2024 Annual Conference. The conference was held on 1-3 May 2024 in beautiful Victoria, British Columbia, at the Victoria Conference Centre, and attracted 293 in-person delegates and five virtual attendees. Several plenary sessions were held on topics such as gene therapy for hemoglobin disorders, optimizing donor selection, graft-versus-host disease (GvHD) strategies, collaborative care, survivorship, graft failure, and CAR-T therapy. Poster authors presented their work during a lively and e

Simultaneous Onset of Haematological Malignancy and COVID: An Epicovideha Survey.

Background: The outcome of patients with simultaneous diagnosis of haematological malignancies (HM) and COVID-19 is unknown and there are no specific treatment guidelines. Methods: We describe the clinical features and outcome of a cohort of 450 patients with simultaneous diagnosis of HM and COVID-19 registered in the EPICOVIDEHA registry between March 2020 to February 2022. Results: Acute leukaemia and lymphoma were the most frequent HM (35.8% and 35.1%, respectively). Overall, 343 (76.2%) patients received treatment for HM, which was delayed for longer than one month since diagnosis in 57 (1

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… This registry was centrally approved by the local ethics committee of the Fondazione Policlinico Universitario Agostino Gemelli—IRCCS, Università Cattolica del Sacro Cuore of Rome, Italy (Study ID: 3226). … Institutional Review Board Statement The study was conducted in accordance with the Declaration of Helsinki, and approved by the Institutional Review Board (or Ethics Committee) of Fondazione Policlinico Universitario Agostino Gemelli—IRCCS, Università Cattolica del Sacro Cuore of Rome, Italy (Study …

Резюме докладов 51st Конференция Европейского общества генетики человека: плакаты

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… Spinella Genoma Group, Rome, Italy Introduction: Conventional cell-free fetal DNA (cfDNA)-based non-invasive prenatal testing (NIPT) focuses on detection of common aneuploidies, leaving a gap of ~17% of clinically relevant chromosomal abnormalities that would go undetected. … Lupski 3,6,7 1 Institute of Clinical Biochemistry, Faculty of Medicine, Catholic University and Policlinico Agostino Gemelli, Rome, Italy, 2 Center for the Study of Rare Hereditary Diseases, Niguarda Ca' Granda Metropolitan Hospital, Milan, Italy, 3 Department of Molecular and Human Genetics, Baylor …

Effect of the BH3 Mimetic Polyphenol (-)-Gossypol (AT-101) on the in vitro and in vivo Growth of Malignant Mesothelioma.

Malignant mesothelioma (MM) is a primary tumor arising from mesothelial cells. The survival of MM patients following traditional chemotherapy is poor, thus innovative treatments for MM are needed. (-)-gossypol (AT-101) is a BH3 mimetic compound which possesses anti-tumoral activity by targeting multiple signaling transduction pathways. Several clinical trials employing AT-101 have been performed and some of them are still ongoing. Accordingly, we investigated the in vitro effects of AT-101 on cell proliferation, cell cycle regulation, pro-survival signaling pathways, apoptosis and autophagy of

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… Mice were bred under pathogen-free conditions in the animal facilities of the University of Rome “Tor Vergata” and handled in compliance with European Union and institutional standards for animal research. … This study was partially supported by a grant from the University of Rome “Sapienza” (RP11715C7C73A80E); partially by a grant from the University of Rome “Tor Vergata” (CUP: E81I18000330005) and a grant from European Project Tempus n.144529-2008. References Al-Abd A. M., Al-Abbasi F. …

Специальный выпуск: резюме 11th Конгресс Европейской академии неврологии, Хельсинки, Финляндия.

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… Cattaneo 1 1 Global Medical Department, Angelini Pharma S.p.A., Rome, Italy; 2 IQVIA, Falls Church, USA Background and aims: Antiseizure medications (ASMs) are a mainstay for patients with epilepsy. Cenobamate is a novel ASM indicated for adults with focal onset seizures (FOS). …

Relationship between circulating syndecan-1 levels (CD138s) and serum free light chains in monoclonal gammopathies.

BackgroundMonoclonal gammopathies encompass a wide range of diseases characterized by the monoclonal expansion of a B-cell clone. Despite emerging therapeutic strategies, chances of survival of patients who are affected are still scarce, which implies that new tools are necessary not only for the diagnosis but also for the follow-up of patients affected by such diseases. In this context, the use of free light chains (FLCs) has been incorporated into many guidelines. Likewise, tumor microenvironment is consistently gaining importance as role player in tumor pathogenesis. Specifically, Syndecan-

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… Materials and methods Patients At the time of the present study, 84 patients (40 women, 44 men, mean age = 63,4 yrs, ±11.6 yrs) affected by MM and light chain disease were available for analysis and were recruited in our center at the National Cancer Institute “Regina Elena” of Rome from 2010 to 2013 … Gemelli” of Rome. Patients were then grouped according to the myeloma type and serum samples were obtained and recorded upon performing check-ups, just before therapy. …

The role and novel use of natural killer cells in graft-versus-leukemia reactions after allogeneic transplantation.

Allogeneic hematopoietic cell transplantation (HCT) has transformed over the past several decades through enhanced supportive care, reduced intensity conditioning (RIC), improved human leukocyte antigen (HLA) typing, and novel graft-versus-host disease (GVHD)-prevention and treatment strategies. Most notably, the implementation of post-transplantation cyclophosphamide (PTCy) has dramatically increased the safety and availability of this life-saving therapy. Given reductions in nonrelapse mortality (NRM) with these advances, the HCT community has placed even greater emphasis on developing ways

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… Biol Blood Marrow Transplant . ( 2016 ) 22 : 2065–76 . doi: 10.1016/j.bbmt.2016.08.008 27530969 103 Romee R Rosario M Berrien-Elliott MM Wagner JA Jewell BA Schappe T . Cytokine-induced memory-like natural killer cells exhibit enhanced responses against myeloid leukemia . … Nature . ( 1981 ) 291 : 335–8 . doi: 10.1038/291335a0 6164929 114 Romee R Schneider SE Leong JW Chase JM Keppel CR Sullivan RP . Cytokine activation induces human memory-like NK cells . …

Reimagination in art and science: Seeing the familiar in a new light and creating new things that didn't exist before.

Many groundbreaking works in art and science owe their origins to the creative spark ignited by reimagination-the process whereby artists and scientists reinterpret and reframe past and existing knowledge, envisioning it in a new context that reveals new possibilities. Artistic and scientific innovation originating from reimagination brings to mind William Faulkner's famous line, "The past is never dead. It's not even past." [W. Faulkner, Requiem for a Nun (1)].

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… Palazzo Doria Pamphili, Rome, Italy. Image credit: Diego Velasquez (artist). ( B ) Francis Bacon. Study after Velasquez’s Portrait of Pope Innocent X. 1953 (CR 53-02). Oil on canvas. 46.5 × 60.2 in. Des Moines Art Center, Des Moines, IA. Image credit: © 2026 The Estate of Francis Bacon. …

К биологическому взгляду на множественный склероз от раннего утонченного до клинического развития: экспертное заключение.

Классификация множественного склероза (МС) на два отдельных этапа восстановления выбросов и прогрессивных процессов, включая первичные прогрессивные и вторичные прогрессивные фенотипы (ППМС и СМПС, соответственно), уже давно принята; однако в связи с этой конкретной моделью существует ряд неудовлетворенных потребностей. Наблюдение за тем, что как воспаление, так и нейродегенерация присутствуют с самого начала НР, привело к изменению парадигмы в сторону НР как континуума болезней, обусловленного патологическими механизмами, лежащими в основе клинической прогрессии. Здесь мы сообщаем о результат

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… Methods The primary objective of this expert opinion paper was to analyse and synthesise the findings from an advisory board meeting held in Rome on 29 May 2023 (see the Supplementary Methods for more details). …

Abstracts

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… Tor Vergata, Rome, Italy 2 Department of Surgical Sciences, University of Rome Tor Vergata, Rome, Italy Oral Presentation: Forensic pathology 1: special session on SARS-CoV-2, June 2, 2021, 9:00 AM - 10:30 AM Introduction : study aim is to examine the capability of SARS-CoV-2 virus particles to persist … Gemelli IRCCS (Rome, Italy) a cadaver lab has been instituted for the endocrine surgery. …

Current controversies in classification, management, and prevention of bisphosphonate-related osteonecrosis of the jaw.

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… In the research article “The “CROMa” project: a care pathway for clinical management of patients with bisphosphonate exposure” the authors describe the activity of “CROMa” (Coordination of Research on Osteonecrosis of the Jaws) project of “Sapienza” University of Rome evaluating the risk variables of …