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Glutathione Transferase P1-1 an Enzyme Useful in Biomedicine and as Biomarker in Clinical Practice and in Environmental Pollution.

Glutathione transferase P1-1 (GSTP1-1) is expressed in some human tissues and is abundant in mammalian erythrocytes (here termed e-GST). This enzyme is able to detoxify the cell from endogenous and exogenous toxic compounds by using glutathione (GSH) or by acting as a ligandin. This review collects studies that propose GSTP1-1 as a useful biomarker in different fields of application. The most relevant studies are focused on GSTP1-1 as a biosensor to detect blood toxicity in patients affected by kidney diseases. In fact, this detoxifying enzyme is over-expressed in erythrocytes when unusual amo

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… Subjects from six different areas of that region showed 18%–44% increased levels of e-GST when compared to 400 volunteers living in the Rome hinterland, and the highest GST levels were observed in the areas of higher risk of pollution ( Figure 10 ). … Funding This research was funded by University of Rome Tor Vergata Grant Mission: Sustainability (Decreto Rettorale 2817/2016) to A.B.; Federazione Medico Sportiva Italiana by a financial support to N.D.D. Conflicts of Interest The authors declare no conflict of interest. …

Неделя ГЭЭ 2017 Презентации на плакате

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Launch and Post-Launch Prices of Injectable Cancer Drugs in the US: Clinical Benefit, Innovation, Epidemiology, and Competition.

BackgroundRising cancer drug prices adversely affect patients' adherence and survival.ObjectiveWe aimed to identify and quantify factors associated with launch prices and post-launch price changes of injectable cancer drugs in the US from 2005 to 2023.Data and methodsAll anticancer drugs with US FDA approval between 2000 and 2022 were identified in the Drugs@FDA database. The sample was then restricted to cancer drugs covered under Medicare Part B (injectable drugs). Data characterizing each drug's clinical benefits, disease epidemiology, approved indications, competition, and price were obtai

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… Rome BN Egilman AC Kesselheim AS Trends in prescription drug launch prices, 2008–2021 JAMA 2022 327 2145 2147 10.1001/jama.2022.5542 35670795 PMC9175077 2. … Rome BN Feldman WB Desai RJ Kesselheim AS Correlation between changes in brand-name drug prices and patient out-of-pocket costs JAMA Netw Open 2021 4 e218816 e218816 10.1001/jamanetworkopen.2021.8816 33944925 PMC8097497 11. …

Enhancement of Neuroblastoma NK-Cell-Mediated Lysis through NF-kB p65 Subunit-Induced Expression of FAS and PVR, the Loss of Which Is Associated with Poor Patient Outcome.

High-risk neuroblastoma (NB) is a rare childhood cancer whose aggressiveness is due to a variety of chromosomal genetic aberrations, including those conferring immune evasion. Indeed, NB cells adopt several molecular strategies to evade recognition by the immune system, including the downregulation of ligands for NK-cell-activating receptors. To date, while molecular strategies aimed at enhancing the expression of ligands for NKG2D- and DNAM-1-activating receptors have been explored, no evidence has been reported on the immunomodulatory mechanisms acting on the expression of death receptors su

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… Plasmids and Transfection NF-kB p65 vector, kindly provided by Dr Massimo Levrero (Rome Oncogenomic Center (R.O.C.), Regina Elena Institute, Rome, Italy), and the corresponding empty vector (pcDNA3) were used to transfect NB cell lines using Lipofectamine 2000 (Invitrogen, Waltham, MA, USA). … Funding This research was funded by the Italian Ministry of Health (Rome, Italy) Grant GR-2011-02352151 to Loredana Cifaldi. …

What are safe hemoglobin, neutrophil and platelet counts for people with hematological malignancies to participate in exercise and activities of daily living: a scoping review.

PurposeThe aim of this scoping review was to summarize the extent of the literature in relation to safe levels of platelet, hemoglobin and neutrophil count for people with hematological cancers to participate in exercise or activities of daily living (ADLs).MethodsA comprehensive search for this scoping review was completed in July 2024 across five databases: the Cochrane Library, Embase, PEDro, PubMed and OTSeeker. Original studies, reviews and expert opinion papers were included if they focused on people with active hematological cancer diagnoses or those undergoing treatment affecting bone

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… N/A Rome et al. 2011 [ 50 ] Expert opinion Patient cohort: multiple myeloma Delay exercise other than ADLs until condition improves or approved by Physician: Platelet: < 50 Hemoglobin: < 80 Neutrophil: < 1.0 should avoid gyms and other public places until white blood cell counts return to normal levels … Rate of decrease important as opposed to insidious drop Neutrophil: Should not preclude active participation, unless acute medical instability exists. | N/A Rome et al. 2011 [ 50 ] Expert opinion | Patient cohort: multiple myeloma | Delay exercise other than ADLs until condition improves or approved …

Идентификация схемы рецептов на кладрибин в MS: итальянское многоцентральное исследование.

Характеристика рецептов кладрипиновых таблеток в повседневной клинической практике имеет решающее значение для оптимизации лечения множественным склерозом (МС). ЦЕЛИ: Описание эффективности, характеристик безопасности и новых предписаний в отношении корректирующей болезни терапии (ДМТ) после лечения кладрибина. DESIGN: Независимое ретроспективное когортное исследование пациентов проводилось в шести итальянских центрах MS. МЕТОДЫ: Пациенты, у которых был диагностирован повторный синдром MS (RMS) в соответствии с критериями McDonald 2017 года, включавшие кладрипин в период с января 2019 года по

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… Diego Centonze, IRCCS Neuromed, Pozzilli, Italy; Department of System Medicine, Tor Vergata University, Rome, Italy. Andrea Surcinelli, Department of Neuroscience, Multiple Sclerosis Center – Neurology Unit, S. Maria delle Croci Hospital, Azienda USL Romagna, Ravenna, Italy. …

Воздействие телереабилитационного вмешательства пилатеса через Интернет на людей с множественным склерозом: протокол для случайного контролируемого испытания.

Физическая активность (ПА) была рекомендована при множественном склерозе (MS) для поддержания хорошей физической пригодности и психического здоровья, снижения степени серьезности симптомов и риска рецидива, а также улучшения качества жизни. Пилатесы были предложены в качестве идеального ПА для регулирования физических, когнитивных и психологических симптомов MS и в качестве полезного метода поддержания и улучшения баланса и походки. ЦЕЛЬ: В настоящем документе представлен протокол исследования, целью которого является оценка эффективности в физической области (особенно сбалансированности и пох

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… Camillo-Forlanini Hospital (Rome), the Department of Medical and Surgical Sciences and Advanced Technologies “G.F. Ingrassia” (DGFI) of the University of Catania, and the IRCCS Centro Neurolesi “Bonino-Pulejo” (Messina). The assessments will be carried out in person at the several centers. …

Роль мозжечка в множестве проблем со склерозом и инвалидностью.

Фон: Усталость является распространенным и изнурительным симптомом у людей с множественным склерозом (PwMS), что существенно снижает качество жизни. В то время как мозжечок традиционно ассоциируется с управлением мотором, появляющиеся данные указывают на его участие в когнитивных, эмоциональных и интеграционных функциях. Цель этого исследования заключалась в изучении взаимосвязи между компонентами усталости (физической, когнитивной и психосоциальной), клинической инвалидностью и мозговыми структурными изменениями в ПМС, полученными с помощью магнитного резонансного изображения (MRI). Методы: У

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… Study Design, Setting, and Ethical Approval This cross-sectional study was conducted at the IRCCS “Santa Lucia” Foundation in Rome, Italy. …

Nursing management of treatment-related venous thromboembolism in patients with multiple myeloma.

ObjectivesVenous thromboembolism (VTE) is a common complication among patients with newly diagnosed multiple myeloma (NDMM). Therefore, this study aimed to analyze the incidence and risk factors associated with VTE in the current era of thromboprophylaxis and to propose appropriate nursing measures.MethodsA total of 1,539 NDMM patients were retrospectively analyzed. All patients underwent VTE risk assessment and received aspirin or low molecular weight heparin (LMWH) to prevent thrombosis, followed by appropriate care based on their individual thrombosis risk. The incidence of VTE and its rela

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… Rome S, Doss D, Miller K, Westphal J. Thromboembolic events associated with novel therapies in patients with multiple myeloma: Consensus statement of the imf nurse leadership board. Clin J Oncol Nurs. (2008) 12:21–8. 10.1188/08.CJON.S1.21-27 13. Faiman B. …

A Focus on Relapsed Multiple Myeloma.

Multiple myeloma (MM) is a relapsing disease for many patients with multiple myeloma. At relapse, patients have many options for treatment once disease has progressed. Advanced practitioners are well suited to set expectations for ongoing therapy and underscore the importance of continued disease monitoring. Criteria for relapsed myeloma rely on biomarker and radiologic imaging, as well as physical exam and awareness of new bone pain or changes in physiologic function. The treatment of patients with relapsed MM requires a personalized approach and considers patient desires in regard to aggress

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… Rome have no conflicts of interest to disclose. References Attal, M., Lauwers-Cances, V., Hulin, C., Leleu, X., Caillot, D., Escoffre, M.,…Munshi, N. (2017). Lenalidomide, bortezomib, and dexamethasone with transplantation for myeloma. …

Abstract Book for the 3rd European Myeloma Network Meeting

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Potentiation of natural killer cells to overcome cancer resistance to NK cell-based therapy and to enhance antibody-based immunotherapy.

Natural killer (NK) cells are cellular components of the innate immune system that can recognize and suppress the proliferation of cancer cells. NK cells can eliminate cancer cells through direct lysis, by secreting perforin and granzymes, or through antibody-dependent cell-mediated cytotoxicity (ADCC). ADCC involves the binding of the Fc gamma receptor IIIa (CD16), present on NK cells, to the constant region of an antibody already bound to cancer cells. Cancer cells use several mechanisms to evade antitumor activity of NK cells, including the accumulation of inhibitory cytokines, recruitment

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… Wagner JA, Rosario M, Romee R, Berrien-Elliott MM, Schneider SE, Leong JW, et al. CD56bright NK cells exhibit potent antitumor responses following IL-15 priming. J Clin Invest (2017) 127:4042–58. doi: 10.1172/JCI90387 55. Yang Y, Lundqvist A. … Romee R, Cooley S, Berrien-Elliott MM, Westervelt P, Verneris MR, Wagner JE, et al. First-in-human phase 1 clinical study of the IL-15 superagonist complex ALT-803 to treat relapse after transplantation. Blood (2018) 131:2515–27. doi: 10.1182/blood-2017-12-823757 60. …

Realizing Innate Potential: CAR-NK Cell Therapies for Acute Myeloid Leukemia.

Next-generation cellular immunotherapies seek to improve the safety and efficacy of approved CD19 chimeric antigen receptor (CAR) T-cell products or apply their principles across a growing list of targets and diseases. Supported by promising early clinical experiences, CAR modified natural killer (CAR-NK) cell therapies represent a complementary and potentially off-the-shelf, allogeneic solution. While acute myeloid leukemia (AML) represents an intuitive disease in which to investigate CAR based immunotherapies, key biological differences to B-cell malignancies have complicated progress to dat

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… Romee R. Rosario M. Berrien-Elliott M.M. Wagner J.A. Jewell B.A. Schappe T. Leong J.W. Abdel-Latif S. Schneider S.E. Willey S. Cytokine-induced memory-like natural killer cells exhibit enhanced responses against myeloid leukemia Sci. Transl. …

Natural Killer Cells in Immunotherapy: Are We Nearly There?

Natural killer (NK) cells are potent anti-tumor and anti-microbial cells of our innate immune system. They are equipped with a vast array of receptors that recognize tumor cells and other pathogens. The innate immune activity of NK cells develops faster than the adaptive one performed by T cells, and studies suggest an important immunoregulatory role for each population against the other. The association, observed in acute myeloid leukemia patients receiving haploidentical killer-immunoglobulin-like-receptor-mismatched NK cells, with induction of complete remission was the determinant to begin

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… Romee, R. et al. [ 25 ] | Haploidentical PB-NK + 12–16 h: IL-15, IL-12 and IL-18. 3 doses: 0.5, 1 and 10 6 NK/Kg | R/R AML ( n = 13, 9 evaluable). | Well tolerated, no GvHD. OR: 55% CR: 45% NCT02271711 . Phase I. … Romee R., Rosario M., Berrien-Elliott M.M., Wagner J.A., Jewell B.A., Schappe T., Leong J.W., Abdel-Latif S., Schneider S.E., Willey S., et al. Cytokine-induced memory-like natural killer cells exhibit enhanced responses against myeloid leukemia. Sci. Transl. …

Long-term survival, prevalence, and cure of cancer: a population-based estimation for 818 902 Italian patients and 26 cancer types.

BackgroundPersons living after a cancer diagnosis represent 4% of the whole population in high-income countries. The aim of the study was to provide estimates of indicators of long-term survival and cure for 26 cancer types, presently lacking.Patients and methodsData on 818 902 Italian cancer patients diagnosed at age 15-74 years in 1985-2005 were included. Proportions of patients with the same death rates of the general population (cure fractions) and those of prevalent patients who were not at risk of dying as a result of cancer (cure prevalence) were calculated, using validated mixture cure

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… Gigli (Institute for Research on Population and Social Sciences, National Research Council, Rome); S. Francisci (National Institute of Health, Rome); P. Baili, G. Gatta (Foundation IRCSS, National Cancer Institute of Milan); M. …

Use of real-world evidence in the Medicare Drug Price Negotiation Program: A checklist for the Centers for Medicare and Medicaid Services and manufacturers.

Under the Inflation Reduction Act's (IRA's) - Medicare Drug Price Negotiation Program, the Centers for Medicare & Medicaid Services' (CMS's) "maximum fair price" must be informed by evidence on factors such as therapeutic advance of the selected drug compared with its alternative, comparative effectiveness across clinical and patient-reported outcomes, the impact on specific populations, and the ability to address unmet medical needs. This paper describes how real-world evidence could improve CMS decision-making and creates a best practices checklist to help CMS evaluate the quality of any man

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… Hwang TJ, Kesselheim AS, Rome BN. New reforms to prescription drug pricing in the US: opportunities and challenges. JAMA. 2022;328(11):1041–1042. 3. Seshamani M. …

Relapsed Chronic Lymphocytic Leukemia Heralded by Parathyroid Hormone Related Peptide-Mediated Hypercalcemia.

Hypercalcemia is a common, serious complication in patients with malignancy and is associated with significant morbidity. Compared to patients with solid tumor malignancies, the reported incidence of hypercalcemia in patients with indolent lymphoid malignancies is lower and rare in those with chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL). In this report, we describe the case of a patient with a history of CLL/SLL previously treated with multiple lines of therapy and thought to be in remission who presented with symptomatic, severe hypercalcemia. Her calcium initially improv

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… M., Rome R. S., and Reagan J. L., “Mechanisms of Hypercalcemia in Non‐Hodgkin Lymphoma and Associated Outcomes: A Retrospective Review,” Clinical Lymphoma, Myeloma & Leukemia 18, no. 2 (2018): e123–e129, 10.1016/j.clml.2017.12.006. 12. Seymour J. F., Gagel R. F., Hagemeister F. B., Dimopoulos M. …

Isolated cranial nerve disorder as presenting sign in multiple sclerosis: optic nerve versus "the others".

BACKGROUND: The prevalence of cranial nerve involvement in Multiple Sclerosis (MS) varies across studies. It has been speculated that first presentation of disease with cranial nerve involvement - except for optic neuritis - may be associated with milder progression. AIM: This study compares the clinical outcome of patients with MS in a 4-year follow-up of patients with initial symptoms of optic neuritis (ON) versus those with other cranial nerve (OCN) involvement. MATERIALS AND METHODS: Retrospective analysis of MS patient database of a tertiary referral university MS center. We included tr

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… Ethics statement The studies involving humans were approved by University La Sapienza of Rome, Neurology Department. The studies were conducted in accordance with the local legislation and institutional requirements. …

Levels of heavy metals in adolescents living in the industrialised area of Milazzo-Valle del Mela (northern Sicily).

In the Milazzo-Valle del Mela area, the presence of industrial plants and the oil refinery make local residents concerned for their health. For this reason, we evaluated the levels of heavy metals in 226 children aged 12-14 years, living in the 7 municipalities of the area. A control age-matched population (n = 29) living 45 km far from the industrial site was also enrolled. Arsenic, cadmium, chromium, mercury, nickel, and vanadium were analysed in 24 h urine samples, while lead concentration was evaluated in blood samples. A questionnaire regarding life style and risk perception was also admi

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… environmental toxic substances International Journal of Hygiene and Environmental Health 2002 205 6 501 503 2-s2.0-0036802732 12455272 10.1078/1438-4639-00179 5 Alimonti A Petrucci F Krachler M Bocca B Caroli S Reference values for chromium, nickel and vanadium in urine of youngsters from the urban area of Rome …

Abstracts of the ICARE 2024 78th SIAARTI National Congress

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