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[The eye manifestations in chronic postencephalitic congenital toxoplasmosis].

It is presented the examination of a child of 6 months old with microcephaly, delay in the psychomotor development, cerebral calcifications hepatosplenomegaly, sequellae of the chronic congenital Toxoplasma. The child has a bilateral cicatrised macular chorioretinopathy with sistagnus and divergent strabismus at the left eye. The clinical aspects of the chronic congenital postencephalitic toxoplasma is so clear for the oculist.

[Current concepts in malignant glaucoma].

The paper reports on the main pathogenic types of anatomical blocking of the aqueous humor circulation in malignant glaucoma: pupillary, secondary iridolenticular, ciliovitreolenticular, iridociliovitreous blocks and in suprachoroidal effusion. The paper also presents some of the entities correlated with malignant glaucoma: glaucoma with blocked angle following the administration of miotics, traumatisms, the operations of scleral obstruction for retina detachment, panretinal photocoagulation and thrombosis of the retina central vein.

[Hyphema, a risk factor in the glaucomatous eye].

A hemorrhage in the anterior chamber is a frequent phenomenon, very often treated too easily. Our investigation followed for 3 years (1985-1987) the way in which hyphema were resorbed after the eye contusions in the patients operated by cataract or glaucoma. The causes of hyphemas, their onset, the aspect of the blood and the resorption period are analyzed. The majority of hyphemas were resorbed in the first 7 days (in the case of contusions 87%, after operation of cataract 84%) but in the glaucomatous patients the resorption in the first 7 days appeared only in 50% of the cases; the blood rem

Резюме

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Global perspectives on lupus nephritis: a review of clinical trials and therapeutic innovations.

BACKGROUND AND OBJECTIVES: Lupus nephritis (LN) remains a leading cause of morbidity and mortality in systemic lupus erythematosus (SLE). Although recent years have witnessed the approval of several targeted therapies, achieving long-term, drug-free remission remains challenging. This commentary evaluates the global landscape of interventional LN clinical trials from 2001 to 2026 to identify emerging trends and strategic gaps in drug development. METHODS: We analyzed 200 interventional pharmacological trials retrieved from three major global registries: ClinicalTrials.gov, Chinadrugtrials.org

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… III, IV, V NCT00089804 (Terminated) | Phase III | 2004 | Abetimus sodium (LJP 394) | United States, Argentina, Australia, Belarus, Brazil, Bulgaria, Czechia, Georgia, Germany, Hong Kong (China), Hungary, India, Indonesia, Italy, Lebanon, Malaysia, Mexico, Philippines, Poland, Portugal, Puerto Rico, Romania … Mexico, Netherlands, Philippines, Russia, South Korea, Spain,Thailand,United Kingdom | NCT01714817 (Terminated) | Phase III | 2013 | Abatacept (BMS-188667) | United States, Argentina, Australia, Brazil, Canada, Chile, China, Colombia, Czechia, India, Israel, Italy, Japan, Mexico, Peru, Puerto Rico, Romania …

Vodobatinib for patients with Philadelphia chromosome-positive chronic myeloid leukaemia resistant or intolerant to multiple lines of previous therapy: an open-label, multicentre, phase 1/2 trial.

BACKGROUND: Resistance or intolerance to the available tyrosine kinase inhibitors (TKIs) remains a treatment challenge for patients with chr … al was conducted at 28 clinical sites across ten countries (Belgium, France, Hungary, India, Italy, Romania, South Korea, Spain, UK, and the USA). Patients aged 18 years or older with Ph-positive chronic myeloid leukaemia or acute lymphoblastic leukaemia (eligible only for the phase 1 study), and an Eastern Cooperative Oncology Group performance status of …

Abstracts

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… Popa University Of Medicine And Pharmacy, Iasi, Romania 2 Institute of Legal Medicine, Iasi, Romania Oral Presentation: Bioethics and medical law, June 2, 2021, 11:00 AM - 12:18 PM The Istanbul Convention states that domestic violence means all acts of physical, sexual, psychological or economic violence … The target population was represented by practicing doctors in Romania, and the completion of the questionnaire was voluntary and anonymous. …

Динамический воспламенительный и эритроцитно-деривый биомаркеры в новых диагностированных множественных миеломах: продольный анализ классических и новых индексов.

Фон/цели: Воспаление и гематологические индексы, полученные в результате обычных анализов крови, все чаще изучаются в качестве перспективных биомаркеров во многих миеломах (ММ). Однако их клиническая полезность остается непоследовательной, и в MM отсутствуют данные по новым составным индексам, таким, как среднее отношение объема к лимфоциту (MCVL) и кумулятивный подстрекательский индекс (IIC). Методы: Мы провели ретроспективное исследование, включая 122 у пациентов с новым диагнозом MM. Оценка гематологовых и подстрекательских индексов проводилась на базовом уровне и после four циклы индуктивн

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… Study Design and Patient Selection This retrospective single-center observational study included 122 patients with newly diagnosed MM treated at the Hematology Department of the Clinical Municipal Hospital Filantropia Craiova, Romania, between January 2018 and October 2024. … ), Dolj, Romania. …

Burden of non-communicable diseases among adolescents aged 10-24 years in the EU, 1990-2019: a systematic analysis of the Global Burden of Diseases Study 2019.

BackgroundDisability and mortality burden of non-communicable diseases (NCDs) have risen worldwide; however, the NCD burden among adolescents remains poorly described in the EU.MethodsEstimates were retrieved from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019. Causes of NCDs were analysed at three different levels of the GBD 2019 hierarchy, for which mortality, years of life lost (YLLs), years lived with disability (YLDs), and disability-adjusted life-years (DALYs) were extracted. Estimates, with the 95% uncertainty intervals (UI), were retrieved for EU Member Stat

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… Significantly higher rate differences between Member States and the EU overall were observed at level 2 causes for the following diseases and countries: cardiovascular diseases (Bulgaria, Romania, and Latvia), digestive diseases (Bulgaria, Romania, and Lithuania), diabetes and kidney diseases (Bulgaria … ), neoplasms (Bulgaria, Romania, Latvia, and Malta), and substance use disorders (Estonia; appendix pp 26–28 ). …

Longitudinal Analysis of P100 Wave Amplitude and Latency in Multiple Sclerosis: A 19-Year Retrospective VEP Study.

Background: The diagnosis of multiple sclerosis (MS) relies on identifying neurological signs and symptoms, supported by evidence of central nervous system (CNS) dissemination of lesions across time and space. The visual pathway is commonly involved in MS, with a frequent involvement of optic neuritis (ON) episodes. Our study aims to assess the relationship between neuronal damage and optic nerve demyelination by analyzing the latency and amplitude of the p100 wave complex using visual evoked potentials (VEPs). Methods: We conducted a retrospective longitudinal study, analyzing VEP records of

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… Materials and Methods We conducted a retrospective study, analyzing the medical records of MS patients under the care of the Neurology Clinic at the Rehabilitation Hospital in Iași, Romania, from 2004 to 2024. … The study design and protocol were performed according to the tenets of the Declaration of Helsinki for research involving human subjects and approved by the Ethics Committee of the Rehabilitation Hospital Iasi, Romania (No. 13/6 October 2020). …

Всемирный конгресс по болезням остеопороза, остеоартрита и мускулоскелета 2025).

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Clinical and Biological Characteristics of Four Patients with Aggressive Systemic Mastocytosis Treated with Midostaurin.

Systemic mastocytosis (SM) is a rare and heterogeneous disorder characterized by clonal proliferation and accumulation of neoplastic mast cells in one or more organs, most commonly the bone marrow, liver, spleen, and skin. Among its clinical variants, aggressive SM (ASM) presents organ damage and debilitating symptoms due to extensive mast cell infiltration. The management of ASM remains challenging, primarily because treatment must address both symptom control and disease progression. Background/Objectives: Recent therapeutic approaches have focused on tyrosine kinase inhibitors (TKIs) that t

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… This case series aims to present the experience of the largest known cohort of patients with aggressive systemic mastocytosis (ASM) treated with midostaurin in Romania. … Conversely, targeted therapy with midostaurin was started, and she became the first patient in Romania to receive this agent. …

Surveillance of West Nile virus infections in humans and animals in Europe, monthly report - data submitted up to 3 December 2025.

In 2025, and as of 3 December, 14 countries in Europe reported 1112 locally acquired human cases of WNV infection. The earliest and latest date of onset were on 19 May 2025 and 27 October 2025, respectively. Locally acquired cases have been reported by Italy (779), Greece (96, of which 1 with unknown place of infection), France (62), Serbia (62), Romania (49), Spain (36), Hungary (14), Croatia (4), Albania (3), Germany (2), North Macedonia (2), Bulgaria (1), Kosovo (1) and Türkiye (1). In Europe, 97 deaths were reported. Case numbers reported this year were above the average for the past decad…

33rd Европейский конгресс патологии - резюме.

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… OFP-01-003 Pandemics of our times: AH1N1 influenza versus COVID-19 – features of fatal cases in Romania C. Popp* , L. Nichita, M. Neagu, C. Constantin, C. Dumitru, M. Bușcă, M. Cioplea, L. Sticlaru, A. Cioroianu, C. Mogodici, S.A. … Zurac *Colentina University Hospital, Romania Background & objectives: During the last two decades, we faced two severe pandemics of air-borne infections: 2009-2010 pandemic of AH1N1 influenza (AI) and the present COVID-19 pandemic. …

High serum level of interleukin-6 is linked with dyslipidemia in oral lichen planus.

Oral lichen planus (OLP) is a complex chronic inflammatory disorder in which autocytotoxic CD8+ T cells, locally present in the affected tissue, induce basal keratinocyte apoptosis, through the release of several cytokines, such as interleukin-6 (IL-6). IL-6 is a proinflammatory cytokine that is related to alterations in lipid metabolism in psoriasis patients. Impaired lipid metabolism together with high serum levels of triglycerides have been found in association with OLP. However, the correlation between serum levels of IL-6 and dyslipidemia has not yet been studied in this disorder. The pre

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… The study was conducted at the Dermatology Clinic of the University Hospital of the Railways System, Iasi, Romania from January 2015 to December 2019, and patients were followed up for a period of 6 months. … Ethical approval from The Ethics Committee of the Railways University Hospital Iasi (Iasi, Romania) and an informed written consent from all 36 enrolled patients were obtained. …

Mechanistic Insights in Hemophagocytic Lymphohistiocytosis: Subsequent Acute Hepatic Failure in a Multiple Myeloma Patient Following Therapy with Ixazomib-Lenalidomide-Dexamethasone.

Hemophagocytic lymphohistiocytosis (HLH) is a rare, elusive, and life-threatening condition that is characterized by the pathologic and uncontrolled secondary activation of the cytotoxic T-cells, natural killer cells (NK-cells), and macrophages of the innate immune system. This condition can develop in sporadic or familial contexts associated with hematological malignancies, as a paraneoplastic syndrome, or linked to an infection related to immune system deficiency. This leads to the systemic inflammation responsible for the overall clinical manifestations. Diagnosis should be thorough, and tr

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… Institutional Review Board Statement The study was conducted according to the guidelines of the Declaration of Helsinki, and approved by the Ethics Committee of the Iuliu Hatieganu University of Medicine and Pharmacy in Cluj-Napoca, Romania. … Informed Consent Statement The study was reviewed and approved by the Ethics Committee of the Iuliu Hatieganu University of Medicine and Pharmacy in Cluj-Napoca, Romania, waiving the need for consent from study participants. Data were accessed anonymously. …

Six months therapy for tuberculous meningitis.

BACKGROUND: Tuberculous meningitis (TBM) is the main form of tuberculosis that affects the central nervous system and is associated with hig … pants. Four studies were conducted in India, three in Thailand and one each in China, South Africa, Romania, Turkey and Vietnam, between the late 1970s and 2011.The proportion of participants classified as having stage III disease (severe) was higher in the cohorts treated for six months (33.2% versus 16.9%), but the proportion with known concurrent HIV w …

Бремя инфекций и профилактические стратегии у пациентов с рецидивистской/охлажденной миеломой, которые лечатся с помощью биконкретных антител.

Биконкретные антитела (BsAbs) представляют собой новый класс терапии для реанимированных/отверженных множественных миелом (RRMM), что приводит к глубоким и долговременным реакциям у пациентов, прошедших тщательное лечение. Их использование связано с большим бременем инфекций, особенно с антибиотиками, направленными против БЦМА. Это ретроспективное одноцентральное исследование 50 пациентов, проходящих лечение с помощью антиБКМА, или anti-GPRC5D BsAbs, из которых 13 принял обоих агентов из-за развития болезни. Стандартные профилактические стратегии включают вакцинацию, антимикробную профилактику

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… Methods Study design and patient population A retrospective observational study was conducted at a tertiary university hospital in Romania, within the Haematology Department, between October 2022 and March 2026. … This aspect is particularly important in Romania and other Eastern European countries, where declining coverage increases vulnerability to vaccine-preventable diseases. …