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Ход работы сессии 25th Европейский конгресс педиатрической ремуматологии (ПСР) 2018) Лиссабон, Португалия. 5-8 сентябрь 2018

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… , Italy; 7 Hospital La Paz, Madrid, Spain; 8 Hacettepe University Faculty of Medicine, Ankara, Turkey; 9 BIOP, Reinach, Switzerland; 10 Novartis Pharma B.V., Arnhem, Netherlands; 11 IRCCS Ospedale Bambino Gesú, Rome, Italy Correspondence: Isabelle Kone-Paut Introduction: AIDAI is a novel and unique … ; 3 Rheumatology, Giannina Gaslini Institute, Genoa; 4 Institute of Translational Pharmacology, CNR, Rome, Italy Correspondence: Gian Marco Moneta Introduction: Interferons (IFNs) seem to play an important role in the pathogenesis of juvenile dermatomyositis (JDM). …

Резюме докладов 53rd Конференция Европейского общества генетики человека: интерактивные электронные постеры.

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… Pizzuti 1 1 Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy, 2 Laboratory of Medical Genetics, Ospedale Pediatrico Bambino Gesù, Rome, Italy, 3 Department of Maternal and Child Health and Urologic Science, Sapienza University of Rome, Rome, Italy, 4 Pediatrics and Child … Neuropsychiatry Department, Sapienza University of Rome, Rome, Italy Introduction: Arthrogryposis multiplex congenita (AMC) is characterized by the development of multiple joint contractures. …

Ассоциация традиционной физической терапии больных с множественным склерозом: доклад по делу.

Было упомянуто о том, что 55-летняя женщина с множественным склерорисом (MS) проходит курс обычной физиотерапии и когнитивно-роботной реабилитации. Неврологический анализ выявил атаксическую походку, дисметрию, нейстагмус, когнитивное нарушение внимания и памяти, слабость четырёх конечностей. Для того чтобы улучшить баланс и навыки ходьбы, было предписано проведение 20 занятий по реабилитации на основе традиционной физиотерапии и виртуальной реальности. Результаты были оценены с помощью весовых и пешеходных испытаний и с помощью объективного испытания C-GAIT. В докладе по этому делу показано у

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… Lucia Hospital in Rome. In 2021, the patient came again to IRCCS Centro Neurolesi Bonino Pulejo, for a new rehabilitation cycle. …

A new era of natural killer cell immunotherapy in tumor treatment: latest advances and cutting-edge perspectives from basic research to clinical practice.

As early as 1863, Virchow observed that cancer often arises at sites of chronic inflammation. Modern epidemiological and clinical studies have confirmed the link between inflammation and cancer. Natural Killer (NK) cells actively participate in and regulate inflammatory processes; however, they are not strictly classified as classic 'inflammatory cells' in cellular taxonomy. NK cells rapidly identify and eliminate malignantly transformed cells in a non-major histocompatibility complex (MHC)-restricted manner, a characteristic that distinguishes them from other immune cells. Furthermore, their

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… PMID: 32161598 PMC7052388 86 Shapiro RM Romee R . iPSC-derived CD19 CAR NK cells for relapsed or refractory lymphoma . Lancet . ( 2025 ) 405 : 98–9 . doi: 10.1016/S0140-6736(24)02524-8 . … PMID: 39948608 PMC11827236 91 Romee R Rosario M Berrien-Elliott MM Wagner JA Jewell BA Schappe T . Cytokine-induced memory-like natural killer cells exhibit enhanced responses against myeloid leukemia . Sci Transl Med . ( 2016 ) 8 : 357ra123 . doi: 10.1126/scitranslmed.aaf2341 . …

History and Development of Autologous Stem Cell Transplantation for Acute Myeloid Leukemia.

This review describes the development of cryopreservation, the birth of autologous stem cell transplantation (ASCT) and its past and present use to consolidate adult patients with acute myelogenous leukemia (AML). It summarizes the first autografts in patients in relapse, the experience of autografting in complete remission (CR), using bone marrow unpurged or purged in vitro with cyclophosphamide-derivatives, and the important shift to peripheral blood stem cells. The review also discusses the results of recent studies in favor of the use of ASCT to consolidate good- and intermediate-risk pati

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… In CR2, the two largest series came from Baltimore (purging with 4HC) with a LFS of 30% in 80 patients, and from Rome (no in vitro purge) in 60 patients who received the specific BAVC pre-transplant regimen with a LFS of 42% at 10 years [ 57 ]. … A specific reduced toxicity regimen, the busulfan, amsacrine, etoposide, cytosine-arabinoside (BAVC) was developed in Rome [ 57 ] and was well tolerated in older patients. …

Abstracts from the 53rd European Society of Human Genetics (ESHG) Conference: e-Posters.

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Hematopoietic stem cell transplantation: an Italian monocentric experience on the health assessment and eligibility of adult-related donors.

IntroductionIndications for HSCT are increasing worldwide, paralleled by a growing demand for donors of therapeutic cells.MethodsHerein, we report our real-world experience of adult HPC donor assessment during a 5-year study period (2018-2023): we have retrospectively revised data of 455 potential related stem cell donors, consecutively evaluated at our center. Donor medical history was assessed by a questionnaire and an interview with a trained physician experienced in donation procedures to evaluate donor fitness and medical history. Pre-existing health disorders were fully investigated. Beh

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… Gemelli IRCCS of Rome (Italy) and allo-HSCT consecutively performed from selected related donors at the Transplant Unit of the same hospital between 1 January 2018 and 31 October 2023. … Ethics statement The studies involving humans were approved by The Ethics Committee of the Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Largo Agostino Gemelli, 8, 00168, Rome, Italy. The studies were conducted in accordance with the local legislation and institutional requirements. …

The GIMEMA-ALLIANCE Digital Health Platform for Patients With Hematologic Malignancies in the COVID-19 Pandemic and Postpandemic Era: Protocol for a Multicenter, Prospective, Observational Study.

BACKGROUND: The COVID-19 pandemic has raised unprecedented challenges in the management of patients with cancer and has increased the demands for digital health tools that, for example, could facilitate remote monitoring of patients. Based on this, the Gruppo Italiano Malattie Ematologiche dell'Adulto (GIMEMA) has recently developed a digital health tool dedicated to patients with hematologic malignancies: the GIMEMA-ALLIANCE platform. OBJECTIVE: The main objectives of this web-based platform are to generate relevant data to better understand quality of life, symptoms, and medication adherenc

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… GIMEMA is a nonprofit research organization with a long-standing history of clinical research in hematology; it consists of a well-established network of about 150 affiliated hematology centers throughout Italy, including both community and university-based hospitals, plus a data center located in Rome … Ethics Approval, Consent to Participate, and Trial Registration This study is currently funded by GIMEMA and was approved by the Ethics Committee of the University of Sapienza, Rome (study reference No. 5822, Protocol 366/2020). Documented informed consent must be obtained for all patients. …

Case Report: longitudinal immunoglobulin abnormalities preceding IgA-λ MGUS and colonic DLBCL: a case suggesting immune-driven B-cell dysregulation.

Monoclonal gammopathy of undetermined significance (MGUS) is a common premalignant condition typically associated with progression to plasma cell disorders. Research suggests that MGUS may also coexist with or precede other lymphoid malignancies, potentially reflecting shared mechanisms involving chronic immune dysregulation. We report a 73-year-old man with more than 10 years of long-standing polyclonal immunoglobulin elevation, who subsequently developed IgA-λ MGUS and was later diagnosed with primary colonic diffuse large B-cell lymphoma (DLBCL). Molecular analysis identified mutations in T

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… Edited by: Anna Maria Testi , Sapienza University of Rome, Italy Reviewed by: Gianluca Gaidano , Università degli Studi del Piemonte Orientale, Italy Eleonora Longhi , Marche Polytechnic University, Italy Data availability statement The original contributions presented in the study are included in …

Design and development of the Australian and New Zealand (ANZ) myeloma and related diseases registry.

BACKGROUND: Plasma cell dyscrasias (PCD) are a spectrum of disorders resulting from the clonal expansion of plasma cells, ranging from the pre-malignant condition monoclonal gammopathy of undetermined significance (MGUS) to multiple myeloma (MM). MM generates a significant burden of disease on the community and it is predicted that it will increase in both incidence and prevalence owing to an ageing population and longer survival secondary to new therapeutic options. Robust and comprehensive clinical data are currently lacking but are required to define current diagnostic, investigational and

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… Links were initially established at the International Myeloma Workshop in Rome in 2015, and then further consolidated with a proposal currently under development for a comparative study on health-care models, first-line therapy and response in MM in collaborating countries. …

The 48th Annual Meeting of the European Society for Blood and Marrow Transplantation: Nurses Group - Poster Sessions (NP001 - NP054).

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Proteasome inhibition by bortezomib parallels a reduction in head and neck cancer cells growth, and an increase in tumor-infiltrating immune cells.

Head and neck cancer (HNC) has frequently an aggressive course for the development of resistance to standard chemotherapy. Thus, the use of innovative therapeutic drugs is being assessed. Bortezomib is a proteasome inhibitor with anticancer effects. In vitro antitumoral activity of Bortezomib was investigated employing human tongue (SCC-15, CAL-27), pharynx (FaDu), salivary gland (A-253) cancer cell lines and a murine cell line (SALTO-5) originated from a salivary gland adenocarcinoma arising in BALB-neuT male mice transgenic for the oncogene neu. Bortezomib inhibited cell proliferation, trigg

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… Antibody-antigen binding was revealed by the Horseradish Peroxidase-3,3-diaminobenzidine (HRP-DAB) Detection Kit (UCS Diagnostic, Rome, Italy). The count of cleaved caspase 3-positive cells (apoptotic cells) was performed on 10 microscopic fields at 200 × magnification. … Funding This research was funded by a grant from the University of Rome “Tor Vergata”, Mission Sustainability (Codice Unico di Progetto (CUP): E81I18000330005 to R.B.). Competing interests The authors declare no competing interests. …

Pregnancy Exposure to Anti-CD20 Monoclonal Antibodies in Patients With Multiple Sclerosis: Results From an Italian Multicenter Registry Study.

BACKGROUND AND OBJECTIVES: Although anti-CD20 monoclonal antibodies (anti-CD20s) theoretically represent an ideal treatment option for women with multiple sclerosis (wwMS) planning a pregnancy, the paucity of real-world data still limits their use in this context. Through our Italian registry "CD20-PREGNANCY," we aim to report pregnancy, infant, and maternal outcomes in wwMS treated with anti-CD20s. METHODS: In this observational study, wwMS having received rituximab (RTX), ocrelizumab (OCR), or ofatumumab (OFA) before and/or during pregnancy (≤12 months for RTX/OCR, ≤6 months for OFA) were i

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… Coinvestigators Name Location Role(s) Contribution(s) Francesca Napoli Multiple Sclerosis Clinical and Research Unit, Tor Vergata University, Rome PhD Student in Neuroscience Data acquisition Maria Triassi Department of Public Health University Federico II, Naples Full Professor of Public Health and … acquisition Maria Assunta Rocca IRCCS Ospedale San Raffaele, Milan; Vita-Salute San Raffaele University, Milan Associate Professor of Neurology, Neurologist Data acquisition Name | Location | Role(s) | Contribution(s) Francesca Napoli | Multiple Sclerosis Clinical and Research Unit, Tor Vergata University, Rome …

Многоцентральное тематическое исследование по вопросу о взаимосвязи между COVID-19 вакцины и неврологические расстройства (COVIVAX).

В исследовании COVIVAX была проведена оценка связи между COVID-19 - вакцинация и риск общих неврологических расстройств в многоцентровом режиме контроля. Вакцинация сравнивалась между лицами с первым диагнозом неврологического расстройства (делопроизводства) и контроля за возрастом и полом. Всего 624 Участники были зачислены, а после случайного посещения 1::1 совпадение 265 случаи и случаи 265 Комбинированные механизмы контроля (всего) 530 Участники) были включены в анализ. Наиболее частым неврологическим диагнозом в таких случаях был инсульт.60.4%), множественный склероз (11.3%) и изъятия6.4%

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… Ethics and data collection The study protocol was approved by the Ethics Committee of Spallanzani Institute, Rome, which is responsible for all clinical studies regarding COVID-19 vaccines in Italy. The study conforms with World Medical Association Declaration of Helsinki. …

Evidence of clinical benefit of cancer medicines considered for funding in Australia.

ObjectivesTo describe the type of evidence and the clinical benefit of cancer medicines assessed for funding in Australia by the Pharmaceutical Benefits Advisory Committee (PBAC) and to assess it with the European Society of Medical Oncology Magnitude of Clinical Benefit Scale version 1.1 (ESMO-MCBS).MethodsAll data on applications submitted to PBAC between 2010 and 2020 were extracted from PBAC Public Summary Documents available online. ESMO-MCBS ratings were retrieved from the ESMO-MCBS website.ResultsThen, 182 cancer indications for 100 cancer medicines were examined by PBAC, including 124

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… Deshmukh AD, Kesselheim AS, Rome BN. Timing of confirmatory trials for drugs granted accelerated approval based on surrogate measures from 2012 to 2021. JAMA Health Forum. 2023;4:e230217. 22. Gyawali B, de Vries EGE, Dafni U, et al. …

The SMARTIE Program: A Novel Initiative to Evaluate the Impact of AP Continuing Education on Clinical Practice.

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… Siobhan O’Donnell Angela Orrico Cecilia Otoo Amy Ottman Gwendolyn Parker Cathy Payne Dawn Paynter Michele Peetz Rasheda Persinger Rebecca Phillips Victoria Poillucci Jessica Portu Victoria Pressling Alicia Price Allyson Price Jaime Rees Kasandra Risch Karen Roesser Barbara Rogers Robin Rome …

Metronomic chemotherapy.

Toxic effects and chemoresistance are major hurdles in chemotherapy and to avoid these problems caused by traditional chemotherapeutic regimens, a new modality of drug administration called "metronomic chemotherapy" has emerged. Such regimen involves the frequent administration of conventional chemotherapeutic agents at very low doses to target activated endothelial cells in tumors, the advantages of which include minimal adverse effects and a rare chance of developing acquired drug resistance. Previously it was thought that they act by targeting angiogenesis, but recently additional mechanism

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… solid tumors in children and young adults Pediatr Blood Cancer 2005 45 25 31 15795880 10.1002/pbc.20380 35 De Vita S De Matteis S Laurenti L Chiusolo P Reddiconto G Fiorini A Secondary Ph+acute lymphoblastic leukemia after temozolomide Ann Hematol 2005 84 760 2 16044311 10.1007/s00277-005-1093-6 36 Rome …

UEG Week 2015 Poster Presentations

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… Gasbarrini 1 , on behalf of the GuLiver group 1 Internal Medicine and Gastroenterology, 2 Institute of Microbiology, A Gemelli Hospital, Rome, Italy Contact E-mail Address: francesca.ponziani@yahoo.it Introduction: Gut microbiota (GM) contributes to host metabolism and energy balance, and significant …

Ход работы сессии 29th Европейский конгресс педиатрии.

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… Policlinico, Milan, Italy; 6 Division of Rheumatology, Department of Pediatrics, Children's Hospital of Philadelphia and University of Philadelphia Perelman School of Medicine, Philadelphia, United States; 7 Laboratory of Immuno-Rheumatology; 8 Division of Rheumatology, Bambino Gesù Children's Hospital, Rome … first step healthy donor serum samples spiked with defined concentrations of recombinant S100 proteins, CXCL9, CXCL10, IL-18 and sCD25 were distributed in blinded manner among all participating centers (CARRA member sites: Cincinnati, Philadelphia, Toronto, Vancouver; PReS centers: Leuven, Muenster, Rome …

The application, safety, and future of ex vivo immune cell therapies and prognosis in different malignancies.

IntroductionImmunotherapy has revolutionized how cancer is treated. Many of these immunotherapies rely on ex vivo expansion of immune cells, classically T cells. Still, several immunological obstacles remain, including tumor impermeability by immune cells and the immunosuppressive nature of the tumor microenvironment (TME). Logistically, high costs of treatment and variable clinical responses have also plagued traditional T cell-based immunotherapies.MethodsTo review the existing literature on cellular immunotherapy, the PubMed database was searched for publications using variations of the phr

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… Leong JW, Chase JM, Romee R, Schneider SE, Sullivan RP, Cooper MA, et al. Preactivation with IL-12, IL-15, and IL-18 induces CD25 and a functional high-affinity IL-2 receptor on human cytokine-induced memory-like natural killer cells. … Romee R, Rosario M, Berrien-Elliott MM, Wagner JA, Jewell BA, Schappe T, et al. Cytokine-induced memory-like natural killer cells exhibit enhanced responses against myeloid leukemia. Sci Transl Med. 2016;8:357ra123. doi: 10.1126/scitranslmed.aaf2341. 86. Habib S, Tariq SM, Tariq M. …