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A prospective randomized study of transurethral resection of the prostate and transurethral vaporization of the prostate as a therapeutic alternative in the management of men with BPH.

OBJECTIVE: The common goals of new surgical treatment for benign prostatic hyperplasia (BPH) are to improve subjective and objective symptom … ical transurethral resection syndrome. There were no major complications. Sphincteric incontinence, urethral strictures or bladder neck contractures were not recorded. At 3 months postoperatively, 13 patients in the TURP group and 7 patients in the TUVP group had retrograde ejaculation. CONCLUSION: Our initial experience of TUVP suggests advantages over conventiona …

Antifibrotic therapy for Lower Urinary Tract Symptoms secondary to Benign Prostatic Hyperplasia.

BACKGROUND: Lower Urinary Tract Symptoms secondary to Benign Prostatic Hyperplasia (LUTS/BPH) are a ubiquitous condition estimated to affect over 50% of men over the age of 50 years. Various treatment options exist for men presenting with LUTS/BPH, including lifestyle and behavioral modification and medical or surgical treatment. Although multiple medical treatments exist, innovation for the medical treatment of BPH has not significantly progressed. METHODS: A comprehensive narrative review was performed to evaluate prostate fibrosis as a contributor to LUTS/BPH and to identify potential anti

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… Moreover, in a rat model of urethral injury, pirfenidone significantly attenuated the formation of fibrotic urethral strictures compared to untreated animals. … Li Z , Huang X , Chen S , Zhang Z , Liang X , Li H , Pirfenidone alleviates urethral stricture following urethral injury in rats by suppressing TGF-β1 signaling and inflammatory response . …

Radiofrequency induced hyperthermia in non-muscle invasive bladder cancer: Oncologic outcomes in a real-world scenario.

OBJECTIVES: Patients with non-muscle invasive bladder cancer (NMIBC) face a high risk of recurrence and progression after transurethral rese … tment limiting bladder spasms in 11 (19%) patients, low bladder compliance in 11 (19%) patients and urethral strictures in 5 (8%) patients. CONCLUSION: In our analyses, RITE resulted in notable antitumor activity and allows for the avoidance of more aggressive and quality-of-life-limiting therapies, such as radical cystectomy. RITE might be considered as a second-l …

Outcomes with ureteral access sheath in retrograde intrarenal surgery: a retrospective comparative analysis.

BACKGROUND: Retrograde intrarenal surgery is used for treatment of urinary system stones. The ureteral access sheath (UAS) is used to decrea … between 2012-2019. Patients who had kidney anomalies, were <18 years old, and who had ureteral and urethral strictures were excluded from the study. The demographic characteristics, stone type, complications, intraoperative and postoperative data of the patients were reviewed. A successful outcome was defined as being stone free or having clinically insignificant r …

Acellular bi-layer silk fibroin scaffolds support tissue regeneration in a rabbit model of onlay urethroplasty.

Acellular scaffolds derived from Bombyx mori silk fibroin were investigated for their ability to support functional tissue regeneration in a rabbit model of urethra repair. A bi-layer silk fibroin matrix was fabricated by a solvent-casting/salt leaching process in combination with silk fibroin film casting to generate porous foams buttressed by homogeneous silk fibroin films. Ventral onlay urethroplasty was performed with silk fibroin grafts (Group 1, N = 4) (Width × Length, 1 × 2 cm(2)) in adult male rabbits for 3 m of implantation. Parallel control groups consisted of animals receiving small

Postoperative surgical complications of lymphadenohysterocolpectomy.

UNLABELLED: Rationale The current standard surgical treatment for the cervix and uterine cancer is the radical hysterectomy (lymphadenohyste … e the bladder dysfunction (21.6% III vs 16.35% II) , lower limb lymphedema (13.5% III vs 11.5% II), urethral strictures (10.8% III vs 4.8% II) , incisional hernias ( 8.1% III vs 7.2% II), persistent pelvic pain (18.91% III vs 7.7% II), bowel obstruction (5.4% III vs 1.4% II) and deterioration of sexual function (83.3% III vs 53.8% II). PRS class II radical hysterect …

[Combination of bilateral pelvic lymphadenectomy, permanent iodine-125 implantation and percutaneous irradiation of localized prostate carcinoma. 2: Discussion and conclusions].

Severe complications (urethral stricture, ulcer at the anterior rectum wall, prostato-rectal fistula) have been observed in 28%(5/18) of patients treated by combined percutaneous and interstitial therapy for locally confined prostatic cancer. These complications were caused above all by charging the big prostatic volumes with an excessive number of iodine-125 seeds applied through cannulas arranged too closely and by an insufficient distance between the mucous membrane of the rectum and the first seed. The evaluation of our data showed insignificant complications up to a total activity of 28 m…

Treatment and outcomes of primary urethral cancer treated with radiation therapy.

BACKGROUND: Primary urethral cancer (PUC) is a heterogeneous and aggressive malignancy that accounts for less than 1% of all genitourinary malignancies. Due to its rarity, no prospective data exists to guide treatment paradigms. The purpose of this study is to report our clinical experience treating PUC with external beam radiation therapy (EBRT) with or without high-dose rate brachytherapy (HDR-BT) as part of curative-intent therapy. METHODS: Adult patients who had received treatment for PUC between January 2000 and December 2023 within a multi-center academic hospital system were queried in

Retrospective study on prevention of bladder neck contracture by local injection of betamethasone after transurethral resection of the prostate in patients with small-volume prostate.

OBJECTIVE: Bladder neck contracture (BNC) is a challenging postoperative complication of transurethral resection of the prostate (TURP), esp … the incidence of other postoperative complications (urinary tract infection, secondary hemorrhage, urethral stricture, urinary incontinence) between the two groups (all p > 0.05).Conclusion: Local injection of betamethasone during TURP significantly reduces the incidence of BNC in patients with small-volume prostates without increasing perioperative complications. …

Oxidative stress in bladder outlet obstruction: a narrative review.

BACKGROUND AND OBJECTIVE: Partial bladder outlet obstruction (pBOO) is a common urological disorder characterized by impaired urinary flow and elevated intravesical pressure, usually resulting from benign prostatic hyperplasia (BPH), urethral stricture, or other obstructive pathologies. pBOO induces progressive bladder dysfunction (BD) through complex mechanisms, in which oxidative stress (OS) plays an important role. This review aims to systematically elucidate the role of reactive oxygen species (ROS) and related signaling pathways in the pathogenesis of pBOO-induced BD, and summarize emergi…

Preoperative Risk Factors for Failure After Fixed Sling Implantation for Postprostatectomy Stress Urinary Incontinence (FORESEE): A Systematic Review and Meta-analysis.

BACKGROUND AND OBJECTIVE: Controversy exists regarding factors affecting the efficacy of fixed male slings. We aimed to systematically evalu … igh certainty for pelvic irradiation, 24-h pad use, and 24-h urine loss, and moderate certainty for urethral stricture, previous incontinence therapy, detrusor overactivity, higher Male Stress Incontinence Grading Scale score, and unfavourable repositioning test. Age and time from prostatectomy did not appear to affect slings outcomes (moderate certainty). Low/very …

Evaluation of tunica vaginalis flap-covering combined with modified Glenn-Anderson in one-stage repair of proximal hypospadias with incomplete penoscrotal transposition.

OBJECTIVE: To explore a novel repair method for proximal hypospadias with incomplete penoscrotal transposition in children and evaluate its … between the two groups in incidence of stenosis of the urinary meatus (2.38% vs. 4.54%, P = 0.279), urethral stricture (2.38% vs. 2.27%, P = 0.948), urinary fistula (7.14% vs. 6.82%, P = 0.907), or urinary infection (7.14% vs. 4.55%, P = 0.309). Additionally, there was no statistical difference between the groups in operation time (63.21 ± 5.20 vs. 62.07 ± 4.47 min, …

Overexpression of semaphorin 3A in patients with urothelial cancer.

OBJECTIVE: A highly sensitive and specific urine marker for the detection of recurrent urothelial cancer and for screening healthy populatio … s with other nonmalignant urological conditions such as prostatic hyperplasia, stress incontinence, urethral stricture, ureteral and kidney stones, and from healthy volunteers with no history of urothelial malignancy and no urological symptoms. Semaphorin 3A (sema3A) protein level was measured using enzyme-linked immunosorbent assay in every sample and levels were c …

[Transvesical single-site laparoscopic radical prostatectomy of 39 cases: technique and clinical outcomes].

Objectives: To present the surgical technique of transvesical single-site laparoscopic radical prostatectomy (TVSSLRP) and to evaluate its c … ith an IIEF-5 score≥18. Two cases demonstrated biochemical recurrence and one case presented vesico-urethral stricture during an average follow-up of 39 months (range 12 to 60 months). Conclusions: TVSSLRP is suitable for low-risk organ-confined prostate cancer. It can provide satisfactory continence and potency recovery, less complications and good oncological resu …

Time Course and Accumulated Risk of Severe Urinary Adverse Events After High- Versus Low-Dose-Rate Prostate Brachytherapy With or Without External Beam Radiation Therapy.

PURPOSE: Severe urinary adverse events (UAEs) include surgical treatment of urethral stricture, urinary incontinence, and radiation cystitis. We compared the incidence of grade 3 UAEs, according to the Common Terminology Criteria for Adverse Events, after low-dose-rate (LDR) and high-dose-rate (HDR) brachytherapy, as well as after LDR plus external beam radiation therapy (EBRT) and HDR plus EBRT. METHODS AND MATERIALS: Men aged >65 years with nonmetastatic prostate cancer were identified from the Surveillance, Epidemiology, and End Results-Medicare database who were treated with LDR (n=12,801…

Twin left circumflex arteries in a patient undergoing aortic valve replacement.

PURPOSE: Benign prostatic hyperplasia (BPH) is one of the most common problems in elderly men. Transurethral resection of the prostate (TURP) can be performed for most patients who need re-do prostate surgery, but open prostatectomy should be considered in patients with prostate size larger than 70 grams. This study assessed the feasibility of open prostatectomy (OP) after previous TURP in patients whose prostate size was larger than 70 grams. MATERIALS AND METHODS: We subdivided patients into two groups: group 1 included patients who had a history of prostate surgery presented with severe vo

Thulium laser resection versus plasmakinetic resection of prostates larger than 80 ml.

PURPOSE: To compare the safety and efficiency of thulium laser resection of the prostate-tangerine technique (TmLRP-TT) and plasmakinetic re … d transfusion perioperatively. During the 18-month follow-up, one patient in each group experienced urethral stricture and one patient in the PKRP group experienced bladder neck contracture. Minor complications that required no or noninterventional treatment occurred in 6 (13.33 %) of TmLRP-TT group (Clavien grade 1, 13.33 % and grade 2, 0 %) and 10 (22.22 %) of PKR …

Pure bipolar plasma vaporization of the prostate: the Zürich experience.

INTRODUCTION AND OBJECTIVES: Bipolar plasma vaporization (BPV) has been introduced as an alternative to transurethral resection of the prost … 11 mL (0-190 mL)]. The PSA reduction was 60% at study conclusion. Three patients (3.6%) developed a urethral stricture and four patients (4.8%) bladder neck sclerosis. Re-resections were not necessary. CONCLUSIONS: Contemporary BPV is a safe and efficacious treatment option even for patients undergoing PAI. Early urinary retention and temporary dysuria seem to be s …

Can we predict the outcome of 532 nm laser photoselective vaporization of the prostate? Time to event analysis.

PURPOSE: We evaluated the safety, efficacy and predictability of the long-term outcome of GreenLight™ (532 nm laser) photoselective vaporiza … reoperation was indicated in 7.6% of cases. The overall rates of bladder neck contracture, de novo urethral stricture and residual/recurrent adenoma were 3.4% (10 cases), 2.1% (6) and 2.1% (6) with no statistically significant difference between vaporization with the KTP and HPS lasers. Most adverse events occurred during year 1 postoperatively. More bladder neck c …

120-W 2-µm thulium:yttrium-aluminium-garnet vapoenucleation of the prostate: 12-month follow-up.

UNLABELLED: Study Type - Therapy (case series) Level of Evidence 4 What's known on the subject? and What does the study add? Thulium VapoEnu … pecific antigen reduction and prostate volume reduction were 87% and 80% respectively at follow-up. Urethral stricture and bladder neck contracture developed in 1.45% and 1.93% respectively of the patients. CONCLUSION: 120-W ThuVEP is a safe and efficacious procedure for the treatment of symptomatic benign prostatic obstruction. The incidence of complications with …