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High serum level of interleukin-6 is linked with dyslipidemia in oral lichen planus.

Oral lichen planus (OLP) is a complex chronic inflammatory disorder in which autocytotoxic CD8+ T cells, locally present in the affected tissue, induce basal keratinocyte apoptosis, through the release of several cytokines, such as interleukin-6 (IL-6). IL-6 is a proinflammatory cytokine that is related to alterations in lipid metabolism in psoriasis patients. Impaired lipid metabolism together with high serum levels of triglycerides have been found in association with OLP. However, the correlation between serum levels of IL-6 and dyslipidemia has not yet been studied in this disorder. The pre

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… Apprehending the link with carcinogenesis and unveiling new research avenues Int J Oncol 52 637 655 2018 10.3892/ijo.2018.4256 29393378 PMC5807043 8 Boda D Neagu M Constantin C Voinescu RN Caruntu C Zurac S Spandidos DA Drakoulis N Tsoukalas D Tsatsakis AM HPV strain distribution in patients with genital warts …

Anti-carcinogenic and Anti-bacterial Properties of Selected Spices: Implications in Oral Health.

"Let food be thy medicine and medicine be thy food", as said by the father of medicine, Hippocrates in 431 B.C. Nature has provided us with a variety of treatment modalities in the form of food. For the first 5,000 years of civilization, humans relied on herbs and foods for medicine. Only in the past 60 years have we forgotten our medicinal "roots" in favor of patented medicines. While pharmaceutical ingredients have their value, we should not overlook the well-documented, non-toxic and inexpensive healing properties of food. As an individual we consume food several times a day without a compl

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… Topical and dietary garlic has been used in the treatment of diseases like dermatologic infections and warts [ 19 ]. Ginger Ginger is one of the most widely used condiments [ 1 23 ]. …

Инфекции у пациентов с множественным склерозом, которые лечатся с помощью методов лечения, позволяющих видоизменить заболевания: когортное исследование по сравнительной оценке риска.

Справочная информация: Основными режимами лечения множественных склерозов (МS) являются методы лечения, корректирующие заболевания (ДМТ). Обычными осложнениями этих лекарств являются грибные, вирусные и бактериальные инфекции. Кроме того, само МЗ является хроническим заболеванием, связанным с иммунизацией, которое может скомпрометировать их инфекцию. Таким образом, НР может быть фактором риска инфекционных осложнений. Методы: Настоящий документ представляет собой ретроспективное когортное исследование, проведенное с февраля 2020 по январь 2022 с использованием перспективных данных от каждого п

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… reactivation, and pneumonia. 14 , 15 Fingolimod and mycophenolate mofetil increase the risk of herpes zoster, leading to disseminated varicella infection. 16 Interferon may increase the risk of viral upper respiratory infections. 17 Cyclophosphamide can increase the risk of opportunistic infections like warts …

Tatami Mats: A Source of Pitted Keratolysis in a Martial Arts Athlete?

Dear Editor, Pitted keratolysis (PK), also known as keratosis plantaris sulcatum, is a non-inflammatory, bacterial, superficial cutaneous in … extremely prone to this condition (2). Physicians commonly misdiagnose it as tinea pedis or plantar warts. Treatment is quite simple and straightforward, with an excellent expected outcome if treated properly. We report a case of a 32-year-old male patient with skin changes of approximately one-year duration diagnosed as plantar verrucae, who was referr …

Global first-in-class drugs approved in 2023-2024: Breakthroughs and insights.

First-in-class (FIC) drugs are considered the main drivers of new drug discovery and have novel targets and mechanisms. The proportion of FIC drugs among new drugs provides fundamental guidance for both academic and pharmaceutical research. From a global perspective, 81 FIC drugs were approved in 2023 and 2024. Among them, small-molecule drugs account for a greater percentage (51.9%), illustrating the discovery of new chemical entities. Macromolecule drugs (48.1%), which mainly consist of antibody analogs, represent a growing trend as new biotechnology techniques have emerged. In terms of FIC

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… gene replacement 69 sotatercept-csrk macromolecule pulmonary arterial hypertension activin signaling inhibitor that binds to activin A and other TGF-β superfamily ligands 70 nogapendekin alfa inbakicept macromolecule bladder cancer IL-15 receptor agonist 71 mavorixafor macromolecule WHIM syndrome (warts … sotatercept-csrk | macromolecule | pulmonary arterial hypertension | activin signaling inhibitor that binds to activin A and other TGF-β superfamily ligands 70 | nogapendekin alfa inbakicept | macromolecule | bladder cancer | IL-15 receptor agonist 71 | mavorixafor | macromolecule | WHIM syndrome (warts …

Dermoscopic Features of Giant Molluscum Contagiosum in a Patient with Acquired Immunodeficiency Syndrome.

Giant molluscum contagiosum (MC) is a peculiar variant of the disease with the presence of multiple or single lesions larger than 5 mm. In contrast to typical molluscum contagiosum, dermoscopic features of giant lesions have been poorly described, and none of the reports included multiple giant lesions in an immunocompromised patient. We present a patient with acquired immunodeficiency syndrome diagnosed with multiple giant molluscum contagiosum along with the dermoscopic features of this entity. We examined a 40-year-old patient who had been diagnosed with acquired immunodeficiency syndrome (

Evaluation of PD-L1 Expression and HPV Genotyping in Anal Squamous Cell Carcinoma.

Anal squamous cell carcinoma (SCC) is a rare cancer with increasing incidence. Infection with high-risk human papillomavirus (HPV) subtypes is the major cause for its development. We retrospectively analyzed tumor samples from 54 anal SCC patients for infection with a panel of 32 HPV subtypes in a PCR-based approach, determined the PD-L1 expression status, and correlated the findings with the clinical data and the survival of the patients. Forty-two patients (77.8%) were HPV-positive and harbored at least one carcinogenic HPV subtype. HPV16 was the most frequently detected (n = 39, 72.2%). Fou

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… Today, HPV infection with the two most common subtypes, HPV16 and HPV18, can be effectively prevented by the three commercially available vaccines, which cover distinct HPV subtypes that are associated with HPV-related cancers and the formation of genital warts [ 33 , 34 , 35 ]. …

Structured benefit-risk evaluation for medicinal products: review of quantitative benefit-risk assessment findings in the literature.

A favorable benefit-risk profile remains an essential requirement for marketing authorization of medicinal drugs and devices. Furthermore, prior subjective, implicit and inconsistent ad hoc benefit-risk assessment methods have rightly evolved towards more systematic, explicit or "structured" approaches. Contemporary structured benefit-risk evaluation aims at providing an objective assessment of the benefit-risk profile of medicinal products and a higher transparency for decision making purposes. The use of a descriptive framework should be the preferred starting point for a structured benefit-

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… Based on this analysis, the marketing authorization holder concluded that the benefit–risk profile of qHPV vaccine was positive with respect to prevention of anal cancer, with impact on genital warts being the most important beneficial effect. …

Набор на работу в клиники Версус на уровне общин для экспериментальной программы профилактики детского диабета, Восточный Гарлем, Нью-Йорк, 2011-2012.

ВВЕДЕНИЕ: Казино в значительной степени связаны с улучшением здоровья некоторых коренных американцев, проживающих на племенных землях. Увеличение объема связанных со здравоохранением общинных ресурсов, связанных с владением казино племенами, может привести к увеличению объема ресурсов, выделяемых на цели здравоохранения. one - механизм улучшения состояния здоровья коренных американцев. Однако ни в одном из исследований не проводилось количественной оценки того, связаны ли казино с наличием большего объема ресурсов на уровне общин. В целях изучения связи между собственностью казино и общественн

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… Other forms of late syphilis, with symptoms 095 and 095.X Late syphilis, latent 096 Other and unspecified syphilis 097 and 097.X Gonococcal infections 098 and 098.X and 098.XX A54 and A54.X and A54.XX Other venereal diseases 099 and 099.X and 099.XX Genital herpes 054.1 Genital warts …

Xerostomia due to systemic disease: a review of 20 conditions and mechanisms.

Xerostomia is a common complaint of nearly half of the elderly population and about one-fifth of younger adults. It causes several signs and symptoms, and compromise oral functions and health-related quality-of-life. Multiple reasons are proposed to describe the etiology of xerostomia such as local factors, psychogenic factors, and systemic diseases. In order to manage xerostomia effectively, identification of the main causality is mandatory. The aim of this review was to present systemic diseases leading to xerostomia with their mechanisms of action. We used various general search engines and

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… The more common HIV-related lesions include oral candidiasis, herpes simplex infection, oral Kaposi's sarcoma, oral hairy leukoplakia, parotid gland enlargement, periodontal diseases (linear gingival erythema and necrotizing ulcerative periodontitis), human papilloma virus-associated warts, and ulcerative …

Drug repurposing for breast cancer therapy: Old weapon for new battle.

Despite tremendous resources being invested in prevention and treatment, breast cancer remains a leading cause of cancer deaths in women globally. The available treatment modalities are very costly and produces severe side effects. Drug repurposing that relate to new uses for old drugs has emerged as a novel approach for drug development. Repositioning of old, clinically approved, off patent non-cancer drugs with known targets, into newer indication is like using old weapons for new battle. The advances in genomics, proteomics and information computational biology has facilitated the process o

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… Advanced DNA intercalation Antibiotic from Streptomyces peucetius bacterium Antimetabolite Capecitabine Xeloda Metastatic and advanced False building block incorporation during cell growth Colon cancer Fluorouracil Adrucil, Carac Early, advanced and metastatic Keratoacanthomas, actinic keratosis, and skin warts … intercalation | Antibiotic from Streptomyces peucetius bacterium Antimetabolite | Capecitabine | Xeloda | Metastatic and advanced | False building block incorporation during cell growth | Colon cancer Fluorouracil | Adrucil, Carac | Early, advanced and metastatic | Keratoacanthomas, actinic keratosis, and skin warts …

ESCP 36th European Symposium on Clinical Pharmacy ‘Implementing Clinical Pharmacy in Community and Hospital Settings: Sharing the Experience’, Istanbul, Turkey 25–27 October 2007; Abstracts

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… PT-201 Use of anti-TNF-alfa in rheumatoid arthritis PT-217 Topical cidofovir for the treatment of plantar warts: case report PT-227 Safety of platinum salts skin testing PT-237 Measuring compliance with antibiotic prophylaxis guidelines at a Belgian university hospital PT-240 Non-specific immunoglobulins …

Photocarcinogenesis study of glycolic acid and salicylic acid (CAS Nos. 79-14-1 and 69-72-7) in SKH-1 mice (simulated solar light and topical application study).

UNLABELLED: Acidic solutions have been used for decades to treat a variety of skin conditions. Many of these solutions consist of organic ac … used by dermatologists to treat ichthyosis, acne, xerosis, actinic keratosis, seborrheic keratoses, warts, and psoriasis. AHA have recently been used to treat photoaged skin and are now included in many commercially available cosmetic skin treatments. When used in a formulation for a chemical peel, topical treatment of skin with AHA and BHA can result i …

Population Pharmacokinetics and Model-Informed Dose Optimization of Teicoplanin in Adults with Hematological Malignancies.

Background: Teicoplanin is widely used for the empirical and targeted treatment of febrile neutropenia in patients with hematological malignancies. However, the pathophysiological alterations typical of this population may substantially affect drug exposure. The aim of this study was to develop and validate a population pharmacokinetic (PopPK) model of teicoplanin in adult hematological patients and to propose individualized dosing strategies. Methods: A retrospective, single-center study including 151 patients and 263 serum concentrations was conducted, with participants assigned to developme

Neurotoxicity associated with cancer chemotherapy: the first study in the Palestinian healthcare system.

BackgroundChemotherapy-induced neurotoxicity is a significant concern in cancer treatment as it adversely affects treatment outcomes. However, research on this subject within the Palestinian healthcare system is limited. This study aimed to evaluate the prevalence, clinical manifestations, and associated factors of neurotoxicity in cancer patients receiving chemotherapy in Palestine.MethodsThis retrospective cohort study included 196 cancer patients who underwent chemotherapy at multiple hospitals across Palestine. Data on patient demographics, cancer characteristics, chemotherapy regimens, an

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… necessarily true arthritis - can move from joint to joint | 74 (37.8) | 18 (9.2) | 31 (15.8) | 32 (16.3) | 41 (20.9) 53 | Difficulty losing weight regardless of diet or exercise | 71 (36.2) | 23 (11.7) | 31 (15.8) | 36 (18.4) | 35 (17.9) 54 | Persistent fungal or viral infection, including athlete’s foot, warts …

Precision medicine: The use of tailored therapy in primary immunodeficiencies.

Primary immunodeficiencies (PID) are rare, complex diseases that can be characterised by a spectrum of phenotypes, from increased susceptibility to infections to autoimmunity, allergy, auto-inflammatory diseases and predisposition to malignancy. With the introduction of genetic testing in these patients and wider use of next-Generation sequencing techniques, a higher number of pathogenic genetic variants and conditions have been identified, allowing the development of new, targeted treatments in PID. The concept of precision medicine, that aims to tailor the medical interventions to each patie

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… The WHIM syndrome is characterized by the presence of warts, hypogammaglobulinemia, infection and myelokathexis that leads to neutropenia due to the retention of these cells’ precursors in the bone marrow ( 63 , 64 ). … This drug in a dosage of 400 mg a day in an adult population showed a good safety profile, increased the absolute neutrophil count (ANC) and contributed for a long-term reduction of the number of cutaneous warts and infection rates ( 68 ). …

The Clinical Application of Ozonetherapy

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… Common warts ( Verrucae vulgaris and plana ) may be present in children, while plantar warts ( Verrucae plantaris ) are painful and fairly common in young adults. … Anogenital warts (venereal warts) can reach monstrous proportions and may be associated with cervical cancer. Effective conventional therapies include cryosurgery, surgical excision and ablation with a laser. …

Medical Management of the Kidney Transplant Recipient : Infections and Malignant Neoplasms

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… In addition, immunosuppression in combination with enhanced sunlight exposure may induce malignant changes in papilloma-induced warts. …

Application of toll-like receptors (TLRs) and their agonists in cancer vaccines and immunotherapy.

Toll-like receptors (TLRs) are pattern recognition receptors (PRRs) expressed in various immune cell types and perform multiple purposes and duties involved in the induction of innate and adaptive immunity. Their capability to propagate immunity makes them attractive targets for the expansion of numerous immunotherapeutic approaches targeting cancer. These immunotherapeutic strategies include using TLR ligands/agonists as monotherapy or combined therapeutic strategies. Several TLR agonists have demonstrated significant efficacy in advanced clinical trials. In recent years, multiple reports est

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… . | NCT03206138 TLR8 | Imiquimod | Cervical intraepithelial lesions | Active, not recruiting | Alone or in combination with HPV vaccination | II | NCT02864147 TLR8 | Imiquimod | Genital warts | Completed | In combination with a DNA-based vaccine | II | NCT03180684 TLR8 | Imiquimod | Chronic lymphocytic … Imiquimod, another imidazoquinoline marketed as Aldara (5% imiquimod cream), was approved by the European Medicines Agency and FDA in 1997 for treating human papillomavirus (HPV) induced genital warts ( 181 ). …

Epigenetic and Genetic Keys to Fight HPV-Related Cancers.

Cervical cancer ranks as the fourth most prevalent cancer among women globally, with approximately 600,000 new cases being diagnosed each year. The principal driver of cervical cancer is the human papillomavirus (HPV), where viral oncoproteins E6 and E7 undertake the role of driving its carcinogenic potential. Despite extensive investigative efforts, numerous facets concerning HPV infection, replication, and pathogenesis remain shrouded in uncertainty. The virus operates through a variety of epigenetic mechanisms, and the epigenetic signature of HPV-related tumors is a major bottleneck in our

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… Innate and inflammatory response stimulators like Imiquimod are used to treat external genital warts [ 114 ]. The mechanism of action of Imiquimod is not entirely clear, but it likely involves binding to the Toll-like Receptor 7 (TLR7) on immune cells, activating helper T lymphocytes. … Detection of Human Papillomavirus Types 6 and 11 in Pubic and Perianal Hair from Patients with Genital Warts. J. Clin. Microbiol. 1999;37:2270–2273. doi: 10.1128/JCM.37.7.2270-2273.1999. 68. Egawa N., Egawa K., Griffin H., Doorbar J. …