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Shoulder Pain in a 33-Year-Old Male Found to Have Multiple Myeloma.

Multiple myeloma (MM) is a blood cancer involving monoclonal plasma cells, mainly diagnosed in older adults. Only a very small percentage of patients are diagnosed before age 40. A 33-year-old male presented with hip and shoulder pain and was diagnosed with Immunoglobulin G (IgG) kappa multiple myeloma. Of the CRAB (calcium elevation, renal insufficiency, anemia, and bone lesions) criteria, he only exhibited anemia and bone lesions. He was found to have extensive osseous lesions throughout his skeleton and a bone marrow biopsy showing plasma cell myeloma involving 30% of medullary cellularity.

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… Physical exam revealed a bony protrusion felt on the right clavicle and tenderness to palpation of the right iliacus. … Figure 2 Total body PET/CT (Positron Emission Tomography / Computed Tomography) scan showing known widespread lesions with increased fluorodeoxyglucose uptake in the head of the right clavicle (left image, blue arrow) and right iliac bone and acetabulum (right image, green arrow), indicating areas with …

Lenalidomide in heavily pretreated refractory diffuse large B-cell lymphoma: a case report.

IntroductionIn diffuse large B-cell lymphoma, first-line treatment with rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone; salvage with cisplatin-based regimens for relapsing patients; and autologous stem cell therapy are standards of care. Treatment approaches are less clear for patients who are refractory or who are not candidates for autologous stem cell therapy. Options may include palliative regimens or clinical trial enrollment. One therapy under investigation in diffuse large B-cell lymphoma is lenalidomide, an immunomodulatory agent with antiangiogenic activity.Case

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… Our patient remained free of symptoms until March of year 5, when PET-CT (Figure 5 ) revealed lesions of increased SUV in his pelvis, bilateral femur and tibia, left ankle, and the humeral end of his right clavicle; SUVmax of these lesions was up to 4.5, MBPS 2.8. … (a) Acromial extremity of the right clavicle, March of year 4. (b) Thoracic vertebra T12, March of year 4. (c) Right ilium, March of year 5. (d) Distal extremity of the femur bones, March of year 5. …

Anti-fracture Efficacy of Monthly Risedronate Compared with That of Weekly Risedronate in Postmenopausal Korean Women with Osteoporosis: A Nationwide Cohort Study.

BackgroundIntermittent dosing regimens for oral risedronate (once-monthly and once-weekly) were developed for patient convenience. While several studies have reported the anti-fracture efficacy of weekly dosing, few have assessed monthly dosing. The lower efficacy of monthly dosing has been previously suggested. The aim of this study was to compare the anti-fracture efficacy of monthly and weekly dosing.MethodsWe obtained information from the Korea National Health Insurance Service database from 2012 to 2017 of Korean women of ≥50 years of age who used weekly or monthly risedronate. We compare

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… Any clinical fracture that occurred during the 5 years before entry into the study in the vertebra, hip, pelvis, humerus, wrist, clavicle, lower leg, or ankle was defined as a history of fracture. … osteoporotic fracture, which can be caused by low-energy trauma, was defined based on following ICD-10 codes: fracture of the thoracic spine (S22.0 and S22.1); fracture of the lumbar spine (S32.0, S32.7, and 32.8); fracture of the ribs (S22.3 and S22.4); fracture of the pelvis (S32.1–32.5); fracture of the clavicle …

Debridement Technique for Single-Stage Revision Shoulder Arthroplasty.

BACKGROUND: The incidence of revision shoulder arthroplasty continues to rise, and infection is a common indication for revision surgery. Tr … that an adequate incision is made in order to allow for identification of the deltoid origin on the clavicle and insertion on the humerus.The superior border of the pectoralis major can be traced laterally to the humerus to correctly identify the deltopectoral interval.Subdeltoid dissection is complete when you are able to identify deep deltoid fibers supe …

The top 100 most cited articles on intramedullary nail fixation from 2018-2022: a bibliometric and visualized analysis.

OBJECTIVE: Intramedullary nails are commonly used for the purposes of internal fixation in the repair of tubular bone fractures, allowing for optimal fixation while minimizing intraoperative bleeding, surgical incision size, and associated stress. These nails are thus often utilized to repair hip and peripheral fractures, femur fractures, tibial fractures, humerus fractures, and clavicle fractures. Recent life expectancy increases, rising economic standards, and technological innovations have led to the application of a wider range of materials and techniques in the context of orthopedic devic…

Deep Learning Assistance Closes the Accuracy Gap in Fracture Detection Across Clinician Types.

BACKGROUND: Missed fractures are the most common diagnostic errors in musculoskeletal imaging and can result in treatment delays and prevent … er condition). These cases were comprised of radiographs from 12 different anatomic regions (ankle, clavicle, elbow, femur, forearm, hip, humerus, knee, pelvis, shoulder, tibia and fibula, and wrist) and were randomly selected from 12 hospitals and healthcare centers. The gold standard for fracture diagnosis was the majority opinion of three US board-certi …

Primary gastric plasmacytoma evolving to non-secretory multiple myeloma: A case report.

RATIONALE: Primary gastric plasmacytoma is a rare form of extramedullary plasmacytoma that may mimic gastric adenocarcinoma or lymphoma. Although it is generally considered a localized disease, delayed histologic remission after radiotherapy and subsequent systemic progression remain poorly characterized. PATIENT CONCERNS: A 75-year-old man was referred after screening endoscopy revealed an approximately 3-cm protruding gastric mass initially suspected to represent advanced gastric cancer. DIAGNOSES: Repeat biopsy demonstrated atypical plasmacytoid cell proliferation with CD138 positivity an

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… Subsequent PET/CT performed in April 2026 demonstrated multifocal hypermetabolic lesions involving the maxillae and extensive skeletal sites, including the clavicle, vertebral column, sternum, ribs, pelvis, and femur (Fig. 7 A and B). … Subsequently, the patient developed a pathologic fracture of the left clavicle. …

Immediate family support is important to discharge home for cancer patient with bone metastasis after rehabilitation: A retrospective study.

AbstractThe purpose of this study is to investigate the predictive factors of home discharge for rehabilitation patients with cancer bone metastasis.Cancer patients with bone metastasis who underwent rehabilitation between April 2014 and March 2017 were retrospectively enrolled. Data on discharge destination were collected from medical records as outcomes. Multiple regression analyses were carried out to investigate the predictive factors of home discharge.Ninety-eight patients (mean age: 68.6 years, 42 females and 56 males) were included. Fifty patients were discharged home, 38 patients were

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… Renal | 5 (5) Skin | 3 (3) Bladder | 2 (2) Lymphoma | 2 (2) Other | 7 (7) The previous treatment of primary cancer Surgery | 25 Chemo/hormonal therapy | 94 Radiation therapy | 56 Collected data The sites of bone metastasis were 81 spine, 49 pelvis, 35 femur, 16 rib, 6 scapula, 3 humerus, 3 skull, 2 clavicle … | Number (%) The sites of bone metastasis Spine | 81 Pelvis | 49 Femur | 35 Rib | 16 Scapula | 6 Humerus | 3 Skull | 3 Clavicle | 2 Sternum | 1 Forearm bone | 1 The numbers of bone metastasis 6 | 4 (4) 5 | 8 (3) 4 | 14 (14) 3 | 23 (23) 2 | 24 (24) 1 | 17 (17) The treatments of the bone metastasis Surgery …

Severe Headache and Deterioration of Vision in Left Eye in a Chronic Hemodialysis Patient Revealing a Brown Tumor of Sphenoid Sinus.

BACKGROUND/OBJECTIVES: Brown tumors are rare bone lesions associated with hyperparathyroidism, particularly secondary hyperparathyroidism (SHPT), in chronic renal failure. While brown tumors commonly affect bones rich in marrow, the involvement of the sphenoid sinus is extremely rare and can present with neurological symptoms. This study reports a case of a sphenoid sinus brown tumor in a patient on hemodialysis, highlighting its clinical presentation and diagnostic challenges. METHODS: A 31-year-old woman undergoing chronic hemodialysis presented with a severe headache, diplopia, and progres

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… They may affect various bone sites, such as the ribs, clavicles, pelvic bones, and mandible [ 7 ]. A body of evidence supports the involvement of the parathyroid gland in the pathogenesis of BTs, with uncontrolled HPT being the direct etiology of the disease [ 9 ]. … The most common affected sites of a brown tumor are bones with rich marrow content, such the mandible, maxilla, clavicle, ribs, and pelvic bones. Consequently, the occurrence of brown tumors in the sphenoid sinus is extremely rare [ 8 ]. …

Thalidomide upper limb embryopathy - pathogenesis, past and present management and future considerations.

This review article provides a comprehensive overview of thalidomide upper limb embryopathy including updates about its pathogenesis, a historical account of the management of the paediatric thalidomide patient, experience with management of the adult patient, as well as creating awareness about early onset age-related changes associated with limb differences. Despite its withdrawal from the market in November 1961, novel discoveries have meant thalidomide is licensed again and currently still in use to treat a variety of conditions, including inflammatory disorders and some cancers. Yet, if n

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… The clavicle was present and usually normal, and there was a scapula, but the shoulder joint itself was always absent, meaning that the hand was not stable on the trunk ( Lamb et al., 1971 ) ( Figure 2 ). … Note the presence of the scapula and clavicle. The hand has a major radial deficit and is attached to a short bone that has some features of a humerus. …

:: Терапия антиB клеток антихимерной антигенной рецепции Т для лечения амилоидоза и конъюнктурного возврата/отвлечения нескольких миеломы: предварительная эффективность и безопасность.

В то время как иммунотерапии, такие, как терапия CAR T и би-специальные антитела, революционизировали лечение множественной миэломы (ММ), пациенты с амилоидозом были исключены из испытаний с этими агентами из-за проблем, связанных с основной автономией, сердечной травмой и почечной дисфункцией, что может привести к смертельной токсичности этих препаратов. В этом сообщении мы описали результаты two Пациенты с амилоидозом и одновременно с этим MM с основной сердечной и/или почечной дисфункцией, которые прошли антиBCMA CAR T клеточную терапию с синдромом id-cel или цилта-cel, получили профилактик

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… . | ND | ND NYHA stage | II | II | II PET scan | Multiple hypermetabolic lytic lesions seen in the bilateral acromion, clavicles, and sternum | ND | New lytic hypermetabolic right eighth and left tenthth rib lesions. … While on ixazomib, cyclophosphamide, and dexamethasone, the patient developed multiple hypermetabolic lytic lesions in their axial skeleton, most concentrated in the bilateral acromion, clavicles, and sternum. …

Predicting Pathological Fractures at Metastatic Humeral Lesions.

UNLABELLED: The humerus is the second most common site of metastatic disease involving long bones, yet it is still unclear which patients are at high risk for a fracture and may require prophylactic surgical fixation. The goal of this study was to assess the validity of the Mirels score to predict fractures of metastatic lesions in the humerus. METHODS: We performed a retrospective electronic chart review of patients with humeral metastases at our institution (2005 to 2021), with 188 patients meeting the inclusion criteria. Sixty-one of the patients developed a fracture during follow-up. The

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… We also excluded 120 patients who had other upper-extremity lesions (clavicle, scapula, ulna, radius), 150 patients who died or were lost to follow-up before 6 months, and 9 patients who had prophylactic stabilization because they were not able to tolerate nonoperative treatment. … Hoban et al. examined all upper-extremity pathological fractures (humerus, ulna, radius, clavicle, scapula), whereas the present study examined only the humerus. …

Gracilis Free Flap Technique for Elbow Flexion Reconstruction.

BACKGROUND: Brachial plexus injuries (BPI) can be devastating for patients, often resulting in notable physical, psychological, and socioeco … The muscle is then transferred to the upper extremity, where its proximal origin is anchored to the clavicle and its distal tendon is inserted into the biceps tendon with use of a Pulvertaft weave. Vascular anastomoses are performed utilizing branches of the thoracoacromial trunk and venous couplers under a microscope. The muscle is innervated with the spi …

Surgical management with radiation therapy for metastatic spinal tumors located on cervicothoracic junction : a single center study.

ObjectiveThe cervicothoracic junction (CTJ) is a biomechanically and anatomically complex region that has traditionally posed problems for surgical access. In this retrospective study, we describe our clinical experiences of the treatment of metastatic spinal tumors at the CTJ and the results.MethodsFrom June 2006 to December 2011, 23 patients who underwent surgery for spinal tumors involving the CTJ were enrolled in our study. All of the patients were operated on through the posterior approach, and extent of resection was classified as radical, debulking, and simple neural decompression. Adju

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… Various bony structures, such as chest wall, shoulder, rib cage, clavicle, and scapula, and visceral structures including the lung, heart, and great vessels disturb the surgical approach 13 , 19 , 29) and use of intraoperative C-arm fluroscopy 20) . … Dissection of the sternoclavicular joint or clavicle resection induces shoulder instability, weakness, and deformity 7 , 9) . In patients harboring metastatic tumor, however, the goal of surgery is palliation in most cases, so usually there is no need to bear the risk. …

No Short-term Clinical Benefit to Bovine Collagen Implant Augmentation in Primary Rotator Cuff Repair: A Matched Retrospective Study.

BACKGROUND: Bovine bioinductive collagen implants (herein, "bovine collagen implant") can be used to augment rotator cuff repair. Concern ex … ore likely to be White (58% versus 23%; p < 0.001), with a smaller proportion of concomitant distal clavicle excisions (43% versus 21%; p = 0.003), and a smaller proportion of "other" concomitant procedures (17% versus 6%; p = 0.011) compared with the implant cohort. After matching, the cohorts were well matched in all demographic variables. The primary st …

Malignant Melanoma Bone Metastasis With Unknown Primary Site: A Case Report and Literature Review.

IntroductionCases of malignant melanoma first identified in bone are relatively uncommon. Approximately 4.3% of the patients will have metastasis, among which 23% will have metastasis to the bone.Case presentationThis article presents a case involving malignant melanoma with a metastatic lesion located at the distal femur, which was the initial symptom observed. The patient was a 21-year-old male who was admitted to the hospital due to intermittent pain in his lower left thigh. Imaging studies indicated bone destruction in the distal left femur, and pathological and immunohistochemical confirm

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… A review of the literature indicates that reports of MM bone metastases are relatively scarce, particularly those involving sites such as the clavicle [ 9 ], maxilla [ 10 ], ribs [ 11 ], skull [ 12 ], and sphenoid bone [ 13 ]. … Tozum H., Ozkan K., Reddy K., Turkmen I., Ciloglu U., Senol S., and Graci C., Solitary Secondary Malignant Melanoma of Clavicle Two Years After Enuclation for Ocular Melanoma, Case Reports in Orthopedics. (2013) 2013, no. 1, 591679, 10.1155/2013/591679, 23424696. 10. …

Posterior Approach for Open Reduction and Internal Fixation for Scapular Fractures.

BACKGROUND: This technique utilizes a full-thickness flap to provide a posterior approach to the scapula for open reduction and internal fra … in this regard.Lateral positioning offers easier imaging and allows for exposure to the coracoid or clavicle if these structures are also injured and require operative fixation.Drawing a boomerang-shaped incision with the horizontal limb paralleling the scapular spine and vertical limb along the posterior axillary fold of the arm allows the skin flap to be …

PB2108: SPINAL INVOLVEMENT IS ASSOCIATED WITH HIGH INCIDENCE OF SKELETAL RELATED EVENTS AND INFERIOR OVERALL SURVIVAL IN PATIENTS WITH MULTIPLE MYELOMA. A SINGLE CENTRE EXPERIENCE IN 653 PATIENTS.

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… Fractures distribution: C1-C7: 11, T1-T6: 46, T7-T12: 131, lumbar: 96, femora (2), clavicles (2), sacrum (3), pubic rami (5), sternum (5), humeri (6) and ribs (20). …

Бремя костных заболеваний не влияет на общее выживание вновь диагностированных пациентов с множественной миеломой - единый центр, ретроспективный анализ изображений 119 Пациенты.

Множественная миелома (ММ) часто вызывает миеломное заболевание костей (МБД), проявляющееся в остеолитических повреждениях и событиях, связанных с скелетами (СР), что существенно снижает качество жизни и повышает заболеваемость. Низкая доза для всего тела (WBLDT) стала стандартом для оценки участия костей в диагностике, однако ее прогнозируемое значение остается неясным. Цель этого исследования состояла в том, чтобы оценить нагрузку МБМР на вновь диагностированных пациентов ММ с использованием WBLDT и изучить связи между характеристиками изображений и результатами выживаемости.МЕТОДЫ: В этом р

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… Each skeletal site (skull, cervical spine, thoracic spine, lumbar spine, sacrum, left and right innominates, left and right ribs, left and right clavicles, left and right scapulae, sternum, left and right femurs, left and right humerus) was assessed separately (Supplemental Fig. 1). … 26.3) Bone disease burden evaluated by WBLDCT Regarding osteolysis assessment, the median (range) number of osteolyses in each bone group were as follows: 2 (0–96) for the spine (cervical spine, thoracic spine, lumbar spine, sacrum), 0 (0–30) for the skull, 0 (0–41) for the shoulder (left and right clavicles …

Случаи и предотвращение событий, связанных со скелетом, у многих пациентов, страдающих миэломой: опыт реальной жизни населения.

Новейшее лечение в миеломе (ММ) может повлиять на частотность событий, связанных со скелетом (СРП). Мы ставили перед собой цель изучить распространенность SRE и профилактическое использование остеокластных ингибиторов (ОИ) в группе пациентов ММ в эпоху современного лечения. В этом ретроспективном исследовании реального мира мы включили 199 пациентов с диагнозом MM в период с января 1, 2010, и декабрь 31, 2019, с последующими мерами на Сент-Луисе. Больница Университета Олава. Данные были взяты из регистра миеломы в центральной части Норвегии. ИСП произошли в 46% пациентов на базовом уровне и 55

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… SREs were defined as the same event if they occurred within 21 days of each other and were in the same skeletal area (vertebral column, costae, sternum, clavicle, pelvis, cranium, upper or lower extremity), to ensure that interconnected events were not counted as distinct SREs. … SREs were defined as the same event if they occurred within 21 days of each other and were in the same skeletal area (vertebral column, costae, sternum, clavicle, pelvis, cranium, upper or lower extremity), to ensure that interconnected events were not counted as distinct SREs. …