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Characterization of human T cells that regulate neutrophilic skin inflammation.

It is unknown whether neutrophilic inflammations can be regulated by T cells. This question was analyzed by studying acute generalized exanthematous pustulosis (AGEP), which is a severe drug hypersensitivity resulting in intraepidermal or subcorneal sterile pustules. Recently, we found that drug-specific blood and skin T cells from AGEP patients secrete high levels of the potent neutrophil-attracting chemokine IL-8/CXCL8. In this study, we characterize the phenotype and function of CXCL8-producing T cells. Supernatants from CXCL8(+) T cells were strongly chemotactic for neutrophils, CXCR1, and…

Empirical antimicrobial treatment in haemato-/oncological patients with neutropenic sepsis.

Neutropenic sepsis in haemato-/oncological patients is a medical emergency, as infections may show a fulminant clinical course. Early differentiation between sepsis and febrile neutropenic response often proves to be challenging. To assess the severity of the illness, different tools, which are discussed in this article, are available. Once the diagnosis has been established, the correct use of early empirical antibiotic and antifungal treatment is key in improving patient survival. Therefore, profound knowledge of local resistance patterns is mandatory and carefully designed antibiotic regime

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… If history of a type IV penicillin allergy (ie, drug exanthema) is present or suspected for the patient in question, alternatively an initial cefepime therapy with escalation to cefepime/linezolid is advisable. …

Cutaneous Skin Toxicities of Oncological Targeted Therapies: Comprehensive Overview of Mechanisms, Management, and Research Gaps-A Narrative Review.

Targeted therapies in oncology have become a mainstay in therapy of numerous types of cancers. They work by targeting and utilizing (activating, inhibiting, or modulating) molecular pathways that are crucial in pathogenesis of certain cancers and can be divided into numerous classes according to their mechanism. However, since the antigens and molecules they target can take part in homeostasis of the skin and the integument, cutaneous toxicities are a common occurrence. The frequency of certain cutaneous adverse events (CAEs) depends on the causal drug and varies even between drugs of the same

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… toxicities Frequency (all grades) Severe (≥ Grade 3) Trastuzumab, pertuzumab Rash ~ 1% Rare Lapatinib Rash, PPE Rash 27–52%, PPE 49% Rash 1–4%, PPE 7% Neratinib Rash 10%, PPE 46% Rash 0%, PPE 10% Pyrotinib Rash 5%, PPE 79% Rash 2%, PPE 26% Tucatinib Rash 20%, PPE 63% Rash –, PPE 13% PPE palmar-plantar exanthema … /erythrodysesthesia Table 2 Comparison of cutaneous skin toxicities during anti-HER2/HER therapy with monoclonal antibodies and tyrosine kinase inhibitors [ 19 , 24 ] PPE palmar-plantar exanthema/erythrodysesthesia Drug | Common cutaneous toxicities | Frequency (all grades) | Severe (≥ Grade 3) Trastuzumab …

The avoidance of G-CSF and the addition of prophylactic corticosteroids after autologous stem cell transplantation for multiple myeloma patients appeal for the at-home setting to reduce readmission for neutropenic fever.

BackgroundAutologous stem cell transplantation (ASCT) remains the standard of care for young multiple myeloma (MM) patients; indeed, at-home ASCT has been positioned as an appropriate therapeutic strategy. However, despite the use of prophylactic antibiotics, neutropenic fever (NF) and hospital readmissions continue to pose as the most important limitations in the outpatient setting. It is possible that the febrile episodes may have a non-infectious etiology, and engraftment syndrome could play a more significant role. The aim of this study was to analyze the impact of both G-CSF withdrawal an

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… Skin rash was defined as macular-papular exanthema mimicking acute graft versus host disease involving >25% of body surface area. Pulmonary infiltrates were considered secondary to ES in the absence of clinical and laboratory evidence of infection, cardiac failure, or pulmonary embolism. …

Real-world results with IgPro20 for hypo- or agammaglobulinemia in Japan.

BackgroundSubcutaneous immunoglobulin is one of the standard treatments for hypogammaglobulinemia in primary immunodeficiencies (PID) worldwide. In Japan, IgPro20 (Hizentra® ; l-proline-stabilized 20% human subcutaneous immunoglobulin) is approved for agammaglobulinemia or hypogammaglobulinemia due to PID or secondary immunodeficiency (SID); however, its safety and effectiveness has not previously been assessed in a real-world setting.MethodsThis multicenter, open label post-marketing surveillance study was conducted between January 2014 and March 2019. Patients who received IgPro20 due to PID

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… ) | 0 | 1 (4.0) Gastrointestinal disorders | 3 (3.5) | 1 (1.7) | 2 (8.0) Diarrhea | 1 (1.2) | 1 (1.7) | 0 Nausea | 2 (2.4) | 0 | 2 (8.0) Vomiting | 1 (1.2) | 0 | 1 (4.0) Skin and subcutaneous tissue disorders | 4 (4.7) | 2 (3.3) | 2 (8.0) Acne | 1 (1.2) | 0 | 1 (4.0) Prurigo | 1 (1.2) | 1 (1.7) | 0 Exanthema …

Real-World Dermatologic Adverse Events of CAR T-Cell Therapy: A Decade-Wide Disproportionality Analysis of the FDA Adverse Event Reporting System.

Background: Chimeric antigen receptor (CAR) T-cell therapy has transformed haematological-malignancy care, but its dermatologic safety profile remains incompletely characterised across products and indications. Methods: We analysed 8,431,841 deduplicated FDA Adverse Event Reporting System reports from 2016 Q3 to 2026 Q1. Seven approved CAR T-cell products were identified. The primary outcome was any dermatologic adverse event, defined using the MedDRA Skin and subcutaneous tissue disorders system organ class. Secondary outcomes included broad severe cutaneous adverse reactions, narrow Stevens-

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… Some events coded as SJS/TEN may represent cytokine-driven mucocutaneous inflammation or severe exanthema, while some true cutaneous toxicities may be under-reported if low-grade or clinically overshadowed by CRS, ICANS, infection or cytopenias. …

Detection of potential complications in cancer survivors after chemotherapy and development of a regional care network: the PASCA feasibility study.

Complications are often poorly identified and managed in cancer survivors after treatment and restoring their initial quality of life remains a challenge, particularly in a context of unequal access to care nationwide. The PASCA "Parcours de Santé au cours du Cancer [in English: healthcare pathways with cancer]" feasibility study was conducted in the Léon Bérard Comprehensive Cancer Center (Lyon, France) to assess the feasibility of a complications detection program, in cancer survivors who have received intensive chemotherapy. An initial network of physicians and healthcare professionals was

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… BMI and waist circumference and data from patient record on BMI values before the diagnosis of cancer Endocrinology | Fasting blood glucose, total testosterone, TSH, 25-hydroxyvitamin D, data from patient record on endocrinological history before the diagnosis of cancer Dermatology | Maculo papular exanthema …

Reconvalescent plasma/camostat mesylate in early SARS-CoV-2 Q-PCR positive high-risk individuals (RES-Q-HR): a structured summary of a study protocol for a randomized controlled trial.

OBJECTIVES: Currently, there are no approved treatments for early disease stages of COVID-19 and few strategies to prevent disease progressi … breath, sore throat, headache, fatigue, smell/and or taste disorder, diarrhea, abdominal symptoms, exanthema) and symptom duration of not more than 3 days. Further inclusion criteria comprise: Presence of at least one of the following criteria indicating increased risk for severe COVID-19: Age > 75 years Chronic obstructive pulmonary disease (COPD) and/or …

MR and CT angiography in the diagnosis of vasculitides.

Vasculitides represent the wide-ranging series of complex inflammatory diseases that involve inflammation of blood vessel walls. These conditions are characterized according to the caliber of the predominantly involved vessels. The work-up of vasculitides often includes imaging to narrow a differential diagnosis and guide management. Findings from CT and MR angiography in conjunction with a thorough history and physical exam are of utmost importance in making an accurate diagnosis. Further, imaging can be used for follow-up, in order to monitor disease progression and response to treatment. Th

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… The clinical diagnosis is made by at least 5 days of fever, and four of the five following criteria: acute injury reactions such as desquamation of fingers and toes, peripheral edema (particularly in the distal extremities), erythema of the palm and soles; polymorphous exanthema, diffuse maculopapular …

Liver Disease Associated with Non-Hepatitis Viruses

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… Primary infection with either virus commonly occurs at young age and can lead to a febrile illness known as exanthema subitum or roseola infantum ( Leach, 2000 ). Pityriasis rosea reflects primary infection with HHV-7. …

Skin Changes in Suspected Lyme Disease.

Dear Editor, Ticks carry many diseases, bacteria, and viruses and represent a very important healthcare issue both in Croatia and globally. … or the dermatological exam, the patient had observed the appearance of edema and demarcated macular exanthema around both ankles and subsequently on the dorsum of the right hand, which spread to the left hand and with gradual spread to both lower legs and the lower extremities, with more pronounced changes on the left leg. The initial dermatological examina …

Role of Proteasomes in Inflammation.

The ubiquitin-proteasome system (UPS) is involved in multiple cellular functions including the regulation of protein homeostasis, major histocompatibility (MHC) class I antigen processing, cell cycle proliferation and signaling. In humans, proteasome loss-of-function mutations result in autoinflammation dominated by a prominent type I interferon (IFN) gene signature. These genomic alterations typically cause the development of proteasome-associated autoinflammatory syndromes (PRAAS) by impairing proteasome activity and perturbing protein homeostasis. However, an abnormal increased proteasomal

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… Autoinflammation manifests early and is accompanied by bipolar oral and genital ulcers, inflammation of the eyes, exanthemas, and arthralgia/arthritis (ref). Furthermore, mutations within TNFAIP3 have been found in autoimmune–lymphoproliferative syndrome (ALPS) [ 105 ]. …

Allergy in Cancer Care: Antineoplastic Therapy-Induced Hypersensitivity Reactions.

As the backbone of oncological treatments, systemic chemotherapy is still one of the main pawns in cancer care, alone or in combination with newer targeted agents. All chemotherapy agents can be associated with a type of adverse event called an infusion reaction, which can be characterized as unpredictable, non-dose related, and unexplained by the cytotoxic profile of the drug. For some of these events, a certain immunological mechanism can be identified by blood or skin testing. In this case, we can speak of true hypersensitivity reactions that occur as a response to an antigen/allergen. The

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… The DPT contraindications are uncontrolled asthma/underlying chronic disease, pregnancy, use of beta-blockers, personal history of heart disease (may impend the use of adrenaline), vasculitis syndromes, bullous exanthemas, acute generalized exanthematous pustulosis, drug-induced autoimmune disease/hypersensitivity …

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… perifascicular atrophy Elevated serum creatine kinase (MM-isoenzyme), aldolase and myoglobin levels Multifocal myopathic changes on electromyography (small, short and polyphasic potentials) with increased insertion activity, with or without spontaneous potentials A rash typical for DM, especially heliotropic exanthema …

Drug-Induced Periocular and Ocular Surface Disorders: An EAACI Position Paper.

Various systemic and topical medications can induce ocular and periocular cutaneous adverse effects (AEs), ranging from mild to severe. These AEs may lead to ocular surface (OS) damage and, in some cases, life-threatening complications. Drug-induced ocular adverse reactions are generally classified into two primary categories: toxic reactions and/or allergic hypersensitivity reactions, which can be IgE or non-IgE-mediated. Systemic antibiotics, antivirals, and anticonvulsants can trigger adverse reactions that may involve the OS. Drugs like antihistamines, beta-blockers, antipsychotics, antide

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… Delayed reactions: these involve the skin of the eyelid, the lid margin, and/or the conjunctiva, potentially leading to eyelid exanthemas/eczema, blepharitis, follicular conjunctivitis, cicatrizing conjunctivitis, and ocular pseudo‐pemphigoid. …

Monoclonal Antibodies Approved for Cancer Therapy

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Историческое развитие иммуноэндокринных концепций психических расстройств и их терапии.

Отношения между центральной нервной, иммунной и эндокринной системами являются предметом психиатрических исследований, особенно в области депрессии и шизофрения. У поля длинные предтечи. Наблюдаемые явления, связанные с этими отношениями, восходят к неолитической эпохе. Теории иммуноэндокринной системы в самом широком смысле записаны в древности. В 19th Крепелин и Вагнер-Джаурег сообщили о первых клинических наблюдениях у пациентов психиатрических учреждений. Von Bestow, Эддисон и Кушинг описали психические симптомы у пациентов, страдающих эндокринными заболеваниями. :: 20th откровение века с

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… He also found cases in which patients with an extremely unfavourable prognosis were cured after they suffered from an intercurrent disease such as thyphoid, cholera, malaria intermittens, acute exanthema or erysipelas [ 79 , 80 ]. …

Decoding Waldenström Macroglobulinemia Through Genomics, Epigenomics and Cellular Interactions

Waldenström macroglobulinemia is a rare lymphoplasmacytic malignancy characterized by bone marrow infiltration and monoclonal immunoglobulin M production. Despite its indolent clinical course, the disease exhibits considerable biological complexity driven by recurrent genetic alterations, dysregulated signaling pathways, and a supportive bone marrow microenvironment. The identification of MYD88 and CXCR4 mutations has significantly advanced understanding of disease pathogenesis, clonal evolution, and treatment response. Additional insights from cytogenetic, epigenetic, and microRNA studies hav

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… The associated exanthema often affects the entire body [ 49 , 50 ]. The lesions are transient and generally resolve within 48 h. The rash tends to follow a distinct daily pattern, often worsening in the evening hours before gradually subsiding [ 50 , 51 ]. 3. …

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… The family comprises five genera, Vesivirus that includes feline calicivirus , vesicular exanthema of swine virus, and San Miguel sea lion virus; Lagovirus that includes rabbit hemorrhagic disease virus and European Brown hare syndrome virus; Norovirus, which includes viruses that cause gastroenteritis … systemic strain has been identified, which is capable of causing severe systemic disease with high fever, pulmonary edema, abdominal effusion, hepatic necrosis, disseminated intravascular coagulopathy (DIC), facial and limb edema, ulceration of the skin, and death. porcine c. the cause of vesicular exanthema …

Extraglandular Manifestations of Sjögren’s Syndrome (SS): Dermatologic, Arthritic, Endocrine, Pulmonary, Cardiovascular, Gastroenterology, Renal, Urology, and Gynecologic Manifestations

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… Polymorphous exanthema Bilateral conjunctival injection Changes of lips and oral cavity, with injection of oral and pharyngeal mucosa Cervical lymphadenopathy Summary Primary Sjögren’s syndrome (1° SS) is an autoimmune disorder characterized by dry eyes (keratoconjunctivitis sicca) and dry mouth due …