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The Lived Experience of Adolescents With Type 1 Diabetes Mellitus in Bahir Dar, Ethiopia: Phenomenological Study.

BACKGROUND: Type 1 diabetes mellitus (T1DM) is one of the most common chronic diseases among adolescents and is posing a threat to health and potentially endangering life. It can have a significant impact on the physical, social, and emotional development of adolescents. Understanding the lived experiences of adolescents with T1DM is crucial for improving their health outcomes and future aspirations. However, there is currently limited research, and existing studies on psychosocial and self-care perspectives do not highlight their lived experiences in Ethiopia. OBJECTIVE: This study aimed to

Types of Challenges and Barriers in Accessing Paediatric Palliative Care in Romania: A Qualitative Study Based on Focus Groups Guided by a Semi-Structured Discussion Guide.

Background and Objectives: Paediatric palliative care in Romania is underdeveloped and unevenly distributed, which creates major difficulties in accessing services for children with life-limiting illnesses and their families. The lack of a dedicated national strategy, the shortage of specialised staff, and socio-economic barriers exacerbate the vulnerability of these groups. This study aimed to explore parents' and caregivers' experiences, to analyse the perspectives of public institutions and NGOs involved in supporting these children, and to identify the main barriers and facilitators in acc

Barriers to and Facilitators of Older People's Engagement With Web-Based Services: Qualitative Study of Adults Aged >75 Years.

BACKGROUND: The COVID-19 pandemic has accelerated the shift toward the digital provision of many public services, including health and social care, public administration, and financial and leisure services. COVID-19 services including test appointments, results, vaccination appointments and more were primarily delivered through digital channels to the public. Many social, cultural, and economic activities (appointments, ticket bookings, tax and utility payments, shopping, etc) have transitioned to web-based platforms. To use web-based public services, individuals must be digitally included. Th

Qualitative Evaluation of the Africa Malaria Task Force Symposia Effectiveness on African Partner Nations' Malaria Vector Management Capacity.

INTRODUCTION: Creating health alliances to build meaningful networks is critical to combating regional and global burdens of disease. These … sease through incorporation into health security alliance networks by the provision of training and financial support is key to reinforcing this success at the national level. One such example of this is the U.S. Africa Command (USAFRICOM) established and partner nation (PN) led Africa Malaria Task Force (AMTF) program. USAFRICOM's mission for AMTF as a health secu …

Pediatric outpatient non-invasive ventilation program: Reflections on the first experience from the Middle East.

Long-term noninvasive ventilation (NIV) is being progressively used in children. The current guidelines recommend NIV initiation in the hospital during overnight polysomnography (PSG) titration study. Due to the logistic, socioeconomic, and financial difficulties including bed availability, an outpatient program for NIV initiation and patients/parents counseling to prevent delay and provide cost-effective care has been commissioned. Hence, this study reports on the clinical outcome of our program as it represents the first reported experience from the middle east. A retrospective review of ele

Surviving Cancer, Lacking Support: The Hidden Burden of Modern Radiation Oncology in the Treatment of Oligometastatic Disease.

The management of oligometastatic disease has undergone a significant paradigm shift over the past two decades. Once considered uniformly incurable, selected patients with metastatic disease can now achieve prolonged progression-free survival, durable disease control, and, in carefully selected cases, long-term remission or cure through metastasis-directed therapies. Advances in stereotactic ablative radiotherapy (SABR), surgery, systemic therapies, and the emerging concept of Curative Oligometastatic Radiotherapy (CORT) have challenged the traditional distinction between curative and palliati

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… Richard Berman reports a relationship with UK Association of Supportive Care in Cancer that includes board membership and non-financial support. Funding Statement This research received no external funding. …

Improving pneumonia case-management in Benin: a randomized trial of a multi-faceted intervention to support health worker adherence to Integrated Management of Childhood Illness guidelines.

BACKGROUND: Pneumonia is a leading cause of death among children under five years of age. The Integrated Management of Childhood Illness strategy can improve the quality of care for pneumonia and other common illnesses in developing countries, but adherence to these guidelines could be improved. We evaluated an intervention in Benin to support health worker adherence to the guidelines after training, focusing on pneumonia case management. METHODS: We conducted a randomized trial. After a health facility survey in 1999 to assess health care quality before Integrated Management of Childhood Ill

Community perspective on feasibility of malaria mass drug administration: a qualitative evidence from the Eastern Region of Ghana.

BACKGROUND: Malaria remains the leading cause of morbidity and mortality in Ghana, particularly in rural high-burden communities. Mass drug administration (MDA) has re-emerged as a complementary strategy to reduce transmission, yet community acceptability and implementation challenges remain underexplored. METHODS: We conducted a cross-sectional study in the Pokrom subdistrict following pilot mass drug administration (MDA) interventions. Data were collected through eleven focus group discussions (FGDs), nine with community members and two with healthcare providers, comprising 97 participants,

The effects of parental adverse childhood experiences (ACEs) and childhood threat and deprivation on adolescent depression and anxiety: an analysis of the longitudinal study of Australian children.

AIMS: Evidence on the effects of parental Adverse Childhood Experiences (ACEs) on adolescent mental health remains limited. This study investigates the associations between parental ACEs, children's exposure to threat- and deprivation-related ACEs, and adolescent depression and anxiety using data from the Longitudinal Study of Australian Children. METHODS: We conducted a secondary analysis of the Longitudinal Study of Australian Children (LSAC), a population-based longitudinal cohort study. Parental ACEs were retrospectively reported by caregivers. Children's exposure to ACEs was assessed fro

Angiectatic Sinonasal Polyp: A Diagnostic Challenge.

BACKGROUND: Mantle cell lymphoma (MCL) is a heterogeneous disease with variable clinical presentations, pathological types, and molecular ch … ohorts are needed to be studied with the evaluation of the novel therapies when feasible. Enhancing financial support is crucial to improve MCL patients' care in our country.

Therapeutic monoclonal antibodies repurposing in oncology via IMGT/mAb-KG embeddings.

BACKGROUND: Cancer remains one of the leading causes of mortality worldwide, accounting for approximately 9.7 million deaths in 2022. Faced with this significant public health challenge, therapeutic monoclonal antibodies (mAbs) have emerged as promising alternatives that may minimize the side effects associated with conventional treatments such as radiotherapy and chemotherapy. To support mAb research and development, IMGT®, the international ImMunoGeneTics information system, has established two standardized data sources namely IMGT/mAb-DB, a comprehensive database for mAbs, and, more recentl

Effects of an e-Media-Supported, Exercise-Based Phase II Cardiac Rehabilitation in Coronary Artery Bypass Grafting Surgery Patients: A Randomized Controlled Trial.

Background and objective Coronary artery bypass grafting (CABG) surgery patients undergo cardiac rehabilitation (CR) programs postoperatively to improve their course of recovery. The effectiveness of traditional CR programs is hampered by time constraints, financial burdens, transportation issues, and geographic restrictions. The coronavirus 2019 (COVID-19) pandemic and technological advances have led to the emergence of home-based CR programs using e-media, thereby improving accessibility. This study aimed to analyze the effects of e-media-supported, exercise-based phase II CR in post-CABG pa

Evaluation of Multi-Stakeholder Perspectives on the Preparedness of Ghana's Animal Health Services for African Swine Fever Control: A Cross-Sectional Study.

BACKGROUND AND AIMS: African Swine Fever (ASF) is a highly fatal viral disease of pigs that has persisted in Ghana since its first introduction in 1999, causing recurrent outbreaks with devastating socioeconomic consequences for livelihoods and food security. Despite control measures implemented by Ghana's veterinary services, outbreaks continue, reflecting critical gaps in national preparedness and institutional support. This study assessed the preparedness of Ghana's animal health services to manage and control ASF. METHODS: A mixed-method of cross-sectional design was employed, combining s

Reducing hospital-provided plastic water bottle use in an intensive care unit: Environmental, economical, and behavioural outcomes of a sustainability initiative.

INTRODUCTION: The Australian healthcare system generates substantial quantities of plastic waste annually, with hospital-provided water bottles (HPWBs) representing a potentially modifiable source of nonclinical, single-use plastic consumption. Evidence regarding pragmatic, low-cost strategies to reduce HPWB use in Australian healthcare settings remains limited. This study evaluated the environmental, financial, and behavioural impact of a multifaceted intervention designed to reduce HPWB utilisation. METHODS: A quality improvement study was conducted in a regional Australian intensive care u

Increased Avoidance Learning in Chronic Opioid Users.

IMPORTANCE: The opioid crisis remains a global public health issue, with poor clinical outcomes, low treatment adherence, and early dropouts being major challenges. These may be driven by a pathological increase in avoidance tendencies in opioid addiction, although this has not yet been demonstrated in humans. OBJECTIVE: To determine whether opioid addiction is characterized by increased avoidance learning and whether this is also observed in individuals with chronic nonaddicted opioid use. DESIGN, SETTING, AND PARTICIPANTS: This case-control study conducted in Hamburg, Germany, used a proba

Financial incentives for maintaining postpartum smoking abstinence: 3-4-year follow-up of the Financial Incentives for Prevention of Postpartum Return to Smoking (FIPPS) randomised controlled trial.

BACKGROUND AND AIMS: We followed up a financial incentives trial aimed at maintaining smoking cessation postpartum, which showed some positive effects at one year, to assess sustained abstinence at 3-4 years postpartum. DESIGN, SETTING AND PARTICIPANTS: Secondary analysis of longer-term outcomes of a pragmatic, multi-centre, three-arm randomized controlled trial, recruiting 462 postpartum women in England, aged ≥16 years, having stopped smoking during pregnancy with financial incentives, validated as abstinent at end of pregnancy or early postpartum. INTERVENTIONS: (1) usual care (UC); (2) U

Transdiagnostic Compulsivity Traits in Problematic Use of the Internet Among UK Residents: Cross-Sectional Network Analysis Study.

BACKGROUND: The societal and public health costs of problematic use of the internet (PUI) are increasingly recognized as a concern across all age groups, presenting a growing challenge for mental health research. International scientific initiatives have emphasized the need to explore the potential roles of personality features in PUI. Compulsivity is a key personality trait associated with PUI and has been recognized by experts as a critical factor that should be prioritized in PUI research. Given that compulsivity is a multidimensional construct and PUI encompasses diverse symptoms, differen

Multiple-component interventions to increase rotavirus vaccine uptake in children: a randomised controlled trial.

BACKGROUND: Rotavirus vaccine has not been included in the Hong Kong Government's Childhood Immunisation Programme. This randomised controlled trial examined whether a simple intervention package can increase rotavirus vaccine uptake in Hong Kong children. METHODS: Postpartum mothers were recruited from two public hospitals in Hong Kong and randomly allocated into three groups using block randomisation, with block sizes kept unknown to investigators and research staff. Control-subjects received public rotavirus information. Subjects in intervention group 1 additionally received: key rotavirus

The burden of very early dropout in infertility care: a nationwide population-based cohort study.

STUDY QUESTION: What is the frequency and the associated factors of very early dropout following unsuccessful clomiphene citrate (CC)/gonadotropin treatment in the context of full coverage of treatment cost. SUMMARY ANSWER: Despite free treatment, almost one in four women had a very early dropout following unsuccessful CC/gonadotropin treatment, with patients below the poverty line being more likely to drop out early. WHAT IS KNOWN ALREADY: Success of infertility care is tarnished by very high dropout rates. Infertility care dropout has been considered as resulting principally from financial

A questionnaire-based study to comprehensively assess the status quo of rare disease patients and care-givers in China.

BACKGROUND: There are over 16.8 million rare disease patients in China, representing a large community that should not be neglected. While the public lack the awareness of their existence and difficult status quo, for one reason that they exist as a rare and special group in our society, for another reason that all sectors of the community haven't introduced and propagandized them suitably. However, as a special group with more difficulties in all aspects than normal healthy persons, they need enough care and love from us. To provide a basis for policy-makers to better understand the status qu