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NK Cell-Based Immunotherapy in Renal Cell Carcinoma.

Natural killer (NK) cells are cytotoxic lymphocytes that are able to kill tumor cells without prior sensitization. It has been shown that NK cells play a pivotal role in a variety of cancers, highlighting their relevance in tumor immunosurveillance. NK cell infiltration has been reported in renal cell carcinoma (RCC), the most frequent kidney cancer in adults, and their presence has been associated with patients' survival. However, the role of NK cells in this disease is not yet fully understood. In this review, we summarize the biology of NK cells and the mechanisms through which they are abl

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… Romee R., Rosario M., Berrien-Elliott M.M., Wagner J.A., Jewell B.A., Schappe T., Leong J.W., Abdel-Latif S., Schneider S.E., Willey S., et al. Cytokine-induced memory-like natural killer cells exhibit enhanced responses against myeloid leukemia. Sci. Transl. … Romee R., Schneider S.E., Leong J.W., Chase J.M., Keppel C.R., Sullivan R.P., Cooper M.A., Fehniger T.A. Cytokine activation induces human memory-like NK cells. Blood. 2012;120:4751–4760. doi: 10.1182/blood-2012-04-419283. 126. …

Указываемые данные об автономной и аллогенетической трансплантации гематопоэтики стем-целлов у взрослых: состояние искусства.

Пересадка стволовых клеток (ХХСТ) гематополиетическая трансплантация превратилась из процедуры спасания лейкемии в лечебную форму, охватывающую почти все виды гематологической злокачественности и несколько ненасыщенных расстройств. Современный ландшафт был видоизменен тремя совпадающими силами: усовершенствованием стратификации с учетом конкретных рисков заболеваний (European LeukemiaNet [ELN] 2022 для острой миелоидной лейкемии, Молекулярной международной системы прогнозирования (IPSS-M) для миэлодипластических синдромов, Международной системы мутационного скручивания [MIPSS70+ v.2.0] и Myelo

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Hematopoietic stem-cell transplantation (HSCT) has evolved from a salvage procedure for otherwise-fatal leukemia into a curative modality sp … yeloid leukemia, Molecular International Prognostic Scoring System [IPSS-M] for myelodysplastic syndromes, Mutation-Enhanced International Prognostic Scoring System [MIPSS70+ v2.0], and Myelofibrosis Transplant Scoring System [MTSS] for myelofibrosis); the integration of measurable residual disease (MRD) into dynamic, response-adapted transplant decisi …

Prospects and Advances in Adoptive Natural Killer Cell Therapy for Unmet Therapeutic Needs in Pediatric Bone Sarcomas.

Malignant bone tumors are aggressive tumors, with a high tendency to metastasize, that are observed most frequently in adolescents during rapid growth spurts. Pediatric patients with malignant bone sarcomas, Ewing sarcoma and osteosarcoma, who present with progressive disease have dire survival rates despite aggressive therapy. These therapies can have long-term effects on bone growth, such as decreased bone mineral density and reduced longitudinal growth. New therapeutic approaches are therefore urgently needed for targeting pediatric malignant bone tumors. Harnessing the power of the immune

Infections associated with immunotherapeutic and molecular targeted agents in hematology and oncology. A position paper by the European Conference on Infections in Leukemia (ECIL).

A multitude of new agents for the treatment of hematologic malignancies has been introduced over the past decade. Hematologists, infectious disease specialists, stem cell transplant experts, pulmonologists and radiologists have met within the framework of the European Conference on Infections in Leukemia (ECIL) to provide a critical state-of-the-art on infectious complications associated with immunotherapeutic and molecular targeted agents used in clinical routine. For brentuximab vedotin, blinatumomab, CTLA4- and PD-1/PD-L1-inhibitors as well as for ibrutinib, idelalisib, HDAC inhibitors, mTO

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… Alessandro Busca, Turin, Italy; Thierry Calandra, Lausanne, Switzerland; Simone Cesaro, Verona, Italy; Catherine Cordonnier, Créteil, France; Roberto Crocchiolo, Milan, Italy; Julien De Greef, Brussels, Belgium; Rafael de la Camara, Madrid, Spain; Hugues de Lavallade, London, UK; Roberta Di Blasi, Rome … France; Jens Lundgren, Copenhagen, Denmark; Johan Maertens, Leuven, Belgium; Rodrigo Martino, Barcelona, Spain; Georg Maschmeyer, Potsdam, Germany; Sibylle Mellinghoff, Cologne, Germany; Malgorzata Mikulska, Genoa, Italy; David Navarro, Valencia, Spain; Anna Maria Nosari, Milan, Italy; Livio Pagano, Rome …

The 48th Annual Meeting of the European Society for Blood and Marrow Transplantation: Physicians - Poster Session (P001 - P578).

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… Cuore, Istituto di Ematologia, Rome, Italy, 13 King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia, 14 Anadolu Medical Center Hospital, Kocaeli, Turkey, 15 University Hospital Eppendorf, Hamburg, Germany, 16 Hôpital Saint-Antoine, AP-HP, Paris, France, 17 University Hospital Center … Cuore, Rome, Italy, 17 Saint-Antoine Hospital, Paris, France Background: The association of GVHD and GvL after allogeneic SCT is well-established but has not been confirmed in recent years with the introduction of new transplantation techniques. …

Association between the prognostic nutritional index and early mortality of AML patients after allogeneic HSCT: a retrospective cohort analysis.

BACKGROUND: Allogeneic hematopoietic stem cell transplantation (Allo-HSCT) is an effective treatment for Acute Myeloid Leukemia (AML). The pre-transplantation Prognostic Nutritional Index (PNI) plays a critical role in determining patient prognosis, however, its correlation with mortality within 180 days after SCT is currently unclear. OBJECTIVE: This study aimed to investigate the association between PNI and mortality within 180 days among AML patients who underwent HSCT. METHODS: We conducted a cohort study by retrospectively collecting data from AML patients who underwent HSCT. The PNI wa

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… Edited by: Pasquale Niscola , Sant’Eugenio Hospital of Rome, Italy Reviewed by: Adele Santoni , University of Siena, Italy Stefania Braidotti , Institute for Maternal and Child Health Burlo Garofolo (IRCCS), Italy Data availability statement The raw data supporting the conclusions of this article …

Диагностическое значение индекса свободной цепи освещения каппы при множественном склерозе под 2024 Критерий позитива CSF: многоцентральное исследование на олигоклоналовых пациентах-отрицательных.

ВВЕДЕНИЕ: Для определения позитива цереброспинарной жидкости (CSF) в качестве альтернативы олигоколональным полосам (OCB) был установлен индекс бескаппы световых цепей (PP-FLC), который может способствовать многократному склерозу (MS). 2024 Пересмотренные диагностические критерии MS. Цель этого исследования состояла в том, чтобы оценить вклад индекса ОВ-ФЛК в диагностику МУ на основе критерия позитивности УБК у пациентов, страдающих от отрицания OCB. МЕТОДЫ: пациенты с отрицательным содержанием OCB, диагностированные с помощью MS в любое время в соответствии с 2017 Критерии McDonald были включ

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… Footnotes Edited by: Maria Eleftheria Evangelopoulos , National and Kapodistrian University of Athens, Greece Reviewed by: Juan Francisco Delgado De La Poza , Hospital de Sabadell, Spain Franz Felix Konen , Hannover Medical School, Germany Massimo Pieri , University of Rome Tor Vergata, Italy Data …

Provider billing margin and cancer treatment selection: population based cohort study.

ObjectiveTo estimate the association between the billing (profit) margin and clinical benefit of cancer treatments and use by oncologists.DesignRetrospective population based cohort study SETTING: Population based sample using fee-for-service Medicare claims data.ParticipantsMedicare beneficiaries with an incident cancer diagnosis from 2015 to 2020; included all patients with cancer treatment indications for which the available treatment options varied in clinical benefit and billing margin.Main outcomes and measuresThe primary outcome was the cancer treatment each patient received among treat

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… JAMA Intern Med 2022 ; 182 : 603 - 11 . 10.1001/jamainternmed.2022.1022 . 35435948 PMC9016607 11 Feldman WB Rome BN Brown BL Kesselheim AS . Payer-specific negotiated prices for prescription drugs at top-performing US hospitals . …

Efficacy and safety of biosimilar Peg-filgrastim after autologous stem cell transplant in myeloma and lymphoma patients: a comparative study with biosimilar Filgrastim, Lenograstim, and originator Peg-filgrastim.

Data about biosimilar Peg-filgrastim (bioPEG) in autologous stem cell transplant (ASCT) are still scarce. The aim of this study has been to assess efficacy and safety of bioPEG among lymphoma and myeloma patients undergoing ASCT, comparing these data with historical controls receiving other G-CSFs. Furthermore, an economic evaluation has been included to estimate the savings by using bioPEG. This is a prospective cohort study comparing lymphoma and myeloma patients undergoing ASCT and receiving bioPEG (n = 73) with three historical consecutive cohorts collected retrospectively who received oth

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… Comparison between biosimilar vs other granulocyte-colony stimulating factor formulations (originator filgrastim, peg-filgrastim and lenograstim) after autologous stem cell transplantation: a retrospective survey from the Rome Transplant Network. …

Comparison of novel oncology drugs that received dual approval from the US accelerated approval and EU conditional marketing authorisation pathways, 2006-2021: a cross-sectional study.

ObjectiveWe aimed to provide insight into differences in drug review decisions made by the US Food and Drug Administration's (FDA) accelerated approval (AA) pathway and the European Medicines Agency's (EMA) conditional marketing authorisation (CMA) pathway, and to add to the current knowledge base of drug approval processes.Design, setting, participantsThis cross-sectional study thoroughly examines novel oncology drugs with dual approval through FDA AA and EMA CMA between 2006 and 2021. Statistical analysis was performed from June to July 2022.Primary and secondary outcome measuresThe study ex

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… Gyawali B, Rome BN, Kesselheim AS. Regulatory and clinical consequences of negative Confirmatory trials of accelerated approval cancer drugs: retrospective observational study. BMJ 2021;374:n1959. 10.1136/bmj.n1959 37. US Food and Drug Administration . …

Results of a multicenter phase I/II trial of TCRαβ and CD19-depleted haploidentical hematopoietic stem cell transplantation for adult and pediatric patients.

Hematopoietic stem cell transplantation (HSCT) from haploidentical donors is a viable option for patients lacking HLA-matched donors. Here we report the results of a prospective multicenter phase I/II trial of transplantation of TCRαβ and CD19-depleted peripheral blood stem cells from haploidentical family donors after a reduced-intensity conditioning with fludarabine, thiotepa, and melphalan. Thirty pediatric and 30 adult patients with acute leukemia (n = 43), myelodysplastic or myeloproliferative syndrome (n = 6), multiple myeloma (n = 1), solid tumors (n = 6), and non-malignant disorders (n…

The Key Role of Hepcidin-25 in Anemia in Multiple Myeloma Patients with Renal Impairment.

Background and objectives: Anemia is common in multiple myeloma (MM) and is caused by a complex pathomechanism, including impaired iron homeostasis. Our aim is to evaluate the biomarkers of iron turnover: serum soluble transferrin receptor (sTfR) and hepcidin-25 in patients at various stages of MM in relation with markers of anemia, iron status, inflammation, renal impairment and burden of the disease and as predictors of mortality. Materials and methods: Seventy-three MM patients (six with smoldering and 67 with symptomatic disease) were recruited and observed for up to 27 months. Control gro

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… The immunophenotype of the monoclonal protein was determined by serum immunofixation on agarose gel (EasyFix G26, Interlab, Rome, Italy). …

Perceived benefits and barriers to exercise for recently treated patients with multiple myeloma: a qualitative study.

BACKGROUND: Understanding the physical activity experiences of patients with multiple myeloma (MM) is essential to inform the development of evidence-based interventions and to quantify the benefits of physical activity. The aim of this study was to gain an in-depth understanding of the physical activity experiences and perceived benefits and barriers to physical activity for patients with MM. METHODS: This was a qualitative study that used a grounded theory approach. Semi-structured interviews were conducted in Victoria, Australia by telephone from December 2011-February 2012 with patients w

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… Rome S, Jenkins B, Lilleby K. Mobility and safety in the multiple myeloma survivor. Clin J Oncol Nurs. 2011;15:41–52. doi: 10.1188/11.S1.CJON.41-52. Coleman EA, Coon S, Hall-Barrow J, Richards K, Gaylor D, Stewart B. Feasibility of exercise during treatment for multiple myeloma. …

Impact of epoetin beta on quality of life in patients with malignant disease.

This open-label, prospective study was conducted to compare the impact of epoetin beta vs standard care on quality of life (QoL) in anaemic patients with lymphoid or solid tumour malignancies. A total of 262 anaemic patients (haemoglobin [Hb]or=2 g dl(-1) increase in Hb level without need of transfusion after the initial 4 weeks of treatment. Baseline to final visit changes in SF-36 PCS, FACT-F and VAS scores were significantly greater with epoetin beta than with standard care (P<0.05); changes in FACT-An subscale score tended to be greater with epoetin beta (P=0.076). Epoetin beta significant

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… Infirmary, Aberdeen, UK; Dr KU Petry, KH Oststadt, Hannover, Germany; Professor D Amadorim, Ospedale Morgagni-Pierantoni, Div Oncologia, Vechiazzano-Forli, Italy; Professor Rossi Ferrini, Policlinico Careggi, Div Ematologia, Florence, Italy; Professor F Cognetti, Instituto Regina Elena, Oncologia Nedica I, Rome …

From Sjögren syndrome to Sjögren disease: rethinking classification and diagnostic complexity.

Sjögren syndrome (SS), traditionally regarded as a sicca-predominant condition, is now recognized as a systemic autoimmune disease characterized by type I interferon activation, B-cell hyperactivity, and periepithelial lymphocytic infiltration. This conceptual shift has prompted changes in terminology, with "SS" increasingly replaced by "Sjögren disease (SjD)" and "secondary SS" by "associated SjD," reflecting the concept of polyautoimmunity and ensuring equal clinical standing. In this review, we trace the historical evolution of SS classification criteria and examine their limitations in rea…

Hypercalcemia in Cancer: Causes, Effects, and Treatment Strategies.

Calcium plays central roles in numerous biological processes, thereby, its levels in the blood are under strict control to maintain homeostatic balance and enable the proper functioning of living organisms. The regulatory mechanisms ensuring this balance can be affected by pathologies such as cancer, and as a result, hyper- or hypocalcemia can occur. These states, characterized by elevated or decreased calcium blood levels, respectively, have a significant effect on general homeostasis. This article focuses on a particular form of calcium metabolism disorder, which is hypercalcemia in neoplasm

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… Shallis R.M., Rome R.S., Reagan J.L. Mechanisms of Hypercalcemia in Non-Hodgkin Lymphoma and Associated Outcomes: A Retrospective Review. Clin. Lymphoma Myeloma Leuk. 2018;18:e123–e129. doi: 10.1016/J.CLML.2017.12.006. 24. Kandil E., Noureldine S., Khalek M.A., Daroca P., Friedlander P. …

Specialist palliative and end-of-life care for patients with cancer and SARS-CoV-2 infection: a European perspective.

BACKGROUND: Specialist palliative care team (SPCT) involvement has been shown to improve symptom control and end-of-life care for patients with cancer, but little is known as to how these have been impacted by the COVID-19 pandemic. Here, we report SPCT involvement during the first wave of the pandemic and compare outcomes for patients with cancer who received and did not receive SPCT input from multiple European cancer centres. METHODS: From the OnCovid repository (N = 1318), we analysed cancer patients aged ⩾18 diagnosed with COVID-19 between 26 February and 22 June 2020 who had complete sp

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… Cancer Medicine Department, Instituto Nazionale dei Tumori, Milan, Italy); Nadia Harbeck (Department of Gynaecology and Obstetrics, Breast Centre and Gynaecological Cancer Centre and CCC Munich, University Hospital Munich, Munich, Germany); Bruno Vincenzi (Policlinico Universitartio Campus Bio-Medico, Rome …

61st Annual Conference of Indian Society of Gastroenterology, Virtual Diamond Jubilee ISGCON 2020, 19-20th December 2020.

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… Methods In this randomized placebo-controlled trial children (≤18 years) diagnosed as FAPD based on ROME IV criteria were randomized to amitriptyline (10 mg for <35 kg and 25 mg for > 35 kg for 12 weeks) or placebo for 12 weeks. …

2021 ACMT Annual Scientific Meeting Abstracts-Virtual.

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… Nicholas E Walter 1 , Matteo Di Nardo 2 , Danilo Alunnifegatelli 3 , Marco Marano 2 , Reem Al Falasi 1 , Daniel L Herr 4 , Hong K Kim 5 1 Department of Emergency Medicine, University of Maryland Medical Center, Baltimore, MD, USA. 2 Pediatric Intensive Care Unit, Bambino Gesu Children’s Hospital, IRCCS, Rome … , Rome, Italy. 3 Department of Public Health and Infectious Disease, Sapienza University of Rome, Rome, Rome, Italy. 4 Department of Internal Medicine, University of Maryland School of Medicine, Baltimore, MD, USA. 5 Department of Emergency Medicine, University of Maryland School of Medicine, Baltimore …

Бремя множественной миеломы в азиатских странах 1990 в адрес 2021 и прогнозирование тенденций 2050:: анализ, основанный на Глобальном исследовании бремени болезней 2021.

Множественная миелома (ММ) создает растущую угрозу для здоровья населения во всем мире, причем региональные различия в бремени болезней становятся все более заметными. Являясь самым густонаселенным континентом, Азия переживает быстрые демографические и социально-экономические изменения и играет решающую роль в формировании эволюционной траектории глобального бремени ММ. Цель этого исследования заключается в оценке бремени болезней, связанных с множественной миеломой в азиатских странах. 1990 в адрес 2021Данные этого исследования были получены на основе исследования глобального бремени болезней

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… Bertolotti P Pierre A Rome S Faiman B . Evidence-based guidelines for preventing and managing side effects of multiple myeloma. Semin Oncol Nurs . ( 2017 ) 33 : 332 – 47 . 10.1016/j.soncn.2017.05.008 28729122 21. …