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Pediatric multiple sclerosis.

Diagnosing multiple sclerosis (MS) in a child is challenging because of the limited diagnostic criteria and their overlap with acute disseminated encephalomyelitis. Pediatric-onset MS patients are more likely to be male, have seizures, and have brainstem and cerebellar symptoms than adults, and are less likely to have spinal cord symptoms than adults. They mostly experience a relapsing-remitting course. Their initial brain MRI shows more frequent involvement of the posterior fossa, less well-defined ovoid lesions, and more confluent lesions that decrease over time in patients with prepubertal …

Multiple Sclerosis: Immunotherapy.

Given our current knowledge, there is a need for the early institution of immunomodulatory therapy, especially for patients with poor progno … imen before irreversible and considerable disability has accumulated. For the majority of patients, multiple sclerosis (MS) is a chronic condition. Therefore, until a curative treatment has been developed, the available repertoire of immunosuppressive or immunomodulatory treatments should be assessed with respect to the possibility of long-term use. This is particul …

Infections and multiple sclerosis: Recommendations from the French Multiple Sclerosis Society.

INTRODUCTION: Viral, bacterial, or fungal infections are suspected of triggering multiple sclerosis (MS) and promoting relapses of the disease and are likely to be promoted by immune-active treatments. This raises questions about the infectious workup and preventive treatment of these infections prior to their initiation. OBJECTIVES: To establish recommendations on infections and MS. Provide information to patients and healthcare professionals on the minimal infectious workup to be performed in an MS patient at diagnosis and prior to initiation of immuno-active therapy in MS. METHODS: The re…

Characteristics of pediatric multiple sclerosis: The Turkish pediatric multiple sclerosis database.

OBJECTIVE: To document the clinical and paraclinical features of pediatric multiple sclerosis (MS) in Turkey. METHODS: Data of MS patients with onset before age 18 years (n = 193) were collected from 27 pediatric neurology centers throughout Turkey. Earlier-onset (<12 years) and later-onset (≥12 years) groups were compared. RESULTS: There were 123 (63.7%) girls and 70 (36.3%) boys aged 4-17 years, median 14 years at disease onset. Family history of MS was 6.5%. The first presentation was polysymptomatic in 55.4% of patients, with brainstem syndromes (50.3%), sensory disturbances (44%), motor…

Multiple system atrophy masking multiple sclerosis.

Multiple system atrophy (MSA) and multiple sclerosis (MS) are progressive neurological disorders with overlapping clinical signs and symptoms. However, due to the course of the disease and the age of onset both disorders are rarely differential diagnosis for each other. We here report the remarkable association of the two diseases in one patient. As MSA dominated the clinical presentation, diagnosis and therapy of MS were delayed. We discuss the clinical symptoms in our patient and highlight the features that allow to differentiate both diseases.

Multiple sclerosis, solitary sclerosis or something else?

BACKGROUND: Inflammatory demyelinating diseases of the central nervous system represent a wide spectrum of entities and their classification cannot currently be regarded complete. OBJECTIVE: Our aim is to describe a series of patients presenting with progressive myelopathy associated to a single demyelinating lesion of the spinal cord. METHODS: We identified the patients affected by chronic progressive spinal cord dysfunction related to a single spinal cord lesion not satisfying the diagnostic criteria for any of the currently defined diseases. RESULTS: Seven females and one male were inclu

Проверка шведского реестра множественных склерозов для педиатрии с множественным склерозом.

На педиатрическом склерозе (POMS) было проведено небольшое число контролируемых испытаний методов лечения, позволяющих регулировать заболевания (DMT), что привело к широкому немаркированному использованию методов лечения, утвержденных только для взрослых. Это подчеркивает потребность в реальных данных, которыми можно руководствоваться при клинической практике. Клинические реестры могут предоставлять высококачественные данные, однако необходимо учитывать такие ограничения, как отсутствие и ошибочная информация. В ходе этого исследования по проверке данных шведского реестра с множественным склер

Совпадение в аннотации оригинала
Few controlled trials of disease-modifying therapies (DMTs) have been conducted on the pediatric-onset multiple sclerosis (PoMS) population, leading to extensive off-label use of therapies approved only for adults. This highlights the need for real-world evidence to guide clinical practice. Clinical registries can offer high-quality data, but limitations suc…

Cancer and multiple sclerosis: 2023 recommendations from the French Multiple Sclerosis Society.

BACKGROUND: Epidemiological data reveal that 45% of persons with multiple sclerosis (PwMS) in France are more than 50 years. This population more than 50 is more susceptible to cancer, and this risk may be increased by frequent use of immunosuppressive drugs. Consequently, concerns have arisen about the potential increased risk of cancer in PwMS and how patients should be screened and managed in terms of cancer risk. OBJECTIVE: To develop evidence-based recommendations to manage the coexistence of cancer and multiple sclerosis (MS). METHODS: The French Group for Recommendations in MS collect…

An autopsy case of the Marburg variant of multiple sclerosis (acute multiple sclerosis).

We herein report an autopsy case of the Marburg variant of multiple sclerosis (MS). A 29-year-old woman developed acute and progressive neurological symptoms. A diagnosis of MS was suspected based on the patient's clinical background and brain MRI findings and the lack of evidence of malignancy on a brain biopsy. Despite the administration of typical treatment for MS, a fatal outcome occurred three months after disease onset. The autopsy revealed multiple inflammatory demyelinating lesions in the central nervous system. In addition, two noteworthy histopathological features were observed compa…

[Artificial intelligence capabilities in multiple sclerosis].

OBJECTIVE: To systematize current data on the potential use of artificial intelligence (AI) in multiple sclerosis (MS) research. MATERIAL AND METHODS: The literature search was performed in electronic search engines Scopus, eLibrary, PubMed using the following keywords: multiple sclerosis, diagnosis, prediction, artificial intelligence, machine learning. Scientific articles published between 2018 and 2024 were selected for the review. RESULTS: A summary of AI technologies and machine learning (ML) models is provided. It is shown that AI opens up vast opportunities for studying the pathogenet…

[Hormonal contraception methods and multiple sclerosis].

Multiple sclerosis (MS) is a chronic autoimmune demyelinating disease that is diagnosed in women twice as often as in men, especially in groups of family cases and at the age of up to 35 years. Among patients diagnosed with MS, there are many young and middle-aged women who are planning a pregnancy in the future and want to protect themselves from unwanted pregnancy at the present time. Also, for patients with MS, the importance of reducing the frequency of abortions is obvious. The question arises - what drugs are safe, convenient and effective for this group of patients. Moreover, one of the…