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Genetic Diversity and Virulence Profile of Methicillin and Inducible Clindamycin-Resistant Staphylococcus aureus Isolates in Western Algeria.

Staphylococcus aureus causes a wide range of life-threatening infections. In this study, we determined its prevalence in the hospital environment and investigated nasal carriage among healthcare workers and patients admitted to a hospital in western Algeria. A total of 550 specimens were collected. An antibiogram was performed and the genes encoding resistance to methicillin, inducible clindamycin and toxins were sought among the 92 S. aureus isolates. The spread of clones with a methicillin- and/or clindamycin-resistance phenotype between these ecosystems was studied using genomic analysis. A…

Virulence, Antimicrobial Resistance and Biofilm Production of Escherichia coli Isolates from Healthy Broiler Chickens in Western Algeria.

The aim of this study was to assess the virulence, antimicrobial resistance and biofilm production of Escherichia coli strains isolated from healthy broiler chickens in Western Algeria. E. coli strains (n = 18) were identified by matrix-assisted laser desorption-ionization time-of-flight mass spectrometry. Susceptibility to 10 antibiotics was determined by standard methods. Virulence and extended-spectrum β-lactamase (ESBL) genes were detected by PCR. The biofilm production was evaluated by microplate assay. All the isolates were negative for the major virulence/toxin genes tested (rfbE, fliC,…

MERGE: A Multinational, Multicenter Observational Registry for Myeloproliferative Neoplasms in Asia, including Middle East, Turkey, and Algeria.

Philadelphia chromosome-negative (Ph-) myeloproliferative neoplasms (MPNs) are a heterogeneous group of clonal disorders of the bone marrow, and are associated with a high disease burden, reduced quality of life (QOL), and shortened survival. This multinational, multicenter, non-interventional registry "MERGE" was initiated with an objective to collect data on the epidemiological indices of classical Ph-MPNs, existing treatment patterns, and impact of MPNs on health-related QOL in various countries/regions in Asia, including the Middle East, Turkey, and Algeria. Of the 884 eligible patients wi…

Molecular identification of Actinomadura madurae isolated from a patient originally from Algeria; observations from a case report.

BACKGROUND: Mycetoma is a chronic granulomatous subcutaneous infection caused by anaerobic pseudofilamentous bacteria or fungi. It is commonly prevalent in tropical and subtropical countries. Men are more susceptible to the disease due to greater participation in agricultural works. Mycetoma commonly involves lower extremities, wherein untreated cases lead to aggressive therapeutic choices, such as amputation of the affected body organs and consequently lifelong disability. CASE PRESENTATION: In this report, we present the rare case of a 58-year-old man, originally from Algeria with a left fo…

Присутствие Rickettsia eschlimannii, Candidatus Rickettsia barbariae и Coxiella signetii в клещах от скота в северо-западном Алжире.

Скотоводство и его эктопарациты участвуют в эпидемиологии нескольких зоонотических заболеваний. Исследования, касающиеся молекулярного обнаружения инфекционных агентов в клещах из северо-западного Алжира, недостаточны. Таким образом, было расследовано присутствие группы рикеттсии, микроорганизмов Anaplasmaciae и печени Coxiella signetii в клещах, собранных у румын в провинциях Сиди-Бель-Аббес и Сайда. Рикетсия Эшлиманнаи была обнаружена в одном экскавационном бассейне < < Хьяломма > > и одном пуле < < Х. саркатум > > . Более того, "Candidatus Rickettsia barbariae" был н

Совпадение в аннотации оригинала
Livestock and their ectoparasites are involved in the epidemiology of several zoonotic diseases. Studies regarding the molecular detection of infectious agents in ticks from Northwestern Algeria are scarce. Thus, the presence of spotted fever group Rickettsia spp., Anaplasmataceae microorganisms and Coxiella burnetii was investigated in ticks collected from …

Polycyclic aromatic hydrocarbons, phthalates, parabens and other environmental contaminants in dust and suspended particulates of Algiers, Algeria.

Chemicals such as polycyclic aromatic hydrocarbons (PAHs), phthalateesters, parabens, siloxanes and squalene, all of them classified as endocrine-disrupting chemicals (EDCs), have been reported to occur in all environmental compartments. The effects of EDCs on development, reproduction, growth, metabolism and obesity constitute a real public health issue. A list of EDCs (> 40 compounds) were characterised in total suspended particulates (outdoor soot: 92 samples) collected in July-September 2016 in an Algiers urban area; besides, settled indoor dusts (36 samples) were collected between Novembe

RETRACTED: Body lice of homeless people reveal the presence of several emerging bacterial pathogens in northern Algeria.

BACKGROUND: Human lice, Pediculus humanus, are obligate blood-sucking parasites. Body lice, Pediculus h. humanus, occur in two divergent mitochondrial clades (A and D) each exhibiting a particular geographic distribution. Currently, the body louse is recognized as the only vector for louse-borne diseases. In this study, we aimed to study the genetic diversity of body lice collected from homeless populations in three localities of northern Algeria, and to investigate louse-borne pathogens in these lice. METHODOLOGY/PRINCIPAL FINDINGS: In this study, 524 body lice specimens were collected from …

Phlebotomus (Paraphlebotomus) riouxi: a synonym of Phlebotomus chabaudi without any proven vectorial role in Tunisia and Algeria.

Phlebotomus (Paraphlebotomus) riouxi Depaquit, Léger & Killick-Kendrick (Diptera: Psychodidae) was described as a typological species based on a few morphological characters distinguishing it from Phlebotomus (Paraphlebotomus) chabaudi Croset, Abonnenc & Rioux. The naming of P. riouxi coincided with its incrimination as a rural vector of Leishmania tropica Wright (junior synonym: Leishmania killicki Rioux, Lanotte & Pratlong) in Tataouine governorate, an arid region of southern Tunisia. The current report finds insufficient evidence to incriminate either phlebotomine sandfly as a vector of L. 

First comprehensive molecular and phenotypic insights into multidrug resistance and virulence in poultry-associated Enterococcus spp. in Algeria.

BACKGROUND: Enterococci are common members of the gastrointestinal microbiota of humans and animals, but can act as opportunistic pathogens with a strong ability to acquire and disseminate antibiotic resistance, representing a significant public health concern. Surveillance in poultry is essential to monitor the spread of resistant enterococci along the food production chain. This study aimed to characterize the antimicrobial resistance and virulence profiles of Enterococcus species isolated from poultry in Algeria. METHODS AND RESULTS: A total of 163 cloacal swabs were collected from broiler …

Epilepsy in refugee camps in Algeria: clinical characteristics, treatment gaps, and environmental challenges in a low-resource setting.

OBJECTIVES: To describe the clinical and epidemiological characteristics of pediatric epilepsy in Sahrawi refugee camps and to explore treatment gaps and perceived environmental influences in a low-resource desert setting. METHODS: A cross-sectional observational study was conducted during a two-week humanitarian mission (April-May 2025) in two hospitals in Sahrawi Refugee Camps in the Tindouf desertic area (Algeria). Consecutive pediatric patients with suspected or confirmed seizures were enrolled (n = 63). Data were collected using a structured clinical record and the Pediatric Epilepsy Cla…

Seroprevalence and risk factors of toxoplasma gondii infection in goats from underreported Midland and lowland regions of Algeria.

Toxoplasmosis is a parasitic disease affecting both humans and animals and is caused by the protozoan parasite Toxoplasma gondii. In livestock, the infection leads to significant economic losses, mainly due to reproductive disorders such as abortion, and may cause severe clinical manifestations in pregnant and immunocompromised hosts. Despite its importance, updated epidemiological data on caprine toxoplasmosis in underreported regions of Algeria remain limited. Therefore, this study provides recent epidemiological insights from midland and lowland goat-rearing areas of the country. The presen…

Epidemiology and Imipenem Resistance in Acinetobacter baumannii Isolates at the Regional Military University Hospital of Oran (HMRUO), Algeria.

Globally, Acinetobacter baumannii has emerged as an important nosocomial pathogen and as highly resistant to clinically relevant antibiotics, namely, carbapenems. In this study, we aimed to determine the epidemiological profile and the imipenem (IPM) resistance rate of a clinical collection of A. baumannii isolates. This study was carried out at the Central Laboratory of the Oran Regional University Military Hospital (Hôpital militaire régional universitaire d'Oran) over a period of 7 years (January 2010-December 2016). The frequency of A. baumannii isolates was not constant over the 7 years;

Epidemiological trends and animal-human relationships of brucellosis in Algeria from 2010 to 2022: A one health approach.

Brucellosis is a bacterial disease transmitted from livestock to humans, causing fever, joint pain, and reproductive disorders in animals and people. In Algeria, tens of thousands of human cases are reported, yet animal sources are incompletely captured by routine surveillance. Thus, a retrospective epidemiological study using 13 years of national human surveillance data, combined with a cross-sectional seroprevalence survey of 816 dairy cattle in eastern Algeria, was carried out to better characterize the epidemiological link between human and animal brucellosis. Cattle blood samples were scr…

Detection and Characterization of Colistin Heteroresistance in an Enterobacter cloacae ST48 Strain Isolated From Raw Milk in Algeria.

An Enterobacter cloacae ST48 isolate exhibiting a colistin-heteroresistant phenotype was obtained from raw cow milk in Algeria. Two subpopulations were detected, both carrying the blaTEM-1 gene. While one subpopulation (E. cloacae TS34-a) was highly susceptible to colistin (MIC 0.06 µg/mL), the other (E. cloacae TS34-b) was resistant (MIC 8 µg/mL). Population analysis profiling (PAP) confirmed heteroresistance. PCR amplification revealed the absence of mcr genes in both subpopulations. However, multiple non-synonymous mutations, including a stop-codon mutation in phoP gene, were found in the r…

Clinical, etiological, radiological characteristics and outcomes of a cohort of 23 children with cerebral venous thrombosis in western Algeria.

BACKGROUND: Cerebral venous thrombosis (CVT) is a rare condition in children, and its description remains limited in North Africa. The objective of our study was to describe the clinical, etiological, radiological, therapeutic, and evolutionary characteristics of children with CVT in western Algeria. METHODS: This was a retrospective observational study involving children with CVT. The study was conducted at the unit of intensive care of Canastel Children's Hospital and the pediatric intensive care unit (PICU) of Oran Hospital Center (Algeria) from January 2012 to December 2022. RESULTS: A t…

The Burden of Congenital Hypothyroidism Without Newborn Screening: Clinical and Cognitive Findings from a Multicenter Study in Algeria.

The absence of biochemical newborn screening (NBS) delays the diagnosis and treatment of congenital hypothyroidism (CH), resulting in irreversible neurodevelopmental damage. To determine the age at diagnosis for CH among Algerian children and to describe its clinical and biological characteristics, etiology, and outcome, we conducted a multicenter retrospective cohort study involving 288 children with CH across 20 pediatric centers between 2005 and 2023. The median age at diagnosis was 1.6 months, and only 28% of patients started treatment before 30 days. Prolonged neonatal jaundice was the mo…

Microscopic and molecular prevalence and associated risk factors with Toxocara and Blastocystis infection in dogs and cats in Mitidja, Algeria.

Domestic dogs and cats can serve as a source of environmental contamination with Toxocara spp. and Blastocystis spp., and this represents a neglected public and veterinary health problem. We assessed the microscopic and molecular prevalence of these species in a locality in Algeria and identified the associated risk factors. The faeces of 225 dogs and 78 cats were collected in Mitidja between March and July 2022. The samples were analysed by coproscopy and by polymerase chain reaction (PCR) targeting the Internal Transcribed Spacer 2 (ITS2) and Small Subunit Ribosomal (SSU-RNA) of T. canis and…

A new canid host for subcutaneous ticks: A report from Algeria in an African golden wolf (Canis lupaster).

BACKGROUND: Ticks are hematophagous ectoparasites that feed on the skin surface of their host. Subcutaneous localizations of ticks have pred … of subcutaneous ticks was found in an African golden wolf (Canis lupaster) collected from Northern Algeria; no other cases of unusual tick locations were observed. Based on morphological criteria the tick was identified as Ixodes ricinus / I. inopinatus. CONCLUSION: This study represents the first documentation of subcutaneous tick in an African golden …

Climate change and cutaneous leishmaniasis in the province of Ghardaïa in Algeria: A model-based approach to predict disease outbreaks.

BACKGROUND: Cutaneous leishmaniasis (CL) is a vector-borne disease prevalent in Algeria since 2000. The disease has significant impacts on affected communities, including morbidity and social stigma. OBJECTIVE: Investigate the association between environmental factors and the incidence of CL in the province of Ghardaïa and assess the predictive capacity of these factors for disease occurrence. DESIGN: Retrospective SETTING: The study area included both urban and rural communities. METHODS: We analyzed a dataset on CL in the province of Ghardaïa, Algeria, spanning from 2000 to 2020. The data…