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Подход к созданию двух виртуальных клинических испытаний для многоразового склероза и их высвобождения в виде открытых наборов данных: исследование по оценке.

СПРАВОЧНАЯ ИНФОРМАЦИЯ: Обмен информацией, полученной на основе индивидуальных данных о пациентах, ограничивается нормативно-правовой базой по соображениям конфиденциальности. Генерирующий искусственный интеллект может генерировать общие виртуальные популяции пациентов в качестве прокси для чувствительных справочных наборов данных. Требуется эксплицитная демонстрация неприкосновенности частной жизни. ЦЕЛЬ: В этом исследовании была проведена оценка того, может ли технология конфиденциальности, называемая "аватарами", генерировать синтетические наборы данных, воспроизводящие всю сообщенную информ

Совпадение в аннотации оригинала
BACKGROUND: Sharing information derived from individual patient data is restricted by regulatory frameworks due to privacy concerns. Generat … privacy is demanded. OBJECTIVE: This study evaluated whether a privacy-by-design technique called "avatars" can generate synthetic datasets replicating all reported information from randomized clinical trials (RCTs). METHODS: We generated 2160 synthetic datasets from two phase 3 RCTs for patients with multiple sclerosis (NCT00213135 and NCT00906399; n= …

Neurobiology of social reward valuation in adults with a history of anorexia nervosa.

OBJECTIVE: Anorexia nervosa (AN) is a disorder characterized by atypical patterns of reward valuation (e.g. positive valuation of hunger). A … dies). These findings did not extend to smiling face stimuli. Advances in technology (e.g., virtual avatars, text messaging) may provide novel means to build relationships, including therapeutic relationships, to support improved social connections without threats to symptom provocation.

Virtual Reality Technology Design and Its Applications in Preventing and/or Managing Paediatric Chronic Pain: A Scoping Review.

BACKGROUND AND OBJECTIVE: Virtual reality (VR) has emerged as a novel non-pharmacological intervention tool, offering immersive environments … : relaxing environments, gamified movement-based environments, simulation of everyday settings, and avatar-based interactive environments. CONCLUSION: These findings informed an adaptation of an existing holistic framework for paediatric VR-based pain interventions, originally developed in the context of acute pain, to paediatric CP. This adapted model …

Toward Brain-Computer Interface motor rehabilitation for people with Multiple Sclerosis.

BACKGROUND: Multiple Sclerosis (MS) is a chronic neurodegenerative disease in which the immune system attacks the myelin sheaths around nerves. People with MS (pwMS) often experience pain, fatigue, cognitive dysfunction, and reduced mobility. Today, MS is incurable, and treatments can at best slow the progression of the disease and manage symptoms. We conducted a preliminary, single-arm study using a motor-imagery brain-computer interface (MI-BCI) with functional electrical stimulation (FES) and virtual reality avatar targeting gait in pwMS. METHODS: Twenty-six pwMS were enrolled; 24 complete…

Intervention mapping for systematic development of a community-engaged CVD prevention intervention in ethnic and racial sexual minority men with HIV.

INTRODUCTION: Cardiovascular disease (CVD) is a leading cause of mortality in the United States, disproportionately affecting marginalized p … ance objectives and change objectives. Strategies included leveraging eHealth technologies, such as avatar-led interactive videos, to provide private, culturally relevant health education and reduce barriers like medical distrust. Community-based participatory methods were integral to ensure the intervention was culturally resonant and acceptable. DISCU …

Innovations in communication training for medical and nursing students: Virtual reality communication tool for application and evaluation with key stakeholders and students (VR-TALKS) - a study protocol.

BACKGROUND: In healthcare education, virtual reality (VR), simulating real-world situations, is emerging as a tool to improve communication skills, particularly in sensitive scenarios involving patients and caregivers. While promising, VR-based education also poses challenges such as avatar realism, cognitive load, and the need for pedagogical grounding. OBJECTIVE: This protocol paper presents the VR-TALKS project, which aims to develop, apply, and evaluate VR scenarios designed to teach healthcare students communication skills in serious illness scenarios. Barriers and facilitators to integr…

Adaptive training with full-body movements to reduce bradykinesia in persons with Parkinson's disease: a pilot study.

BACKGROUND: Bradykinesia (slow movements) is a common symptom of Parkinson's disease (PD) and results in reduced mobility and postural instability. The objective of this study is to develop and demonstrate a technology-assisted exercise protocol that is specifically aimed at reducing bradykinesia. METHODS: Seven persons with PD participated in this study. They were required to perform whole body reaching movements toward targets placed in different directions and at different elevations. Movements were recorded by a Microsoft Kinect movement sensor and used to control a human-like avatar, whi…

Exploring the Psychological and Physiological Effects of Operating a Telenoid: The Preliminary Assessment of a Minimal Humanoid Robot for Mediated Communication.

BACKGROUND: As the Internet of Things (IoT) expands, it enables new forms of communication, including interactions mediated by teleoperated robots like avatars. While extensive research exists on the effects of these devices on communication partners, there is limited research on the impact on the operators themselves. This study aimed to objectively assess the psychological and physiological effects of operating a teleoperated robot, specifically Telenoid, on its human operator. METHODS: Twelve healthy participants (2 women and 10 men, aged 18-23 years) were recruited from Osaka University. …

[The evolution of personalized medicine: publications review].

The personalized medicine is based on suggestion that each person has unique characteristics at molecular, physiological, ecological and beh … al toxicity of therapy, prevention of relapse of disease and its prevention. The technology of cell avatars will permit to prognose development of diseases and, possibly, life expectancy too. The personalized approach in reproductology based on genetic research will permit to eliminate a number of hereditary, orphan diseases in XXI century the same way a …

Acute Hemodynamic Effects of Virtual Reality-Based Therapy in Patients of Cardiovascular Rehabilitation: A Cluster Randomized Crossover Trial.

OBJECTIVE: To analyze the acute hemodynamic effects of adding virtual reality-based therapy (VRBT) using exergames for patients undergoing c … uring warm-up, in the VRBT session, games were performed with sensors to reproduce the movements of avatars and, in the CR session, patients were required to reproduce the movements of the physiotherapists. In the conditioning phase for VRBT, games were also played with motion sensors, dumbbells, and shin guards. The CR session consisted of exercises per …

Personalized Virtual Reality Future Selves Elicit Introspective Brain Activation in Early Substance Use Disorder Recovery.

Substance use disorder (SUD) recovery typically requires transformative change and prioritizing long-term healthy goals. Unfortunately, successful recovery is threatened by relapse rates that often exceed 50% in the first year. We previously reported on an experiential virtual reality (VR) SUD recovery intervention using personalized future self-avatars that produced emotional engagement and positive behavioral change, ie, stronger connection with the future self and future rewards and reduced craving. Here, we used fMRI to identify brain engagement to a future self experience with divergent f…

Personalized Virtual Reality Future Selves Elicit Introspective Brain Activation in Early Substance Use Disorder Recovery.

INTRODUCTION: Substance use disorder (SUD) recovery typically requires transformative change and prioritizing long-term healthy goals. Unfortunately, successful recovery is threatened by relapse rates that typically exceed 50% in the first year. We previously reported on an experiential virtual reality (VR) SUD recovery intervention using personalized future self-avatars that produced emotional engagement and positive behavioral change, ie, stronger connection with the future self and future rewards, and reduced craving. Here, we used fMRI to identify brain engagement to a future self experien…

Exploring the moderating role of maternal attachment style on the impact of a virtual reality environment on parental empathy and style: A pilot study.

Research has demonstrated that parental empathy, a factor implicated in risk of child maltreatment, could be enhanced using Virtual Reality (VR) by helping mothers to take a child perspective. However, whether parental attachment style could affect the efficacy of this approach is unclear. In this pilot study, a sample of nineteen British mothers participated in a VR study where they were embodied in a child avatar and interacted with a virtual mother adopting a harsh and critical (negative) or warm and supportive (positive) parenting style. Participants completed the Adult Adolescent Parentin…

Long-Term Mutual Training for the CYBATHLON BCI Race With a Tetraplegic Pilot: A Case Study on Inter-Session Transfer and Intra-Session Adaptation.

CYBATHLON is an international championship where people with severe physical disabilities compete with the aid of state-of-the-art assistive technology. In one of the disciplines, the BCI Race, tetraplegic pilots compete in a computer game race by controlling an avatar with a brain-computer interface (BCI). This competition offers a perfect opportunity for BCI researchers to study long-term training effects in potential end-users, and to evaluate BCI performance in a realistic environment. In this work, we describe the BCI system designed by the team Mirage91 for participation in the CYBATHLON…

Differential Infiltration of Key Immune T-Cell Populations Across Malignancies Varying by Immunogenic Potential and the Likelihood of Response to Immunotherapy.

Background: Solid tumors vary by the immunogenic potential of the tumor microenvironment (TME) and the likelihood of response to immunothera … pancreatic carcinomas. Real-world data were collected under the Total Cancer Care Protocol and the Avatar® project (NCT03977402) across 18 cancer centers. Furthermore, we compared the survival outcomes following immune checkpoint inhibitors (ICIs) based on immune cell gene expression. Results: In melanoma and bladder cancer, the estimated infiltration o …

Development of a 3D, networked multi-user virtual reality environment for home therapy after stroke.

BACKGROUND: Impairment of upper extremity function is a common outcome following stroke, to the detriment of lifestyle and employment opport … same virtual space even though they may be physically remote. Each user's own movement controls an avatar through kinematic measurements made with a low-cost, Kinect™ device. The system was explicitly designed to train movements important to rehabilitation and to provide real-time feedback of performance to users and clinicians. To obtain user feedback …

Co-designing meaningful extended reality for physical rehabilitation: a stakeholder-driven approach to embodied telehealth.

INTRODUCTION: Extended Reality (XR) technologies offer unprecedented opportunities to redefine physical rehabilitation experiences through e … ointments and asynchronous clinician-authored patient home exercise programs with full-body tracked avatars and biomechanical assessments. RESULTS: Stakeholder feedback reinforced the need for embodied agency with adaptive input modalities for diverse patient needs, ensuring clinical authenticity through real-time full-body tracking for accurate movemen …

Integrating Telemedicine and Embodied Virtual Reality: A Novel Functional Training Intervention for Chronic Shoulder Pain.

Chronic shoulder pain is a common musculoskeletal pain condition that can have a profound impact on a sufferer's life and a large socioecono … echniques from graded motor imagery, such as visual mirror feedback and augmentation of the virtual avatar's movements. Eight assessments on function and psychological aspects relevant to chronic pain were measured prior to the first session, at week 4, and at the end of 8 weeks in order to investigate the effect of the virtual embodiment training on the …

Methodology for generating chorioallantoic membrane patient-derived xenograft (CAM-PDX) models of pleural mesothelioma and performing preclinical imaging for the translation of cancer studies and drug screening.

BACKGROUND: Pleural mesothelioma is a cancer of the lung lining associated with asbestos exposure. Platinum/pemetrexed chemotherapy has been … vel treatment strategies and drug combinations, with the potential for development of patient tumor avatars for predicting clinical response.

A comprehensive comparison of facial skin hydration based on capacitance and conductance measurements in Chinese women.

OBJECTIVES: The aim of this study was to compare the data of conductance and capacitance measurements of facial skin hydration and to evaluate and discuss the advantages and disadvantages of the different approaches. METHODS: We measured skin capacitance (Corneometer® CM 825) and skin conductance (Skicon-200EX®) on 30 pre-defined facial sites of 125 Chinese women, resulting in 3750 readings per device. The data were analysed and compared, and continuous colour maps were generated on a 3D avatar for capacitance, conductance, relative difference (Δ%) and correlation (R-value) by interpolating b…