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MAO-B Inhibitory and Antioxidant Properties of Flavonoids from Chenopodium album: Implications for Neuroprotection.

INTRODUCTION: Neurodegenerative diseases, especially Parkinson's disease, have been linked with oxidative stress, mitochondrial malfunction, neuroinflammation, and dopamine metabolism impairment. On the other hand, C. album is a medicinal plant containing high concentrations of flavonoids, which provide neuroprotective potential by acting as antioxidants and MAO-B inhibitors. METHODS: In this review, scientific data obtained by various approaches such as phytochemical screening, in vitro, in vivo, and computational analysis about significant flavonoids of C. album (e.g., quercetin, kaempferol…

Flavonoids as Dual Topoisomerase I and II Inhibitors: Mechanistic Insights and Emerging Anticancer Strategies.

Flavonoids, a diverse class of plant-derived polyphenolic compounds found in fruits, vegetables, and medicinal herbs, have gained considerable attention for their chemopreventive and anticancer properties. A key mechanism underlying their therapeutic potential is the modulation of DNA topoisomerases, enzymes essential for DNA replication, transcription, and recombination. Inhibition of topoisomerase I and II induces DNA damage, replication stress, and apoptosis in rapidly proliferating cancer cells. Flavonoids such as quercetin, kaempferol, myricetin, and epigallocatechin-3-gallate (EGCG) act …

Developmental Rhythm and Differential Accumulation of Flavonoids in Single- and Double-Flowered Rosa xanthina.

To clarify the utilization value of Rosa xanthina germplasm resources, single-flowered and double-flowered Rosa xanthina were used as experimental materials. The dynamic accumulation of total flavonoids and four flavonoid-related substances was determined in three floral developmental stages and three fruit developmental stages of single-flowered Rosa xanthina. Total flavonoids, rutin, hyperoside, quercetin and anthocyanins were measured by aluminum nitrate colorimetry, high-performance liquid chromatography (HPLC) and extraction method, respectively. Combined with correlation analysis and pri…

Flavonoids as Redox-modulating Therapeutics: Structure-activity Relationships and Nanocarrier Strategies in Medicinal Chemistry.

Flavonoids are a class of phenolic compounds that display significant antioxidant, antiinflammatory, and cytoprotective activities. Despite their considerable pharmacological activities, flavonoids and their derivatives face significant barriers in their clinical application due to their poor aqueous solubility, rapid first-pass metabolism, and limited inability to traverse biological barriers. Recent progress in the field of nanotechnology has stimulated the design and application of multi-functional nano-carriers for flavonoids, which are tailored to overcome these barriers and maximize flav…

Ziziphora clinopodioides Flavonoids improve ischemic stroke by targeting FUNDC1-mediated mitophagy to reduce ferroptosis.

BACKGROUND: Ischemic stroke (IS) is a major global cause of disability and death, with its complex pathophysiology posing a significant challenge for effective therapy. Although flavonoids from Ziziphora clinopodioides Flavonoids (ZCF) have demonstrated neuroprotective potential, their comprehensive mechanisms of action remain incompletely understood. OBJECTIVE: The purpose of this study is to systematically elucidate the improvement effect of ZCF on ischemic stroke and its potential mechanism by integrating multi-omics analysis and in vitro and in vivo experimental verification. METHODS: In…

Research progress on the metabolic fate of citrus flavonoids and strategies to improve bioavailability.

Citrus flavonoids have various health-promoting effects, such as antioxidant, anti-inflammatory, and metabolic regulatory activities, whereas their low oral bioavailability greatly impairs their in vivo efficacy. Substitution patterns of hydroxyl, methoxyl, and glycosyl groups determine their metabolic fate. As a narrative review, this paper follows the thread of "structure-metabolism-efficacy" and reviews literature covering metabolism, gut microbiota, delivery systems, structural modifications, in vivo bioactivity, and clinical studies. Molecular-structure-based comparisons of bioavailabilit…

Dietary flavonoids target the gut-liver axis for the management of cholestatic liver injury.

Cholestatic liver injury (CLI) is a progressive liver disorder characterized by impaired bile acid (BA) synthesis, transport, and excretion. … A imbalance, impaired intestinal barrier integrity, hepatic inflammation, and fibrotic progression. Flavonoids, a major class of polyphenols present in various foods, possess microbial-dependent biotransformation and gut enrichment characteristics. Through coordinated modulation of gut microbiota, BA metabolism, and host signaling pathways, flavonoids displa …

Mechanism and Experimental Validation of Total Flavonoids of Rhizoma Drynariae in Treating Gouty Arthritis.

Gouty arthritis (GA) is an inflammatory joint disease caused by the deposition of monosodium urate (MSU) crystals within the joint space and surrounding tissues. In traditional Chinese medicine, Rhizoma Drynariae (Gusuibu) has long been widely used in the clinical treatment of GA, and flavonoids are considered its key bioactive constituents. This research employed network pharmacology to construct a component-target network of total flavonoids of Rhizoma Drynariae (TFRD) against GA, thereby identifying key components, core targets, and related pathways. Rat models were established by intra-art…

Harnessing flavonoids as innovative agents for the modulation of platelet activation and thrombotic disorders.

Thrombotic diseases remain a leading cause of global mortality and a significant public health burden. While conventional antiplatelet and anticoagulant therapies are cornerstone strategies, their clinical application is frequently hindered by a significant risk of hemorrhagic complications and limited efficacy in certain patient populations. Consequently, there is an urgent need for safer and more effective antithrombotic agents. Flavonoids, a diverse class of plant-derived polyphenols, have garnered considerable attention due to their potent antiplatelet and antithrombotic activities coupled…

A Comprehensive Review of Natural and Synthetic Flavonoids as Antibiofilm Agents Against Bacterial Biofilms.

Bacterial biofilms are a major contributor to antimicrobial resistance due to their ability to protect embedded cells from antibiotics and host immune responses. This review systematically summarizes and critically evaluates recent advances in the development of natural and synthetic flavonoids as antibiofilm agents against clinically relevant bacterial biofilms. The manuscript is organized to first outline the molecular basis of biofilm formation and resistance, followed by a detailed analysis of plant-derived flavonoids reported to inhibit biofilm formation, disrupt mature biofilms or interf…

Extraction process and antioxidant and antimicrobial activities of total flavonoids from Broussonetia papyrifera leaves.

This study developed an efficient extraction process for flavonoids from Broussonetia papyrifera leaves using the response surface methodology. The optimized flavonoids exhibited remarkable antioxidant activity, effectively scavenging DPPH, hydroxyl, and ABTS radicals. UPLC-MS/MS analysis preliminarily identified numerous flavonoid compounds in the extract.. The extract also demonstrated potent broad-spectrum antibacterial efficacy against Staphylococcus aureus, Escherichia coli, and Candida albicans. These findings indicate that the extracted flavonoids may serve as natural antioxidants and a…

Optimization of Antioxidant Flavonoids Extraction From Helianthus annuus L. Ray Florets for Cardioprotective Nutraceuticals.

The aim of this study was to investigate the ultrasound-assisted extraction (UAE) of antioxidant flavonoids from sunflower (Helianthus annuus) ray florets through the optimization of the parameters (temperature, extraction ratio, and solvent concentration) using a response surface methodology (RSM), then to validate the model conducting wet-lab analyses, and finally, to characterize the optimized extracts for composition and in vitro cardioprotective potential. Within RSM, the parameters of UAE were optimized by maximization of the response variables yield of flavonoid extraction and Trolox eq…

Coreopsis Tinctoria flavonoids phospholipid complex: molecular dynamics simulation, preparation, characterization, and in vitro release.

OBJECTIVE: To prepare the Coreopsis tinctoria flavonoids phospholipid complex(CTF-PC) and evaluate its physical characterization and release profile. SIGNIFICANCE: Coreopsis Tinctoria flavonoids (CTF) have excellent antioxidant and liver-protective activity. However, CTF exhibits low solubility and permeability, restricting its in vivo absorption and effectiveness. The phospholipid is a nontoxic amphiphilic substance with excellent biocompatibility. It can complex drugs to promote absorption and is expected to be a potentially effective drug delivery system. METHODS: In this study, the follo…

Флавоноиды в регулировании нейроинфламмации с помощью микрогилия; сосредоточьтесь на фисетине, рутине и веркетине.

Нейроинфламмация представляет собой критический механизм в провокационных расстройствах центральной нервной системы (КНС), охватывающий такие заболевания, как болезнь Альцгеймера (AD), болезнь Паркинсона (PD), болезнь Хантингтона (HD), множественный склероз (MS), травма мозга (TBI), энцефалит, повреждение спинного мозга (SCI) и церебральный инсульт. Нейроинфламмация характеризуется повышением проницаемости кровеносных сосудов, инфильтрацией лейкоцитов, активацией глиальных клеток и увеличением производства подстрекательских посредников, таких, как хемокины и цитокины. Микроглиа выступает в кач

Совпадение в аннотации оригинала
Neuroinflammation is a critical mechanism in central nervous system (CNS) inflammatory disorders, encompassing conditions such as Alzheimer' … e M2 antiinflammatory phenotype may serve as a sensible therapeutic strategy for neuroinflammation. Flavonoids, including rutin, fisetin, and quercetin, function as crucial chemical reservoirs with unique structures and diverse actions and are extensively used to modulate microglial polarization in treating neuroinflammation. This paper highlights the detrim …

Flavonoids effects against bacteria associated to periodontal disease and dental caries: a scoping review.

This scoping review focused on exploring the efficacy of flavonoids against bacteria associated with dental caries and periodontal diseases. Inclusion criteria comprise studies investigating the antibacterial effects of flavonoids against bacteria linked to caries or periodontal diseases, both pure or diluted in vehicle forms. The search, conducted in August 2023, in databases including PubMed/MEDLINE, Scopus, Web of Science, Embase, LILACS, and Gray Literature. Out of the initial 1125 studies, 79 met the inclusion criteria, majority in vitro studies. Prominent flavonoids tested included epiga…

Exploring the role of flavonoids in caries-affected dentin adhesion: A comprehensive scoping review.

OBJECTIVES: The aim of this scoping review was to evaluate the available scientific evidence regarding the use of flavonoids in the treatment of caries-affected dentin focusing on bonding to dentin. METHODS: A comprehensive literature search was performed in five databases from March 2022 and updated in April 2023: PubMed, EMBASE, Scopus, Web of Science, and Scielo. Additionally, the references of included studies were manually searched. Gray literature was excluded from the review. STUDY SELECTION: Inclusion criteria included in vitro, in situ, and in vivo studies (animal or human) publishe…

The relationship between dietary total flavonoids and thyroid function in U.S.adults, NHANES 2007-2010.

BACKGROUND: Although small studies have shown that flavonoids can affect thyroid disease, few epidemiological studies have explored the relationship between dietary total flavonoids (TFs) intake and serum thyroid function. The aim of this research was to evaluate the relationship between TFs and serum thyroid function. METHODS: Our study included 4,949 adults from the National Health and Nutrition Examination Survey (NHANES) 2007-2010. Multivariable linear regression, subgroup analyses, and interaction terms were used to explore the relationships between TFs and thyroid function. And we also …

Inhibition of DNA Topoisomerase Ι by Flavonoids and Polyacetylenes Isolated from Bidens pilosa L.

Human DNA topoisomerase I (Topo I) is an essential enzyme in regulating DNA supercoiling during transcription and replication, and it is an important therapeutic target for anti-tumor agents. Bidens pilosa L. is a medicinal herb that is used as a folk medicine for cancers in China. A new flavonoid (1) and a new polyacetylene (20), along with eighteen flavonoids (2-19) and nine polyacetylenes (21-29), were isolated and identified from the methanol extract of the whole plant of B. pilosa, and some of the compounds (4, 5, 6 and 7) exhibited potent cytotoxicity against a panel of five human cancer…

Quantification of flavonoids, minerals, and pigments present in "Nanicão" bananas during the ripening process.

Banana is one of the most consumed and popular fruits in all regions of the world, being cultivated mainly in tropical countries. It is not only a rich source of vitamins A, C, and B, calcium, iron, potassium, phosphorus, and other vitamins and nutrients, but it also contains several types of antioxidants with high nutritional value. In this context, the current study aimed to quantify the content of ascorbic acid, flavonoids, pigments, and minerals present in "Nanicão" bananas during the ripening process. As demonstrated, the level of flavonoids was higher in ripe and overripe fruits, whereas…

Protective Roles and Mechanism of Action of Plant Flavonoids against Hepatic Impairment: Recent Developments.

BACKGROUND: The liver is one of the crucial organs in humans and is responsible for the regulation of diverse processes, including metabolism, secretion, and detoxification. Ingestion of alcohol and drugs, environmental pollutants, and irradiation are among the risk factors accountable for oxidative stress in the liver. Plant flavonoids have the potential to protect the liver from damage caused by a variety of chemicals. OBJECTIVE: The present study aims to summarize up-to-date information on the protective roles of plant flavonoids against liver damage. METHODOLOGY: The literature informati…