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Large differencies in age-specific survival in multiple myeloma in the nordic countries.

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Временные модели выживаемости пациентов из числа населения США среди взрослых, которые лечатся химиотерапией и/или иммунной терапией по множеству миелом, 2000-2020.

Немногие демографические исследования позволили тщательно оценить общие различия в показателях выживаемости (ОС) среди взрослых, прошедших курс химиотерапии и/или иммунотерапии (химиотерапия/иммунотерапия) в отношении множественной миеломы (ММ) в прошлом two десятилетия, когда терапевтический ландшафт претерпел существенные изменения. Мы провели оценку OS среди 50 288 Взрослые, у которых был диагностирован ММ 2000 и 2019 Согласно сообщениям, они прошли первоначальную химиотерапию/иммунотерапию. Мы рассчитывали коэффициенты опасности (HRs) с использованием многовариантной коксовой регрессии для

Population-Based Detection of Cancer Cases Using Digital Platforms in Mangalagiri Mandal of Guntur District, Andhra Pradesh.

Background and objectives Cancer is one of the major causes of illness and mortality in India. The cancer burden in India will roughly triple over the next 20 years. Population-based cancer registries (PBCRs) are crucial not only for formulating cancer control policies and assessing their effectiveness but also offer essential inputs for programs aimed at preventing cancer. The state of Andhra Pradesh after the division in 2014 has been left with no PBCR. Hence, with the aim to pilot the development of a population-based cohort of cancer cases with digital reporting and monitoring mechanisms,

A global, regional, and national survey on burden and Quality of Care Index (QCI) of hematologic malignancies; global burden of disease systematic analysis 1990-2017.

BackgroundHematologic malignancies (HMs) are a heterogeneous group of cancers that comprise diverse subgroups of neoplasms. So far, despite the major epidemiologic concerns about the quality of care, limited data are available for patients with HMs. Thus, we created a novel measure-Quality of Care Index (QCI)-to appraise the quality of care in different populations.MethodsThe Global Burden of Disease data from 1990 to 2017 applied in our study. We performed a principal component analysis on several secondary indices from the major primary indices, including incidence, prevalence, mortality, ye

A Comparative Analysis of Multiple Myeloma Disease Burden in China and Globally From 1990 to 2023 and Future Trend Projections.

BACKGROUND: Multiple myeloma (MM) is a prevalent hematologic malignancy. A systematic comparison of the temporal trends in MM disease burden between China and the global level is important for optimizing prevention and control strategies. This study describes trends in the age- and sex-specific burden of MM in China from 1990 to 2023, including incidence, prevalence, mortality, and disability-adjusted life years (DALYs); projects sex-specific incidence to 2050; and compares findings globally. METHODS: Using the Global Burden of Disease (GBD) 2023 database, we extracted data on MM in China and

Temporal Trends in Cancer Burden and 27 Subtypes Among Women of Childbearing Age Globally from 1990 to 2021.

BackgroundCancer among women of childbearing age (WCBA, 15-49 years) has distinct clinical and public health implications. Using modeled estimates from the Global Burden of Disease Study (GBD) 2021, we assessed temporal and spatial patterns of total cancer and 27 cancer subtypes among WCBA from 1990 to 2021.MethodsWe extracted incidence and mortality estimates for WCBA globally, across five socio-demographic index (SDI) regions, 21 GBD regions, and 204 countries and territories. Age-standardized incidence rates (ASIRs) and age-standardized mortality rates (ASMRs) were calculated. Temporal tren

Identifying and describing cancer survivors: Implications for cancer survivorship research and clinical care.

BackgroundGathering information directly from cancer survivors has advanced our understanding of the cancer survivorship experience. However, it is unknown whether surveys can distinguish important subgroups of cancer survivors. This study aimed to describe the current landscape of survey questions used to identify and describe cancer survivors in national cross-sectional studies.MethodsUsing publicly available databases, the authors identified national cross-sectional surveys used in the United States within the past 15 years that included a question on self-reported history of cancer. After

Trends on cancer incidence and mortality in Pasto, Colombia. 15 years experience.

IntroductionIn Colombia it is necessary to continue producing quality and continuously updated information on the magnitude of cancer, derived from population-based cancer registries to contribute to decision making, and implementation of strategies for health promotion, prevention and treatment of cancer in order to reduce the impact on the population.ObjectiveTo describe the incidence, mortality and cancer trends in Pasto-Colombia from 1998 to 2012.MethodsObservational descriptive study of morbi - mortality due to malignant tumours in Pasto. The collection, processing and systematization of

Trends in the incidence and survival of multiple myeloma in South East England 1985-2004.

BACKGROUND: Multiple myeloma is an uncommon cancer with a poor prognosis. Its incidence is expected to increase due to ageing populations and better diagnosis, and new treatments have been developed to improve survival. Our objective was to investigate trends in the epidemiology and survival of multiple myeloma for South East England. METHODS: Data on 15,010 patients diagnosed with multiple myeloma between 1985 and 2004 was extracted from the Thames Cancer Registry database. We calculated the yearly age-standardised incidence rates for males and females and age-specific incidence rates in 10-

Regulatory Convergence in Cell and Gene Therapy: Harmonizing Quality, CMC, and Approval Pathways Across the FDA, EMA, PMDA, and Emerging Markets.

Cell and gene therapies (CGTs) have progressed from proof of concept to an established commercial pipeline, yet global translation remains constrained by fragmented regulatory frameworks; heterogeneous Chemistry, Manufacturing, and Controls (CMC) requirements; and divergent approval pathways. This narrative review compares CGT quality, CMC, and approval-pathway regulation across the US Food and Drug Administration (FDA), European Medicines Agency (EMA), and Japan's Pharmaceuticals and Medical Devices Agency (PMDA), together with five emerging-market agencies: Brazil, Russia, India, China, and

The association between financial toxicity and mortality in hematologic malignancies: a systematic review and meta-analysis.

BackgroundHematologic malignancies impose substantial economic burdens, but the quantitative association between financial toxicity and overall survival remains poorly defined across diverse clinical settings and disease lineages.MethodsAdhering to PRISMA and MOOSE guidelines, we searched electronic databases through January 2026 for studies reporting multivariable-adjusted hazard ratios (aHRs) for the association between financial toxicity and mortality in adults diagnosed with hematologic malignancies. A random-effects model with Hartung-Knapp adjustment was used for data synthesis. Small-st

Quality indicators and development targets in the national clinical quality registries in cancer care and screening.

BackgroundThe Danish clinical quality registries monitor and improve the quality of care, using quality indicators and defined development targets referred to as 'standards'. This study aims to investigate the fulfilment of standards in the Danish clinical quality registries in cancer care and screening.MethodsData was included from annual reports in the 27 Danish clinical quality registries in cancer care and screening. The most recent report from each registry was downloaded the 13 December 2023. Indicators were included if: evaluating care or screening over 12 months, presenting a well-defi

Physical health outcomes and step cadence improvements: a digital physical activity intervention in cancer survivors.

BackgroundCancer survivors experience symptoms that can often be managed with moderate-to-vigorous physical activity. Most studies are short, small, and in-person, limiting scalability. This study evaluated a 12-month digital moderate-to-vigorous physical activity intervention and its impact on long-term physical health outcomes in a large sample of cancer survivors.MethodsThis 2-arm trial was embedded within the Cancer Prevention Study-3 prospective cohort study and included survivors with cancers associated with physical inactivity. Eligible participants were randomly assigned to a digital m

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… The authors would like to acknowledge the contribution to this study from central cancer registries supported through the Centers for Disease Control and Prevention’s National Program of Cancer Registries and cancer registries supported by the National Cancer Institute’s Surveillance Epidemiology and …

Диверсификация глобальных тенденций заболеваемости раком ранней стадии: сопоставление с тенденциями заболеваемости раком более поздней стадии и тенденциями смертности от рака ранней стадии.

Глобальное увеличение заболеваемости раком в раннем возрасте (определяемым как рак, диагностируемый на 20-49 ) является серьезной проблемой в области здравоохранения. Мы расследовали 1) отличается ли тенденция заболеваемости раком раннего зарождения от тенденции заболевания раком на более позднем этапе и 2) увеличиваются ли одновременно как частотность, так и смертность от рака раннего возраста. 2000 и 2017 от раковых заболеваний Five Базы данных о смертности на континентах и Всемирной организации здравоохранения (ВОЗ). Общенациональная распространенность ожирения среди взрослых 20-49 Годы был

Distribution patterns and prediction of lymph, hematopoietic and related tissue cancer incidence in Chinese cancer registration areas from 2005 to 2050.

ObjectiveBy analyzing the spatiotemporal distribution of lymph, hematopoietic and related tissue cancer incidence in cancer registration areas of China from 2005 to 2019 and predicting future trends, this study provides references for the prevention and control of related cancers in China.MethodsThe data on lymph, hematopoietic and related tissue cancer (ICD-10, C81-C85, C88, C90, and C96) incidence were from the China Cancer Registry Annual Report. The Joinpoint regression model was employed to calculate the average annual percentage change (AAPC) for describing time trends, the age-period-co

Cancer Prevalence Projections in Japan and Decomposition Analysis of Changes in Cancer Burden, 2020-2050: A Statistical Modeling Study.

BACKGROUND: We provide comprehensive sex-stratified projections of cancer prevalence for 22 cancer sites in Japan from 2020 to 2050. METHODS: Using a scenario-based approach, we projected cancer prevalence by combining projected incidence cases and survival probabilities. Age-specific incidences were forecasted using age-period-cohort models, while survival rates were estimated using a period-analysis approach and multiple parametric survival models. To understand changes in cancer prevalence, decomposition analysis was conducted, assessing the contributions of incidence, survival, and popula

Donor Evaluation for Hematopoietic Stem and Progenitor Cell Collection

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Phase-specific and lifetime costs of cancer care in Ontario, Canada.

BackgroundCancer is a major public health issue and represents a significant economic burden to health care systems worldwide. The objective of this analysis was to estimate phase-specific, 5-year and lifetime net costs for the 21 most prevalent cancer sites, and remaining tumour sites combined, in Ontario, Canada.MethodsWe selected all adult patients diagnosed with a primary cancer between 1997 and 2007, with valid ICD-O site and histology codes, and who survived 30 days or more after diagnosis, from the Ontario Cancer Registry (N = 394,092). Patients were linked to treatment data from Cancer

World Trade Center Health Program: First Decade of Research.

The terrorist attacks on 11 September 2001 placed nearly a half million people at increased risk of adverse health. Health effects research began shortly after and continues today, now mostly as a coordinated effort under the federally mandated World Trade Center (WTC) Health Program (WTCHP). Established in 2011, the WTCHP provides medical monitoring and treatment of covered health conditions for responders and survivors and maintains a research program aimed to improve the care and well-being of the affected population. By 2020, funds in excess of USD 127 M had been awarded for health effects

Population-Based Clinical Cancer Registration in Germany.

IntroductionIn 2013, a new federal law obligated all German federal states to collect additional clinical data in population-based cancer registries as an active tool for monitoring and improving the quality of cancer care, increasing transparency and promoting health research. Now, 10 years later, the current status of the expanded cancer registration is presented, including current figures on cancer in Germany.MethodsReporting of cancer is mandatory for physicians, and about 5 to 10 reports from different healthcare providers are expected for each case. A uniform national dataset of about 13