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Piperacillin/tazobactam: a pharmacoeconomic review of its use in moderate to severe bacterial infections.

UNLABELLED: Piperacillin/tazobactam is a beta-lactam/beta-lactamase inhibitor combination with a broad spectrum of antibacterial activity ag … al costs than clindamycin plus gentamicin or imipenem/cilastatin in intra-abdominal infections, and ticarcillin/ clavulanic acid in community-acquired pneumonia. Piperacillin/tazobactam plus amikacin had lower total costs than ceftazidime plus amikacin in another cost analysis of patients with febrile neutropenic episodes modelled in nine European countries. …

Characterization of acquired β-lactamases in Pseudomonas aeruginosa and quantification of their contributions to resistance.

Pseudomonas aeruginosa is a highly problematic opportunistic pathogen that causes a range of different infections. Infections are commonly t … a variety of clinically used antibiotics, including carbapenems (meropenem, imipenem), penicillins (ticarcillin, piperacillin), cephalosporins (ceftazidime, cefepime), and a monobactam (aztreonam). Different enzymes acted on different β-lactams. β-lactamases encoded by the genomes of P. aeruginosa clinical isolates had similar effects to the enzymes expressed …

Antimicrobial resistance and the presence of extended-spectrum beta-lactamase genes in Escherichia coli isolated from the environment of horse riding centers.

The aim of the study was to determine the antimicrobial resistance profile and the occurrence of extended-spectrum beta-lactamase genes and … er was obtained from SKH Nielepice. The strains were mostly resistant to ampicillin, aztreonam, and ticarcillin. The tested strains were most frequently resistant to one or two antibiotics, with a maximum of ten antimicrobials at the same time. Two multidrug-resistant (MDR) strains were detected in OJK Pegaz while in KJK Szary there were two MDR and one exten …

Levofloxacin: an updated review of its use in the treatment of bacterial infections.

UNLABELLED: Levofloxacin is the L-form of the fluoroquinolone antibacterial agent, ofloxacin. In in vitro studies, levofloxacin demonstrated … ons. A higher dosage of sequential levofloxacin 750mg once daily proved as effective as intravenous ticarcillin/clavulanic acid (+/- oral switch to amoxicillin/clavulanic acid) in the treatment of complicated skin and skin structure infections. Pharmacoeconomic studies suggest that levofloxacin may be cost-saving in comparison to conventional therapies. CONC …

Prevalence of Salmonella typhi in among febrile patients in a tertiary care hospital of South West Rajasthan.

BACKGROUND: Salmonella enterica, serotype typhi, remains the predominant Salmonella species causing enteric fever in India. The mode of Salm … other higher antibiotics such as betalactamase inhibitors - piperacillin tazobactam (95%-100%) and Ticarcillin-clavulanic acid (100%). They were also highly susceptible (100%) to carbapenams (imipenem, merpenem, doripenem, and ertapenem) but showed a fairly decreased susceptibility was towards nalidixic acid with 15% for Salmonella typhi and 50% for other Sa …

[Analysis of resistance phenotype and homology of Klebsiella pneumoniae in burn patients].

OBJECTIVE: To study the resistance phenotype and homology of Klebsiella pneumoniae (KPN) in burn patients with infection. METHODS: Fifty-four strains of KPN were isolated from wound excretion, blood, sputum, venous catheter, feces, and oral cavity of patients hospitalized in Institute of Burn Research of Southwest Hospital (briefly called our institute) from January 2007 to June 2011. Drug resistance of the 54 strains of KPN to 18 antibiotics commonly used in clinic, including ampicillin, ticarcillin, etc, was tested by K-B paper disk diffusion method after being identified. Extended-spectrum…

[Infectious keratitis and cosmetic lenses: a five-case retrospective study].

PURPOSE: To determine the characteristics of infectious keratitis related to plano cosmetic lenses. METHODS: Retrospective case study of a series of infectious keratitis among plano cosmetic lenses wearers. The main parameters were demographic data, medical history, risk factors for infectious complications and keratitis severity criteria, microbiological results, clinical course, and final visual acuity. RESULTS: Five patients were included, all females, ranging from 15 to 50 years of age. Four were emmetropic. One patient had undergone refractive photokeratectomy a few months before. All h

Antibiotic regimens for early-onset neonatal sepsis.

BACKGROUND: Neonatal sepsis is a major cause of morbidity and mortality. It is the third leading cause of neonatal mortality globally consti … plus gentamicin; one trial compared piperacillin plus tazobactam with amikacin; one trial compared ticarcillin plus clavulanic acid with piperacillin plus gentamicin; one trial compared piperacillin with ampicillin plus amikacin; and one trial compared ceftazidime with benzylpenicillin plus gentamicin. None of the five comparisons found any evidence of a dif …

Levofloxacin: a review of its use in the treatment of bacterial infections in the United States.

UNLABELLED: Levofloxacin (Levaquin) is a fluoroquinolone antibacterial agent with a broad spectrum of activity against Gram-positive and Gra … s intravenous and/or oral levofloxacin 750mg for 7-14 days was at least as effective as intravenous ticarcillin/clavulanic acid (+/- switch to oral amoxicillin/clavulanic acid) administered for the same duration. Levofloxacin is generally well tolerated, with the most frequently reported adverse events being nausea and diarrhoea; in comparison with some other …

Differences and trends in pathogens between ventilator-associated pneumonia and non-ventilator-associated pneumonia: data from 61 hospitals in Suzhou, China, 2020-2024.

OBJECTIVE: To investigate the differences in pathogenic bacterial profiles between ventilator-associated pneumonia (VAP) and non-ventilator- … als. S. maltophilia exhibited a ceftazidime resistance rate exceeding 36%, and B. cepacia exhibited ticarcillin/clavulanate and cefoperazone/sulbactam resistance rates exceeding 67%. The resistance rates of S. aureus and MRSA to penicillin, erythromycin and clindamycin ranged from 41.83% to 98.72%. The resistance rates of C. albicans to commonly used antifung …

Prospective study evaluating the incidence of bacteraemia and bacteruria in afebrile and febrile neutropaenic dogs undergoing chemotherapy.

The purpose of this prospective study was to determine the incidence and character of bacteraemia and bacteruria in afebrile and febrile neutropaenic dogs undergoing cytotoxic chemotherapy. Fifty-five neutropaenic dogs presenting to the University of Wisconsin Veterinary Medical Teaching Hospital were enrolled for a total of 57 neutropaenic episodes. The overall incidence of bacteraemia was 12.3% (n = 7/57). Three afebrile dogs and four febrile dogs were bacteraemic; this difference was not significant (P = 0.6968). The overall incidence of bacteruria was 7.5% (n = 4/53). Two afebrile dogs and

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… The pseudomonas was resistant to ticarcillin and ticarcillin/clavulanic acid. The following organisms were isolated from blood cultures in febrile patients; Streptococcus canis, Staphylococcus intermedius, Staphylococcus pseudintermedius and Staphylococcus epidermidis . … The pseudomonas grown was resistant to ticarcillin and ticarcillin/clavulanic acid, which is common for this bacterium (Hariharan et al . 2006 ; Hillier et al . 2006 ; Mekić et al . 2011 ). Three of the positive blood cultures were from afebrile, asymptomatic dogs. …

Analysis of Microbiological and Clinical Characteristics of Bacterial Infection in Patients with Pulmonary Infection.

OBJECTIVE: Using data investigation, the microbiology of bacterial infection in patients with pulmonary infection was discussed, and its cli … % for cefazolin sodium. Regarding Pseudomonas aeruginosa, the drug resistance rates were 29.31% for ticarcillin sodium-potassium clavulanate, 27.59% for piperacillin sodium, and 24.14% for gentamicin. Regarding Stenotrophomonas maltophilia, the drug resistance rates were 79.55% for ceftazidime, 38.64% for chloramphenicol, and 31.82% for levofloxacin. Regardin …

Inclusion of supplemental antibiotics (amikacin - penicillin) in a commercial extender for stallion semen: Effects on sperm quality, bacterial growth, and fertility following cooled storage.

In this study, the effectiveness of supplementing INRA-96® extender (INRA-Control; original antibiotic formulation: potassium penicillin G = 38 μg/mL; gentamicin sulfate = 105 μg/mL; amphotericin B = 0.315 μg/mL) with amikacin sulfate and potassium penicillin G (AP) was determined. In Exp. 1, two sources of amikacin (INRA-AP-Sigma or INRA-AP-GoldBio) in combination with penicillin G were compared with ticarcillin/clavulanate (INRA-Tim) or no-supplemental antibiotics (INRA-Control) to examine effects on sperm quality and commensal bacterial growth. No differences were detected in semen quality …

Outcome and Adequacy of Empirical Antibiotherapy in Post-Operative Peritonitis: A Retrospective Study.

Background: Empirical antibiotherapy (EA) should target all bacteria in post-operative peritonitis (PP). Nevertheless, recent studies failed to prove a link between adequacy of EA and prognosis of PP. We sought to confirm this loss of association between adequate EA and prognosis and to analyze the evolution of patients' characteristics and antimicrobial strategies. Methods: This is was retrospective study. Patients with a positive fungal culture were excluded. The cohort was divided into two time periods. Data of survivors and non-survivors were compared within each time period. Differences b

Two cases of diskitis attributable to anaerobic bacteria in children.

Diskitis, an inflammation of the intervertebral disk, is generally attributable to Staphylococcus aureus and rarely Staphylococcus epidermid … ight growth of Fusobacterium nucleatum. The organism produced beta-lactamase and was susceptible to ticarcillin-clavulanate, clindamycin, metronidazole, and imipenem. Therapy with clindamycin 450 mg every 8 hours was given parenterally for 3 weeks and orally for 3 weeks. Back pain resolved within 2 weeks. A 2-year follow-up showed complete resolution and no r …

Infectious Diseases

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… 3–4 g IV q4–6 h ++ ++Pseudo ++ Yes (dose + interval) Ticarcillin/clavulanate 3.1 g IV q4–6 h ++ ++Pseudo +++ Yes (dose + interval) Monobactam and Carbapenems Aztreonam 1–2 g IV q6–8 h Bactericidal, cell wall synthesis inhibition and lysis +++Pseudo +++ Yes (dose) Imipenem 500 mg IV q6h +++ ++Pseudo … 3–4 g IV q4–6 h | | ++ | ++Pseudo | ++ | | Yes (dose + interval) Ticarcillin/clavulanate 3.1 g IV q4–6 h | | ++ | ++Pseudo | +++ | | Yes (dose + interval) Monobactam and Carbapenems Aztreonam 1–2 g IV q6–8 h | Bactericidal, cell wall synthesis inhibition and lysis | | +++Pseudo | +++ | | Yes ( …

Sphingobacterium multivorum cellulitis: case report and mini-review.

BACKGROUND: Sphingobacterium multivorum is a gram-negative, non-fermentative, oxidase-positive, catalase-positive bacillus. S multivorum has been identified in urinary tract infections, respiratory tract infections, spontaneous peritonitis, septic arthritis, meningitis, bacteraemia and septic shock. Ours is the second case of skin and soft tissue infection sustained by S. multivorum (a case of necrotizing fasciitis with septic shock has been previously reported). In this paper, we furnish a review of the literature on all the cases of S multivorum described in the medical literature (with the

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… | | | | | | | | | | R | R | | | Amoxicillin – clavulanate | | | | | S | | | | S | | | | | I | | | | | Piperacillin | S | | 128 | S | I | | | R | | | | I | | R | R | | | | R Piperacillin-tazobactam | | | | | | | | R | | R | R | | R | | R | R | | S | R Ticarcillin-clavulanate …

Plesiomonas shigelloides Bacteremia: A Scoping Review of Epidemiology, Clinical Characteristics, Outcomes, and Implications of Antimicrobial Stewardship.

Plesiomonas shigelloides, an aquatic Gram-negative bacillus often associated with self-limiting gastroenteritis, has been reported worldwide. However, to date, no reviews have specifically investigated P. shigelloides bacteremia, which is rare and potentially fatal. This scoping review aimed to examine the existing literature to identify the epidemiology, clinical characteristics, antimicrobial susceptibility, and outcomes of P. shigelloides bacteremia. A PRISMA-ScR-guided search of PubMed, Scopus, Web of Science, and Embase identified 22 published cases, all reported as single-patient case re

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… Resistance to other penicillin-based agents, including ticarcillin [ 11 ] and piperacillin [ 13 , 30 ], and third- or fourth-generation cephalosporins [ 22 ], was uncommon. …

Clinical Outcome of Febrile Neutropenia and Associated Factors Among Adult Patients with Cancer Treated at Ethiopian Oncology Centers: A Retrospective Observational Study.

IntroductionFebrile neutropenia (FN) is a major cause of dose-limiting complications in cancer treatment that predisposes patients to serious infections. Despite advancements in therapies, including empirical and definitive antibiotics, FN remains a major morbidity and mortality issue among patients with cancer undergoing cancer treatment. Little is known about the 30-day all-cause mortality rates from FN in Ethiopia, particularly in the Northwest Ethiopia oncology centers.MethodsThis retrospective cross-sectional study was conducted via chart review without direct patient contact at two North

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… The extended-spectrum cephalosporins (cefepime or ceftazidime), carbapenems (imipenem or meropenem), and the antipseudomonal penicillin (piperacillin–tazobactam or ticarcillin–clavulanate) are the mainstay of empiric monotherapy or combination therapy among patients with FN [ 7 ]. …

Клиническое представление лептоспироза: ретроспективное исследование 34 Пациенты поступили в одно учебное заведение во Франции.

Лептоспироз имеет весьма изменчивое клиническое представление, которое может быть связано с различными заражающими сероварами, факторами хост-компьютеров или их комбинацией. Это исследование проводилось ретроспективно 34 Число пациентов с серологическим подтвержденным лептоспирозом, принятых в течение отчетного периода 1992-2002. Наиболее частыми симптомами при поступлении в школу были лихорадка (см.100%), головная боль75%), миальгии55%), артхальгии45%) и рвотой (т.е.39%). Применяемые лабораторные исследования включали в себя лимфопенцию (см.85%), тромбоцитопенсия75%), повышенные ферменты пече

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… Conclusions: (1)Yearly prevalence and incidence rates for Sm in CF patients showed no trends. (2)the resistance to ticarcillin/ clavulanic acid is gradually increasing. P1241: Subclonal variation of a cystic fibrosis epidemic strain of Pseudomonas aeruginosa S. Panagea, J.E. Corkill, C. … Most PSA isolates were susceptible to AM, TAZ, piperacillin/tazobactam, ticarcillin and imipenem (IMI) in both departments (74-100%). …