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Probabilistic assessment of health risks of methylmercury from burning coal.

This paper describes a probabilistic assessment of neurological risks incurred from consuming fish containing methylmercury (MeHg), focusing … s of blood to body burden and hair to blood MeHg. Each person's diet consists of varying amounts of tuna fish, freshwater sportfish, and marine fish and shellfish, the MeHg contents of which are characterized by national distribution statistics, as are the consumption rates for marine fish. The consumption rates for freshwater fish are specific to the …

Altered pH gradient at the plasma membrane of osteosarcoma cells is a key mechanism of drug resistance.

BACKGROUND: Vitamin D is crucial in maintaining bone strength and supporting immune function and may also influence metabolic health, includ … c outcomes. RESULTS: The mean dietary vitamin D intake was 150 ± 140 international units/day, with tuna, yogurt, pita bread, and non-fortified Ultra-High Temperature (UHT) milk as primary sources. Total dietary vitamin D intake showed no significant association with fasting blood glucose but was inversely correlated with HbA1c (r = -0.38, P < 0.05). D …

[Food protein-induced enterocolitis syndrome (FPIES) in 14 children].

INTRODUCTION: Food protein-induced enterocolitis syndrome (FPIES) is a particular non-IgE-mediated food allergy, manifested by profuse and r … .5 years after the first reaction. A child with a white fish FPIES was able to introduce salmon and tuna. CONCLUSION: FPIES is a pathology that has suffered from a lack of knowledge, delaying diagnosis for many months. The progression of chronic forms to acute forms and acute forms to an IgE-mediated allergy is not rare. Doctors need more detailed kno …

Foodborne and Waterborne Disease in Canada - 1982 Annual Summary.

Data on foodborne disease in Canada in 1982 are compared with those for 1981. A total of 988 incidents comprising 791 outbreaks and 197 sing … re the most frequently implicated. Unusual chemical problems included ammonia from decomposition in tuna, strychnine in vitamin pills (murder), tartaric acid in gum, excess licorice in candy, calcium chloride in a popsicle, sodium acetate in potato chips and sodium hydroxide in pretzels. Some of these are discussed in more details under the narrative r …

Health benefits of docosahexaenoic acid (DHA).

Docosahexaenoic acid (DHA) is essential for the growth and functional development of the brain in infants. DHA is also required for maintena … the severity of Type II diabetes and coronary heart disease. DHA is present in fatty fish (salmon, tuna, mackerel) and mother's milk. DHA is present at low levels in meat and eggs, but is not usually present in infant formulas. EPA, another long-chain n-3 fatty acid, is also present in fatty fish. The shorter chain n-3 fatty acid, alpha-linolenic acid …

[Neuroendocrine and neurobehavioral effects associated with exposure to low doses of mercury from habitual consumption of marine fish].

OBJECTIVES: To evaluate neuroendocrine and neurobehavioral effects possibly associated with increased dietary intake of organic mercury (Hg), a group of 22 subjects living on the island of Carloforte (south-west Sardinia) was examined, who were regular consumers of tuna fish with relatively high Hg content. This group, never exposed occupationally to either Hg or to other neurotoxic substances, was compared with 22 age-matched controls employed at a chemical plant in Portotorres (northern Sardinia). METHODS: Hg in urine (HgU) and serum prolactin (PRL) were measured in all cases, whereas measu…

Assessment of Determinants of Dietary Vitamin D Intake in a Polish National Sample of Male Adolescents.

BACKGROUND/OBJECTIVES: Calcitriol, the active form of vitamin D, has a broad physiological effect, and its deficiency has been identified as … containing 7-15 µg of vitamin D in 100 g of product), and halibut, mackerel, brook trout, sole, and tuna (fish species containing 1.05-4 µg of vitamin D in 100 g of product), and these fish were consumed in the largest quantities by male adolescents. Dietary vitamin D intake was notably higher in adolescents from the North-Western macroregion of Poland …

[How to plan the treatment of prostatic adenoma today?].

Surgical treatment, mainly transurethral resection of the prostate, still remains the reference treatment for benign prostatic hyperplasia ( … rious energy sources: microwaves (thermotherapy), laser (interstitial laser), radiofrequency waves (TUNA). These techniques are perfectly adapted to outpatient surgery with local or regional anaesthesia. They do not interfere with continence, sexual function, but may be followed by high dysuria or retention rates, with a variable cathererization time, …

CASE-CONTROL STUDY ON VITAMIN D STATUS IN CHILDREN AND ADOLESCENTS WITH EOSINOPHILIC ESOPHAGITIS.

BACKGROUND: Vitamin D is an essential fat-soluble steroid hormone and vitamin D deficiency is a global public health problem especially amon … EoE patients - and self-reported intake of vitamin D food sources: milk and dairy products, canned tuna and sardines, Bull's liver, chicken eggs - applied in both groups), and daily time of sun exposure (≥30 min or ≤30 min) were recorded. The samples were collected for serum levels of 25-hydroxy-vitamin D, where sufficiency levels >30 ng/mL were consi …

Evidence-based guidelines for the management of lower urinary tract symptoms related to uncomplicated benign prostatic hyperplasia in Italy: updated summary.

BACKGROUND AND SCOPE: Despite the high prevalence and huge socio-economic impact of benign prostatic hyperplasia (BPH) in Italy, no national … geons are available. Transurethral microwave thermotherapy (TUMT) or transurethral needle ablation (TUNA) may be proposed to motivated patients who prefer to avoid surgery and/or do not respond to medical treatment. The possible effects of medical or surgical treatments on sexual function should always be discussed. CONCLUSIONS: These guidelines are i …

DHA at nutritional doses restores insulin sensitivity in skeletal muscle by preventing lipotoxicity and inflammation.

Skeletal muscle plays a major role in the control of whole body glucose disposal in response to insulin stimulus. Excessive supply of fatty acids to this tissue triggers cellular and molecular disturbances leading to lipotoxicity, inflammation, mitochondrial dysfunctions, impaired insulin response and decreased glucose uptake. This study was conducted to analyze the preventive effect of docosahexaenoic acid (DHA), a long-chain polyunsaturated n-3 fatty acid, against insulin resistance, lipotoxicity and inflammation in skeletal muscle at doses compatible with nutritional supplementation. DHA (3

How can we Preserve Sexual Function after Ablative Surgery for Benign Prostatic Hyperplasia?

Our aim was to provide a narrative review regarding the prevalence, the associated pathophysiologic pathways and the potential management me … niques, including photoselective vaporization of the prostate (PVP), transurethral needle ablation (TUNA), Transurethral Microwave Therapy (TUMT), Convective Water Vapor Energy Ablation (Rezum®) and Aquablation®, have been proposed as treatment methods able to reduce treatment-related complications for BPE patients, including adverse effects on erectil …

The clinical effectiveness and cost-effectiveness of treatments for children with idiopathic steroid-resistant nephrotic syndrome: a systematic review.

OBJECTIVES: To assess the clinical effectiveness and cost-effectiveness of treatments for children with idiopathic steroid-resistant nephrot … o creatinine ratio decreased statistically significantly with high-dose but not low-dose enalapril. Tuna fish oil was not associated with any statistically significant improvements in proteinuria, creatinine clearance, serum creatinine or lipid profiles compared with placebo. A very limited literature was found on costs associated with SRNS in children …

[Urinary and blood markers of internal mercury dose in workers from a chlorakali plant and in subjects not occupationally exposed: relation to dental amalgam and fish consumption].

OBJECTIVES: The aim of this paper was both to evaluate the internal dose of Hg in occupationally exposed workers (35 Chloralkali workers) compared to that of non occupationally exposed controls (40 workers of the same plant of Portotorres and 22 residents on the island of Carloforte, usual consumers of local fish, mostly tuna fish with relatively high Hg levels) and to assess the relevance of environmental and individual exposure factors linked to lifestyle, sea fish consumption and amalgam fillings. METHODS: All subjects filled out a questionnaire concerning the working history and lifestyle…

Hazards of heavy metal contamination.

The main threats to human health from heavy metals are associated with exposure to lead, cadmium, mercury and arsenic. These metals have bee … particular, pregnant women should avoid a high intake of certain fish, such as shark, swordfish and tuna; fish (such as pike, walleye and bass) taken from polluted fresh waters should especially be avoided. There has been a debate on the safety of dental amalgams and claims have been made that mercury from amalgam may cause a variety of diseases. Howev …

Long-term results of the treatment of Hodgkin's lymphoma in a resource-constrained setting: Real-world data from a single center.

BackgroundThe outcomes of Hodgkin´s lymphoma (HL) in México have not been widely reported. Simplified and affordable treatments have been adopted in middle-income countries.AimThe aim was to evaluate long-used therapies for HL in México in a long-term basis.MethodsIn a 34-year time period, 88 patients with HL were treated at a single institution in México. Patients were treated with adriamycin bleomycin vinblastine and dacarbazine (ABVD) or mechlorethamine, vincristine, procarbazine, and prednisone (MOPP). Relapsed or refractory patients were given ifosfamide, carboplatin, and etoposide (ICE)

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… Arrais C, Avendaño Flores O, Barroso F, Basquiera AL, Cao C, Cugliari MS, Enrico A, Foggliatto LM, Galvez KM, Gomez D, Gomez A, de Iracema D, Farias D, Lopez L, Mantilla WA, Martínez D, Mela MJ, Miguel CE, Ovilla R, Palmer L, Pavlovsky C, Ramos C, Remaggi G, Santucci R, Schusterschitz S, Sossa CL, Tuna-Aguilar … Chiattone C, Gomez-Almaguer D, Pavlovsky C, Tuna-Aguilar EJ, Basquiera AL, Palmer L, de Farias DLC, da Silva Araujo SS, Galvez-Cardenas KM, Gomez Diaz A, Lin JH, Chen YW, Machnicki G, Mahler M, Parisi L, Barreyro P. …

WT1: The Hinge Between Anemia Correction and Cancer Development in Chronic Kidney Disease.

Hypoxia-inducible factor-prolyl hydroxylase inhibitors (HIF-PHIs) emerge as promising agents to treat anemia in chronic kidney disease (CKD) but the major concern is their correlated risk of cancer development and progression. The Wilms' tumor gene, WT1, is transcriptionally regulated by HIF and is known to play a crucial role in tumorigenesis and invasiveness of certain types of cancers. From the mechanism of action of HIF-PHIs, to cancer hypoxia and the biological significance of WT1, this review will discuss the link between HIF, WT1, anemia correction, and cancer. We aimed to reveal the re

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… HER2 has been shown to upregulate WT1 expression through the AKT signaling pathway, promoting breast cancer cell proliferation and inhibiting cellular apoptosis ( Tuna et al., 2005 ). In lung cancer, there is a positive feedback loop between WT1 and AKT-1. … Pathol. 157 ( 2 ), 411 – 421 . 10.1016/s0002-9440(10)64554-3 10934146 PMC1850121 Tuna M. Chavez-Reyes A. Tari A. M. ( 2005 ). HER2/neu Increases the Expression of Wilms' Tumor 1 (WT1) Protein to Stimulate S-phase Proliferation and Inhibit Apoptosis in Breast Cancer Cells . …

Visualizing immunotherapy for multiple myeloma worldwide from 2013 to 2023: A bibliometric analysis.

Multiple myeloma (MM) is a malignant, clonal proliferative disease of plasma cells that remains incurable. This paper aims to analyze the current research status and emerging trends in immunotherapy for MM through bibliometric methods, thereby providing valuable references and guidance for future research and clinical practice. This study presents a bibliometric analysis of 1,018 English-language publications related to MM immunotherapy, which were published in the Web of Science (WoS) Core Collection database from 2013 to 2023. VOSviewer and CiteSpace were employed to visualize the research h

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… Rank Cited authors Frequency Author Article counts 1 Lonial, Sagar 340 Anderson, Kenneth C 27 2 Palumbo, Antonio 331 Einsele, Hermann 25 3 Kumar, Shaji K 282 van de Donk, Niels W C J 22 4 Tai, Yu-Tzu 268 Mutis, Tuna 17 5 Dimopoulos, Meletios A 263 Tai, Yu-Tzu 16 6 Moreau, Philippe 254 Avigan, David 14 … Rank | Cited authors | Frequency | Author | Article counts 1 | Lonial, Sagar | 340 | Anderson, Kenneth C | 27 2 | Palumbo, Antonio | 331 | Einsele, Hermann | 25 3 | Kumar, Shaji K | 282 | van de Donk, Niels W C J | 22 4 | Tai, Yu-Tzu | 268 | Mutis, Tuna | 17 5 | Dimopoulos, Meletios A | 263 | Tai, Yu-Tzu …

Marine Bioactive Compounds from Functional Seafoods: Pharmacological Mechanisms and Health Applications.

Functional seafoods derived from marine organisms, including fish, shellfish and algae, are gaining increasing attention due to their high content of bioactive compounds, such as omega-3 fatty acids, peptides, polysaccharides and antioxidants, which provide health benefits beyond basic nutrition. These marine-derived compounds exhibit a wide range of biological activities and have been investigated for their potential roles in the prevention and management of chronic diseases, including cardiovascular, neurodegenerative, cancer and gastrointestinal disorders. Their effects are largely mediated

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… cardiovascular health and inflammation | [ 36 ] Mackerel | Protein, Omega-3 fatty acids, Vitamin D, Vitamin B12 | Associated with reduced cardiovascular risk, anti-inflammatory effects and support of brain function; particularly relevant for brain health, inflammation and cardiovascular health | [ 37 ] Tuna … Cited Study) | References Carotenoids | Shrimp, algae and seaweeds | Antioxidant and anti-inflammatory | Neutralisation of free radicals and reduction in oxidative stress and inflammation | Experimental studies including in vitro and in vivo models | [ 86 , 87 ] Omega-3 Fatty Acids | Fish (salmon, tuna …

Foodborne Disease Outbreaks Associated with Marine Toxins - Foodborne Disease Outbreak Surveillance System, United States, 2011-2023.

PROBLEM/CONDITION: Marine toxins cause most of the noninfectious outbreaks reported to CDC's Foodborne Disease Outbreak Surveillance System … the 189 scombroid toxin outbreak reports with a reported food source, the majority (76%) implicated tuna. Of the 131 scombroid toxin outbreak reports with information on importation status, 70 (53%) implicated imported foods. Of the 181 scombroid toxin outbreak reports with a single location of food preparation, sit-down dining restaurants were identif …