Результаты поиска

Current Use of Total Body Irradiation in Haploidentical Allogeneic Hematopoietic Stem Cell Transplantation.

Total body irradiation (TBI) is included in the conditioning regimen for allogeneic hematopoietic stem cell transplantation (HSCT), with unique advantages such as uniform distribution over the whole body and decreased exposure to cytotoxic chemotherapeutic agents. For individuals who lack matched sibling or matched unrelated donors, the use of haploidentical donors has been increasing despite challenges such as graft rejection and graft-versus-host disease (GVHD). Although a limited number of studies have been performed to assess the clinical role of TBI in haploidentical HSCT, TBI-based condi

Совпадение в полном тексте источника
… Srour SA, Milton DR, Bashey A, Karduss-Urueta A, Al Malki MM, Romee R, et al. Haploidentical transplantation with post-transplantation cyclophosphamide for high-risk acute lymphoblastic leukemia. Biol Blood Marrow Transplant. 2017;23(2):318–324. doi: 10.1016/j.bbmt.2016.11.008. 27. …

2021 ACMT Annual Scientific Meeting Abstracts-Virtual.

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Совпадение в полном тексте источника
… Nicholas E Walter 1 , Matteo Di Nardo 2 , Danilo Alunnifegatelli 3 , Marco Marano 2 , Reem Al Falasi 1 , Daniel L Herr 4 , Hong K Kim 5 1 Department of Emergency Medicine, University of Maryland Medical Center, Baltimore, MD, USA. 2 Pediatric Intensive Care Unit, Bambino Gesu Children’s Hospital, IRCCS, Rome … , Rome, Italy. 3 Department of Public Health and Infectious Disease, Sapienza University of Rome, Rome, Rome, Italy. 4 Department of Internal Medicine, University of Maryland School of Medicine, Baltimore, MD, USA. 5 Department of Emergency Medicine, University of Maryland School of Medicine, Baltimore …

Бремя множественной миеломы в азиатских странах 1990 в адрес 2021 и прогнозирование тенденций 2050:: анализ, основанный на Глобальном исследовании бремени болезней 2021.

Множественная миелома (ММ) создает растущую угрозу для здоровья населения во всем мире, причем региональные различия в бремени болезней становятся все более заметными. Являясь самым густонаселенным континентом, Азия переживает быстрые демографические и социально-экономические изменения и играет решающую роль в формировании эволюционной траектории глобального бремени ММ. Цель этого исследования заключается в оценке бремени болезней, связанных с множественной миеломой в азиатских странах. 1990 в адрес 2021Данные этого исследования были получены на основе исследования глобального бремени болезней

Совпадение в полном тексте источника
… Bertolotti P Pierre A Rome S Faiman B . Evidence-based guidelines for preventing and managing side effects of multiple myeloma. Semin Oncol Nurs . ( 2017 ) 33 : 332 – 47 . 10.1016/j.soncn.2017.05.008 28729122 21. …

Больше, чем сумка его частей: разорванная периферия мультиплексных сетей мозга в множестве склероза.

У людей с множественным склерозом (PwMS) были выявлены нарушения в работе сетей мозга, измеряемые с помощью структурных (MRI), диффузионных (dMRI) или функциональных (fMRI) MRI, что свидетельствует об актуальности регионов в ядре коннектома, но дает неоднозначные результаты в зависимости от изученной области подключения. Используя многослойный сетевой подход, мы интегрировали эти three Условия для отображения обогащенного представления организации мозга с ядром и исследования его изменений в PwMS. В этом ретроспективном поперечном исследовании мы выбрали PwMS и здоровый контроль с полными муль

Совпадение в полном тексте источника
… The group is run by a steering committee whose members are: Frederik Barkhof (Amsterdam), Nicola de Stefano (Siena), Jaume Sastre‐Garriga (Barcelona Co‐Chair), Olga Ciccarelli (London), Christian Enzinger (Graz), Massimo Filippi (Milan), Claudio Gasperini (Rome), Ludwig Kappos (Basel), Jacqueline Palace …

Research Progress of Nanomaterials Acting on NK Cells in Tumor Immunotherapy and Imaging.

The prognosis for cancer patients has declined dramatically in recent years due to the challenges in treating malignant tumors. Tumor immunotherapy, which includes immune target inhibition and chimeric antigen receptor cell treatment, is currently evolving quickly. Among them, natural killer (NK) cells are gradually becoming another preferred cell immunotherapy after T cell immunotherapy due to their unique killing effects in innate and adaptive immunity. NK cell therapy has shown encouraging outcomes in clinical studies; however, there are still some problems, including limited efficacy in so

Совпадение в полном тексте источника
… Romee R. Berrien Elliott M.M. Schneider S.E. Leong J.W. Sullivan R.P. Jewell B.A. Becker Hapak M. Schappe T. CD56bright NK cells exhibit potent antitumor responses following IL-15 priming J. Clin. Investig. 2017 127 4042 4058 10.1172/JCI90387 28972539 PMC5663359 18. Bournazos S. Wang T.T. Dahan R. …

Osteolytic vs. Osteoblastic Metastatic Lesion: Computational Modeling of the Mechanical Behavior in the Human Vertebra after Screws Fixation Procedure.

Metastatic lesions compromise the mechanical integrity of vertebrae, increasing the fracture risk. Screw fixation is usually performed to guarantee spinal stability and prevent dramatic fracture events. Accordingly, predicting the overall mechanical response in such conditions is critical to planning and optimizing surgical treatment. This work proposes an image-based finite element computational approach describing the mechanical behavior of a patient-specific instrumented metastatic vertebra by assessing the effect of lesion size, location, type, and shape on the fracture load and fracture p

Совпадение в полном тексте источника
… The images were acquired without a calibration phantom and were anonymized for their use, fulfilling the ethical protocols at the University Hospital Campus Bio-Medico of Rome. …

ISEV2020 Резюме

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Construction and validation of a risk prediction model for perianal infection in HSCT patients: a retrospective cohort study.

BackgroundPerianal infection is a frequent and detrimental complication in patients undergoing hematopoietic stem cell transplantation (HSCT), leading to significant morbidity and extended hospital stays. Despite its clinical significance, a substantial gap remains in our ability to proactively identify high-risk individuals. However a validated predictive model is actually lacking and it is still unclear how to identify these patients before the onset of infection.ObjectiveThis study aimed to develop and to validate a risk prediction model for the accurate assessment of perianal infection ris

Совпадение в полном тексте источника
… Footnotes Edited by: Maria Ilaria Del Principe , University of Rome Tor Vergata, Italy Reviewed by: Antonio Giovanni Solimando , University of Bari Aldo Moro, Italy Adele Santoni , University of Siena, Italy Data availability statement The original contributions presented in the study are included …

CXCL13 как биомаркер: фон и полезность в многоразовом склерозе.

CXCL13 — хемокин, регулируемый в рамках CNS в множестве склерозов, нейроборлиозе Лайма и других подстрекательских болезнях, который все чаще используется в качестве биомаркера. Этот обзор служит основой для понимания его функций в иммунной системе и его связи с эктическими лимфоидными фолликулами. Кроме того, был рассмотрен вопрос о его полезности в случае множественного склероза и нейроборлиоза Лайма, а также потенциальные проблемы в его измерении. CXCL13 может быть исключительно полезным биомаркером для целого ряда подстрекательских заболеваний.

Совпадение в полном тексте источника
… After initial work in EAE [ 6 ], Magliozzi and her collaborators in Rome in work published in 2004 detected ELFs and CXCL13 expression in the meninges of two out of three patients with SPMS; the ELFs contained CD138+ plasma cells and proliferating B cells [ 37 ]. …

Epigenetic Mechanism and Therapeutic Implications of Atrial Fibrillation.

Atrial fibrillation (AF) is the most common arrhythmia attacking 1. 5-2.0% of general population worldwide. It has a significant impact on morbidity and mortality globally and its prevalence increases exponentially with age. Therapies like catheter ablation or conventional antiarrhythmic drugs have not provided effective solution to the recurrence for AF over the past decades. Over 100 genetic loci have been discovered to be associated with AF by Genome-wide association studies (GWAS) but none has led to a therapy. Recently potential involvement of epigenetics (DNA methylation, histone modific

Совпадение в полном тексте источника
… Doñate Puertas R, Arora R, Rome S, Asatryan B, Roderick HL, Chevalier P. Epigenetics in atrial fibrillation: a reappraisal. Heart Rhythm. (2021) 18:824–32. 10.1016/j.hrthm.2021.01.007 9. Mahmood N, Rabbani SA. DNA methylation readers and cancer: mechanistic and therapeutic applications. …

Стабильность и адаптируемость урожайности зерновых в генотипах квиноа four где находится Иран.

Генотип х взаимодействие с окружающей средой one - эффективные факторы выявления и внедрения сортовых культур со стабильной урожайностью зерна в различных средах. Существует множество статистических методов оценки взаимодействия генотипа х в окружающей среде, среди которых анализы AMMI и ГПЭ-билот дают лучшие и более интерпретируемые результаты. Цель этого исследования заключалась в оценке взаимодействия генотипа х с окружающей средой, а также адаптируемости и стабильности окружающей среды. 40 Генотипы квиноа. Эксперимент проводился в произвольно выбранной полной конструкции блока с three тира

Совпадение в полном тексте источника
… State of the Art Report on Quinoa Around the World in 2013 Vol. 603 (Rome: FAO and CIRAD; ). Available at: http://www.fao.org/3/a-i4042e.pdf . Bazile D., Pulvento C., Verniau A., Al-Nusairi M. S., Ba D., Breidy J., et al. (2016). …

Casein Kinase 2 Inhibitor, CX-4945, Induces Apoptosis and Restores Blood-Brain Barrier Homeostasis in In Vitro and In Vivo Models of Glioblastoma.

Background: In oncology, casein kinase 2 (CK2), a serine/threonine kinase, has a dual action, regulating cellular processes and acting as an oncogenic promoter. Methods: This study examined the effect of CX-4945, a selective CK2 inhibitor, in a human U-87 glioblastoma (GBM) cell line, treated with CX-4945 (5, 10, and 15 μM) for 24 h. Similarly, the hCMEC/D3 cell line was used to mimic the blood-brain barrier (BBB), examining the ability of CX-4945 to restore BBB homeostasis, after stimulation with lipopolysaccharide (LPS) and then treated with CX-4945 (5, 10, and 15 μM). Results: We reported t

Совпадение в полном тексте источника
… Materials CX-4945 (brand name Silmitasertib) was purchased from Selleckchem (Rome, Italy) (Cat# HY-50855/CS-0563; MCE ® ). CX-4945 dissolved in dimethyl sulfoxide (DMSO), following manufacturer’s instructions. LPS from E. coli (0111:B4) was obtained from Sigma-Aldrich (St. …

< < Элотузумаб > > CD16-Independent NK Спутниковая цитотоксичность против ячеек миеломы путем регулирования нескольких NK-подкрепляющих генов

Множественная миелома (ММ) — неразрешимая гематологическая порча, вызванная аномалиями в плазменных клетках. Комбинированная терапия с использованием антител и эффектов естественного убийцы (НК), которые являются врожденными иммунными клетками с безопасной и мощной антитумбурной активностью, является перспективным подходом к онкологической иммунной терапии и может усилить антитумберные эффекты. Elotuzumab (Elo) — антитело с иммунной оптимистикой, предназначенное для семейства молекул лимфоцитной активации. 7 (SLAMF7) на поверхности клеток MM и NK. Мы подтвердили, что Эло активно пропагандирует

Совпадение в полном тексте источника
… Romee R., Foley B., Lenvik T., et al. NK cell CD16 surface expression and function is regulated by a disintegrin and metalloprotease-17 (ADAM17) Blood . 2013;121(18):3599–3608. doi: 10.1182/blood-2012-04-425397. 26. Wu J., Mishra H. K., Walcheck B. …

Estimating complete cancer prevalence in Europe: validity of alternative vs standard completeness indexes.

IntroductionComparable indicators on complete cancer prevalence are increasingly needed in Europe to support survivorship care planning. Direct measures can be biased by limited registration time and estimates are needed to recover long term survivors. The completeness index method, based on incidence and survival modelling, is the standard most validated approach.MethodsWithin this framework, we consider two alternative approaches that do not require any direct modelling activity: i) empirical indices derived from long established European registries; ii) pre-calculated indices derived from U

Совпадение в полном тексте источника
… Tallon (Istituto Superiore di Sanità, Rome) ; L. Boni (Genova CR) ; S. Iacovacci (Latina CR) ; V. Gennaro (Liguria, mesotheliomas CR) ; A.G. Russo; F. Gervasi (Province of Milan and Lodi CR) ; G. Spagnoli (Modena CR) ; L. Cavalieri d’Oro (Monza and Brianza CR) ; M. Fusco; M.F. …

Tips and Tricks and Clinical Outcome of Cryopreserved Human Amniotic Membrane Application for the Management of Medication-Related Osteonecrosis of the Jaw (MRONJ): A Pilot Study.

Medication-related osteonecrosis of the jaw (MRONJ) is a complication of certain pharmacological treatments such as bisphosphonates, denosumab, and angiogenesis inhibitors. There are currently no guidelines on its management, particularly in advanced stages. The human amniotic membrane (hAM) has low immunogenicity and exerts anti-inflammatory, antifibrotic, antimicrobial, antiviral, and analgesic effects. It is a source of stem cells and growth factors promoting tissue regeneration. hAM acts as an anatomical barrier with suitable mechanical properties (permeability, stability, elasticity, flex

Совпадение в полном тексте источника
… Rome, Italy, September 15–17, 2020. Editor O. Proceedings. Google Scholar Gindraux F., Laurent R., Nicod L., Billy B., Meyer C., Zwetyenga N., et al. (2013). Human Amniotic Membrane: Clinical Uses, Patents and Marketed Products. Recent Pat. Regen. …

Effects of pegylated G-CSF on immune cell number and function in patients with gynecological malignancies.

BackgroundPegylated granulocyte colony-stimulating factor (G-CSF; pegfilgrastim) is a longer-acting form of G-CSF, whose effects on dendritic cell (DC) and regulatory T cell (Treg) mobilization, and on the in vivo and ex vivo release of immune modulating cytokines remain unexplored.MethodsTwelve patients with gynecological cancers received carboplatin/paclitaxel chemotherapy and single-dose pegfilgrastim as prophylaxis of febrile neutropenia. Peripheral blood was collected prior to pegfilgrastim administration (day 0) and on days +7, +11 and +21, to quantify immunoregulatory cytokines and to a

Совпадение в полном тексте источника
… Acknowledgements GS and SR are supported by Fondazione Roma , Rome, Italy (Stem Cell Project). SR receives an Investigator Grant (n. 8556) from Associazione Italiana per la Ricerca sul Cancro (AIRC), Milan, Italy. References Molineux G. …

Ход работы сессии 31st Европейский педиатрический конгресс по педиатрии: часть 1.

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Совпадение в полном тексте источника
… Francesca Minoia 3 , Francesco Licciardi 4 , Angela Miniaci 5 , Ilaria Maccora 6 , Clotilde Alizzi 7 , Giusi Prencipe 2 , Fabrizio De Benedetti 1 , Claudia Bracaglia 1 1 Division of Rheumatology, ERN-RITA center; 2 Laboratory of Immuno-Rheumatology, ERN-RITA center, IRCCS Ospedale Pediatrico Bambino Gesù, Rome …

Proximal femur replacement in oncologic lesion: hemiarthroplasty vs total hip arthroplasty-a multicentric retrospective study.

IntroductionThis study aimed to evaluate the outcomes and complications associated with proximal femur replacement (PFR) in patients undergoing treatment for primary bone tumors or metastatic lesions. This research specifically compared modular hemiarthroplasty (HA) and total hip arthroplasty (THA) to ascertain the optimal approach regarding functionality and postoperative complications.Materials and methodsA retrospective multicenter review was conducted involving 85 patients who underwent prosthetic femoral reconstruction (PFR) between the years 2015 and 2022 at two specialized medical cente

Совпадение в полном тексте источника
… Institutional Review Board Statement: The research protocol was approved by the Institutional Review Board of Fondazione Policlinico Universitario “A Gemelli” IRCCS—Rome. Data availability Data available upon request. …

Bortezomib-Loaded Mesoporous Silica Nanoparticles Selectively Alter Metabolism and Induce Death in Multiple Myeloma Cells.

A mesoporous silica-based nanodevice bearing the antineoplastic drug bortezomib (BTZ), whose release is triggered in acidic environment and grafted with folic acid (FOL) as a targeting function (FOL-MSN-BTZ) was tested on folate receptor overexpressing (FR+) multiple myeloma (MM) cells and on FR negative (FR-) normal cells. FOL-MSN-BTZ efficacy studies were conducted by means of growth experiments, TEM, TUNEL assay and Western Blotting analysis (WB). Metabolic investigations were performed to assess cells metabolic response to MSNs treatments. FOL-MSN-BTZ exclusively killed FR+ MM cells, leadi

Совпадение в полном тексте источника
… Mycoplasma negativity was tested monthly (PlasmoTest, Invivogen, Aurogene, Rome, Italy). For cell treatments, MSNs were resuspended in serum-free media (SFM) on a magnetic stirrer, and a ratio of 1 μg MSNs/10 5 cells was used on the basis of titration experiments and added to the cells for 1 h. …

Innovative Clinical Perspectives for CIK Cells in Cancer Patients.

Cytokine-induced killer (CIK) cells are T lymphocytes that have acquired, in vitro, following extensive manipulation by Interferon gamma (IFN-γ), OKT3 and Interleukin 2 (IL-2) addition, the expression of several Natural Killer (NK) cell-surface markers. CIK cells have a dual "nature", due to the presence of functional TCR as well as NK molecules, even if the antitumoral activity can be traced back only to the NK-like structures (DNAM-1, NKG2D, NKp30 and CD56). In addition to antineoplastic activity in vitro and in several in-vivo models, CIK cells show very limited, if any, GvHD toxicity as we

Совпадение в полном тексте источника
… On the basis of the results of our phase I study, at the end of 2009, we started a phase II protocol authorized by the national authority (Agenzia Italiana del Farmaco, AIFA, Rome, Italy) and the local ethical committees (EC). …