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Machine learning-based prognostic model for bloodstream infections in hematological malignancies using Th1/Th2 cytokines.

OBJECTIVE: Bloodstream infection (BSI) is a significant cause of mortality in patients with hematologic malignancies(HMs), particularly amid rising antibiotic resistance. This study aimed to analyze pathogen distribution, drug-resistance patterns and develop a novel predictive model for 30-day mortality in HM patients with BSIs. METHODS: A retrospective analysis of 231 HM patients with positive blood cultures was conducted. Logistic regression identified risk factors for 30-day mortality. Th1/Th2 cytokines were collected at BSI onset, with LASSO regression and restricted cubic spline analysis

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… Escherichia coli had the lowest rate of antibiotic resistance to tigecyoline (2.74%), followed by amikacin (4.11%), meropenem (10.96%) and imipenem (10.96%). … The rates of antibiotic resistance of Klebsiella pneumoniae to tigecyoline, amikacin, imipenem, and meropenem were 3.77%, 5.66%, 24.53%, and 24.53%, respectively. The frequencies for ESBL-producing Escherichia coli and Klebsiella pneumoniae strains were 43.84% and 22.64%, respectively. …

Purpura fulminans secondary to Capnocytophaga canimorsus bacteraemia following a dog bite: A case report and review of literature.

IntroductionInfection due to Capnocytophaga canimorsus may result in a wide variety of clinical presentations. We present a case of life-threatening Capnocytophaga canimorsus infection with evolution of ecchymosis to purpura fulminans.Case descriptionWe present a case of a 43-year-old male with a history of excessive alcohol consumption who presented with features of sepsis following a dog bite. This was associated with a striking, widespread purpuric rash. A causative pathogen, C. canimorsus was identified through blood culture and 16S RNA sequencing. His initially purpuric rash underwent bul

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… Capnocytophaga spp. are typically sensitive to clindamycin, linezolid, tetracycline, chloramphenicol, imipenem and beta-lactamase inhibitor combinations. … Whole genome sequencing of Capnocytophaga spp. has revealed presence of Class D beta-lactamase genes (blaOXA-347), associated with phenotypic resistance to penicillin, cephalosporin, and to imipenem [ 15 ]. …

Proceedings of Réanimation 2020, the French Intensive Care Society International Congress.

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Risk factors and characteristics of blood stream infections in patients with newly diagnosed multiple myeloma.

BackgroundPatients with multiple myeloma are generally immune-compromised either due to pronounced depression in primary antibody responses or because of anti-myeloma therapy. Infection is a major risk factor for early deaths among these patients. The impact of blood stream infections (BSI) on newly diagnosed myeloma patients has been less studied. We aimed to study the incidence and risk factors of BSI within 3 months after diagnosis of multiple myeloma in a tertiary referral center.MethodsBetween November 2002 and December 2008, consecutive patients with multiple myeloma in Taipei Veterans G

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… - - Coagulase-negative Staphylococcus species Ceftazidime - 3 (79) Y VAD Implanted port Y Coagulase-negative Staphylococcus species Klebsiella pneumoniae Teicoplanin/isepamicin Y 4 (27) - MP - - Klebsiella pneumoniae Cefepime - 5 (62) Y MPT Non-tunneled CVC Y Klebsiella pneumoniae Ciprofloxacin - > Imipenem … /teicoplanin | Y 6 (78) | - | - | - | - | Escherichia coli | | Y 7 (198) | Y | VAD | Non-tunneled CVC | - | Escherichia coli | Cefuroxime/clindamycin | Y 8 (168) | Y | VAD/thalidomide | Non-tunneled PICC | - | Escherichia coli | Imipenem/vancomycin/amikin | Y 9 (175) | Y | VAD | - | - | Escherichia …

[Susceptibilities of bacteria isolated from patients with lower respiratory infectious diseases to antibiotics (1996)].

The bacteria isolated from the patients with lower respiratory tract infections were collected by institutions located throughout Japan, sin … highest activities against both S. aureus and MRSA with MIC80s of 1 microgram/ml. 2) S. pneumoniae Imipenem (IPM) and panipenem (PAPM) of carbapenems showed the most potent activities with MIC80s of 0.063 microgram/ml. Faropenem (FRPM) showed the next potent activity with MIC80 of 0.125 microgram/ml. The other drugs except erythromycin (EM), clindamycin ( …

[Risk factors and antibiotic use in methicillin-resistant Staphylococcus aureus bacteremia in hospitalized patients at Hacettepe University Adult and Oncology Hospitals (2004-2011) and antimicrobial susceptibilities of the isolates: a nested case-control study].

The aim of this study was to evaluate methicillin-resistant Staphylococcus aureus (MRSA) bacteremia cases who were followed at the Infectiou … lin-clavulanate, fluoroquinolones, aminoglycosides, piperacillin-tazobactam (TZP), meropenem (MEM), imipenem (IPM), vancomycin (VAN), cephalosporins and teicoplanin (TEC)] were found to be statistically significantly higher in the case group by univariate analysis (p< 0.05). In multivariate analysis, it was determined that TZP (OR= 6.82; p< 0.001), IPM (OR …

[Comparative studies on activities of antimicrobial agents against causative organisms isolated from patients with urinary tract infections (1995). I. Susceptibility distribution].

The frequencies of isolation and susceptibilities to antimicrobial agents were investigated on 704 bacterial strains isolated from patients with urinary tract infections (UTIs) in 11 hospitals during the period of June 1995 to May 1996. Of the above bacterial isolates, Gram-positive bacteria accounted for 29.8% and a majority of them were Enterococcus faecalis. Gram-negative bacteria accounted for 70.2% and most of them were Escherichia coli. Susceptibilities of several isolated bacteria to antimicrobial agents were as followed; 1. Enterococcus faecalis Ampicillin (ABPC) and imipenem (IPM) sho…

[Analysis of epidemiological characteristics and risk factors of catheter-associated urinary tract infections in patients with perineal and/or hip burns].

Objective: To explore the epidemiological characteristics and risk factors of catheter-associated urinary tract infections in patients with … esistance rates of Klebsiella pneumoniae to cefoxitin, cefoperazone/sulbactam, cefepime, meropenem, imipenem, and piperacillin/tazobactam ranged from 56.3% to 68.8%, and the resistance rates of Klebsiella pneumoniae to ceftazidime and tigecycline were lower than 50.0%. The resistance rates of Enterococcus faecalis to ciprofloxacin and penicillin were both …

Critically Ill Immunosuppressed Host

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… Perianal tenderness Include anaerobic agents such as metronidazole, imipenem, meropenem, or piperacillin-tazobactam. Abdominal involvement Add antianaerobic agent (e.g., metronidazole, meropenem, imipenem, or piperacillin-tazobactam). … Perianal tenderness | Include anaerobic agents such as metronidazole, imipenem, meropenem, or piperacillin-tazobactam. Abdominal involvement | Add antianaerobic agent (e.g., metronidazole, meropenem, imipenem, or piperacillin-tazobactam). …

Empirical antimicrobial treatment in haemato-/oncological patients with neutropenic sepsis.

Neutropenic sepsis in haemato-/oncological patients is a medical emergency, as infections may show a fulminant clinical course. Early differentiation between sepsis and febrile neutropenic response often proves to be challenging. To assess the severity of the illness, different tools, which are discussed in this article, are available. Once the diagnosis has been established, the correct use of early empirical antibiotic and antifungal treatment is key in improving patient survival. Therefore, profound knowledge of local resistance patterns is mandatory and carefully designed antibiotic regime

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… In patients with a history of anaphylactic shock during penicillin or aminopenicillin treatment, initial therapy should consist of aztreonam (first choice), meropenem or imipenem/cilastatin, as cross-reactions are extremely rare. … Should previously found extended spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae exhibit resistance to piperacillin/tazobactam, empirical therapy should cover these resistances. 17 In escalation therapy, algorithms should favour meropenem or imipenem/cilastatin over cephalosporins, for example …

[Chinese expert consensus on the management of lower respiratory tract infections of Pseudomonas aeruginosa in adults(2022)].

Pseudomonas aeruginosa (PA) is the second common Gram-negative bacterium for hospital acquired pneumonia (HAP) in China (16.9%-22.0%). The p … A), if an agent of new enzyme inhibitor, such as ceftolozane/tazobactam, ceftazidime/avibactam, and imipenem/cilastatin/relebactam shows in vitro sensitivity, it is recommended as the first-line choice; cefiderocol may serve as the second-line treatment. Combination therapy based on polymyxins may also be considered. Other potentially successful approaches …

Revolutionising health care: Exploring the latest advances in medical sciences.

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… FDA Approves Merck’s RECARBRIO TM (imipenem, cilastatin, and relebactam) for the Treatment of Adults with Hospital-Acquired and Ventilator-Associated Bacterial Pneumonia (HABP/VABP). … Available: https://www.merck.com/news/fda-approves-mercks-recarbrio-imipenem-cilastatin-and-relebactam-for-the-treatment-of-adults-with-hospital-acquired-and-ventilator-associated-bacterial-pneumonia-habp-vabp/ . Accessed: 28 November 2022. 54. CDC. …

Pseudomonas aeruginosa Infections in Cancer Patients.

Pseudomonas aeruginosa (P. aeruginosa) is one of the most frequent opportunistic microorganisms causing infections in oncological patients, especially those with neutropenia. Through its ability to adapt to difficult environmental conditions and high intrinsic resistance to antibiotics, it successfully adapts and survives in the hospital environment, causing sporadic infections and outbreaks. It produces a variety of virulence factors that damage host cells, evade host immune responses, and permit colonization and infections of hospitalized patients, who usually develop blood stream, respirato

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… The possible therapeutic options are: antipseudomonal β-lactams (e.g., ceftazidime, cefepime, piperacillin/tazobactam, imipenem, meropenem, aztreonam), fluroquinolones (ciprofloxacin, levofloxacin), aminoglycosides (amikacin, tobramycin), polymyxins (colistin), and fosfomycin, as well as a few drugs … These novel antibiotics are as follows: β-lactam/β-lactamase inhibitors (BL/BLI) such as ceftolozane/tazobactam (C/T), ceftazidime/avibactam (C/A), meropenem/vaborbactam (M/V), imipenem/relabactam (I/R) and cefiderocol as well as aminoglycoside plazomycin [ 61 ]. …

sMAdCAM-1 is decreased after allo-HCT, along with gut microbiota dysbiosis, and is associated with hematopoietic recovery.

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… Abbreviations: aGvHD, acute GvHD; ATG, antithymocyte globulin; cGvHD, chronic GvHD; CsA, cyclosporin A; DRI, disease risk index; GvHD, graft‐versus‐host disease; MMF, mycophenolate mofetil; MTX, methotrexate; PIM, piperacillin‐tazobactam, imipenem‐cilastatin or meropenem; PTCy, post‐transplant cyclophosphamide … reported, using the same data set, that patients with a higher Shannon index had a better outcome, in particular a better disease‐free survival. 10 We then assessed the impact of antibiotic exposure on sMAdCAM‐1 levels, focusing on antibiotics with a broad anti‐anaerobic spectrum, piperacillin‐tazobactam, imipenem‐cilastatin …

Prophylaxis and Empirical Therapy of Infection in Cancer Patients

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Two cases of diskitis attributable to anaerobic bacteria in children.

Diskitis, an inflammation of the intervertebral disk, is generally attributable to Staphylococcus aureus and rarely Staphylococcus epidermid … uced beta-lactamase and was susceptible to ticarcillin-clavulanate, clindamycin, metronidazole, and imipenem. Therapy with clindamycin 450 mg every 8 hours was given parenterally for 3 weeks and orally for 3 weeks. Back pain resolved within 2 weeks. A 2-year follow-up showed complete resolution and no recurrence. This report describes, for the first time, …

[Mechanism of electroacupuncture combined with antibiotics targeting dorsal motor nucleus of vagus nerve to activate vagus-adrenal axis, alleviate inflammatory response and reduce mortality in septic mice].

OBJECTIVES: To explore the mechanism by which electroacupuncture (EA) combined with antibiotics regulates the vagus-adrenal axis via the dor … nce daily for 3 consecutive days. Mice in the antibiotic group were intraperitoneally injected with imipenem-cilastatin sodium (30 mg/kg) every 12 h for 3 consecutive days. Mice in the EA+antibiotic group received EA and antibiotic treatment the same as the above. The 3-day survival rate and body weight changes of mice in each group were recorded. ELISA wa …

Antimicrobial resistance phenotypes, disinfectant susceptibility, and resistance-associated gene detection in carbapenem-resistant Pseudomonas aeruginosa from two tertiary hospitals in Urumqi, China.

OBJECTIVE: To characterise antimicrobial resistance phenotypes, in vitro susceptibility to four commonly used disinfectants, and the distrib … 24 (30.00%) were extensively drug-resistant (XDR) and 56 (70.00%) were non-XDR. Resistance rates to imipenem and meropenem were 83.70% and 68.70% respectively, and no isolate was susceptible to either agent. Overall resistance rates to aztreonam, piperacillin/tazobactam, levofloxacin, ceftazidime, cefepime, amikacin, and tobramycin were 37.50%, 30.00%, 26. …

Resistance profiles and genotyping of extended-spectrum beta-lactamase (ESBL) -producing and non-ESBL-producing E. coli and Klebsiella from retail market fishes.

Studies on antimicrobial resistance (AMR) profiles and epidemiological affirmation for AMR transmission are limited in fisheries and aquacul … ella isolates were susceptible to AN, SCP, MEM and TZP, although two K. aerogenes were resistant to imipenem. DHA and LAT genes were detected, respectively, in 7(16%) and 1(2%) of the E. coli strains while a single K. oxytoca (4.34%) isolate carried MOX, DHA and blaCMY-2 genes. The fluoroquinolone resistance genes identified in E. coli included qnrB (71%), …

Short versus extended treatment with a carbapenem in patients with high-risk fever of unknown origin during neutropenia: a non-inferiority, open-label, multicentre, randomised trial.

BACKGROUND: Early antibiotic discontinuation has been advocated in haematology patients with fever of unknown origin during chemotherapy-ind … ected for ≥7 days) were eligible. After onset of fever, patients received either 500 mg intravenous imipenem-cilastatin four times a day or 1000 mg intravenous meropenem three times a day. Between 48 h and 72 h of treatment, participants were randomly assigned (1:1) by a computer-generated sequence to receive a short-term (72 h [60-84]; short treatment gro …