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Targeting Tumor Glycans for Cancer Therapy: Successes, Limitations, and Perspectives.

Aberrant glycosylation is a hallmark of cancer and can lead to changes that influence tumor behavior. Glycans can serve as a source of novel clinical biomarker developments, providing a set of specific targets for therapeutic intervention. Different mechanisms of aberrant glycosylation lead to the formation of tumor-associated carbohydrate antigens (TACAs) suitable for selective cancer-targeting therapy. The best characterized TACAs are truncated O-glycans (Tn, TF, and sialyl-Tn antigens), gangliosides (GD2, GD3, GM2, GM3, fucosyl-GM1), globo-serie glycans (Globo-H, SSEA-3, SSEA-4), Lewis anti

ISEV2025 Резюме книги.

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Research Progress of NK Cells in Glioblastoma Treatment.

NK cells are a type of antitumor immune cell with promising clinical application, following T cells. The activity of NK cells is primarily regulated by their surface receptors and immune microenvironment. In gliomas, the tumor microenvironment exerts a strong immunosuppressive effect, which significantly reduces the clinical efficacy of NK cell immunotherapy. Therefore, this review aims to discuss the latest research on the role of NK cells in glioma immunotherapy, focusing on aspects such as NK cell development, function, and localization. It summarizes information on the compounds, monoclona

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… Romee R , Rosario M , Berrien-Elliott MM , et al. Cytokine-induced memory-like natural killer cells exhibit enhanced responses against myeloid leukemia . Sci Trans Med . 2016 ; 8 ( 357 ): 357ra123 . doi: 10.1126/scitranslmed.aaf2341 PMC5436500 27655849 31. Huang Q , Huang M , Meng F , Sun R . …

Economic Burden of Intravenous Decitabine Administration in Patients Affected by Acute Myeloid Leukemia Ineligible for Induction Chemotherapy and Impact of Oral Formulation Introduction: A Micro-Costing Study in Italy.

PurposeIntravenous (IV) decitabine is a therapeutic option for patients with newly diagnosed acute myeloid leukemia (AML) ineligible for induction chemotherapy. Recently, the oral formulation of decitabine-cedazuridine demonstrated comparable efficacy and safety to IV decitabine, and pharmacokinetic equivalence. This study estimates the direct non-drug healthcare costs of IV decitabine administration in Italy, including central venous catheter (CVC) and infection management, and assesses the economic impact of oral decitabine introduction.MethodsA micro-costing analysis from the Italian Nation

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… Rome: agenzia Italiana del Farmaco, 2023) . 41. Maki DG , Kluger DM , Crnich CJ . The risk of bloodstream infection in adults with different intravascular devices: a systematic review of 200 published prospective studies . …

Low-dose anti-thymocyte globulin plus low-dose post-transplant cyclophosphamide-based regimen for prevention of graft-versus-host disease after haploidentical peripheral blood stem cell transplants: a large sample, long-term follow-up retrospective study.

INTRODUCTION: The novel low-dose anti-thymocyte (ATG, 5 mg/kg) plus low-dose post-transplant cyclophosphamide (PTCy, 50 mg/kg) (low-dose ATG/PTCy)-based regimen had promising activity for prevention of graft-versus-host disease (GVHD) in haploidentical-peripheral blood stem cell transplantation (haplo-PBSCT), but its impacts on long-term outcomes remain to be defined. METHODS: We performed a large sample, long-term follow-up retrospective study to evaluate its efficacy for GVHD prophylaxis. RESULTS: The study enrolled 260 patients, including 162 with myeloid malignancies and 98 with lymphoid

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… Srour SA, Milton DR, Bashey A, Karduss-Urueta A, Al Malki MM, Romee R, et al. Haploidentical transplantation with post-transplantation cyclophosphamide for high-risk acute lymphoblastic leukemia. Biol Blood Marrow Transplant (2017) 23(2):318–24. doi: 10.1016/j.bbmt.2016.11.008 23. …

Cytokine Release Syndrome in the Immunotherapy of Hematological Malignancies: The Biology behind and Possible Clinical Consequences.

Cytokine release syndrome (CRS) is an acute systemic inflammatory syndrome characterized by fever and multiple organ dysfunction associated with (i) chimeric antigen receptor (CAR)-T cell therapy, (ii) therapeutic antibodies, and (iii) haploidentical allogeneic stem cell transplantation (haplo-allo-HSCT). Severe CRS can be life-threatening in some cases and requires prompt management of those toxicities and is still a great challenge for physicians. The pathophysiology of CRS is still not fully understood, which also applies to the identifications of predictive biomarkers that can forecast the…

The Evolution of AIFA Registries to Support Managed Entry Agreements for Orphan Medicinal Products in Italy.

Italy has a well-established prominent system of national registries to support managed entry agreements (MEAs), monitoring innovative medicinal products (MPs) with clinical as well as economic uncertainties to ensure appropriate use and best value for money. The technological architecture of the registries is funded by pharmaceutical companies, but fully governed by the national medicines agency (AIFA). A desktop analysis was undertaken of data over a 15-year timeframe of all AIFA indication-based registries and associated EMA information. The characteristics of registries were evaluated, com

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… Hoffmann Roche, Genzyme Sanofi, IQVIA , Infomedica, Insmed, Intexo SB, MA Provider, Medi-Qualitè Omega, Partners4Access, Sanitanova, Sarepta, Simon-Kucher & Partners, Verpora, Vifor, and different Lecturer with collaboration agreement for research project with Catholic University of Rome Sacred Heart …

Severe infections and infection-related mortality in a large series of haploidentical hematopoietic stem cell transplantation with post-transplant cyclophosphamide.

Severe infections and their attributable mortality are major complications in recipients of allogeneic hematopoietic stem cell transplantation (alloSCT). We herein report 236 adult patients who received haploSCT with PTCy. The median follow-up for survivors was 37 months. The overall incidence of bloodstream infections by gram-positive and gram-negative bacteria at 37 months was 51% and 46%, respectively. The incidence of cytomegalovirus infection was 69%, while Epstein Barr virus infections occurred in 10% of patients and hemorrhagic cystitis in 35% of cases. Invasive fungal infections occurr

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… Slade M Goldsmith S Romee R DiPersio JF Dubberke ER Westervelt P Epidemiology of infections following haploidentical peripheral blood hematopoietic cell transplantation Transpl Infect Dis 2017 19 e12629 10.1111/tid.12629 PMC5459579 28030755 30. …

Natural Killer Cell Therapy: A New Treatment Paradigm for Solid Tumors.

In treatments of solid tumors, adoptive transfer of ex vivo expanded natural killer (NK) cells has dawned as a new paradigm. Compared with c … of NK cell specific genetic defects in cancer development and treatment, and NK cell deficiency syndrome should be revisited to enhance our understanding. Overall, it is clear that NK cell therapy is safe and promises a new paradigm for the treatment of solid tumors.

A multicountry ecological study of cancer incidence rates in 2008 with respect to various risk-modifying factors.

Observational and ecological studies are generally used to determine the presence of effect of cancer risk-modifying factors. Researchers generally agree that environmental factors such as smoking, alcohol consumption, poor diet, lack of physical activity, and low serum 25-hdyroxyvitamin D levels are important cancer risk factors. This ecological study used age-adjusted incidence rates for 21 cancers for 157 countries (87 with high-quality data) in 2008 with respect to dietary supply and other factors, including per capita gross domestic product, life expectancy, lung cancer incidence rate (an

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… Food and Agriculture Organization of the United Nations Food Balance Sheets, 1992–94 Average FAO Rome, Italy 1997 17. Harashima E. Nakagawa Y. Urata G. Tsuji K. Shirataka M. Matsumura Y. Time-lag estimate between dietary intake and breast cancer mortality in Japan Asia Pac. J. Clin. …

Артериальный тромбоэмболизм

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… Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy; 4 Dept. Computer Control and Management Engineering, Sapienza University of Rome, Rome, Italy; 5 Dept. … Clinical, Internal, Anesthesiology and Cardiovascular Sciences, Sapienza University of Rome, Rome, Italy Background : Although cardiovascular disease is the leading cause of mortality in both females and males, women are more likely to have non‐obstructive ischemic heart disease (IHD) than men. …

Определение стабильных и высокоурожайных генотипов кукурузы с использованием показателей стабильности на основе БЛУП и многопробегового отбора в различных средах.

Мейз (Zea Mays L.) one Наиболее важные зерновые культуры во всем мире служат основным источником продовольствия, корма и промышленного сырья; однако выявление высокоурожайных и стабильных генотипов кукурузы в различных средах является одной из ключевых целей программ улучшения кукурузы. Всего 60 Проведена оценка генотипов кукурузы four среды [лето] 2023 (E1), зима 2023 (E2), лето 2024 (Е3) и зима 2024 (Е4)] в конструкции альфа-латице с two тиражирование, включая six неполные блоки с 10 данные в блоке. Впоследствии 15 Для выявления более совершенных и стабильных генотипов кукурузы в различных с

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… Descriptors for Maize ( Zea Mays L.) ( Mexico City : International Maize and Wheat Improvement Center (CIMMYT) and Rome : International Board for Plant Genetic Resources (IBPGR) ), 1 – 88 . Covarrubias-Pazaran G. ( 2016 ). …

Cardiometabolic health in people with HIV: expert consensus review.

ObjectivesTo develop consensus data statements and clinical recommendations to provide guidance for improving cardiometabolic health outcomes in people with HIV based on the knowledge and experience of an international panel of experts.MethodsA targeted literature review including 281 conference presentations, peer-reviewed articles, and background references on cardiometabolic health in adults with HIV published between January 2016 and April 2022 was conducted and used to develop draft consensus data statements. Using a modified Delphi method, an international panel of 16 experts convened in

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… Supplementary Material Acknowledgements Data included in this manuscript have previously been presented in part at the European Meeting on HIV & Hepatitis 2023; 7–9 June 2023; Rome, Italy; Poster 85. …

Влияние краткосрочной прогрессивной физической тренировки на активность заболевания у пациентов с подозрительной множественной миеломой и моноклональной гамма-патологией неопределенного значения: односторонний пилотный исследование.

ОБЪЕКТ: Высокий уровень физической активности связан с уменьшением риска развития крови опухоли множественной миеломы (ММ). ММ предшествует асимптоматическим стадиям моноклональной гамма-патологии неопределенного значения (MGUS) и дымящей множественной миеломы (SMM), которые клинически управляются методом наблюдения. Случайный исследователь (N = 1) бывшего высшего спортсмена в возрасте 44 лет показал, что многофакторная программа физических упражнений обратила активность SMM. С учетом результатов этого предыдущего тематического исследования в настоящем экспериментальном исследовании сначала ра

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… Protein electrophoresis and densitometry (Interlab, Rome, Italy) were used to quantify serum M-protein concentration. …

History of hematopoietic cell transplantation: challenges and progress.

After more than 60 years of research in allogeneic hematopoietic cell transplantation (HCT), this therapy has advanced from one that was declared dead in the 1960s to a standard treatment of otherwise fatal malignant and non-malignant blood diseases. To date, close to 1.5 million hematopoietic cell transplants have been performed in more than 1,500 transplantation centers worldwide. This review will highlight the enormous efforts by numerous investigators throughout the world who have brought the experimental field of HCT to clinical reality, examine ongoing challenges, and provide insights fo

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… Rashidi A, Slade M, DiPersio JF, Westervelt P, Vij R, Romee R. Post-transplant high-dose cyclophosphamide after HLA-matched vs haploidentical hematopoietic cell transplantation for AML. Bone Marrow Transplant. 2016;51(12):1561-1564. 53. Sangiolo D, Storb R, Deeg HJ, et al. …

Diffusion MRI for Assessment of Bone Quality; A Review of Findings in Healthy Aging and Osteoporosis.

Diffusion MRI (dMRI) is a growing imaging technique with the potential to provide biomarkers of tissue variation, such as cellular density, tissue anisotropy, and microvascular perfusion. However, the role of dMRI in characterizing different aspects of bone quality, especially in aging and osteoporosis, has not yet been fully established, particularly in clinical applications. The reason lies in the complications accompanied with implementation of dMRI in assessment of human bone structure, in terms of acquisition and quantification. Bone is a composite tissue comprising different elements, ea

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… Assessment of fracture risk and its application to screening for postmenopausal osteoporosis: Report of a WHO study group [meeting held in Rome from 22 to 25 June 1992] 1994 . 7941614 5 Griffith JF , Genant HK . New advances in imaging osteoporosis and its complications . …

Brazilian Nutritional Consensus in Hematopoietic Stem Cell Transplantation: Elderly.

The Brazilian Nutritional Consensus in Hematopoietic Stem Cell Transplantation: Elderly was elaborated by nutritionists, nutrologists and hematologists physicians from 15 Brazilians reference centers in hematopoietic stem cell transplantation, in order to emphasize the importancy of nutritional status and the body composition during the treatment, as well as the main characteristics related to patient's nutritional assessment. Establishing the consensus, we intended to improve and standardize the nutritional therapy during the hematopoietic stem cell transplantation. The Consensus was approved

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… Rome RB, Luminais HH, Bourgeois DA, Blais CM. The role of palliative care at the end of life. Oschner J. 2011;11(4):348–352. 135. Menezes RA. Health care for terminal patients: between medical practices and religious beliefs. Rev Eletr Com Inf Inov Saúde. 2010;4(3):25–33. 136. Favarim AM. …

Abstracts of the 3rd International Conference on Cancer Cachexia, September 23–25, 2016 in Washington, DC, USA

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… Lineu Prestes, 1524, 05508‐900, São Paulo, Brazil; 2 Department of Surgery Clinical, University Hospital, University of São Paulo, São Paulo, Brazil; 3 Department of Clinical Medicine, Sapienza University of Rome, Italy Cachexia is a multifactorial and multiorgan syndrome associated with cancer and …

Mortality and Morbidity Effects of Long-Term Exposure to Low-Level PM2.5, BC, NO2, and O3: An Analysis of European Cohorts in the ELAPSE Project.

INTRODUCTION: Epidemiological cohort studies have consistently found associations between long-term exposure to outdoor air pollution and a … , Denmark, England, the Netherlands, Norway, and Switzerland as well as an administrative cohort in Rome, Italy. We developed central exposure assessment using Europewide hybrid land use regression (LUR) models, which incorporated European routine monitoring data for PM2.5, NO2, and O3, and ESCAPE monitoring data for BC and PM2.5 composition, land use, …

MSC-EV therapy for bone/cartilage diseases.

Mesenchymal stromal cells (MSCs) have been utilized in cell therapy for various diseases. Recent studies have demonstrated that extracellular vesicles (EVs) released by MSCs play an important role in their therapeutic activities. EVs contain a variety of bioactive molecules such as proteins, messenger RNAs (mRNAs), and micro RNAs (miRNAs) and modify the function of the recipient cells by transferring these molecules. Despite the promising potential of EV therapy as a substitute for MSC therapy, there are challenges that need to be addressed for the clinical success of EV therapy. EV quality ha