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62nd Annual Conference of the Indian Society of Gastroenterology, February 10th - 13th, 2022, Pune.

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Targeting Metal Ion Homeostasis for Regulated Cell Death-Amplified Tumor Nanomedicine.

Amidst escalating global health challenges, neoplastic diseases remain a predominant cause of morbidity and mortality, exerting complex and far-reaching effects on human health and societal well-being. The advent of precision medicine has ushered in an era of tailored therapeutic strategies, leveraging individual genetic profiles, tumor microenvironmental features, and exogenous factors to redefine oncology care. Central to these advances is the understanding of cell death, a fundamental biological process encompassing both programmed and non-programmed forms. Programmed cell death is orchestr

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… Li et al proposed a novel therapeutic strategy using a biodegradable magnesium-based implant to combat bone tumors ( Figure 11A ). 171 The implant, presumably composed of magnesium alloys, utilizes a multifunctional coating to enhance corrosion resistance and enable responsive ion release. … However, limitations involve potential premature corrosion in physiological environments, challenges in controlling precise ion release kinetics, and the need for further validation in large animal models to assess long-term safety and immune modulation efficacy. …

Устные доклады

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Are Levels of Blood Metal Nanoparticles Elevated After Spinal Fusion and Implantation in Patients With Adolescent Idiopathic Scoliosis?

BACKGROUND: Implantation of titanium alloys (Ti-6Al-4V) or cobalt-chromium-molybdenum alloys (Co-Cr-Mo) for long-segment spinal fixation is … ion with the use of Co-Cr-Mo implants (β = 0.58; p < 0.001). SEM analysis confirmed implant surface corrosion and nanoscale defects consistent with metal release. CONCLUSION: Serum levels of Ti, Co, and Cr increase after posterior spinal fusion in patients with AIS, reaching a peak at 12 months after operation, and remaining elevated for at least 4 years, …

In Vivo Bone Tissue Engineering Strategies: Advances and Prospects.

Reconstruction of critical-sized bone defects remains a tremendous challenge for surgeons worldwide. Despite the variety of surgical techniques, current clinical strategies for bone defect repair demonstrate significant limitations and drawbacks, including donor-site morbidity, poor anatomical match, insufficient bone volume, bone graft resorption, and rejection. Bone tissue engineering (BTE) has emerged as a novel approach to guided bone tissue regeneration. BTE focuses on in vitro manipulations with seed cells, growth factors and bioactive scaffolds using bioreactors. The successful clinical

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… heat Ethylene oxide Electron beam irradiation Gamma irradiation UV irradiation Metallic scaffolds | Biocompatibility High mechanical strength and stiffness Osteoconductive properties Ability to promote osteointegration Individualized scaffolds Easily sterilized and visualized Controlled pore size | Corrosion … Metal stiffness is increasing during the early stages of the corrosion process [ 120 ]. Strength and stiffness are particularly important for load-bearing applications of the metallic constructs. …

Advanced biomaterial-based approaches for medication-related osteonecrosis of the jaw.

Medication-related osteonecrosis of the jaw (MRONJ) is a debilitating adverse effect linked to anti-resorptive and anti-angiogenic therapies, with an incidence of 4.34 % (6.22 % in oncology patients and 0.59 % in osteoporosis patients) based on a pooled analysis of 92 observational studies (2015-2020), characterized by persistent bone exposure and poor healing. Conventional treatment modalities often yield suboptimal outcomes, with recurrence and procedural morbidity. In recent years, biomaterial-based strategies have emerged as promising alternatives by targeting MRONJ's complex pathophysiolo

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… However, conventional metals such as stainless steel and titanium alloys have notable limitations, including corrosion-related toxicity, lack of osteoinductive properties, and non-degradability, often necessitating secondary surgical removal, which is particularly problematic in maxillofacial surgery …

Indocyanine Green (ICG) and Colorectal Surgery: A Literature Review on Qualitative and Quantitative Methods of Usage.

Background: Due to its many benefits, indocyanine green (ICG) has gained progressive popularity in operating rooms (ORs) globally. This literature review examines its qualitative and quantitative usage in surgical treatment. Method: Relevant terms were searched in five international databases (1. Pubmed, 2. Sciencedirect, 3. Scopus, 4. Oxfordjournals, 5. Reaxys) for a comprehensive literature review. The main benefits of using ICG in colorectal surgery are: intraoperative fluorescence angiography; fluorescence-guided lymph node involvement detection and the sentinel technique; the fluorescent

The potential therapeutic role of extracellular vesicles in critical-size bone defects: Spring of cell-free regenerative medicine is coming.

In recent years, the incidence of critical-size bone defects has significantly increased. Critical-size bone defects seriously affect patients' motor functions and quality of life and increase the need for additional clinical treatments. Bone tissue engineering (BTE) has made great progress in repairing critical-size bone defects. As one of the main components of bone tissue engineering, stem cell-based therapy is considered a potential effective strategy to regenerate bone tissues. However, there are some disadvantages including phenotypic changes, immune rejection, potential tumorigenicity,

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… They have ideal biocompatibility, including non-toxicity, optimal porosity suitable for cell migration and proliferation, high mechanical strength and corrosion resistance. … Polyetheretherketone, which has solid mechanical strength and favourable biocompatibility, such as transmissivity and anti-chemical corrosion, is now regarded as an alternative metal scaffold in BTE. …

Probiotics and nanoparticle-mediated nutrient delivery in the management of transfusion-supported diseases.

Bone marrow is vital for hematopoiesis, producing blood cells essential for oxygen transport, immune defense, and clotting. However, disorders like leukemia, lymphoma, aplastic anemia, and myelodysplastic syndromes can severely disrupt its function, leading to life-threatening complications. Traditional treatments, including chemotherapy and stem cell transplants, have significantly improved patient outcomes but are often associated with severe side effects and limitations, necessitating the exploration of safer, more targeted therapeutic strategies. Nanotechnology has emerged as a promising a

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… For a biomaterial to be effective, it must exhibit several critical characteristics: biocompatibility to prevent adverse reactions, nontoxicity to ensure safety, appropriate mechanical and physical properties to function properly, rust and corrosion resistance to avoid degradation, and the ability to …

Clinical performance of implanted devices used in surgical treatment of patients with spinal tumors: a systematic review.

PURPOSE: Implanted devices used in metastatic spine tumor surgery (MSTS) include pedicle screws, fixation plates, fixation rods, and interbody devices. A material to be used to fabricate any of these devices should possess an array of properties, which include biocompatibility, no toxicity, bioactivity, low wear rate, low to moderate incidence of artifacts during imaging, tensile strength and modulus that are comparable to those of cortical bone, high fatigue strength/long fatigue life, minimal or no negative impact on radiotherapy (RT) planning and delivery, and high capability for fusion to

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… Ti6Al4V has replaced stainless steel due to its higher corrosion and fatigue resistance, lower density and lower modulus of elasticity (E) [ 17 ]. However, Ti6Al4V has some shortcomings, including a larger E compared to that of cortical bone (respectively 110 GPa vs. 17–21 GPa). … polyetheretherketone”, “PEEK,”, “PAEK”, “PMMA”, “silicon nitride”, “HA coated PEEK”, “hydroxyapatite coated“, “titanium PEEK”, “Ti35Nb4Sn”, “carbon”, “carbon fiber” “carbon fiber PEEK”, ‘‘stainless steel”, ‘‘polyetheretherketone”, ‘‘hydroxyapatite”, “radiolucent”, “porosity”, “elastic modulus,”, “weight-bearing”, “corrosion …

Toxicology and carcinogenesis studies of sodium nitrite (CAS NO. 7632-00-0) in F344/N rats and B6C3F1 mice (drinking water studies).

UNLABELLED: Sodium nitrite is used as a color fixative and preservative in meats and fish. It is also used in manufacturing diazo dyes, nitroso compounds, and other organic compounds; in dyeing and printing textile fabrics and bleaching fibers; in photography; as a laboratory reagent and a corrosion inhibitor; in metal coatings for phosphatizing and detinning; and in the manufacture of rubber chemicals. Sodium nitrite also has been used in human and veterinary medicine as a vasodilator, a bronchial dilator, an intestinal relaxant, and an antidote for cyanide poisoning. Sodium nitrite was nomin…

Açai Berry Attenuates Cyclophosphamide-Induced Damage in Genitourinary Axis-Modulating Nrf-2/HO-1 Pathways.

Cyclophosphamide (CYP) is used to treat different malignancies and autoimmune disorders in men. This chemotherapy frequently reduces tumors, which is beneficial, but also causes infertility because of severe oxidative stress, inflammation, and apoptosis in the bladder and testes brought on by its metabolite, acrolein. The goal of this study was to assess the efficacy of a novel food, açai berry, in preventing CYP-induced damage in the bladder and testes.MethodsCYP was administered intraperitoneally once during the experiment at a dose of 200 mg/kg body weight diluted in 10 mL/kg b.w. of water.

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… Seed Extracts from Different Varieties: A Source of Proanthocyanidins and Eco-Friendly Corrosion Inhibition Activity. Molecules. 2021;26:3433. doi: 10.3390/molecules26113433. 61. …

Rolling contact fatigue dataset for AISI 52100 bearing steel balls under calcium grease lubrication.

Rolling contact fatigue (RCF) is a dominant failure mechanism in bearings; however, open-access datasets analyzing RCF under varying lubrication conditions remain scarce. This study aims to address this problem, in which AISI 52100 bearing steel balls were tested using a four-ball tribometer according to IP 300 standard. Three calcium-soap-thickened greases of National Lubricating Grease Institute (NLGI) grades 0, 00, and 000 were used and each was formulated with extreme-pressure additives. A total of 63 trials (21 per grade) were conducted at 1470 rpm, under a peak axial load of 5739 N. The

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… Although bearings can fail in a variety of ways, such as adhesive wear, abrasive wear, fretting, corrosion fatigue, electrically induced pitting, and rolling contact fatigue (RCF), the service life of bearings is designed and standardized around RCF. …

Структура и состав микробных сообществ в водной толще Южного залива Мексики и обнаружение предполагаемых микроорганизмов, деградирующих углеводороды.

В ходе этого исследования была проведена оценка сообщества бактериопланктонов и его связи с экологическими переменными, включая общую концентрацию нефтяных углеводородов (ТПГ), в районе шельфа Юкатан в Южном заливе Мексики. Анализ разнообразия бета на основе последовательности 16S rRNA показал различия в структуре общины бактериопланктона между участками отбора проб. ПЕРМАНОВА указала, что эти изменения могут быть связаны главным образом с глубокими изменениями (см.5 в адрес 180 m), концентрация растворенного кислорода (2.06 в адрес 5.93 мг L-1), и концентрация хлорофилла (0.184 в адрес 7.65 м

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… . & Han , Y. ( 2019 ) The mutual influence between corrosion and the surrounding soil microbial communities of buried petroleum pipelines . RSC Advances , 9 , 18930 – 18940 . …

63rd Annual Conference of the Indian Society of Gastroenterology, ISGCON 2022-January 5th - 8th, 2023 in Jaipur.

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The inhibition of RANKL-induced osteoclastogenesis through the suppression of p38 signaling pathway by naringenin and attenuation of titanium-particle-induced osteolysis.

The aim of this study was to assess the effect of naringenin on osteoclastogenesis and titanium particle-induced osteolysis. Osteolysis from wear-induced particles and aseptic loosening are the most frequent late complications of total joint arthroplasty leading to revision of the prosthesis. Osteolysis during aseptic loosening is most likely due to increased bone resorption by osteoclasts. Through in vitro studies, we demonstrated that naringenin, a naturally occurring flavanone in grapefruit and tomatoes, exerts potent inhibitory effects on the ligand of the receptor activator of nuclear fac

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… Previous studies have indicated that metal implants undergo corrosion inside the human body by various mechanisms [ 47 ]. Metallic ions are released into the tissue surrounding metal implants, as well as distant organs (liver, spleen, and lymph nodes) and body fluids (serum and urine) [ 48 ]. …

Cancer and Obesity: An Obesity Medicine Association (OMA) Clinical Practice Statement (CPS) 2022.

BackgroundThis Obesity Medicine Association (OMA) Clinical Practice Statement (CPS) provides an overview of cancer and increased body fat.MethodsThe scientific information for this CPS is based upon published scientific citations, clinical perspectives of OMA authors, and peer review by the Obesity Medicine Association leadership.ResultsTopics include the increased risk of cancers among patients with obesity, cancer risk factor population-attributable fractions, genetic and epigenetic links between obesity and cancer, adiposopathic and mechanistic processes accounting for increased cancer risk

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… Common examples of the natural consequences of oxidation include: Oxidation of iron is rust or corrosion due to formation of iron oxide Oxidation of therapeutic fish oils causes rancidity due to hydroperoxides that can be mitigated by incorporation of vitamin E (an antioxidant) Oxidation of a cut …

Methods of Topical Administration of Drugs and Biological Active Substances for Dental Implants-A Narrative Review.

Dental implants are, nowadays, established surgical devices for the restoration of lost teeth. Considered as an alternative for traditional prosthetic appliances, dental implants surpass them in reliability and patient feedback. Local drug delivery around the implants promotes osseointegration and reduces peri-implantitis. However, there are currently no methods of a multiple, precise topical administration of drugs to the implant area. Engineering coatings on the implants, drug application on carriers during implantation, or gingival pockets do not meet all requirements of dental surgeons. Th

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… A dual-task design of corrosion-controlling and osteo-compatible hexamethylenediaminetetrakis- (methylene phosphonic acid) (HDTMPA) coating on magnesium for biodegradable bone implants application. J. Biomed. Mater. Res. A. 2015;103:1640–1652. doi: 10.1002/jbm.a.35301. 57. …

The Rationale for Using Neridronate in Musculoskeletal Disorders: From Metabolic Bone Diseases to Musculoskeletal Pain.

Neridronate or ((6-amino-1-hydroxy-1-phosphonohexyl) phosphonic acid) is an amino-bisphosphonate (BP) synthetized in Italy in 1986. Bisphosphonates are molecules with a P-C-P bond in their structure that allows strong and selectively binding to hydroxyapatite (HAP) as well as osteoclasts inhibition through different mechanisms of action. Neridronate was initially used to treat Paget disease of the bone, demonstrating effectiveness in reducing bone turnover markers as well as pain. The interesting molecular properties of neridronate foster its wide use in several other conditions, such as osteo

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… However, these compounds, now referred to as BPs, had already been discovered in 1894 by the pharmacist Theodor Salzer, for use in some industrial processes (i.e., textile, fertilizer, and oil industry) as corrosion inhibitors or as complexing agents [ 15 ]. …

Toxicology and carcinogenesis studies of diethylamine (CAS No. 109-89-7) in F344/N rats and B6C3F1 mice (inhalation studies).

UNLABELLED: Diethylamine is used mainly as a chemical intermediate to produce the corrosion inhibitor N,N-diethylethanolamine and a lesser amount is used to produce pesticides and insect repellants and in rubber processing. Diethylamine was nominated for study by the National Institute of Environmental Health Sciences based upon its high production volume and ubiquitous natural occurrence in trace amounts and because of the lack of chronic toxicity and carcinogenicity data on the chemical. Male and female F344/N rats and B6C3F1 mice were exposed to diethylamine (approximately 99.9% pure) by in…