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Microfabrication of controlled release osmotic drug delivery systems assembled from designed elements.

BACKGROUND: This study investigates combining 3D printing with traditional compression methods to develop a multicomponent, controlled-release drug delivery system (DDS). The system uses osmotic tablet layers and a semipermeable membrane to control drug release, similar to modular Lego® structures. METHODS: The DDS comprises two directly compressed tablet layers (push and pull) and a semipermeable membrane, all contained within a 3D-printed frame. The membrane is made from cellulose acetate and plasticizers like glycerol and propylene glycol. Various characterization techniques, including Pos…

PDMS Film-Based Flexible Pressure Sensor Array with Surface Protruding Structure for Human Motion Detection and Wrist Posture Recognition.

Flexible pressure sensors have been widely concerned because of their great application potential in the fields of electronic skin, human-computer interaction, health detection, and so on. In this paper, a flexible pressure sensor is designed, with polydimethylsiloxane (PDMS) films with protruding structure as elastic substrate and poly(3,4-ethylenedioxythiophene)/poly(styrenesulfonate) (PEDOT:PSS)/cellulose nanocrystals (CNC) as conductive-sensitive material. The flexible pressure sensor has a wide linear detection range (0-100 kPa), outstanding sensitivity (2.32 kPa-1), and stability of more…

Facile fabrication of carboxymethylcellulose/ZnO/g-C3N4 containing nutmeg extract with photocatalytic performance for infected wound healing.

New topical antibacterial agents are required to inhibit and development of bacteria and also promoting the wound healing process. This study was evaluating the healing effect of Myristica fragrans extract coated with carboxymethyl cellulose, zinc oxide and graphite carbon nitride (CMC/ZnO/g-C3N4/MyR) by photocatalytic process on the healing process of full-thickness infectious excision wounds in mice. Nanosheets were prepared and physicochemical properties were evaluated. Safety, in vitro release, antibacterial activities under in vitro and in vivo condition, wound contraction, histopathologi…

Potential stem cell-Conditioned medium and their derived exosomes versus omeprazole in treatment of experimental model of gastric ulcer.

Gastric ulcer is a common frequent clinical problem affecting all age and gender. This work aims to compare between the therapeutic effects of stem cell derived exosomes, stem cells conditioned medium and omeprazole on the healing of gastric ulcer model. Fifty rats were, assigned into 5 groups; control, gastric ulcer, omeprazole-treated, conditioned medium- treated, and exosomes-treated groups. Gastric ulcer was induced by aspirin dissolved in 1% carboxymethyl cellulose at a daily dose of 200 mg/kg for 5 consecutive days. Stomach specimens were obtained for histological, biochemical, and immun…

Modulating chitin synthesis in marine algae with iminosugars obtained by SmI2 and FeCl3-mediated diastereoselective carbonyl ene reaction.

Strategies for synthesizing polyhydroxylated piperidines such as iminosugars have received broad attention. These substances are known to interact with carbohydrate related enzymes, glycosidases and glycosyltransferases, to which also the large enzyme families of chitin synthases and cellulose synthases belong. Many chemical and biological aspects of chitin synthases remain unexplored due to the fact that modulating substances are hardly available or expensive. Starting from enantiopure D- and L-amino acids, a series of iminosugars was prepared by a Lewis acid-catalyzed cyclization of amino ac…

Physical Stability and Release Profile of Compounded Gabapentin Containing Pluronic Lecithin Organogel for Neuropathic Pain Management.

The objective of this study was to evaluate the physical stability and drug-release profile of gabapentin from different compounded formulat … tion. The release of gabapentin out of Pluronic lecithin organogel was measured by diffusion across cellulose membranes (0.45 um) in the Franz diffusion cell system. The organoleptic properties were constant during the stability study in all formulations. The values of pH varied depending on the formulation, with slight increases after the the 7th day of th …

Spanlastics gel-A novel drug carrier for transdermal delivery of glimepiride.

Glimepiride (3rd-generation sulfonylurea) is used for treatment of type 2 diabetes, but its oral administration has been associated with sev … permeation of glimepiride from various spanlastics gel formulations were investigated across mixed cellulose membrane and excised rabbit skin. The obtained results indicated that the maximum entrapment efficiency was 65.36% when the tween 60 content was 30%. The drug release and permeation were increase as the concentration of edge activator increased. Spa …

Метод секвенирования (NNA) следующего поколения (NGS) для выявления источников сахарного питания в переносчиках комаров вируса Западного Нила в Израиле.

Москиты рода Culex представляют собой важные векторы патогенных арбовирусов в нашем регионе, включая вирусы Вест-Нил и Рифт-Вэлли. Чтобы лучше понять эпидемиологию и динамику передачи арбовирусов, нам нужно изучить поведение и экологию их векторов. Характер питания переносчиков комаров может оказаться весьма полезным при определении того, каким образом и где сосредоточить усилия по борьбе с этим заболеванием. Например, определение предпочтительных носителей крови у женщин может помочь в осуществлении потенциально эффективных стратегий целенаправленного контроля над женщинами-комаров. Определен

Совпадение в аннотации оригинала
Mosquitoes of the genus Culex comprise important vectors of pathogenic arboviruses in our region, including West Nile and Rift Valley Fever … identification was based mainly on chemical detection of fructose and microscopical observations of cellulose particles in mosquito guts. More recent studies have utilized DNA barcoding capable of identifying plant food sources. In the current study, we identify multiple plant species from which large numbers of mosquitoes obtained their sugar meals in one …

Evidence of intermolecular associations of β-glucan and high-molar mass xylan in a hot water extract of raw oat groat.

High molar mass (HM) β-glucan present in oat products can reduce the risk of diet-related diseases, mainly owing to significantly increased … mass, Mw ~ 3153 kg/mol), which was aggregated with β-glucan (Mw ~ 1029-1589 kg/mol) through its HM cellulose-like region. Of the two low molar mass-AXs (LM-AXs) isolated, the first having C(O)-3-monosubstituted and C(O)-2,3-disubstituted β-d-xylopyranosyl residues was covalently interlinked to HM-xylan. The second highly feruloylated, containing C(O)-3- an …

Anti-Candida Activity of Hyaluronic Acid Combined with Lactobacillus crispatus Lyophilised Supernatant: A New Antifungal Strategy.

Vulvovaginal candidiasis (VVC) and recurrencies are common in reproductive-aged women. The emergence of Candida strains resistant to convent … esistant to conventional antifungals resulted sensitive. A vaginal matrix based on microcrystalline cellulose and containing effective doses of both agents was developed and characterised. This vaginal formulation showed mucoadhesive ability and almost abrogated Candida albicans growth. In conclusion, HA and LCFS from L. crispatus BC5 are thus good candidat …

Dynamic pH and Thermal Analysis of Paper-Based Microchip Electrophoresis.

Paper-based microchip electrophoresis has the potential to bring laboratory electrophoresis tests to the point of need. However, high electr … .5 °C/mm existed in the system. Finally, we report an acid pre-treatment of the separation media, a cellulose acetate paper, mitigated both pH and temperature shifts and provided a stable environment for reproducible HemeChip hemoglobin electrophoresis separation.

Gellan Gum-Based Bilayer Mucoadhesive Films Loaded with Moxifloxacin Hydrochloride and Clove Oil for Possible Treatment of Periodontitis.

BACKGROUND/OBJECTIVE: Periodontitis is a widely spread oral infection and various antibiotics are utilized for its treatment, but high oral … chnique having an antibiotic in the gellan gum-based primary layer with clove oil in a hydroxyethyl cellulose-based secondary layer. RESULTS: Prepared films were transparent, flexible, and showed high antibacterial response against both gram-positive and gram-negative bacteria. The films showed excellent pharmaceutical attributes in terms of drug content, …

Colored cotton wastes valuation through thermal and catalytic reforming of pyrolysis vapors (Py-GC/MS).

This study aims to analyze the products of the catalytic pyrolysis of naturally colored cotton residues, type BRS (seeds from Brazil), called BRS-Verde, BRS-Rubi, BRS-Topázio and BRS-Jade. The energy characterization of biomass was evaluated through ultimate and proximate analysis, higher heating value, cellulose, hemicellulose and lignin content, thermogravimetric analysis and apparent density. Analytical pyrolysis was performed at 500 °C in an analytical pyrolyzer from CDS Analytical connected to a gas chromatograph coupled to the mass spectrometer (GC/MS). The pyrolysis vapors were reformed…

Yin and Yang of Biofilm Formation and Cyclic di-GMP Signaling of the Gastrointestinal Pathogen Salmonella enterica Serovar Typhimurium.

Within the last 60 years, microbiological research has challenged many dogmas such as bacteria being unicellular microorganisms directed by … ing promotes bacterial biofilm formation and chronic infections, oppositely, Salmonella Typhimurium cellulose biofilm inside immune cells is not endorsed. These observations only touch on the complexity of the interaction of biofilm microbial cells with its host. In this review, we describe the Yin and Yang interactive concepts of biofilm formation and cycl …

Recovery of immune activity by administration of polysaccharides of Toona sinensis and its characterization of major component.

The polysaccharides were acquired from the seeds of T. sinensis by hot water extraction, ethanol precipitation, decoloration with macroporous 900 resin, and deproteinization with sevag reagent, which possessed significantly immunomodulatory activity on the levels of IgA, IgG, and IgM, the relative indices of thymus and spleen, and the phagocytosis index of mice in vivo. T. sinensis seeds polysaccharides (TSP) were separated and purified using DEAE-52 cellulose and Sephacryl S-300 column chromatography to obtain TSP-3a characterized of molecular weight, monosaccharides composition, and other pr…

Impact of Particle and Equipment Properties on Residence Time Distribution of Pharmaceutical Excipients in Rotary Tablet Presses.

Paddle feeders are devices commonly used in rotary tablet presses to facilitate constant and efficient die filling. Adversely, the shear stress applied by the rotating paddles is known to affect the bulk properties of the processed powder dependent on the residence time. This study focuses on the residence time distribution (RTD) of two commonly applied excipients (microcrystalline cellulose, MCC; dicalcium phosphate, DCP), which exhibit different flow properties inside rotary tablet presses. To realistically depict the powder flow inside rotary tablet presses, custom-made tracer powder was de…

Antibacterial composite paper with corn stalk-based carbon spheres immobilized AgNPs.

Silver nanoparticles (AgNPs) have been widely used for sterilization due to their broad-spectrum bactericidal properties. However, there exist the problems of premature releasing and accumulative toxicity when free AgNPs are applied. This study proposed a one-pot hydrothermal strategy to synthesize carbon spheres immobilized silver nanoparticles (AgNPs@CS). The synthesis involves with silver ammonia solution as Ag precursor, and corn stalk as green reducing agent and carbon precursor. Furthermore, AgNPs@CS was anchored by cellulose nanofibers (CNF) to obtain the antibacterial composite paper. …

Physico-Mechanical and Biological Durability of Citric Acid-Bonded Rubberwood Particleboard.

This study investigated the effects of different citric acid content on the physico-mechanical and biological durability of rubberwood particleboard. Particleboards with density of 700 kg/m3 were produced with three different citric acid contents, namely 10, 15 and 20 wt%. Particleboards made from 10 wt% urea formaldehyde (UF) resin were served as control for comparison purposes. FTIR analysis was carried out and the formation of ester linkages between -OH on cellulose and carbonyl groups of citric acid was confirmed. The peak intensity increased along with increasing citric content, which ind…

Ratiometric Fluorescent Paper-Based Sensor Based on CdTe Quantum Dots and Graphite Carbon Nitride Hybrid for Visual and Rapid Determination of Cu2+ in Drinks.

A simple and effective ratiometric fluorescence sensor of CdTe QDs/GCNNs for on-site and rapid analysis of Cu2+ has been established by mixi … rinks with satisfactory results. Moreover, a paper-based sensor, which has been prepared by soaking cellulose acetate membrane in CdTe QDs/GCNNs sensor solution, has a wide semiquantitative detection range for Cu2+ (0.01 ~ 5.0 μg mL-1 ). It has realized successfully on-site and rapid determination of Cu2+ in red wine without any pretreatment procedure and i …

Physico-chemical studies on binary aqueous solutions of Anti-Viral Influenza drugs.

The ultrasonic velocity, density, viscosity and absorption have been measured for solution of Influenza Anti-Viral drugs (Amantadine and Oseltamivir) are presented at room temperature 303K. By taking measurements of Anti Influenza Viral drugs at 0.2, 0.4 and 0.6% concentrations of each solution. The aim of the study is to increase the solubility, stability, sweetness of drugs by the formation of complexation. The ultrasonic velocity, density and viscosity have been measured at 2MHz for the aqueous solutions of (i) Influenza Anti-Viral Drugs + HPMC (Hydroxy Propyl Methyl Cellulose), Lactose and…