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P941 – P1197

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Genus Sophora: a comprehensive review on secondary chemical metabolites and their biological aspects from past achievements to future perspectives.

Sophora is deemed as one of the most remarkable genera of Fabaceae, and the third largest family of flowering plants. The genus Sophora comprises approximately 52 species, 19 varieties, and 7 forms that are widely distributed in Asia and mildly in Africa. Sophora species are recognized to be substantial sources of broad spectrum biopertinent secondary metabolites namely flavonoids, isoflavonoids, chalcones, chromones, pterocarpans, coumarins, benzofuran derivatives, sterols, saponins (mainly triterpene glycosides), oligostilbenes, and mainly alkaloids. Meanwhile, extracts and isolated compoun

Совпадение в полном тексте источника
… extract of seeds | Anti-proliferative activity | Inhibits human hepatocarcinoma HepG2 | Su et al. ( 2018 ) | CH 2 Cl 2 fraction of seeds | Protoscolicidal activity in vivo | Inhibiting effect against growth of Echinococcus granulosus cyst | Luo et al. ( 2018 ) A combinational treatment of alkaloids with albendazole …

63rd Annual Conference of the Indian Society of Gastroenterology, ISGCON 2022-January 5th - 8th, 2023 in Jaipur.

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NF-κB in Cell Deaths, Therapeutic Resistance and Nanotherapy of Tumors: Recent Advances.

The transcription factor nuclear factor-κB (NF-κB) plays a complicated role in multiple tumors. Mounting evidence demonstrates that NF-κB activation supports tumorigenesis and development by enhancing cell proliferation, invasion, and metastasis, preventing cell death, facilitating angiogenesis, regulating tumor immune microenvironment and metabolism, and inducing therapeutic resistance. Notably, NF-κB functions as a double-edged sword exerting positive or negative influences on cancers. In this review, we summarize and discuss recent research on the regulation of NF-κB in cancer cell deaths,

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… Albendazole Inhibits NF-ΚB Signaling Pathway to Overcome Tumor Stemness and Bortezomib Resistance in Multiple Myeloma Cancer Lett. 2021 520 307 320 10.1016/j.canlet.2021.08.009 34390764 100. Peng C. Ouyang Y. Lu N. Li N. …

Hematology and Immune-Related Disorders

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The potential of dibenzazepine carboxamides in cancer therapy.

Cancer is a leading cause of mortality worldwide, with most conventional treatments lacking efficacy and having significant challenges like drug resistance. Finding new molecules is quite challenging in terms of cost, time and setbacks. Hence, drug repurposing is considered sensible for skipping the long process of drug development. Dibenzazepine carboxamides, as traditional anticonvulsants, primarily function by blocking voltage-gated sodium channels, which not only mitigate seizures but also influence mood disorders through modulation of serotonin and dopamine. Recent studies have uncovered

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… Albendazole: a potent inhibitor of vascular endothelial growth factor and malignant ascites formation in OVCAR-3 tumor-bearing nude mice . Clin. Cancer Res. 12 , 1928 – 1935 . 10.1158/1078-0432.CCR-05-1181 16551879 Preboth M. ( 2000 ). FDA approval of oxcarbazepine , 61 . …

Characteristics and advances in signaling pathways, cellular communication, cell junctions, and oxidative stress in lymphedema.

Lymphedema is a chronic inflammatory disease without an effective treatment method, and it results in a high disease burden and psychological distress in patients. Although there have been significant advances in targeted therapies, there are still no effective options to treat this refractory disease. In recent years, new advances and breakthroughs have been made in signaling pathways, including RAS/MAPK, PI3K/AKT, VEGF-C/VEGFR-3, HGF/MET, and TGF-β1, which are important for understanding the pathogenesis and disease progression of lymphedema. Mutations in genes encoding cell junctions affect

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… Prevalence and correlates of lymphatic filariasis infection and its morbidity following mass ivermectin and albendazole administration in mkinga district, north-eastern Tanzania. J. Clin. Med. 9 (5), 1550. 10.3390/jcm9051550 Finegold D. N., Baty C. J., Knickelbein K. Z., Perschke S., Noon S. …

Chest and Mediastinum

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The potential anti-cancer effects of quercetin on blood, prostate and lung cancers: An update.

Cancer is caused by abnormal proliferation of cells and aberrant recognition of the immune system. According to recent studies, natural products are most likely to be effective at preventing cancer without causing any noticeable complications. Among the bioactive flavonoids found in fruits and vegetables, quercetin is known for its anti-inflammatory, antioxidant, and anticancer properties. This review aims to highlight the potential therapeutic effects of quercetin on some different types of cancers including blood, lung and prostate cancers.

Diseases of the Nervous System

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Respiratory and Thoracic Medicine

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61st Annual Conference of Indian Society of Gastroenterology, Virtual Diamond Jubilee ISGCON 2020, 19-20th December 2020.

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TB AND OTHER CHEST INFECTIONS

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ESCP 36th European Symposium on Clinical Pharmacy ‘Implementing Clinical Pharmacy in Community and Hospital Settings: Sharing the Experience’, Istanbul, Turkey 25–27 October 2007; Abstracts

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… On day 5 albendazole (400 mg/day) was added. Subcutaneous ivermectin was then obtained and administered on day 6 (200 μg/kg) in association with ivermectin via nasogastric tube while albendazole was discontinued. The patient’s condition improved during the following days. …

Oral Presentations

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Haematological Diseases in the Tropics

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… eradication of one organism. 60 Treatment of communities at high risk of soil-transmitted helminths improves growth and iron stores in children and reduces anaemia in pregnant women. 61 The treatment of anaemia due to neglected tropical diseases depends on eradication of the parasite with drugs such as albendazole …

Biology and Diseases of Dogs

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Poster Abstracts

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Abstracts from the 37th Annual Meeting of the Society of General Internal Medicine, 2014, San Diego, CA, USA.

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The 4th Global Congress on Sickle Cell Disease Abstract Book 2022

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