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Relapsed/refractory PBML complicated with failed platelet implantation and mixed infection after allo-HSCT: A case report.

RATIONALE: Primary bone marrow lymphoma (PBML) is a rare lymphoma with a poor prognosis, characterized by tumor origin restricted to the bone marrow. Diffuse large B-cell lymphoma (DLBCL) is its most common subtype. PATIENT CONCERNS: We report a case of a 48-year-old female with refractory non-germinal center DLBCL originating in the bone marrow, accompanied by p53 overexpression, complex karyotype, and hemophagocytic lymphohistiocytosis. DIAGNOSES: Given the aforementioned adverse genetic features, together with primary platelet poor graft function following allogeneic hematopoietic stem ce

Effect of leukocyte-reduced platelet-rich plasma on osteoarthritis caused by cranial cruciate ligament rupture: A canine gait analysis model.

The goal of this study was to objectively assess the effect of a platelet-rich plasma (PRP) derivate in English bulldogs with stifle degenerative joint disease secondary to cranial cruciate ligament rupture (CCLR). We used a force platform and affixed electrogoniometers to measure peak vertical force (PVF), vertical impulse (VI), stance time (ST), and angular range of motion (AROM), from 12 lame client-owned English bulldogs with post-CCLR stifle joint abnormalities. The 12 affected subjects were treated with 4 intra-articular injections of PRP, at 30-day intervals. Ten untreated, sound Englis

A single centre study on birth of children with transfusion-dependent thalassaemia in Malaysia and reasons for ineffective prevention.

OBJECTIVE: We aimed to identify factors contributing to ineffective prevention of thalassaemia in Malaysia by studying events leading to the births of children with transfusion-dependent thalassaemia (TDT) including their parents' reproductive choices. METHODS: Thirty children with TDT born in the year 2005 to 2012 were included. Their parents underwent a semi-structured, face-to-face interview in 2012 and were followed up until 2014 to evaluate the actual decisions made during subsequent pregnancy. RESULTS: In 70% of the cases (21/30), neither parent was aware of their carrier status until

A side-effect induced by the combination of a demineralized freeze-dried bone allograft and leucocyte and platelet-rich plasma during treatment for large bone cysts: a 4-year follow-up clinical study.

During platelet activation over 30 growth factors are released from their alpha granules. By concentrating platelets, higher levels of growth factors are obtained and can be used to stimulate the healing processes. Moreover, during blood centrifugation, huge numbers of leukocytes and thrombocytes can be obtained to form leukocyte and platelet-rich plasma (L-PRP). After platelet degranulation the active gelatinous matrix called leukocyte and platelet-rich gel (L-PRG) is formed. In the present clinical study, we report the influence of PLRG and freeze-dried allografts on healing of large femoral

Comparative effectiveness of injection therapies in lateral epicondylitis: a systematic review and network meta-analysis of randomized controlled trials.

BACKGROUND: Injection therapy with glucocorticoids has been used since the 1950s as a treatment strategy for lateral epicondylitis (tennis elbow). Lately, several novel injection therapies have become available. PURPOSE: To assess the comparative effectiveness and safety of injection therapies in patients with lateral epicondylitis. STUDY DESIGN: Systematic review and meta-analysis. METHODS: Randomized controlled trials comparing different injection therapies for lateral epicondylitis were included provided they contained data for change in pain intensity (primary outcome). Trials were asse

[Autotransfusion, with blood drained from a hemothorax, using the ConstaVac device].

The technique of autotransfusion with blood drained from a haemothorax has been described nearly 80 years ago. The shed blood is easy to collect and is incoagulable. This technique as two indications: lifesaving autotransfusion in the prehospital phase and blood saving and/or transfusional safety at hospital arrival. This prospective study assessed its value as well as the advantages and disadvantages of the ConstaVac system in 30 patients suffering from haemothorax. This apparatus consists of a 800 mL collecting reservoir on a support equipped with an electric aspirator and a battery. The col

[Hemostasis disorders after transfusions].

Disturbances of haemostasis caused immunologically and non-immunologically were observed after transfusion of blood and blood derivatives. Transfusion of heparin blood increased the bleeding susceptibility only in case of pre-existing high-degree defects of haemostasis or if they were performed as massive or exchange transfusions. Massive transfusions with blood stored for a long time will induce complex defects. Under intensive substitution therapy of haemophilia A the so-called paradoxical bleeding will occur in spite of a high factor VIII level. These bleedings are supposed to be disturbanc

Prevention of bleeding tendency after open-heart surgery for Tetralogy of Fallot.

Postoperative blood losses after open-heart surgery for Tetralogy of Fallot made re-operation imperative in 15 out of 44 patients (34%, Series A). A surgical bleeding point proved to be the causative factor in only 2 cases; the others were believed to be caused by disturbances of the haemostatic mechanism, particularly by low platelet counts, apparently due to extracorporeal circulation. Administration of a platelet suspension after disconnection of the extracorporeal circuit diminished the number of bleeding complications significantly: in a series of 58 patients (Series B), 8 re-operations (

Management of isoimmune neonatal thrombocytopenia.

Two infants, who presented at birth with isoimmune thrombocytopenic purpura, are the basis for this report. The problems confronting the physician in treating an affected infant, as well as in the management of subsequent pregnancies after an infant with isoimmunization has been delivered, are discussed. In view of the small but serious risk of intracranial hemorrhage during the birth process in these infants, delivery by cesarean section is advocated for all pregnancies known to be at risk i.e., after a previous infant has been shown to be affected.

Development and Internal Validation of a Multivariable Prediction Model for Postoperative Bleeding in Patients Undergoing Bariatric Surgery (The POD 1-DISCHARGE Calculator).

BACKGROUND: Postoperative bleeding is a potentially severe complication of bariatric surgery. reported in 1-4% of patients. Despite recognition of several risk factors. no validated multivariable model combining surgical and early postoperative laboratory data has been developed to support discharge decisions within Enhanced Recovery After Bariatric Surgery (ERABS) pathways. METHODS: We performed a retrospective cohort study of all patients undergoing laparoscopic sleeve gastrectomy or gastric bypass (Roux-en-Y or one-anastomosis) between January 2017 and December 2023 at a high-volume bariat

Effects of Intravenously Administered Plasma from Exercise-Trained Donors on Mitochondrial Respiration in a Rat Model of Alzheimer's Disease.

PURPOSE: Dysfunction of mitochondria is observed early in Alzheimer's disease (AD), possibly driving the pathogenesis of the disease. This study aims to assess whether plasma from exercise-trained donors can enhance mitochondrial function in a transgenic AD model and to gain insight into the proteomic profile of the donor plasma. METHODS: Male McGill-R-Thy1-APP rats (n = 3 per treatment group) were treated at either an early preplaque stage (2.2 months) or a later stage (5.2 months) with plasma from exercise-trained donors (ExPlas), sedentary donors (SedPlas), or saline. The rats received 14

Successful Right Upper Lung Segmentectomy after Esophagectomy: Utilization of 4K 3-Dimensional Endoscopy and Near-Infrared Fluorescence in High-Risk Surgery.

INTRODUCTION: Lung resection after open esophagectomy poses significant technical challenges, particularly when the reconstructed gastrointe … Rubina; Karl Storz, Tuttlingen, Germany). Adhesions were meticulously dissected, and intraoperative platelet transfusions were administered. NIR imaging with ICG identified the intersegmental plane and confirmed blood flow to the gastric tube, preventing ischemic complications. The lung segmentectomy was completed using staplers, preserving the right gastroepiploic ar …

Risk factors for bleeding complications in patients undergoing extracorporeal cardiopulmonary resuscitation following out-of-hospital cardiac arrest: a secondary analysis of the SAVE-J II study.

BACKGROUND: Bleeding is the most common complication in out-of-hospital cardiac arrest (OHCA) patients receiving extracorporeal cardiopulmonary resuscitation (ECPR). No studies comprehensively described the incidence rate, timing of onset, risk factors, and treatment of bleeding complications in OHCA patients receiving ECPR in a multicenter setting with a large database. This study aimed to analyze the risk factors of bleeding during the first day of admission and to comprehensively describe details of bleeding during hospitalization in patients with OHCA receiving ECPR in the SAVE-J II study

Bendamustine is safe and effective for lymphodepletion before tisagenlecleucel in patients with refractory or relapsed large B-cell lymphomas.

BackgroundAnti-CD19 chimeric antigen receptor T-cell immunotherapy (CAR-T) is now a standard treatment of relapsed or refractory B-cell non-Hodgkin lymphomas; however, a significant portion of patients do not respond to CAR-T and/or experience toxicities. Lymphodepleting chemotherapy is a critical component of CAR-T that enhances CAR-T-cell engraftment, expansion, cytotoxicity, and persistence. We hypothesized that the lymphodepletion regimen might affect the safety and efficacy of CAR-T.Patients and methodsWe compared the safety and efficacy of lymphodepletion using either fludarabine/cycloph

Monocentric Analysis of the Effectiveness and Financial Consequences of the Use of Lenograstim versus Filgrastim for Mobilization of Peripheral Blood Progenitor Cells in Patients with Lymphoma and Myeloma Receiving Chemotherapy and Autologous Stem Cell Transplantation.

PurposeGranulocyte-colony stimulating factors (G-CSFs) are widely used to mobilize CD34+ stem cells and to support the engraftment after hematopoietic stem cell transplantation (HSCT). A budget impact analysis and an incremental cost-effectiveness study of two G-CSFs (Lenograstim and Filgrastim biosimilar), considering engraftment, number of hospitalization days and number of G-CSF vials administered were performed.Patients and methodsBetween 2009 and 2016, 248 patients undergoing autologous HSCT have been evaluated and divided into three groups (100 Leno-Leno, 93 Leno-Fil, 55 Fil-Fil) accordi

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… The cost reported in Table 2 was then multiplied by the median number of aphereses, inpatient day, adverse events, platelet transfusions and G-CSF vial used in each group, to assess the differential economic impact of the use of different G-CSFs. … ’ transfusion | 35.00 d | Expert opinion based on hospital financial department’s data Platelets’ transfusion | 80.00 e | Expert opinion based on hospital financial department’s data Lenograstim vial | 50.59 | Filgrastim vial | 17.03 | Statistical Analysis All statistical analyses were performed …