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Association of human papillomavirus and Chlamydia trachomatis with intraepithelial alterations in cervix samples.

The influence of different infectious agents and their association with human papillomavirus (HPV) in cervical carcinogenesis have not been … erpes simplex virus 1 and 2,Neisseria gonorrhoeae, Mycoplasma genitalium, Trichomonas vaginalis, andTreponema pallidum, besides genotyping for most common high-risk HPV. An association between cytological lesions and different behavioural habits such as smoking and sedentariness was observed. Intraepithelial lesions were also associated with HPV and C. trac …

Individual composition of human leukocyte antigens and periodontopathogens in the background of periodontitis.

BACKGROUND: Human leukocyte antigens (HLAs) are a basic precondition to induce the immune response to pathogens. Therefore, this study evaluates associations among periodontitis, five key periodontopathic bacteria, and HLAs to test their impact together with additional risk factors in multivariate analyses. METHODS: Eighty-five patients with generalized aggressive periodontitis (GAgP) and 71 patients with generalized chronic periodontitis (CP) were compared to 88 periodontitis-free controls. HLA Class I and II typing was performed by polymerase chain reaction (PCR) with sequence-specific prim

The del/del genotype of the nuclear factor-kappaB -94ATTG polymorphism and its relation to aggressive periodontitis.

BACKGROUND AND OBJECTIVE: Periodontitis is influenced by specific host-dependent immune responses. Periodontopathogens induce innate immune responses, amongst others, via toll-like receptor 2 (TLR2), resulting in activation of the nuclear transcription factor nuclear factor-kappaB (NF-kappaB). The aim of this case-control study was to evaluate links between genetic variants of these genes and chronic/aggressive periodontitis in a multivariate model. MATERIAL AND METHODS: A total of 141 patients with periodontitis (63 with chronic periodontitis and 78 with aggressive periodontitis) and 81 cont

Комплексное исследование двустороннего взаимодействия между микробиомами человека и злокачественными заболеваниями крови и гематологическими условиями: акцент на новых терапевтических стратегиях.

Микробиота человека играет ключевую роль в поддержании хомостаза, регулируя иммунную реакцию, метаболизм и гематопоисис. Микробиальный дисбиоз все чаще ассоциируется с иммунной дисфункцией, воспалением и аномалиями костного мозга, которые могут привести к гематологическим заболеваниям. В настоящем обзоре резюмируются текущие данные о роли микробиота в нормальном гематопоисе и ее потенциальной причастности к доброкачественным и злокачественным гематологическим расстройствам.МЕТОДЫ: Обзор описательной литературы был проведен на основе всестороннего поиска основных научных баз данных без временны

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… Enhanced iron bioavailability was found to exacerbate periodontitis severity and facilitate the proliferation of periopathogens such as Treponema . … Similarly, the genus Treponema was found to promote immune thrombocytopenia via VEGF‐A mediation, with an effect size of 0.045873 representing 4.28% of the total effect. …

Infectious Diseases

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… (erythema marginatum, subcutaneous nodules) gram - negative cocci —meningococcemia (purpura), disseminated gonococcal infection gram - negative bacilli — Salmonella typhi , Pseudomonas (ecythema gangrenosum), Vibrio vulnificus endocarditis spirochetes — Borrelia burgdorferi (Lyme erythema migrans), Treponema … Trace and treat all partners within the last 60 days SYPHILIS pathophysiology — Treponema pallidum infection. …

Antibiotic therapy for adults with neurosyphilis.

BACKGROUND: Neurosyphilis is an infection of the central nervous system, caused by Treponema pallidum, a spirochete capable of infecting almost any organ or tissue in the body causing neurological complications due to the infection. This disease is a tertiary manifestation of syphilis. The first-line treatment for neurosyphilis is aqueous crystalline penicillin. However, in cases such as penicillin allergy, other regimes of antibiotic therapy can be used. OBJECTIVES: To assess the clinical effectiveness and safety of antibiotic therapy for adults with neurosyphilis. SEARCH METHODS: We search…

Donor Evaluation for Hematopoietic Stem and Progenitor Cell Collection

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… the months of June 1 and October 31 b Evaluation for Chagas disease in draft guidance RCDAD | Evaluation | Specifically listed in CFR | Screening | Testing HIV types 1 and 2 | X | X Hepatitis B | X | X Hepatitis C | X | X HTLV types 1 and 2 | X | X Creutzfeldt-Jakob disease (CJD)/variant CJD | X | Treponema … In accordance with FDA regulation, laboratory testing using FDA-approved assays must be performed on the donor’ blood for, at least, the following infectious disease agents: human immunodeficiency virus 1 and 2 (HIV 1 and 2), hepatitis B virus (HBV), hepatitis C (HCV), Treponema pallidum (syphilis), …

Odanacatib, A Cathepsin K-Specific Inhibitor, Inhibits Inflammation and Bone Loss Caused by Periodontal Diseases.

BACKGROUND: Periodontitis is a bacteria-induced inflammatory disease mainly affecting periodontal tissues, leading to periodontal inflammation, bone breakdown, and loss of the tooth. The main obstacle for treating periodontitis effectively is the difficulty in finding a target that can inhibit bone loss and inflammation simultaneously. Recent studies showed that cathepsin K (CTSK) might have functions in the immune system besides its role in osteoclasts. Thus, targeting CTSK would have a potential therapeutic effect in both the bone system and the immune system during the progression of period

Differential expression of mitogen activating protein kinases in periodontitis.

AIM: Following toll-like receptor (TLR) engagement, lipopolysaccharide (LPS) can stimulate the expression of pro-inflammatory cytokines thus activating the innate immune response. The production of inflammatory cytokines results, in part, from the activation of kinase-induced signalling cascades and transcriptional factors. Of the four distinct classes of mitogen-activated protein kinases (MAPK) described in mammals, p38, c-Jun N-terminal activated kinases (JNK1-3) and extracellular activated kinases (ERK1,2) are the best studied. Previous data have established that p38 MAPK signalling is requ

Infectious Diseases

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

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… (erythema marginatum, subcutaneous nodules) gram-negative cocci —meningococcemia (purpura), disseminated gonococcal infection gram-negative bacilli — S almonella typhi, Pseudomonas (ecythema gangrenosum), Vibrio vulnificus endocarditis spirochetes — Borrelia burgdorferi (Lyme erythema migrans), Treponema … Trace and treat all partners within the last 60 days Syphilis pathophysiology — Treponema pallidum infection. …

[Differential analysis of intestinal flora in patients with hepatic blastomycosis based on second-generation sequencing].

Exploring the variability of the intestinal flora of patients with hepatic blastocysticercosis and searching for members of the intestinal m … top 6 in terms of abundance of Anaplasma, Escherichiaceae, Clostridium, Alternaria, Ruminalia, and Treponema spp. at the genus level; whereas, Segatella, Prevotella, E. faecalis, Rossella, and beneficial rod-shaped bacteria were more abundant in the NC group. There were differences in the abundance and diversity of intestinal flora between the two groups, …

Multisystemic sarcoidosis-important lessons learnt from one of the great imitators.

We report a case of a woman who was admitted with a suspicion of metastatic malignancy of unknown primary origin. A few months prior to her admission, she presented to a rheumatologist with acute anterior uveitis, psoriasiform rashes and polyarthritis. A diagnosis of psoriatic arthropathy was made and she was treated accordingly. Soon after she presented with persistent back and right upper quadrant abdominal pain for which she had a CT scan done with evidence of hilar lymphadenopathy, liver hypodensities and lytic-sclerotic bone lesions. She was referred to our hospital for further investigat

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… A triad of histopathological changes characteristically found includes: reactive follicular hyperplasia, epitheloid histiocytes and monocytoid cells. 28 29 Syphilis Treponemal infections due to Treponema pallidum subspecies pallidum result in chronic granulomatous disorders that often cause diagnostic … N Engl J Med 1973 ; 289 : 878 – 81 . 10.1056/NEJM197310252891702 4580783 30 Tramont EC Treponema pallidium (syphilis) : Mandell GL , Bennett JE , Dolin R , Mandell, Douglas and Bennett’s principles and practice of infectious diseases . 4th edn New York : Churchill Livingstone , 1995 : 2117 – 33 . 31 …

Infiltrative and inflammatory systemic disorders involving the pituitary gland.

The hypothalamic-pituitary region can be affected by a wide and heterogeneous group of infiltrative and inflammatory disorders, including granulomatous, histiocytic, storage, infectious, non-pituitary neoplastic, and autoimmune or inflammatory conditions collectively grouped as hypophysitis. Although individually rare, these disorders are increasingly recognized due to growing awareness, wider use of pituitary imaging, and the emergence of immune checkpoint inhibitor-induced hypophysitis. They typically present with hypopituitarism (often including arginine vasopressin deficiency, which, parti

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… granulomatosis with polyangiitis, tuberculosis, fungal granulomatous infections, Tolosa-Hunt syndrome Histiocytic disorders | Langerhans cell histiocytosis, Erdheim-Chester disease, Rosai-Dorfman disease Storage disorders | Hemochromatosis (iron deposition), amyloidosis Infectious disorders | Neurosyphilis ( Treponema … discrete pituitary mass; pituitary dysfunction is rare; more commonly associated with thyroid, adrenal, pancreatic or testicular involvement | Treatment of the underlying systemic amyloidosis; hormone replacement only if a deficiency is confirmed (rare) Syphilis (neurosyphilis) | Sexually transmitted (Treponema …

Impact of Periodontal Host-Modulation Therapies on Oral-Gut Microbiome Axis in Periodontitis Patients with Hematological Diseases: A Narrative Review.

Host-modulating therapies and oral microbiome-targeted approaches are emerging options in periodontal care and are especially relevant for patients undergoing immunotherapy for hematologic malignancies. Immune dysregulation induced by immune checkpoint inhibitors or CAR-T cell therapy may worsen periodontal inflammation and alter the composition and functions of the oral microbiota. Beyond these, other immunomodulatory treatments commonly employed in hematologic malignancies-including monoclonal antibodies (e.g., rituximab, daratumumab), immunomodulatory drugs (e.g., lenalidomide, thalidomide)

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… At the oral level, dysbiosis is characterized by an increase in proteolytic, anaerobic, and asaccharolytic species such as Porphyromonas gingivalis ( P. gingivalis ), Tannerella forsythia , and Treponema denticola , accompanied by a reduction in commensal genera such as Streptococcus and Actinomyces … However, in periodontitis, environmental changes—such as inflammation, increased gingival crevicular fluid, and immune alterations—select for opportunistic and proteolytic bacteria, including Porphyromonas gingivalis , Tannerella forsythia , and Treponema denticola. …

Обзор необщей внеэпиптической центральной нервной системы (СКС) симптомов заражения вирусом гепатита С (ГКВ): доклад по делу.

Цель настоящего доклада состоит в том, чтобы пролить свет на все более описываемый сценарий внеэптических проявлений центральной нервной системы (СНС) инфекции гепатита С (ГКВ). Мы представляем возможный редкий случай острого распространенного энцефаломиэлита, который проявляется как повреждения кольца на магнитно-резонансной съемке (MRI) в исследовании головы, проведенном на джентльмене в возрасте 50 лет, который представил в больницу неврологические характеристики, с явной демонстрацией рипонуклеиновой кислоты (RNA) в пробах цереброспайнальной жидкости пациента. Был также рассмотрен вопрос о

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… Table 2 Pathological test results CSF: cerebrospinal fluid; PCR: polymerase chain reaction; ANA: antinuclear antibodies; ANCA: antibodies against neutrophil cytoplasm Tests Result Serum Borrelia burgdorferi IgG and IgM screens Negative Treponema pallidum serology screen Negative CSF Aspergillus …

Disappearance of femoral head shortly after femoral neck fracture: a case report and literature review.

This case report describes a woman in her 70s who presented with a 3-month history of hip pain and inability to walk. Upon admission, she was diagnosed with the extremely rare condition of complete femoral head disappearance. A comprehensive examination was conducted to determine the cause and devise an effective treatment strategy, taking the patient's medical history into account. Through interdisciplinary discussions, occult infection and other potential causes were ruled out. The femoral head disappearance was ultimately determined to be due to wear, ischemia, and absorption following a fr

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… B e antibody (chemiluminescence); HBcAb, anti-hepatitis B core antibody (chemiluminescence); HCVAb, anti-hepatitis C virus antibody (chemiluminescence); HEV-IgG, anti-hepatitis E virus IgG antibody (chemiluminescence); HEV-IgM, anti-hepatitis E virus IgM antibody (chemiluminescence); anti-TP, anti- Treponema …

Osteonecrosis of the jaws in patients treated with bisphosphonates.

The literature describes an increasing presence of bisphosphonate-induced osteonecrosis of the jaws (ONJ), characterized by the exposure for over 8 weeks of necrotic bone in the maxillofacial region, after bisphosphonate therapy, in the absence of prior maxillary radiotherapy. The present literature review examines the etiopathogenesis, risk factors, clinical forms, diagnosis, treatment and prevention of bisphosphonate-induced ONJ. In addition, a review is made of all the series involving over 15 patients diagnosed with this disorder between 1 January 2011 and 15 May 2011. A PubMed-Medline sea

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… characteristics of alveolar bone, its fine overlying epithelial layer, mechanical stress caused by chewing, inflammatory processes (periodontitis), and a complex oral microbiota involving the presence of bacteria such as Fusobacterium, Bacillus, Actinomyces, Staphylococcus, Streptococcus, Selenomonas and Treponema …

Двусторонний спонтанный диализ сетчатки в промежуточном увейтете, связанном с множественным склерозом: необычный случай.

ЦЕЛЬ: Сообщить о случае регматального сетчатого отсека (RRD), вызванного спонтанным диализом сетчатки в промежуточном увейтете из-за множественного склероза (MS). ЗАМЕЧАНИЯ: 29-летняя женщина из Ближнего Востока получила диагноз MS после случая двустороннего промежуточного увеита. Позже она представила последовательность RRD в обоих глазах. Пациент перенёс 25-футовый план витректомию. Внезапно был отмечен диализ сетчатки из-за тяги на витроусовой базе. Было также отмечено, что из-за ишемии утонченная сетчатка позвоночника. Постактивно, она восстановила свою зрительную привлекательность в обоих

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… Her initial blood workup included complete blood count (CBC), liver and renal function test, Mantoux test, antinuclear antibody (ANA), antineutrophilic cytoplasmic antibody (ANCA), treponema pallidum antibodies, HLA B-27 along with magnetic resonance imaging (MRI) and fundus fluorescein angiography ( …

Human Amniotic Membrane Dressing as a Non-Surgical Alternative for Extensive Chronic Ulcers: A Comparative Case Study.

Chronic wound management remains a significant clinical challenge, requiring adaptive therapeutic approaches to achieve wound closure that nonetheless frequently prove fruitless. Balancing the initial pro-inflammatory response with debris removal and tissue rebuilding remains elusive in most cases, leading to pain, drastic quality-of-life deterioration, and, eventually, amputation. Meanwhile, patient adherence is an overarching theme. Furthermore, non-surgical alternatives that effectively promote tissue rebuilding are essential for patients seeking to avoid further invasive procedures. We rep

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… Together with placentas, a blood sample from the mother is provided and assessed for HIV, HBV, HCV, CMV, HTLV, Treponema pallidum , Brucella spp., Trypanosoma cruzi, and Toxoplasma gondii. …

Новальная граница в исследовании оксиса Гут-Брэйна: трансплантация фекалий микробиота в неевродегенеративных расстройствах.

Ось кишечника (GBA) представляет собой сложную двунаправленную систему связи, соединяющую центральную нервную систему (CNS) и желудочно-кишечный тракт (GI). Такое взаимодействие происходит главным образом через нейронные, иммунные и метаболические пути. Дисбиоз в кишечной микробиоте связан с многочисленными нейродегенеративными заболеваниями, такими, как болезнь Паркинсона (PD), болезнь Альцгеймера (AD), множественный склероз (MS) и амиотропический боковой склероз (ALS). В последние годы в качестве новаторского терапевтического подхода к трансплантации фекальной микробиоты (ФМТ) была привлечен

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… Blood Testing: (1) Bacteria: Treponema pallidum (syphilis) is screened to prevent transmission risks. (2) Viruses: Comprehensive testing includes Hepatitis A , B , C , and Human Immunodeficiency Virus (HIV). …